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> Dataset: 33539355 Search Result


Summary
Item Summary
Project 33539355
Virus Name HTLV1
Sample Number 59
Disease HTLV1 infection
Country China

Sample
ID Sample ID Age Gender Origin Detail
1 1 47 F China View
2 2 41 M China View
3 3 22 F China View
4 4 31 M China View
5 5 20 M China View
6 6 20 F China View
7 7 23 M China View
8 8 55 F China View
9 9 55 M China View
10 10 42 M China View
11 11 39 M China View
12 12 37 F China View
13 13 47 M China View
14 14 50 F China View
15 15 35 M China View
16 16 31 M China View
17 17 34 F China View
18 18 40 M China View
19 19 32 F China View
20 20 41 F China View
21 21 53 M China View
22 22 23 M China View
23 23 53 M China View
24 24 35 F China View
25 25 43 F China View
26 26 35 M China View
27 27 30 F China View
28 28 60 F China View
29 29 48 M China View
30 30 29 M China View
31 31 42 M China View
32 32 39 F China View
33 33 48 F China View
34 34 48 M China View
35 35 44 M China View
36 36 39 M China View
37 37 30 M China View
38 38 35 M China View
39 39 43 M China View
40 40 32 M China View
41 41 50 M China View
42 42 25 M China View
43 43 48 M China View
44 44 44 M China View
45 45 37 M China View
46 46 39 M China View
47 47 48 M China View
48 48 44 M China View
49 49 19 F China View
50 50 39 F China View
51 51 47 M China View
52 52 30 M China View
53 53 35 M China View
54 54 43 F China View
55 55 32 M China View
56 56 49 F China View
57 57 53 M China View
58 58 48 F China View
59 59 19 F China View

Literature
Item Summary
PMID 33539355
Title Prevalence and evolutionary analyses of human T-cell lymphotropic virus in Guangdong province, China: Transcontinental and Japanese subtype lineages dominate the prevalence.
Abstract To systematically characterize the prevalence and evolution of human T-cell lymphotropic virus (HTLV) infection among voluntary blood donors (BDs) in Guangdong province, China. A three-year survey for HTLV epidemiology among BDs was performed in Guangdong during 2016-2018. Anti-HTLV-1/2 was screened by ELISA and ECLIA, and subsequently confirmed by western blot (WB) and nucleic acid testing (NAT). The prevalence of HTLV in donors from different cities was calculated. The identified HTLV-positive cases were phylogenetically genotyped and analyzed in a Bayesian phylogenetic framework. Among 3,262,271 BDs, 59 were confirmed positive for HTLV-1 (1.81 per 100,000) and no HTLV-2 infection was found. The prevalence of HTLV-1 varied significantly among 21 cities in Guangdong province, China. The highest prevalence was found in donors from Shanwei (13.94 per 100,000), which is a coastal city in eastern Guangdong. Viral genomic sequences genotyped from 55 HTLV-1 carriers showed that 39 were transcontinental subtype and 16 were Japanese subtype. Specially, 13 out of 39 transcontinental subtype sequences were characterized with L55P mutation and 21 out of 55 sequences were characterized with L19F mutation in viral gp46 protein. The L55P mutation seemed be specific to eastern Asia since it only presented in the sequences from Japan, mainland China, and Taiwan. Phylogenetic analysis of gp46 gene shows that HTLV-1a may have been introduced to Guangdong through four different introduction events and formed major transmission clusters: clades I(13,602 years ago), II(16, 010 years ago), III(15,639 years ago) and IV(16,517 years ago). In general, Guangdong is considered to be a low-prevalence region for HTLV-1 infection, but the prevalence is significantly higher in Shanwei city. Transcontinental and Japanese subtype lineages dominate the prevalence in Guangdong. In terms of blood safety, HTLV antibody screening for first-time blood donors can effectively reduce the risk of HTLV transmission.