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HPV Target gene Detail Information

> NR4A2 Gene Search Result


Gene Information
Gene Name NR4A2
Gene ID 4929
Gene Full Name nuclear receptor subfamily 4 group A member 2
Gene Alias NOT; RNR1; HZF-3; NURR1; TINUR
Transcripts ENSG00000153234
Virus HPV
Gene Type protein coding
HPA Location Info Nuclear speckles;
HPA Protein Class Info Cancer-related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Uniport_ID P43354
HGNC ID HGNC:7981
VEGA ID OTTHUMG00000131950
OMIM ID 601828
String ID 9606.ENSP00000344479
PharmGKB ID PA31762
Target gene [NR4A2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5000055 chr2 5726 4311 1949 11986 View
5000342 chr2 274 16 290 View
5000377 chr2 230 22 252 View
5000386 chr2 221 24 245 View
5000786 chr2 85 85 View
5001446 chr2 27 7 34 View
5003601 chr2 2 1 3 View
5401100 chr2 845 423 529 1797 View
5401108 chr2 151 2 153 View
5401109 chr2 132 1 133 View
5402655 chr2 21 7 2 30 View
5402656 chr2 1 5 6 View
5402685 chr2 2 1 3 View
5404314 chr2 873 536 179 1588 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of NR4A2 expression and immune infiltrating cell level correlation result in HPV+ samples
NR4A2 expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of NR4A2 expression and immune infiltrating cell level correlation result in HPV+ samples
NR4A2 expression: Low -> High

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of NR4A2 expression and immune infiltrating cell level correlation result in HPV+ samples
NR4A2 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of NR4A2 expression and immune infiltrating cell level correlation result in HPV+ samples
NR4A2 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of NR4A2 expression and immune infiltrating cell level correlation result in HPV+ samples
NR4A2 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of NR4A2 expression and immune infiltrating cell level correlation result in HPV+ samples
NR4A2 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of NR4A2 expression and immune infiltrating cell level correlation result in HPV+ samples
NR4A2 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of NR4A2 expression and immune infiltrating cell level correlation result in HPV+ samples
NR4A2 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of NR4A2 expression and immune infiltrating cell level correlation result in HPV+ samples
NR4A2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).