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Overview of HBV associated
ID Literature Title Group
1 10091998 Functional analysis of mutations conferring lamivudine resistance on hepatitis B virus.
Mutation
2 10353255 Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues.
Mutation
3 10364324 The mechanism of an immature secretion phenotype of a highly frequent naturally occurring missense mutation at codon 97 of human hepatitis B virus core antigen.
Mutation
4 10377169 Susceptibility of lamivudine-resistant hepatitis B virus to other reverse transcriptase inhibitors.
Mutation
5 10418752 Perspectives for the treatment of hepatitis B virus infections.
Mutation
6 10559327 Subtype-independent immature secretion and subtype-dependent replication deficiency of a highly frequent, naturally occurring mutation of human hepatitis B virus core antigen.
Mutation
7 10573159 Hepatitis B virus maturation is affected by the incorporation of core proteins having a C-terminal substitution of arginine or lysine stretches.
Mutation
8 10613749 In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance.
Mutation
9 10760047 Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L-FMAU, DAPD, penciclovir and lobucavir.
Mutation
10 10775637 A frequent, naturally occurring mutation (P130T) of human hepatitis B virus core antigen is compensatory for immature secretion phenotype of another frequent variant (I97L).
Mutation
11 10982356 Low-level secretion of human hepatitis B virus virions caused by two independent, naturally occurring mutations (P5T and L60V) in the capsid protein.
Mutation
12 11181644 The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance.
Mutation
13 11230757 Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region.
Mutation
14 11287420 Interaction of the hepatitis B virus X protein with the Crm1-dependent nuclear export pathway.
Mutation
15 11312349 Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC).
Mutation
16 11395201 Anti-HBs after hepatitis B immunization with plasma-derived and recombinant DNA-derived vaccines: binding to mutant HBsAg.
Mutation
17 11397661 Detection of hepatitis B virus resistance to antivirals.
Mutation
18 11886250 Reduced antigenicity of the hepatitis B virus HBsAg protein arising as a consequence of sequence changes in the overlapping polymerase gene that are selected by lamivudine therapy.
Mutation
19 12050364 Influence of a putative intermolecular interaction between core and the pre-S1 domain of the large envelope protein on hepatitis B virus secretion.
Mutation
20 12121939 Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus.
Mutation
21 12167344 Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the "fingers" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S gene.
Mutation
22 12414948 Replication advantage and host factor-independent phenotypes attributable to a common naturally occurring capsid mutation (I97L) in human hepatitis B virus.
Mutation
23 12448687 Hepatitis B virus resistance to lamivudine and its clinical implications.
Mutation
24 12500185 Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro.
Mutation
25 12760870 Generation of stable cell lines expressing Lamivudine-resistant hepatitis B virus for antiviral-compound screening.
Mutation
26 12885906 Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions.
Mutation
27 14578867 Deficiency in virion secretion and decreased stability of the hepatitis B virus immune escape mutant G145R.
Mutation
28 14638401 Mutations of the surface protein of hepatitis B virus.
Mutation
29 14645551 Stability and morphology comparisons of self-assembled virus-like particles from wild-type and mutant human hepatitis B virus capsid proteins.
Mutation
30 14688448 Classifying hepatitis B virus genotypes.
Mutation
31 14742682 Reverse transcriptase activity of hepatitis B virus (HBV) DNA polymerase within core capsid: interaction with deoxynucleoside triphosphates and anti-HBV L-deoxynucleoside analog triphosphates.
Mutation
32 14968937 Mechanism of antiviral activities of 3'-substituted L-nucleosides against 3TC-resistant HBV polymerase: a molecular modelling approach.
Mutation
33 15134177 Comparisons of the HBV and HIV polymerase, and antiviral resistance mutations.
Mutation
34 15261293 Molecular mechanisms of adefovir sensitivity and resistance in HBV polymerase mutants: a molecular dynamics study.
Mutation
35 15280461 Basal core promoter and precore mutations in the hepatitis B virus genome enhance replication efficacy of Lamivudine-resistant mutants.
Mutation
36 15308745 Hepatitis B virus capsid assembly is enhanced by naturally occurring mutation F97L.
Mutation
37 15469692 Increased DNA polymerase fidelity of the Lamivudine resistant variants of human hepatitis B virus DNA polymerase.
Mutation
38 15564475 Nucleolar localization of human hepatitis B virus capsid protein.
Mutation
39 15915463 Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir.
Mutation
40 15968333 Hepatitis B Virus e Antigen Variants.
