HBV VIS Detail Information

> This page shows VIS [1006563] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 1006563
VISID TVIS10016705
Chromosome chr1
GRCh38 Location 1674987
Disease Hepatocellular carcinoma  
Sample Tumor
Virus Reference Genome Not given
Target Gene CAMTA1     
Literature Information
PubMed PMID 23842217
Published year 2014
Journal Journal of clinical gastroenterology
Title Impact of hepatitis B virus integration into liver tissue on the efficacy of peginterferon and ribavirin therapy in hepatitis B virus-negative chronic hepatitis C patients.
Author Toyoda H,Kumada T,Tada T,Murakami Y
Evidence BACKGROUND: Integration of hepatitis B virus (HBV) DNA into host hepatic DNA is found in patients without HBV surface antigen (HBsAg). We investigated the prevalence of HBV integration and its association with the outcome of peginterferon (PEG-IFN) and ribavirin combination therapy in HBsAg-negative chronic hepatitis C patients. HBV integration was measured by an Alu-PCR assay with liver specimens obtained by needle biopsy before treatment. RESULTS: HBV integration was identified in 54 of the 157 (34. There were no significant differences between patients with and without HBV integration with regard to baseline characteristics including liver histology, pretreatment HCV RNA levels, and genetic polymorphisms near the IL28B gene. In patients with HCV genotype 1b (n=91), a more favorable viral response was observed in patients with HBV integration during therapy, with higher rates of rapid and complete early virologic response. The rate of sustained virologic response (SVR) was significantly higher in patients with HBV integration than those without (P=0. Multivariate analysis identified HBV integration and IL28B polymorphisms as independent factors associated with SVR. CONCLUSIONS: HBV integration was associated with favorable viral responses and a higher SVR rate to combination therapy with PEG-IFN and ribavirin in patients infected with HCV genotype 1b.

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