HBV Target gene Detail Information

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Gene Information

Gene Name	ALK
Gene ID	238
Gene Full Name	ALK receptor tyrosine kinase
Gene Alias	CD246; NBLST3
Transcripts	ENSG00000171094
Virus	HBV
Gene Type	protein coding
HPA Location Info	Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Gene Function	Oncogene
Uniport_ID	Q9UM73
HGNC ID	HGNC:427
VEGA ID	OTTHUMG00000152034
OMIM ID	105590
String ID	9606.ENSP00000373700
Drugbank ID	BE0000359
Drug (Cytoscape Annotation)	Alectinib;Sunitinib Malate;Crizotinib;Bosutinib;Ceritinib
PharmGKB ID	PA24719
FDA Approved Drug	Entrectinib;Ceritinib;Alectinib;Brigatinib;Crizotinib;Lorlatinib;Atezolizumab;Brentuximab Vedotin;Ipilimumab;Nivolumab;Pembrolizumab

Target gene [ALK] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1004714	chr2	22	10	39	71	View
1010813	chr2	4	5	2	11	View
1013545	chr2	4		1	5	View
1016459	chr2	1			1	View
1400559	chr2	21	14	4	39	View

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).