Mutation
41 15968338 Natural History and Clinical Consequences of Hepatitis B Virus Infection.
Mutation
42 15993954 Validation and comparison of different PCR-based methods for detection of hepatitis B virus precore region mutants.
Mutation
43 16004082 Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative.
Mutation
44 16094714 Biological impacts of "hot-spot" mutations of hepatitis B virus X proteins are genotype B and C differentiated.
Mutation
45 16378961 Point mutations upstream of hepatitis B virus core gene affect DNA replication at the step of core protein expression.
Mutation
46 16461214 Mechanism of HBV genome variability and replication of HBV mutants.
Mutation
47 16461216 The current management of HBV drug resistance.
Mutation
48 16553556 HBsAg diagnostic kits in the detection of hepatitis B virus mutation within "a" determinant.
Mutation
49 16571836 Hepatitis B virus particle formation in the absence of pregenomic RNA and reverse transcriptase.
Mutation
50 16622880 Diagnostic impact of the genetic variability of the hepatitis B virus surface antigen gene.
Mutation
51 16622882 Infections by hepatitis B surface antigen gene mutants in Europe and North America.
Mutation
52 16673294 Antiviral drug resistance: clinical consequences and molecular aspects.
Mutation
53 16801428 Intracellular metabolism and in vitro activity of tenofovir against hepatitis B virus.
Mutation
54 17020942 Analysis of the cytosolic domains of the hepatitis B virus envelope proteins for their function in viral particle assembly and infectivity.
Mutation
55 17215289 In vitro study of the effects of precore and lamivudine-resistant mutations on hepatitis B virus replication.
Mutation
56 17237626 [Resistance to adefovir in patients with chronic hepatitis B].
Mutation
57 17438047 The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro.
Mutation
58 17591025 In vitro susceptibility of adefovir-associated hepatitis B virus polymerase mutations to other antiviral agents.
Mutation
59 17601044 [Impact of amino acid sequence variation of a determinant(s) on the antigenic properties of hepatitis B virus HBsAg].
Mutation
60 17622616 Hepatitis B virus X protein differentially affects the ubiquitin-mediated proteasomal degradation of beta-catenin depending on the status of cellular p53.
Mutation
61 17666334 [Construction of whole-genome lamivudine-resistant hepatitis B virus mutant and its replication and expression in HepG2 cells].
Mutation
62 17763322 Replicative competence of the T131I, K141E, and G145R surface variants of hepatitis B Virus.
Mutation
63 18201182 A valine to phenylalanine mutation in the precore region of hepatitis B virus causes intracellular retention and impaired secretion of HBe-antigen.
Mutation
64 18343830 Effect of basal core promoter and pre-core mutations on hepatitis B virus replication.
Mutation
65 18434744 A unique amino acid substitution, L215Q, in the hepatitis B virus small envelope protein of a genotype F isolate that inhibits secretion of hepatitis B virus subviral particles.
Mutation
66 18597996 [Assessment of sensitivity of commercial test-systems for HBsAg immunodetection according to their ability to detect HBsAg-mutants of hepatitis B virus].
Mutation
67 18765256 Understanding the molecular basis of HBV drug resistance by molecular modeling.
Mutation
68 19028525 Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir.
Mutation
69 19099581 An overview of molecular epidemiology of hepatitis B virus (HBV) in India.
Mutation
70 19196007 A mutant hepatitis B virus core protein mimics inhibitors of icosahedral capsid self-assembly.
Mutation
71 19263474 The rtA194T polymerase mutation impacts viral replication and susceptibility to tenofovir in hepatitis B e antigen-positive and hepatitis B e antigen-negative hepatitis B virus strains.
Mutation
72 19327810 Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.
Mutation
73 19383566 trans-Complementation of HBV rtM204I mutant replication by HBV wild-type polymerase.
Mutation
74 19439550 Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene.
Mutation
75 19570861 A function essential to viral entry underlies the hepatitis B virus "a" determinant.
Mutation
76 19669299 Primary resistance, multidrug resistance, and cross-resistance pathways in HBV as a consequence of treatment failure.
Mutation
77 19710138 Functional surfaces of the hepatitis B virus capsid.
Mutation
78 19759159 The pre-S1 and antigenic loop infectivity determinants of the hepatitis B virus envelope proteins are functionally independent.
Mutation
79 19812261 Biological significance of amino acid substitutions in hepatitis B surface antigen (HBsAg) for glycosylation, secretion, antigenicity and immunogenicity of HBsAg and hepatitis B virus replication.
