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Virus Dataset Sample Info

> Dataset: 33836203 Search Result


Summary
Item Summary
Project 33836203
Virus Name HBV
Sample Number 57
Disease Chronic hepatitis B
Country Egypt
Data Link https://www.ncbi.nlm.nih.gov/nuccore/?term=LC542810:LC542866[pacc]

Sample
ID Sample ID Age Gender Origin Detail
1 Eg1 44 M Egypt View
2 Eg2 49 M Egypt View
3 Eg3 41 F Egypt View
4 Eg4 50 M Egypt View
5 Eg5 40 M Egypt View
6 Eg6 43 M Egypt View
7 Eg7 47 F Egypt View
8 Eg8 50 M Egypt View
9 Eg9 49 F Egypt View
10 Eg10 42 M Egypt View
11 Eg11 49 F Egypt View
12 Eg12 50 M Egypt View
13 Eg13 52 F Egypt View
14 Eg14 59 M Egypt View
15 Eg15 46 M Egypt View
16 Eg16 48 F Egypt View
17 Eg17 52 M Egypt View
18 Eg18 39 F Egypt View
19 Eg19 42 M Egypt View
20 Eg20 38 F Egypt View
21 Eg21 43 F Egypt View
22 Eg22 47 M Egypt View
23 Eg23 55 F Egypt View
24 Eg24 52 M Egypt View
25 Eg25 48 F Egypt View
26 Eg26 40 F Egypt View
27 Eg27 53 F Egypt View
28 Eg28 55 M Egypt View
29 Eg29 54 M Egypt View
30 Eg30 41 F Egypt View
31 Eg31 46 M Egypt View
32 Eg32 43 F Egypt View
33 Eg33 56 F Egypt View
34 Eg34 51 F Egypt View
35 Eg35 46 F Egypt View
36 Eg36 40 F Egypt View
37 Eg37 54 F Egypt View
38 Eg38 46 F Egypt View
39 Eg39 47 F Egypt View
40 Eg40 53 M Egypt View
41 Eg41 49 F Egypt View
42 Eg42 52 M Egypt View
43 Eg43 49 M Egypt View
44 Eg44 42 M Egypt View
45 Eg45 46 M Egypt View
46 Eg46 51 F Egypt View
47 Eg47 57 F Egypt View
48 Eg48 44 M Egypt View
49 Eg49 39 F Egypt View
50 Eg50 50 M Egypt View
51 Eg51 49 M Egypt View
52 Eg52 41 F Egypt View
53 Eg53 47 M Egypt View
54 Eg54 45 F Egypt View
55 Eg55 52 F Egypt View
56 Eg56 39 M Egypt View
57 Eg57 42 F Egypt View

Literature
Item Summary
PMID 33836203
Title Natural variability in surface antigen and reverse transcriptase domain of hepatitis B virus in treatment-naive chronic HBV-infected Egyptian patients.
Abstract Hepatitis B virus (HBV) infection is a serious health problem not only in Egypt, but also worldwide. We collected 57 serum samples from treatment-naive chronic HBV-infected Egyptians. The DNA encoding hepatitis surface antigen (HBsAg) and reverse transcriptase (RT) domain was partially sequenced. All viral isolates belonged to genotype D with ayw2 as a predominant serotype (89%). Regarding HBsAg, 45 substitutions were detected in the collected isolates. Eleven substitutions were found in the major hydrophilic region, including two novel ones (M103 T, G130E) that were not correlated before with genotype D. Additionally, 11 occult samples (19%) were detected, in which the predominant mutations of HBsAg was S143 L (7 samples) followed by D144A and T125 M (4 samples each). Concerning the RT domain, 26 isolates (45%) harbored 19 natural mutations that were reported to be associated with antiviral resistance. Eleven different mutations were not correlated previously with genotype D. The most predominant mutation was Y124H (47 samples, 82%). Interestingly, such mutation was detected in 91% of the uploaded sequences of Egyptian HBV isolates to the GenBank (157 sequences). Furthermore, our data revealed the presence of viral quasispecies in HBsAg (10 samples, 17.5%) and RT domain (9 samples, 15.7%). In conclusion, we elucidated natural substitutions in HBsAg and RT domain of HBV isolates obtained from treatment-naive chronic HBV-infected Egyptian patients. Additionally, we detected viral quasispecies and revealed Y124H as a characteristic substitution in the RT domain for Egyptian HBV isolates. Moreover, novel substitutions in HBsAg and RT domain were reported with genotype D.