HBV VIS Detail Information

> This page shows VIS [1000165] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

DVID	1000165
VISID	TVIS10015723
Chromosome	chr6
GRCh38 Location	4136097
Disease	Hepatocellular carcinoma
Sample	Adjacent tissue
Virus Reference Genome	AY800389.1;AY800390.1;AY800391.1;AY800392.1
Target Gene	ECI2-DT

Literature Information

PubMed PMID	23236287
Published year	2012
Journal	PLoS genetics
Title	Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach.
Author	Ding D,Lou X,Hua D,Yu W,Li L,Wang J,Gao F,Zhao N,Ren G,Li L,Lin B
Evidence	Integration of the viral DNA into host chromosomes was found in most of the hepatitis B virus (HBV)-related hepatocellular carcinomas (HCCs). Applying MAPS to 40 pairs of HBV-related HCC tissues (cancer and adjacent tissues), we identified 296 HBV integration events corresponding to 286 unique integration sites (UISs) with precise HBV-Human DNA junctions. HBV integration favored chromosome 17 and preferentially integrated into human transcript units. Fewer integration events were found in cancers compared to cancer-adjacent tissues, suggesting a clonal expansion model in HCC development. Finally, we identified 8 genes that were recurrent target genes by HBV integration including fibronectin 1 (FN1) and telomerase reverse transcriptase (TERT1), two known recurrent target genes, and additional novel target genes such as SMAD family member 5 (SMAD5), phosphatase and actin regulator 4 (PHACTR4), and RNA binding protein fox-1 homolog (C. Integrating analysis with recently published whole-genome sequencing analysis, we identified 14 additional recurrent HBV target genes, greatly expanding the HBV recurrent target list. This global survey of HBV integration events, together with recently published whole-genome sequencing analyses, furthered our understanding of the HBV-related HCC.