HIV Target gene Detail Information

> PTPN1 Gene Search Result

Gene Information

Gene Name	PTPN1
Gene ID	5770
Gene Full Name	protein tyrosine phosphatase, non-receptor type 1
Gene Alias	PTP1B
Transcripts	ENSG00000196396
Virus	HIV
Gene Type	protein coding
HPA Location Info	Endoplasmic reticulum;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	P18031
HGNC ID	HGNC:9642
VEGA ID	OTTHUMG00000032729
OMIM ID	176885
String ID	9606.ENSP00000360683
Drugbank ID	BE0000623
PharmGKB ID	PA33985

Target gene [PTPN1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000194	chr20	163	249	350	762	View
4001225	chr20	20	156	15	191	View
4003392	chr20	41	11	10	62	View
4008241	chr20	9	4	3	16	View
4008775	chr20	10	4		14	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PTPN1 expression and immune infiltrating cell level correlation result in HIV+ samples
PTPN1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PTPN1 expression and immune infiltrating cell level correlation result in HIV+ samples
PTPN1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).