Mutation
80 19889143 Genomic variability associated with the presence of occult hepatitis B virus in HIV co-infected individuals.
Mutation
81 19889778 Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains.
Mutation
82 19998495 Clinical relevance and public health significance of hepatitis B virus genomic variations.
Mutation
83 20068337 Impacts of vaccination on hepatitis B viral infections in Korea over a 25-year period.
Mutation
84 20169198 Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir.
Mutation
85 20231988 Expression of Hepatitis B virus surface antigen (HBsAg) from genotypes A, D and F and influence of amino acid variations related or not to genotypes on HBsAg detection.
Mutation
86 20516566 Breakthrough HBV infection in vaccinated children in Taiwan: surveillance for HBV mutants.
Mutation
87 20516567 Development of HBV S gene mutants in chronic hepatitis B patients receiving nucleotide/nucleoside analogue therapy.
Mutation
88 20875460 Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery.
Mutation
89 20881037 Impairment of hepatitis B virus virion secretion by single-amino-acid substitutions in the small envelope protein and rescue by a novel glycosylation site.
Mutation
90 20887378 Impact of hepatitis B e antigen-suppressing mutations on the replication efficiency of entecavir-resistant hepatitis B virus strains.
Mutation
91 20944991 Hepatitis B genotype G and high frequency of lamivudine-resistance mutations among human immunodeficiency virus/hepatitis B virus co-infected patients in Brazil.
Mutation
92 20959021 Hepatitis B virus core protein with hot-spot mutations inhibit MxA gene transcription but has no effect on inhibition of virus replication by interferon α.
Mutation
93 21331286 Expression of Hepatitis B Virus Surface Antigen Containing Y100C Variant Frequently Detected in Occult HBV Infection.
Mutation
94 21358805 Serine phosphoacceptor sites within the core protein of hepatitis B virus contribute to genome replication pleiotropically.
Mutation
95 21368417 Identification of recombinant intermediates of hepatitis B virus between genotype B and C in vitro.
Mutation
96 21438026 Interaction of mutant hepatitis B X protein with p53 tumor suppressor protein affects both transcription and cell survival.
Mutation
97 21704589 Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21.
Mutation
98 21786803 Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
Mutation
99 21860069 The YMDD and rtA194T mutations result in decreased replication capacity in wild-type HBV as well as in HBV with precore and basal core promoter mutations.
Mutation
100 21871497 The main hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication.
Mutation
101 21998953 [The cloning, expression, purification and immunological identification of wild-type and mutant hepatitis B virus X gene in pGEX-6P-2 system].
Mutation
102 22100339 The effect of the G1888A mutation of subgenotype A1 of hepatitis B virus on the translation of the core protein.
Mutation
103 22170538 Comprehensive analysis of the prevalence of hepatitis B virus escape mutations in the major hydrophilic region of surface antigen.
Mutation
104 22296790 Variable capacity of 13 hepatitis B virus surface antigen assays for the detection of HBsAg mutants in blood samples.
Mutation
105 22314422 Decreased infectivity of nucleoside analogs-resistant hepatitis B virus mutants.
Mutation
106 22505793 Hepatitis B Virus genotypic differences map structurally close to NRTI resistance hot spots.
Mutation
107 22510145 Natural history of chronic hepatitis B: what exactly has REVEAL revealed?
Mutation
108 22595307 The detection of HBsAg mutants expressed in vitro using two different quantitative HBsAg assays.
Mutation
109 22668794 In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations.
Mutation
110 22967103 Mutations associated with occult hepatitis B virus infection result in decreased surface antigen expression in vitro.
Mutation
111 23166535 Effects of antiviral therapy on the recurrence of hepatocellular carcinoma after curative resection or liver transplantation.
Mutation
112 23237841 2'-Fluoro-6'-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: in vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action.
Mutation
113 23254298 Hepatitis B virus surface antigen (HBsAg)-positive and HBsAg-negative hepatitis B virus infection among mother-teenager pairs 13 years after neonatal hepatitis B virus vaccination.
Mutation
114 23261845 The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir.
Mutation
115 23301549 Hepatitis B e antigen-suppressing mutations enhance the replication efficiency of adefovir-resistant hepatitis B virus strains.
Mutation
116 23400390 Effects of hepatitis B virus mutations on its replication and liver disease severity.
Mutation
117 23403838 A novel method for the analysis of drug-resistant phenotypes of hepatitis B virus.
