HIV Target gene Detail Information

> ATM Gene Search Result

Gene Information

Gene Name	ATM
Gene ID	472
Gene Full Name	ATM serine/threonine kinase
Gene Alias	AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
Transcripts	ENSG00000149311
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Vesicles;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	Q13315
HGNC ID	HGNC:795
VEGA ID	OTTHUMG00000166480
OMIM ID	607585
String ID	9606.ENSP00000278616
Drugbank ID	BE0004823; BE0004874
PharmGKB ID	PA61

Target gene [ATM] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000627	chr11	245	52	42	339	View
4002966	chr11	67	4	2	73	View
4006003	chr11	21	6	1	28	View
4006275	chr11	21	5		26	View
4006669	chr11	18	1	4	23	View
4007898	chr11	13	4		17	View
4009729	chr11	11			11	View
4013389	chr11	1	2		3	View
4014844	chr11	1	1		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ATM expression and immune infiltrating cell level correlation result in HIV+ samples
ATM expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ATM expression and immune infiltrating cell level correlation result in HIV+ samples
ATM expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).