Virus Dataset Sample Info

> Dataset: 26899956 Search Result

Summary

Sample

ID	Sample ID	Age	Gender	Origin	Detail
1	1	36	M	Niger	View
2	2	42	M	Niger	View
3	3	42	M	Niger	View
4	4	36	F	Niger	View
5	5	50	M	Niger	View
6	6	34	M	Niger	View
7	7	52	M	Niger	View
8	8	29	M	Niger	View
9	9	36	F	Niger	View
10	10	42	F	Niger	View
11	11	64	M	Niger	View
12	12	67	M	Niger	View
13	13	45	M	Niger	View
14	14	40	M	Niger	View
15	15	60	F	Niger	View
16	16	37	M	Niger	View
17	17	37	M	Niger	View
18	18	41	F	Niger	View
19	19	N.a.	N.a.	Niger	View
20	20	28	F	Niger	View
21	21	70	F	Niger	View
22	22	21	F	Niger	View
23	23	43	F	Niger	View
24	24	26	M	Niger	View
25	25	62	F	Niger	View
26	26	N.a.	N.a.	Niger	View
27	27	23	F	Niger	View
28	28	28	M	Niger	View
29	29	57	F	Niger	View
30	30	34	M	Niger	View
31	31	31	M	Niger	View

Literature

Item	Summary
PMID	26899956
Title	Molecular characterization of hepatitis B virus from chronically-infected patients in Niamey, Niger.
Abstract	OBJECTIVES: In Niger, 65% of hepatocarcinoma and 75% of cirrhosis cases were due to hepatitis B virus (HBV). We studied the genotypic characteristics of HBsAg in chronically HBV-infected patients in Niamey. METHODS: We studied prospectively HBV genotypic patterns among hospitalized patients with HBV infection in the National Hospital of Niamey, Niger. Patients were screened for hepatitis B surface antigen (HBsAg) and HBV genotyping was performed on the HBsAg-positive patients. RESULTS: In this study, we have confirmed the predominance of the HBV genotype E (HBV-E) in Niger and have identified 2 recombinant forms including HBV-E/D and HBV-A3/E reported previously among blood donors in Niger and Ghana, respectively. Amino acid substitutions found in HBV sequences obtained here included P120T, S143L, G145A and A194T. These substitutions were characterized as being associated with modified antigenicity and, notably, with impaired serological detection of HBsAg, while the A194T variant was found to have a controversial role in reduced susceptibility to tenofovir. CONCLUSIONS: We have identified two recombinant HBV forms and rare genotypic patterns in Niger that may affect hepatitis B surface antigen antigenicity, and improve current knowledge of epidemiological, clinical and virological patterns of hepatitis B in this country.