Virus Dataset Sample Info

> Dataset: 32370607 Search Result

Summary

Item	Summary
Project	32370607
Virus Name	HIV
Sample Number	5
Disease	AIDS/HIV
Country	China
Data Link	https://www.ncbi.nlm.nih.gov/nuccore/?term=MN752125:MN752128[pacc]

Sample

ID	Sample ID	Age	Gender	Origin	Detail
1	XC2014EU01	52	M	China	View
2	LS17S0117	76	M	China	View
3	LS17S0123	57	M	China	View
4	LS18S0082	44	M	China	View
5	LS18S0127	42	M	China	View

Literature

Item	Summary
PMID	32370607
Title	First Detection of a Circulating Recombinant Form of HIV-1 CRF01_AE/08_BC (CRF105_0108) with Drug-Resistant Mutations in Sichuan, China.
Abstract	In this study, we identified a novel circulating recombinant form (CRF) of HIV (CRF105_0108) in a total of five patients with no obvious epidemiological linkage in Sichuan, China. Four strains were found in this study, and another strain (XC2014EU01) was reported in a previous study. The phylogenetic analysis of the five near full-length genomes showed that a CRF08_BC segment was inserted into the CRF01_AE backbone with one recombinant breakpoint in the pol region, which is the first HIV-1 CRF of CRF01_AE and CRF08_BC. Three genetic sequences had drug-resistant mutations, E138Q and V179D, indicating that there were low resistance levels to efavirenz (EFV) and nevirapine (NVP) in Liangshan Yi Autonomous Prefecture. CRF105_0108 increases the diversity and complexity of the prevalent HIV-1 CRFs in Sichuan. Simultaneously, drug-resistant mutations in this CRF may influence the efficacy of highly active antiretroviral treatments (ARTs) in Liangshan Yi Autonomous Prefecture.