|
Summary
| Item |
Summary |
|
Project
|
26598112
|
|
Virus Name
|
HBV |
|
Sample Number
|
17 |
|
Disease
|
occult hepatitis B infection (OBI) |
|
Country
|
|
Sample
| ID |
Sample ID |
Age |
Gender |
Origin |
Detail |
|
1 |
14 |
76 |
Female |
|
View |
|
2 |
40 |
87 |
Male |
|
View |
|
3 |
42 |
133 |
Male |
|
View |
|
4 |
56 |
89 |
Male |
|
View |
|
5 |
65 |
103 |
Male |
|
View |
|
6 |
67 |
109 |
Female |
|
View |
|
7 |
72 |
108 |
Male |
|
View |
|
8 |
84 |
127 |
Male |
|
View |
|
9 |
86 |
133 |
Female |
|
View |
|
10 |
103 |
79 |
Male |
|
View |
|
11 |
106 |
134 |
Female |
|
View |
|
12 |
108 |
102 |
Female |
|
View |
|
13 |
110 |
77 |
Male |
|
View |
|
14 |
112 |
89 |
Male |
|
View |
|
15 |
115 |
75 |
Male |
|
View |
|
16 |
122 |
77 |
Female |
|
View |
|
17 |
125 |
74 |
Female |
|
View |
Literature
| Item |
Summary |
|
PMID
|
26598112 |
|
Title
|
Clearance of HBV DNA in immunized children born to HBsAg-positive mothers, years after being diagnosed with occult HBV infection. |
|
Abstract
|
In a previous study, we observed immunoprophylaxis failure due to occult hepatitis B virus (HBV) infection (OBI) despite the presence of adequate levels of anti-HBs in 21 (28%) of 75 children born to HBsAg-positive mothers. The aim of the study was to explore the maintenance of this cryptic condition in this population. Of 21 OBI-positive children, 17 were enrolled. HBV serological profiles were determined by enzyme-linked immunosorbent assay. Highly sensitive real-time and standard PCR followed by direct sequencing were applied in positive cases. The mean age (+/-SD) of studied patients was 6.57 +/- 2.75 years. All children still were negative for HBsAg. All but one (94%) were negative for HBV DNA. Only two children were positive for anti-HBc. The results of the most recent anti-HBs titration showed that 4 (23.5%) and 13 (76.5%) had low (<10 IU/mL) and adequate (>10 IU/mL) levels of anti-HBs, respectively. The only still OBI-positive patient had an HBV DNA level of 50 copy/mL, carried the G145R mutation when tested in 2009 and again in 2013 in the 'a' determinant region of the surface protein. Further follow-up showed that after 18 months, he was negative for HBV DNA. In high-risk children, the initial HBV DNA positivity early in the life (vertical infection) does not necessarily indicate a prolonged persistence of HBV DNA (occult infection). Adequate levels of anti-HBs after vaccine and hepatitis B immune globulin immunoprophylaxis following birth could eventually clear the virus as time goes by. Periodic monitoring of these children at certain time intervals is highly recommended. |
|
