Overview of HBV associated Occult HBV infection

Occult HBV infection is defined as HBV DNA detection in serum or in the liver by sensitive diagnostic tests in HBsAg-negative patients with or without serologic markers of previous viral exposure. OBI seems to be higher among subjects at high risk for HBV infection and with liver disease. OBI can be both a source of virus contamination in blood and organ donations and the reservoir for full blown hepatitis after reactivation.

ID	Literature	Title	Group
1	31200735	Viral integration drives multifocal HCC during the occult HBV infection.	VIS-cistrome
2	11679975	Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers.	Mutation
3	12014730	Occult HBV infection in cryptogenic liver cirrhosis in an area with high prevalence of HBV infection.	Mutation
4	12210410	Sequence analysis of pre-S/surface and pre-core/core promoter genes of hepatitis B virus in chronic hepatitis C patients with occult HBV infection.	Mutation
5	15486926	Occult hepatitis B virus infection in a North American adult hemodialysis patient population.	Mutation
6	15962285	Functional analysis of hepatitis B virus reactivating in hepatitis B surface antigen-negative individuals.	Mutation
7	16099111	[HBs antigen mutants: prevalence, clinical and diagnostic implications].	Mutation
8	16299727	Genotype, phylogenetic analysis, and transmission pattern of occult hepatitis B virus (HBV) infection in families of asymptomatic HBsAg carriers.	Mutation
9	17134939	Reactivation of an occult hepatitis B virus escape mutant in an anti-HBs positive, anti-HBc negative lymphoma patient.	Mutation
10	17464459	A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in Japan.	Mutation
11	17997353	Frequency and significance of hepatitis B virus surface gene variant circulating among 'antiHBc only' individuals in Eastern India.	Mutation
12	18662283	Prevalence and virological features of occult hepatitis B virus infection in female sex workers who work uncontrolled in Turkey.	Mutation
13	18998047	Molecular epidemiology of hepatitis B virus in an isolated Afro-Brazilian community.	Mutation
14	19070923	Occult hepatitis B virus infection in hepatitis B vaccinated children in Taiwan.	Mutation
15	19077239	Occult hepatitis B infection: an evolutionary scenario.	Mutation
16	19207682	Hepatitis B virus genotypes and hepatitis B surface antigen mutations in family contacts of hepatitis B virus infected patients with occult hepatitis B virus infection.	Mutation
17	19401629	Prevalence of occult hepatitis B virus infection in a general adult population in Korea.	Mutation
18	19431214	A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular carcinoma patients in Taiwan.	Mutation
19	19634759	[Surveillance for occult HBV infection and HBsAg variants in blood donors].	Mutation
20	19817965	Occult hepatitis B virus infection and lamivudine-resistant mutations in isolates from renal patients undergoing hemodialysis.	Mutation
21	19940057	Molecular characteristics of occult hepatitis B virus from blood donors in southeast China.	Mutation
22	20031483	Reactivation of hepatitis B virus infection with persistently negative HBsAg on three HBsAg assays in a lymphoma patient undergoing chemotherapy.	Mutation
23	20130415	Appearance of HbeAg in an occult persistent hepatitis B virus infection.	Mutation
24	20595500	Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia.	Mutation
25	20637763	Occult HBV infection in anti-HBs-positive young adults after neonatal HB vaccination.	Mutation
26	20675695	Prevalence of occult hepatitis B infection in a highly endemic area for chronic hepatitis B: a study of a large blood donor population.	Mutation
27	20799931	Anti-hepatitis B core antigen testing with detection and characterization of occult hepatitis B virus by an in-house nucleic acid testing among blood donors in Behrampur, Ganjam, Orissa in southeastern India: implications for transfusion.	Mutation
28	21063484	Occult hepatitis B in blood donors in Indonesia: altered antigenicity of the hepatitis B virus surface protein.	Mutation
29	21186533	[Occult HBV infection in patients with anti-HBc positive alone].	Mutation
30	21455562	Characteristics of occult hepatitis B virus infection in the Solomon Islands.	Mutation
31	21502674	Molecular and serological characterization of occult hepatitis B infection in blood donors from Mexico.	Mutation
32	22086128	Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection.	Mutation
33	22445262	New natural variants of hepatitis B virus among Amerindians from Argentina with mainly occult infections.	Mutation
34	22617152	High prevalence of occult hepatitis B virus infection in children born to HBsAg-positive mothers despite prophylaxis with hepatitis B vaccination and HBIG.	Mutation
35	22634131	Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors.	Mutation
36	23109450	Occult HBV infection among anti-HBc positive HIV-infected patients in apex referral centre, Eastern India.	Mutation
