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HBV VIS Detail Information

> This page shows VIS [1002179] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 1002179
VISID TVIS10014880
Chromosome chr4
GRCh38 Location 54042613, 54049074
Disease Hepatocellular carcinoma  
Sample Cell line
Virus Reference Genome NC_003977.1
Target Gene CHIC2     
Literature Information
PubMed PMID 24582836
Published year 2014
Journal Cancer cell
Title Viral-human chimeric transcript predisposes risk to liver cancer development and progression.
Author Lau CC,Sun T,Ching AK,He M,Li JW,Wong AM,Co NN,Chan AW,Li PS,Lung RW,Tong JH,Lai PB,Chan HL,To KF,Chan TF,Wong N
Evidence By Sanger sequencing, we confirmed all VFS-identified viral-human transcripts. Moreover, RNA sequences obtained in the chimeras matched the flanking virus-host juncture of genomic sites with identical overlapping microhomologies,In addition to directing viral integrations in cellular genes, an integration event in genomic regions that have undergone possible complex genomic rearrangement was found in two cases: a CDHR3-TRRAP fusion and a chr.5q14-RALGPS1 fusion.
Contents
Description
  • Site Information
Detail information of site [1002179]
  • Literature Information
The details of literature that this site is associated with.