HBV VIS Detail Information

> This page shows VIS [1003269] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	26553052
Published year	2016
Journal	Journal of gastroenterology
Title	Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features.
Author	Kawai-Kitahata F,Asahina Y,Tanaka S,Kakinuma S,Murakawa M,Nitta S,Watanabe T,Otani S,Taniguchi M,Goto F,Nagata H,Kaneko S,Tasaka-Fujita M,Nishimura-Sakurai Y,Azuma S,Itsui Y,Nakagawa M,Tanabe M,Takano S,Fukasawa M,Sakamoto M,Maekawa S,Enomoto N,Watanabe M
Evidence	In hepatitis B surface antigen (HBs Ag)-positive HCC without TERT promoter mutations, HBV integration into TERT locus was found in 47% patients and was mutually exclusive to TERT promoter mutations. CONCLUSIONS: Gene alterations in TERT promoter, TP53, CTNNB1, and HBV integration were closely associated with HCC development, and mutations in TERT promoter are related to poor prognosis.