Virus Dataset Sample Info

> Dataset: 24201445 Search Result

Summary

Item	Summary
Project	24201445
Virus Name	HPV
Sample Number	12
Disease	Cervical cancers, Head and neck cancers
Country	Europe;Africa;Asia
Data Link	https://ega-archive.org/datasets/EGAD00001000691

Sample

ID	Sample ID	Age	Gender	Origin	Detail
1	SiHa		F	Europe	View
2	CaSki		F	Europe	View
3	UM-SCC-104		M	Europe	View
4	UD-SCC-2		M	Europe	View
5	UM-SCC-47		M	Africa	View
6	UPCI:SCC090		M	Europe	View
7	HMS001		M	Asia	View
8	Tumor A		M		View
9	Tumor B		M	Europe	View
10	CAL 27		M		View
11	D562		F		View
12	SCC-25		M		View

Seq Data

GeneBank/SRA/GEO/ENA/EGA ID	URL
EGAS00001000599	https://ega-archive.org/datasets/EGAD00001000691

Literature

Item	Summary
PMID	24201445
Title	Genome-wide Analysis of HPV Integration in Human Cancers Reveals Recurrent, Focal Genomic Instability
Abstract	Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions, and chromosomal translocations. We present a model of "looping" by which HPV integrant-mediated DNA replication and recombination may result in viral-host DNA concatemers, frequently disrupting genes involved in oncogenesis and amplifying HPV oncogenes E6 and E7. Our high-resolution results shed new light on a catastrophic process, distinct from chromothripsis and other mutational processes, by which HPV directly promotes genomic instability.