HBV Mutation Detail Information

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Mutation Information
Mutation Site G145R
Mutation Type Amino acid level
Gene/Protein/Region Type S
Country Korea
Literature Information
PubMed PMID 28373061
Clinical information Yes
Disease Liver cirrhosis; Hepatocellular carcinoma
Published Year 2017
Journal Virus research
Title Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.
Author Zhou H,Gewaily D,Ahn SH,Preskill C,Wang Y,Zong L,Zhang J,Han KH,Wands J,Li J,Tong S
Evidence The G145R immune escape mutation caused low S protein level by Western blot. Remarkably, the D99G mutation completely abolished HBsAg for both cell lysate and culture supernatant (Fig. 6), which could explain the HBsAg negative phenotype of clone 14.3

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation