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Virus Dataset Sample Info

> Dataset: 16009689 Search Result


Summary
Item Summary
Project 16009689
Virus Name HBV
Sample Number 60
Disease Hepatocellular carcinoma (HCC)
Country Japan

Sample
ID Sample ID Age Gender Origin Detail
1 2A 68 F Japan View
2 3A 44 M Japan View
3 5A 59 M Japan View
4 7 48 M Japan View
5 8 48 M Japan View
6 8A 57 M Japan View
7 9 47 M Japan View
8 10 38 M Japan View
9 10A 67 F Japan View
10 11A 62 F Japan View
11 12A 63 M Japan View
12 13 48 M Japan View
13 13A 53 M Japan View
14 14 26 M Japan View
15 15 48 M Japan View
16 16A 49 M Japan View
17 37 66 F Japan View
18 41 42 M Japan View
19 43 57 M Japan View
20 49 69 F Japan View
21 100 26 F Japan View
22 101 36 F Japan View
23 F2T1-4 47 M Japan View
24 F2T1-5 82 M Japan View
25 F2T2-1 51 M Japan View
26 F2T2-2 43 M Japan View
27 F2T2-5 66 M Japan View
28 T2-6 78 M Japan View
29 MN3-3 27 F Japan View
30 TAT6-4 69 F Japan View
31 TAN7-3 57 M Japan View
32 TN-2 52 M Japan View
33 TN-3 47 M Japan View
34 TT-1 60 M Japan View
35 54T 29 F Japan View
36 63T 65 M Japan View
37 77T 53 M Japan View
38 83T 49 M Japan View
39 86T 65 M Japan View
40 95T 17 M Japan View
41 FR2 65 M Japan View
42 FR3 71 M Japan View
43 FR7 45 M Japan View
44 SA1 48 M Japan View
45 SA2 53 M Japan View
46 SA5 59 M Japan View
47 GR1 62 M Japan View
48 GR2 71 M Japan View
49 GR3 66 M Japan View
50 GR10 69 M Japan View
51 BB3 Japan View
52 BE5REV Japan View
53 3T-470 Japan View
54 669Hb Japan View
55 PP5T Japan View
56 PP7T Japan View
57 1217Ha Japan View
58 13T-198 Japan View
59 HC1707-1 Japan View
60 λYH16 Japan View

Literature
Item Summary
PMID 16009689
Title Large Scaled Analysis of Hepatitis B Virus (HBV) DNA Integration in HBV Related Hepatocellular Carcinomas
Abstract Background and aims: Hepatitis B virus (HBV) DNA integration into or close to cellular genes is frequently detected in HBV positive hepatocellular carcinomas (HCC). We have previously shown that viral integration can lead to aberrant target gene transcription. In this study, we attempted to investigate common pathways to hepatocarcinogenesis. Methods: By using a modified Alu-polymerase chain reaction approach, we analysed 50 HCCs along with 10 previously published cases. Results: Sixty eight cellular flanking sequences (seven repetitive or unidentified sequences, 42 cellular genes, and 19 sequences potentially coding for unknown proteins) were obtained. Fifteen cancer related genes and 25 cellular genes were identified. HBV integration recurrently targeted the human telomerase reverse transcriptase gene (three cases) and genes belonging to distinct pathways: calcium signalling related genes, 60s ribosomal protein encoding genes, and platelet derived growth factor and mixed lineage leukaemia encoding genes. Two tumour suppressor genes and five genes involved in the control of apoptosis were also found at the integration site. The viral insertion site was distributed over all chromosomes except 13, X, and Y. Conclusions: In 61/68 (89.7%) cases, HBV DNA was integrated into cellular genes potentially providing cell growth advantage. Identification of recurrent viral integration sites into genes of the same family allows recognition of common cell signalling pathways activated in hepatocarcinogenesis.