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HBV Target gene Detail Information

> SERPINE1 Gene Search Result


Gene Information
Gene Name SERPINE1
Gene ID 5054
Gene Full Name serpin family E member 1
Gene Alias PAI; PAI1; PAI-1; PLANH1
Transcripts ENSG00000106366
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Predicted to be secreted;
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins
Uniport_ID P05121
HGNC ID HGNC:8583
VEGA ID OTTHUMG00000157107
OMIM ID 173360
String ID 9606.ENSP00000223095
Drugbank ID BE0000240
PharmGKB ID PA261
Target gene [SERPINE1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1404527 chr7 18 4 22 View
1404531 chr7 18 4 22 View
1404536 chr7 18 4 22 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of SERPINE1 expression and immune infiltrating cell level correlation result in HBV+ samples
SERPINE1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).