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> Dataset: 24945273 Search Result


Summary
Item Summary
Project 24945273
Virus Name HIV
Sample Number 35
Disease HIV-1 infection
Country China
Data Link https://www.ncbi.nlm.nih.gov/nuccore/?term=KJ544520:KJ544554[pacc]

Sample
ID Sample ID Age Gender Origin Detail
1 JL1001 33 Male China View
2 JL1002 37 Male China View
3 JL1009 37 Female China View
4 JL1013 46 Male China View
5 JL1014 36 Male China View
6 JL1024 39 Male China View
7 JL1030 30 Female China View
8 JL1035 37 Male China View
9 JL1038 42 Female China View
10 JL1041 42 Male China View
11 JL1057 34 Male China View
12 JL1062 52 Male China View
13 JL1064 34 Male China View
14 JL1067 36 Female China View
15 JL2005 35 Male China View
16 JL2006 27 Female China View
17 JL2012 29 Female China View
18 JL2027 41 Male China View
19 JL2036 54 Male China View
20 JL2048 29 Male China View
21 JL2061 57 Male China View
22 JL2065 34 Male China View
23 JL2072 35 Male China View
24 JL2076 23 Male China View
25 JL2084 48 Male China View
26 JL3019 38 Male China View
27 JL3028 38 Male China View
28 JL3038 52 Male China View
29 JL3050 44 Male China View
30 JL3055 34 Female China View
31 JL3059 39 Male China View
32 JL3071 35 Male China View
33 JL3085 45 Male China View
34 JL3087 35 Male China View
35 JL3088 54 Male China View

Literature
Item Summary
PMID 24945273
Title HIV-1 diversity and drug-resistant mutations in infected individuals in Changchun, China.
Abstract OBJECTIVES: Human immunodeficiency virus type 1 (HIV-1) infection has been detected in all provinces of China. Although epidemiological and phylogenetic studies have been conducted in many regions, such analyses are lacking from Jilin province in northeastern China. METHOD: Epidemiological and phylogenetic analyses, as well as detection of drug-resistant mutations, were conducted on 57 HIV-1 infected patients from Changchun city identified and confirmed through annual surveillance by local Centers for Disease Control in Jilin province of northeastern China in 2012. RESULTS: Sexual contact was determined to be the major pathway for HIV-1 transmission in Jilin, where hetero- and homosexual activities contributed almost equally. Phylogenetic analyses detected multiple subtypes of HIV-1 including subtype G circulating in Jilin, with multiple origins for each of them. Both subtype B and CRF01_AE were dominant, and evidence of subtype B transmitting between different high-risk groups was observed. Mutations in the viral protease at position 71 indicated the presence of a selective pressure. Several drug-resistant mutations were detected, although they were predicted with low-level resistance to antiviral treatments. CONCLUSIONS: Information from this study fills the gap in knowledge of HIV-1 transmission in Changchun city, Jilin province, China. By revealing the origin and evolutionary status of local HIV-1 strains, this work contributes to ongoing efforts in the control and prevention of AIDS.