Literature Information
PubMed PMID
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24582836
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Published year
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2014 |
Journal
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Cancer cell |
Title
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Viral-human chimeric transcript predisposes risk to liver cancer development and progression. |
Author
|
Lau CC,Sun T,Ching AK,He M,Li JW,Wong AM,Co NN,Chan AW,Li PS,Lung RW,Tong JH,Lai PB,Chan HL,To KF,Chan TF,Wong N |
Evidence
|
By Sanger sequencing, we confirmed all VFS-identified viral-human transcripts. Moreover, RNA sequences obtained in the chimeras matched the flanking virus-host juncture of genomic sites with identical overlapping microhomologies,In addition to directing viral integrations in cellular genes, an integration event in genomic regions that have undergone possible complex genomic rearrangement was found in two cases: a CDHR3-TRRAP fusion and a chr.5q14-RALGPS1 fusion.
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