Virus Dataset Sample Info

> Dataset: 21264860 Search Result

Summary

Sample

ID	Sample ID	Age	Gender	Origin	Detail
1	1	28	M	Korea	View
2	2	54	M	Korea	View
3	3	49	M	Korea	View
4	4	61	M	Korea	View
5	5	43	M	Korea	View
6	6	36	M	Korea	View
7	7	59	M	Korea	View
8	8	43	M	Korea	View
9	9	31	M	Korea	View
10	10	63	M	Korea	View
11	11	27	M	Korea	View
12	12	40	M	Korea	View
13	13	52	M	Korea	View
14	14	26	M	Korea	View
15	15	24	M	Korea	View
16	16	63	M	Korea	View
17	17	72	M	Korea	View
18	18	59	F	Korea	View
19	19	32	F	Korea	View
20	20	43	F	Korea	View
21	21	62	F	Korea	View
22	22	57	F	Korea	View
23	23	48	F	Korea	View
24	24	28	F	Korea	View
25	25	58	F	Korea	View
26	26	63	F	Korea	View
27	27	44	F	Korea	View
28	28	28	F	Korea	View
29	29	66	F	Korea	View
30	30	52	F	Korea	View
31	31	54	F	Korea	View
32	32	70	F	Korea	View
33	33	28	F	Korea	View
34	34	64	F	Korea	View
35	35	54	F	Korea	View
36	36	53	F	Korea	View
37	37	54	F	Korea	View

Literature

Item	Summary
PMID	21264860
Title	Gender disparity in distribution of the major hydrophilic region variants of hepatitis B virus genotype C according to hepatitis B e antigen serostatus.
Abstract	Hepatitis B virus (HBV) e antigen (HBeAg) seroconversion during chronic HBV infection is known to play an important role in disease progression and patient response to antiviral agents. The aim of the present study was to analyze gender disparity in distribution of major hydrophilic region (MHR) variants according to HBeAg serostatus. Prevalence of MHR variants from 68 Korean patients with chronic hepatitis (31 HBeAg-positive and 37 HBeAg-negative) was examined in terms of HBeAg serostatus and sex by direct sequencing analysis of the MHR. Gender disparity was observed in the distribution of MHR variants according to HBeAg serostatus. In male patients, the prevalence of MHR variants was significantly higher in HBeAg negative patients than in HBeAg positive patients [58.8% (10/17 patients) vs. 14.3% (3/21 patients), P=0.004]. However, the same was not true in female patients [55.0% (11/20 patients) vs. 60.0% (6/10 patients), P=1.000)]. In addition, 2 mutation types (L110I and G145A) related to HBeAg serostatus were found. In conclusion, HBeAg seroconversion in male chronic patients infected with genotype C could lead to mutations of MHR, major target to host immune response, which might in turn contribute to HBV persistence and immune evasion.