Virus Dataset Sample Info

> Dataset: 10762559 Search Result

Summary

Sample

ID	Sample ID	Age	Gender	Detail
1	1	26	M	View
2	2	26	M	View
3	3	36	F	View
4	4	36	M	View
5	5	33	M	View
6	6	48	M	View
7	7	59	M	View
8	8	36	M	View
9	9	34	M	View
10	10	55	M	View
11	11	18	F	View
12	12	61	F	View
13	13	29	M	View
14	14	62	M	View
15	15	67	M	View
16	16	32	F	View
17	17	51	M	View
18	18	25	M	View
19	19	53	M	View
20	20	23	F	View
21	21	33	M	View
22	22	45	M	View
23	23	20	M	View
24	24	68	F	View
25	25	29	M	View
26	26	38	M	View
27	27	25	M	View
28	28	28	M	View

Literature

Item	Summary
PMID	10762559
Title	Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B.
Abstract	Prolonged administration of nucleoside analogues for chronic hepatitis B may result in the emergence of hepatitis B viral polymerase mutants. To gain insight into the mechanism involved in the virus's resistance to famciclovir, the amino acid sequences of the terminal protein and reverse-transcriptase (RT) domains of the viral polymerase were determined during therapy among 28 patients. The antiviral response was independent of viral genotypes, and nonresponse to famciclovir was associated with a complex variability of the RT domain. No mutation in the YMDD motif was observed, whereas an L528M mutation was clearly selected by famciclovir treatment in 2 patients, as well as 14 novel mutations in 7 patients. Clone sequence analysis of the RT domains of patients undergoing retreatment with famciclovir and/or lamivudine showed the selection of a preexisting drug-resistant mutant in one case and indicated that sequential antiviral therapy may allow the rapid selection of resistant strains.