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Virus Dataset Sample Info

> Dataset: 24735963 Search Result


Summary
Item Summary
Project 24735963
Virus Name HTLV1
Sample Number 197
Disease Adult T-cell leukemia/lymphoma (ATL)
Country Japan

Sample
ID Sample ID Age Gender Origin Detail
1 ATL1 F Japan View
2 ATL3 M Japan View
3 ATL4 F Japan View
4 ATL5 M Japan View
5 ATL7 M Japan View
6 ATL8 F Japan View
7 ATL9 F Japan View
8 ATL10 M Japan View
9 ATL11 F Japan View
10 ATL13 F Japan View
11 ATL14 M Japan View
12 ATL15 M Japan View
13 ATL16 M Japan View
14 ATL17 52 F Japan View
15 ATL18 M Japan View
16 ATL20 67 M Japan View
17 ATL21 F Japan View
18 ATL22 M Japan View
19 ATL25 66 F Japan View
20 ATL26 F Japan View
21 ATL27 F Japan View
22 ATL28 71 F Japan View
23 ATL29 77 M Japan View
24 ATL30 F Japan View
25 ATL31 54 F Japan View
26 ATL32 61 F Japan View
27 ATL33 73 M Japan View
28 ATL34 F Japan View
29 ATL35 55 M Japan View
30 ATL36 64 M Japan View
31 ATL37 F Japan View
32 ATL38 77 M Japan View
33 ATL39 46 M Japan View
34 ATL40 65 M Japan View
35 ATL41 44 F Japan View
36 ATL42 45 M Japan View
37 ATL43 43 F Japan View
38 ATL45 M Japan View
39 ATL46 M Japan View
40 ATL47 M Japan View
41 ATL49 F Japan View
42 ATL50 M Japan View
43 ATL51 F Japan View
44 ATL52 77 F Japan View
45 ATL53 F Japan View
46 ATL54 M Japan View
47 ATL55 49 F Japan View
48 ATL56 56 M Japan View
49 ATL57 47 F Japan View
50 ATL58 54 F Japan View
51 ATL60 M Japan View
52 ATL62 M Japan View
53 ATL64 37 M Japan View
54 ATL65 F Japan View
55 ATL66 F Japan View
56 ATL69 M Japan View
57 ATL70 M Japan View
58 ATL71 63 M Japan View
59 ATL73 64 F Japan View
60 ATL74 64 M Japan View
61 ATL75 70 F Japan View
62 ATL78 F Japan View
63 ATL79 M Japan View
64 ATL81 49 F Japan View
65 ATL82 62 F Japan View
66 ATL83 M Japan View
67 ATL84 47 M Japan View
68 ATL85 F Japan View
69 ATL86 75 F Japan View
70 ATL87 M Japan View
71 ATL88 M Japan View
72 ATL89 53 M Japan View
73 ATL90 M Japan View
74 ATL91 M Japan View
75 ATL92 F Japan View
76 ATL93 M Japan View
77 ATL94 33 F Japan View
78 ATL95 41 M Japan View
79 ATL96 74 F Japan View
80 ATL97 51 M Japan View
81 ATL99 M Japan View
82 ATL100 F Japan View
83 ATL102 76 F Japan View
84 ATL103 78 M Japan View
85 ATL104 M Japan View
86 ATL105 Japan View
87 ATL107 Japan View
88 ATL110 Japan View
89 ATL112 Japan View
90 ATL114 67 F Japan View
91 ATL115 Japan View
92 ATL116 Japan View
93 ATL117 Japan View
94 ATL118 F Japan View
95 ATL119 40 F Japan View
96 ATL122 76 F Japan View
97 ATL123 M Japan View
98 ATL125 73 M Japan View
99 ATL128 Japan View
100 ATL129 F Japan View
101 ATL130 M Japan View
102 ATL131 F Japan View
103 ATL132 F Japan View
104 ATL133 Japan View
105 ATL135 53 Japan View
106 ATL136 55 F Japan View
107 ATL137 Japan View
108 ATL138 38 F Japan View
109 ATL139 56 F Japan View
110 ATL141 52 F Japan View
111 ATL142 F Japan View
112 ATL143 M Japan View
113 ATL144 64 F Japan View
114 ATL145 Japan View
115 ATL146 64 Japan View
116 ATL147 M Japan View
117 ATL148 F Japan View
118 ATL149 M Japan View
119 ATL150 50 F Japan View
120 ATL151 61 F Japan View
121 ATL152 66 F Japan View
122 ATL153 M Japan View
123 ATL154 44 M Japan View
124 ATL155 Japan View
125 ATL156 Japan View
126 ATL157 57 Japan View
127 ATL158 68 F Japan View
128 ATL159 71 Japan View
129 ATL161 54 M Japan View
130 ATL162 65 M Japan View
131 ATL163 35 F Japan View
132 ATL164 58 M Japan View
133 ATL165 F Japan View
134 ATL166 52 Japan View
135 ATL167 Japan View
136 ATL168 54 M Japan View
137 ATL169 71 M Japan View
138 ATL171 52 F Japan View
139 ATL172 M Japan View
140 ATL173 79 Japan View
141 ATL174 47 F Japan View
142 ATL175 M Japan View
143 ATL176 Japan View
144 ATL177 55 M Japan View
145 ATL180 43 F Japan View
146 ATL182 Japan View
147 ATL183 69 Japan View
148 ATL185 64 M Japan View
149 ATL186 Japan View
150 ATL187 Japan View
151 ATL189 46 F Japan View
152 ATL190 73 F Japan View
153 ATL191 F Japan View
154 ATL192 49 M Japan View
155 ATL193 F Japan View
156 ATL195 Japan View
157 ATL196 73 M Japan View
158 ATL197 M Japan View
159 ATL198 39 M Japan View
160 ATL199 79 M Japan View
161 ATL200 Japan View
162 ATL201 Japan View
163 ATL202 Japan View
164 ATL204 Japan View
165 ATL205 Japan View
166 ATL206 Japan View
167 ATL207 Japan View
168 ATL208 Japan View
169 ATL209 Japan View
170 ATL210 Japan View
171 ATL211 Japan View
172 ATL212 Japan View
173 ATL215 Japan View
174 ATL217 Japan View
175 ATL218 Japan View
176 ATL220 Japan View
177 ATL221 Japan View
178 ATL222 Japan View
179 ATL223 Japan View
180 ATL224 Japan View
181 ATL225 Japan View
182 ATL226 Japan View
183 ATL227 Japan View
184 ATL229 Japan View
185 ATL230 Japan View
186 ATL231 Japan View
187 ATL232 Japan View
188 ATL233 Japan View
189 ATL234 Japan View
190 ATL235 Japan View
191 ATL236 Japan View
192 ATL237 Japan View
193 ATL238 Japan View
194 ATL239 Japan View
195 ATL240 Japan View
196 ATL241 Japan View
197 ATL242 Japan View

