Virus Dataset Sample Info

> Dataset: 27544241 Search Result

Summary

Sample

ID	Sample ID	Age	Gender	Origin	Detail
1	27	44	M	Tunisia	View
2	28	47	M	Tunisia	View
3	42	29	M	Tunisia	View
4	50	40	F	Tunisia	View
5	59	40	M	Tunisia	View
6	70	42	F	Tunisia	View
7	80	37	F	Tunisia	View
8	81	25	M	Tunisia	View
9	82	36	F	Tunisia	View
10	85	39	M	Tunisia	View
11	86	35	F	Tunisia	View
12	88	28	M	Tunisia	View
13	91	24	M	Tunisia	View
14	97	36	F	Tunisia	View
15	107	37	M	Tunisia	View
16	110	58	F	Tunisia	View
17	124	44	F	Tunisia	View
18	138	39	M	Tunisia	View
19	140	33	M	Tunisia	View
20	144	50	F	Tunisia	View
21	145	38	M	Tunisia	View
22	147	38	F	Tunisia	View
23	151	32	F	Tunisia	View
24	159	42	F	Tunisia	View
25	165	44	M	Tunisia	View
26	171	23	F	Tunisia	View
27	174	38	M	Tunisia	View
28	178	44	F	Tunisia	View
29	179	25	F	Tunisia	View
30	185	19	F	Tunisia	View
31	223	26	M	Tunisia	View
32	227	25	F	Tunisia	View
33	232	43	F	Tunisia	View
34	234	48	F	Tunisia	View
35	238	27	F	Tunisia	View
36	240	46	F	Tunisia	View
37	245	53	M	Tunisia	View
38	259	19	M	Tunisia	View
39	263	32	F	Tunisia	View
40	269	37	M	Tunisia	View
41	276	20	M	Tunisia	View
42	285	26	M	Tunisia	View
43	298	44	F	Tunisia	View
44	303	34	F	Tunisia	View
45	336	31	F	Tunisia	View
46	337	26	F	Tunisia	View
47	363	26	F	Tunisia	View
48	369	52	M	Tunisia	View
49	375	32	M	Tunisia	View
50	379	29	F	Tunisia	View
51	9,094	40	F	Tunisia	View
52	87	71	F	Tunisia	View
53	353	41	M	Tunisia	View
54	357	51	F	Tunisia	View
55	20,322	45	M	Tunisia	View
56	1,995	41	M	Tunisia	View
57	2,660	45	F	Tunisia	View
58	380	63	M	Tunisia	View
59	381	66	M	Tunisia	View
60	377	61	M	Tunisia	View

Literature

Item	Summary
PMID	27544241
Title	Naturally Occurring Surface Antigen Variants of Hepatitis B Virus in Tunisian Patients.
Abstract	In Tunisia, the prevalence of naturally occurring surface (S) gene variants of hepatitis B virus (HBV) has not been determined. In the present study, the prevalence of these variants was examined in terms of the clinical and viral state in a series of 99 Tunisian patients with HBV infection. The S genes were amplified and directly sequenced. Genotype D was predominant (98%), 40.4% isolates belonged to subgenotypes D7 and 1 to subgenotype D2. The most common subtype was ayw2 (95.9%). In total, 60.6% of the studied strains harbored S mutations. Several novel mutation patterns were detected. Interestingly, the presence of S mutations was significantly correlated with the D7 subgenotype, low HBV DNA and advancing age (>/=35 years), and tended to be higher in liver cirrhosis than in chronic infection. The global prevalence of the major hydrophilic region variants was 12.1%, with substitution S143L/T as the most frequent (4%). Only 33.9% of S substitutions produced amino acid changes in the polymerase gene. In conclusion, a high prevalence of naturally occurring HBsAg variants was observed among Tunisian HBV carriers. Natural viral variability in a geographical region and duration of infection are among the major factors associated with the occurrence of S mutations.