HBV VIS Detail Information

> This page shows VIS [1000225] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	25627239
Published year	2015
Journal	Hepatology (Baltimore, Md.)
Title	Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma.
Author	Yan H,Yang Y,Zhang L,Tang G,Wang Y,Xue G,Zhou W,Sun S
Evidence	Here, we report a comparative study of HBV subgenotypes and integration in early- (/=70) HBV-associated HCC using a novel high-throughput viral integration detection method. HBV integration is a common phenomenon, both in early- and late-onset HCC, which favors integrating into human repeat regions. HBV integrating this site results in c-MYC, PVT1, and microRNA-1204 overexpression in tumors, thereby potentially contributing to the development of early-onset HCC. CONCLUSION: HBV genotype and integration patterns may be distinct in early-onset HCC. Further studies are needed to elucidate at which time in tumor development this integration event occurs and whether it plays an important, causative role in HCC development or progression.