|
Mutation Information
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Mutation Site
|
D99G |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
28373061
|
|
Clinical information
|
Yes
|
|
Disease
|
Liver cirrhosis;
Hepatocellular carcinoma
|
|
Published Year
|
2017 |
|
Journal
|
Virus research |
|
Title
|
Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer. |
|
Author
|
Zhou H,Gewaily D,Ahn SH,Preskill C,Wang Y,Zong L,Zhang J,Han KH,Wands J,Li J,Tong S |
|
Evidence
|
The G145R immune escape mutation caused low S protein level by Western blot. Remarkably, the D99G mutation completely abolished HBsAg for both cell lysate and culture supernatant (Fig. 6), which could explain the HBsAg negative phenotype of clone 14.3
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HBV Mutation Detail Information