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HIV Target gene Detail Information

> MDC1 Gene Search Result


Gene Information
Gene Name MDC1
Gene ID 9656
Gene Full Name mediator of DNA damage checkpoint 1
Gene Alias NFBD1
Transcripts ENSG00000224587
Virus HIV
Gene Type protein coding
HPA Location Info Nuclear bodies;Nucleoplasm;
HPA Protein Class Info Cancer-related genes, Predicted intracellular proteins
Gene Function Suppressor gene
Uniport_ID Q14676
HGNC ID HGNC:21163
VEGA ID OTTHUMG00000004846
OMIM ID 607593
String ID 9606.ENSP00000365588
PharmGKB ID PA134942837
Target gene [MDC1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4000896 chr6 186 54 13 253 View
4000952 chr6 186 44 10 240 View
4000957 chr6 186 43 10 239 View
4000973 chr6 186 40 10 236 View
4000993 chr6 185 39 7 231 View
4000996 chr6 185 39 6 230 View
4000997 chr6 185 39 6 230 View
4000998 chr6 185 39 6 230 View
4000999 chr6 185 39 6 230 View
4001000 chr6 185 39 6 230 View
4001001 chr6 185 39 6 230 View
4001002 chr6 185 39 6 230 View
4001003 chr6 185 39 6 230 View
4001006 chr6 184 39 6 229 View
4001017 chr6 183 39 6 228 View
4001018 chr6 183 39 6 228 View
4001019 chr6 183 39 6 228 View
4001020 chr6 183 39 6 228 View
4001021 chr6 183 39 6 228 View
4001022 chr6 183 39 6 228 View
4001023 chr6 183 39 6 228 View
4001024 chr6 183 39 6 228 View
4001025 chr6 183 39 6 228 View
4001030 chr6 182 39 6 227 View
4001031 chr6 182 39 6 227 View
4001032 chr6 182 39 6 227 View
4001065 chr6 177 38 6 221 View
4001097 chr6 174 35 6 215 View
4001104 chr6 174 34 6 214 View
4001512 chr6 149 6 155 View
4002026 chr6 111 5 116 View
4002843 chr6 75 2 77 View
4003556 chr6 50 9 59 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of MDC1 expression and immune infiltrating cell level correlation result in HIV+ samples
MDC1 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of MDC1 expression and immune infiltrating cell level correlation result in HIV+ samples
MDC1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).