Literature
Item Summary
PMID 24735963
Title The Role of HTLV-1 Clonality, Proviral Structure, and Genomic Integration Site in Adult T-cell Leukemia/Lymphoma
Abstract Adult T-cell leukemia/lymphoma (ATL) occurs in 5% of human T-lymphotropic virus type 1 (HTLV-1)-infected individuals and is conventionally thought to be a monoclonal disease in which a single HTLV-1(+) T-cell clone progressively outcompetes others and undergoes malignant transformation. Here, using a sensitive high-throughput method, we quantified clonality in 197 ATL cases, identified genomic characteristics of the proviral integration sites in malignant and nonmalignant clones, and investigated the proviral features (genomic structure and 5' long terminal repeat methylation) that determine its capacity to express the HTLV-1 oncoprotein Tax. Of the dominant, presumed malignant clones, 91% contained a single provirus. The genomic characteristics of the integration sites in the ATL clones resembled those of the frequent low-abundance clones (present in both ATL cases and carriers) and not those of the intermediate-abundance clones observed in 24% of ATL cases, suggesting that oligoclonal proliferation per se does not cause malignant transformation. Gene ontology analysis revealed an association in 6% of cases between ATL and integration near host genes in 3 functional categories, including genes previously implicated in hematologic malignancies. In all cases of HTLV-1 infection, regardless of ATL, there was evidence of preferential survival of the provirus in vivo in acrocentric chromosomes (13, 14, 15, 21, and 22).