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Mutation Information
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Mutation Site
|
Y118N |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
P |
Literature Information
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PubMed PMID
|
10762559
|
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Clinical information
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Yes
|
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Disease
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Chronic hepatitis B
|
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Published Year
|
2000 |
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Journal
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The Journal of infectious diseases |
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Title
|
Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B. |
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Author
|
Seignères B,Pichoud C,Ahmed SS,Hantz O,Trépo C,Zoulim F |
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Evidence
|
Analysis of the TP domain sequence 6 months after cessation of therapy (figure 2, lanes c) showed that 2 mutations—the T62N change and the Y118N substitution—persisted as major viral sequences after treatment and the 5 other mutations were not found after drug withdrawal, suggesting that they may be specifically related to antiviral treatment
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HBV Mutation Detail Information