Virus Dataset Sample Info

> Dataset: 22342276 Search Result

Summary

Sample

ID	Age	Gender	Origin	Detail
1	76	M	French	View
2	71	F	French	View
3	75	F	French	View
4	82	F	French	View
5	61	M	French	View
6	56	M	French	View
7	55	F	French	View
8	73	M	French	View
9	85	F	French	View
10	80	M	French	View
11	75	M	French	View
12	73	M	French	View
13	73	M	French	View
14	66	F	French	View
15	79	M	French	View
16	55	M	French	View
17	81	F	French	View
18	68	M	French	View
19	58	F	French	View
20	74	M	French	View
21	81	M	French	View
22	70	F	French	View
23	64	M	French	View
24	64	F	French	View
25	60	M	French	View
26	72	F	French	View
27	71	F	French	View
28	82	M	French	View
29	72	M	French	View
30	79	F	French	View
31	81	M	French	View
32	80	M	French	View
33	82	F	French	View
34	85	M	French	View
35	63	M	French	View
36	83	M	French	View
37	75	F	French	View
38	75	F	French	View
39	92	F	French	View
40	76	F	French	View
41	71	F	French	View
42	70	M	French	View
43	55	M	French	View
44	82	F	French	View
45	71	M	French	View
46	87	F	French	View
47	70	M	French	View
48	84	F	French	View
49	97	M	French	View
50	84	F	French	View
51	71	M	French	View
52	94	F	French	View
53	66	F	French	View
54	79	M	French	View
55	69	F	French	View
56	80	M	French	View
57	63	M	French	View
58	82	F	French	View
59	91	F	French	View

Literature

Item	Summary
PMID	22342276
Title	Genetic Variability and Integration of Merkel Cell Polyomavirus in Merkel Cell Carcinoma
Abstract	Merkel cell polyomavirus (MCPyV) is associated to Merkel cell carcinoma (MCC). We studied 113 MCC tumoral skin lesions originating from 97 patients. MCPyV detection was higher in fresh-frozen (FF) biopsies (94%) than in formalin-fixed paraffin-embedded biopsies (39-47%). Mean viral load in FF tumor was of 7.5 copies per cell with a very wide range (0.01-95.4). Nineteen complete sequences of LTAg were obtained, mainly from FF biopsies when the viral load was high. Seventeen showed stop codons, all localized downstream of the pRb protein binding domain. Sequence comparison and phylogenetic analysis showed that all sequences clustered in the large C clade of MCPyV strains. MCPyV integration was demonstrated in 19 out of 27 FF MCC DNA biopsies without evidence of specific host cellular genome integration site. In 13/19 cases, the viral junction was located within the second exon of the LTAg, after the pRB binding domain.