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Mutation Information
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Mutation Site
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G232A |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
|
5′LTR |
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Viral Reference
|
J02029.1
|
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Country
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Brazil |
Literature Information
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PubMed PMID
|
22947305
|
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Clinical information
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Yes
|
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Disease
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HTLV1-HIV coinfection
|
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Published Year
|
2012 |
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Journal
|
Virology journal |
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Title
|
LTR point mutations in the Tax-responsive elements of HTLV-1 isolates from HIV/HTLV-1-coinfected patients. |
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Author
|
Magri MC,Costa EA,Caterino-de-Araujo A |
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Evidence
|
In the December 13th, 2011 issue of Virology Journal, Neto and collaborators described point mutations into 21-bp repeat motifs, named Tax-responsive elements (TRE), present in the 5' LTR region of human T-lymphotropic virus type 1 (HTLV-1) isolated among asymptomatic carriers from Sao Paulo, Brazil, and hypothesized that the presence of G232A nucleotide substitution in the A domain of the first TRE (TRE-1) increase viral proliferation and consequently the proviral load (PvL), while the A184G mutation in the A domain of TRE-3 do not have such effect.
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HTLV1 Mutation Detail Information