Virus Dataset Sample Info

> Dataset: 25636086 Search Result

Summary

Item	Summary
Project	25636086
Virus Name	HBV
Sample Number	30
Disease	Liver cancer displaying biliary phenotype (LCB)
Country	Japan

Sample

ID	Sample ID	Gender	Origin	Detail
1	RK067	M	Japan	View
2	RK069	F	Japan	View
3	RK073	M	Japan	View
4	RK084	F	Japan	View
5	RK108	M	Japan	View
6	RK109	M	Japan	View
7	RK112	M	Japan	View
8	RK137	F	Japan	View
9	RK138	F	Japan	View
10	RK142	M	Japan	View
11	RK146	F	Japan	View
12	RK166	M	Japan	View
13	RK182	M	Japan	View
14	RK184	M	Japan	View
15	RK194	M	Japan	View
16	RK204	M	Japan	View
17	RK208	M	Japan	View
18	RK226	M	Japan	View
19	RK269	M	Japan	View
20	RK272	F	Japan	View
21	RK279	M	Japan	View
22	RK298	M	Japan	View
23	RK303	M	Japan	View
24	RK307	F	Japan	View
25	RK308	F	Japan	View
26	RK309	M	Japan	View
27	RK310	F	Japan	View
28	RK312	M	Japan	View
29	RK316	F	Japan	View
30	RK317	M	Japan	View

Literature

Item	Summary
PMID	25636086
Title	Whole-genome Mutational Landscape of Liver Cancers Displaying Biliary Phenotype Reveals Hepatitis Impact and Molecular Diversity
Abstract	Intrahepatic cholangiocarcinoma and combined hepatocellular cholangiocarcinoma show varying degrees of biliary epithelial differentiation, which can be defined as liver cancer displaying biliary phenotype (LCB). LCB is second in the incidence for liver cancers with and without chronic hepatitis background and more aggressive than hepatocellular carcinoma (HCC). To gain insight into its molecular alterations, we performed whole-genome sequencing analysis on 30 LCBs. Here we show, the genome-wide substitution patterns of LCBs developed in chronic hepatitis livers overlapped with those of 60 HCCs, whereas those of hepatitis-negative LCBs diverged. The subsequent validation study on 68 LCBs identified recurrent mutations in TERT promoter, chromatin regulators (BAP1, PBRM1 and ARID2), a synapse organization gene (PCLO), IDH genes and KRAS. The frequencies of KRAS and IDHs mutations, which are associated with poor disease-free survival, were significantly higher in hepatitis-negative LCBs. This study reveals the strong impact of chronic hepatitis on the mutational landscape in liver cancer and the genetic diversity among LCBs.