Home
Virus
Gene
Disease
Dataset
Download
Help
 
HBV Target gene Detail Information

> ALK Gene Search Result


Gene Information
Gene Name ALK
Gene ID 238
Gene Full Name ALK receptor tyrosine kinase
Gene Alias CD246; NBLST3
Transcripts ENSG00000171094
Virus HBV
Gene Type protein coding
HPA Location Info Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Gene Function Oncogene
Uniport_ID Q9UM73
HGNC ID HGNC:427
VEGA ID OTTHUMG00000152034
OMIM ID 105590
String ID 9606.ENSP00000373700
Drugbank ID BE0000359
Drug (Cytoscape Annotation) Alectinib;Sunitinib Malate;Crizotinib;Bosutinib;Ceritinib
PharmGKB ID PA24719
FDA Approved Drug Entrectinib;Ceritinib;Alectinib;Brigatinib;Crizotinib;Lorlatinib;Atezolizumab;Brentuximab Vedotin;Ipilimumab;Nivolumab;Pembrolizumab
Target gene [ALK] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1004714 chr2 22 10 39 71 View
1010813 chr2 4 5 2 11 View
1013545 chr2 4 1 5 View
1016459 chr2 1 1 View
1400559 chr2 21 14 4 39 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of ALK expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
ALK expression: Low -> High
Lollipop of ALK expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of ALK expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ALK expression and immune infiltrating cell level correlation result in HBV+ samples
ALK expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).