Mutation
118 23408582 High frequency of complex mutational patterns in lamivudine resistant hepatitis B virus isolates.
Mutation
119 24053482 Decreased antigenicity profiles of immune-escaped and drug-resistant hepatitis B surface antigen (HBsAg) double mutants.
Mutation
120 24076590 Construction and expression of hepatitis B surface antigen escape variants within the "a" determinant by site directed mutagenesis.
Mutation
121 24175223 Antiviral treatment to prevent chronic hepatitis B or C-related hepatocellular carcinoma.
Mutation
122 24282423 The N-Glycosylation Modification of LHBs (Large Surface Proteins of HBV) Effects on Endoplasmic Reticulum Stress, Cell Proliferation and its Secretion.
Mutation
123 24583110 Generation of a human hepatoma cell line supporting efficient replication of a lamivudine resistant hepatitis B virus.
Mutation
124 24814823 Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance.
Mutation
125 25019072 Hidden secret in hepatitis B viral X protein mutation and hypoxia-inducible factor-1α in hepatocarcinoma cancer.
Mutation
126 25483515 Hepatitis B vaccination.
Mutation
127 25567052 Hepatitis B Virus Core Promoter A1762T/G1764A (TA)/T1753A/T1768A Mutations Contribute to Hepatocarcinogenesis by Deregulating Skp2 and P53.
Mutation
128 25625002 Clinical utility of complex mutations in the core promoter and proximal precore regions of the hepatitis B virus genome.
Mutation
129 25890025 Mutation of arginine residues to avoid non-specific cellular uptakes for hepatitis B virus core particles.
Mutation
130 25942596 The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data.
Mutation
131 26119876 Hepatitis B "e" antigen-mediated inhibition of HBV replication fitness and transcription efficiency in vitro.
Mutation
132 26136564 An Aptamer against the Matrix Binding Domain on the Hepatitis B Virus Capsid Impairs Virion Formation.
Mutation
133 26201776 Hepatitis B virus genotype C encoding resistance mutations that emerge during adefovir dipivoxil therapy: in vitro replication phenotype.
Mutation
134 26220282 Inhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro.
Mutation
135 26322642 Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.
Mutation
136 26336997 Mechanism of Adefovir, Tenofovir and Entecavir Resistance: Molecular Modeling Studies of How A Novel Anti-HBV Agent (FMCA) Can Overcome the Drug Resistance.
Mutation
137 26349829 A novel pyridazinone derivative inhibits hepatitis B virus replication by inducing genome-free capsid formation.
Mutation
138 26478663 Hepatitis B virus infection in Indonesia.
Mutation
139 26541316 New broadly reactive neutralizing antibodies against hepatitis B virus surface antigen.
Mutation
140 26567840 Possible Involvement of Multidrug-Resistant Hepatitis B Virus sW172* Truncation Variant in the ER Stress Signaling Pathway during Hepatocarcinogenesis.
Mutation
141 26598693 High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein.
Mutation
142 27132039 Hepatitis B virus basal core promoter mutations show lower replication fitness associated with cccDNA acetylation status.
Mutation
143 27144395 Betaine Inhibits Hepatitis B Virus with an Advantage of Decreasing Resistance to Lamivudine and Interferon α.
Mutation
144 27158197 Precore/core region mutations of hepatitis B virus related to clinical severity.
Mutation
145 27420729 HBx mutations promote hepatoma cell migration through the Wnt/β-catenin signaling pathway.
Mutation
146 27473751 Enhanced pregenomic RNA levels and lowered precore mRNA transcription efficiency in a genotype A hepatitis B virus genome with C1766T and T1768A mutations obtained from a fulminant hepatitis patient.
Mutation
147 27588233 Compensatory variances of drug-induced hepatitis B virus YMDD mutations.
Mutation
148 27642350 Impacts of the G145R Mutation on the Structure and Immunogenic Activity of the Hepatitis B Surface Antigen: A Computational Analysis.
Mutation
149 27871021 Stop codons in the hepatitis B surface proteins are enriched during antiviral therapy and are associated with host cell apoptosis.
Mutation
150 27919846 Nucleos(t)ide analogues causes HBV S gene mutations and carcinogenesis.
Mutation
151 27976732 Biological characteristics comparison of HBV rtA181T mutants with truncated or substituted HBsAg expression in vitro and in vivo model systems.
Mutation
152 28045894 Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.
Mutation
153 28205569 Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms.
Mutation
154 28260621