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> Dataset: 19950231 Search Result


Summary
Item Summary
Project 19950231
Virus Name HBV
Sample Number 56
Disease chronic hepatitis B (CHB)
Country China

Sample
ID Sample ID Age Gender Origin Detail
1 S1 China View
2 S2 China View
3 S3 China View
4 S4 China View
5 S5 China View
6 S6 China View
7 S7 China View
8 S8 China View
9 S9 China View
10 S10 China View
11 S11 China View
12 S12 China View
13 S13 China View
14 S14 China View
15 S15 China View
16 S16 China View
17 S17 China View
18 S18 China View
19 S19 China View
20 S20 China View
21 S21 China View
22 S22 China View
23 S23 China View
24 S24 China View
25 S25 China View
26 S26 China View
27 S27 China View
28 S28 China View
29 C1 China View
30 C2 China View
31 C3 China View
32 C4 China View
33 C5 China View
34 C6 China View
35 C7 China View
36 C8 China View
37 C9 China View
38 C10 China View
39 C11 China View
40 C12 China View
41 C13 China View
42 C14 China View
43 C15 China View
44 C16 China View
45 C17 China View
46 C18 China View
47 C19 China View
48 C20 China View
49 C21 China View
50 C22 China View
51 C23 China View
52 C24 China View
53 C25 China View
54 C26 China View
55 C27 China View
56 C28 China View

Literature
Item Summary
PMID 19950231
Title PreS deletion mutations of hepatitis B virus in chronically infected patients with simultaneous seropositivity for hepatitis-B surface antigen and anti-HBS antibodies.
Abstract Hepatitis B surface antigen (HBsAg) and anti-HBs antibodies (anti-HBs) may coexist in certain chronic hepatitis B (CHB) patients. This study was designed to further explore the relationship between this coexistence and hepatitis B Virus (HBV) preS deletions. Sera of 28 patients carrying both HBsAg and anti-HBs (Group I) and those of another 28 HBsAg positive but anti-HBs negative patients (Group II) were collected from CHB patients. Direct sequencing of polymerase chain reaction products or sequencing of clones was applied to both groups to determine sequences of HBV preS and S genes. Genotyping of the S gene indicated that all sampled HBVs were either Genosubtype Ba or Genosubtype Ce. Seven samples in Group I harbored HBV preS deletion mutations. Three of the seven samples showed large deletion mutations in 3' terminus of preS1 and co-existence of the mutant type and the full-length wild type, and the remaining four samples showed deletion mutations in 5' terminus of preS2. All mutant strains were found to be genosubtype Ce. Only two samples in Group I showed G145R/A mutation. Only one sample in Group II contained preS deletion mutation. It is therefore concluded that HBV preS deletion mutations are likely to be related to the coexistence of HBsAg and anti-HBs in CHB patients (P-value = 0.024). Some immune reactions may select for the preS deletion in CHB patients with anti-HBs, the possible marker for immune selection.