37	23588723	Molecular analysis of the hepatitis B virus presurface and surface gene in patients from eastern China with occult hepatitis B.	Mutation
38	23658444	Specific amino acid substitutions in the S protein prevent its excretion in vitro and may contribute to occult hepatitis B virus infection.	Mutation
39	23951004	Occult hepatitis B virus infection in anti-HBs-positive infants born to HBsAg-positive mothers in China.	Mutation
40	24119014	Clinical and virological features of occult hepatitis B in patients with HBsAg seroclearance post-treatment or spontaneously.	Mutation
41	24302857	Characterization of the occult hepatitis B virus variants circulating among the blood donors from eastern India.	Mutation
42	24715933	Prevalence and molecular analysis of occult hepatitis B virus infection isolated in a sample of cryptogenic cirrhosis patients in iran.	Mutation
43	25040474	Genetic characterization and genotyping of hepatitis B virus (HBV) isolates from donors with an occult HBV infection.	Mutation
44	25320728	Spontaneous HBsAg loss in Korean patients: relevance of viral genotypes, S gene mutations, and covalently closed circular DNA copy numbers.	Mutation
45	25471066	Occult hepatitis B virus infection among blood donors in Colombia.	Mutation
46	25500663	Occult hepatitis B infection among individuals belonging to the aboriginal Nicobarese tribe of India.	Mutation
47	25521058	Seroepidemiology and occult hepatitis B virus infection in young adults in Banjarmasin, Indonesia.	Mutation
48	25612181	Spontaneous reactivation of hepatitis B virus (HBV) infection in patients with resolved or occult HBV infection.	Mutation
49	25692622	A new vaccine escape mutant of hepatitis B virus causes occult infection.	Mutation
50	26148052	Occult Hepatitis B Virus Infection in Nigerian Blood Donors and Hepatitis B Virus Transmission Risks.	Mutation
51	26420301	Hepatitis B surface gene variants isolated from blood donors with overt and occult HBV infection in north eastern Egypt.	Mutation
52	26457811	Occult HBV Infection May Be Transmitted through Close Contact and Manifest as an Overt Infection.	Mutation
53	26587212	Molecular Characterization of Pre-Core/Core and S Region of Hepatitis B Virus in Hemodialysis Patients With Occult Hepatitis B Infection.	Mutation
54	26598112	Clearance of HBV DNA in immunized children born to HBsAg-positive mothers, years after being diagnosed with occult HBV infection.	Mutation
55	27031988	Functional analysis of 'a' determinant mutations associated with occult HBV in HIV-positive South Africans.	Mutation
56	27182775	Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.	Mutation
57	27486882	Occult HBV infection in HCC and cirrhotic tissue of HBsAg-negative patients: a virological and clinical study.	Mutation
58	27835694	Occult HBV Infection in Immunized Neonates Born to HBsAg-Positive Mothers: A Prospective and Follow-Up Study.	Mutation
59	27882070	Serological Patterns and Molecular Characterization of Occult Hepatitis B Virus Infection among Blood Donors.	Mutation
60	28236303	Characterization of hepatitis B virus (HBV) preS/S gene mutations in blood donors with occult HBV infection in the Baoji area of North China.	Mutation
61	28332361	Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene.	Mutation
62	28396718	Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt.	Mutation
63	28591184	Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India.	Mutation
64	28658511	Occult hepatitis B virus infection in immunized children born to carrier mothers.	Mutation
65	29326804	Occult Hepatitis B Virus Infection and Associated Genotypes among HBsAg-negative Subjects in Burkina Faso.	Mutation
66	29414186	Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay.	Mutation
67	29434654	Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection.	Mutation
68	30345529	Epidemiology, risk factors, and molecular characterization of occult hepatitis B infection among anti-hepatitis B core antigen alone subjects.	Mutation
69	30908666	Molecular and serological characterization of occult hepatitis B virus infection among patients with hemophilia.	Mutation
70	31153830	Occult HBV infection in patients with autoimmune hepatitis: A virological and clinical study.	Mutation
71	31269905	Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.	Mutation
72	31516090	Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains.	Mutation
73	31601912	Pro-oncogenic, intra host viral quasispecies in Diffuse large B cell lymphoma patients with occult Hepatitis B Virus infection.	Mutation
74	31877352	Occurrence of occult hepatitis B virus infection associated with envelope protein mutations according to anti-HBs carriage in blood donors.	Mutation
75	32336003	Novel hepatitis B virus surface antigen mutations associated with occult genotype B hepatitis B virus infection affect HBsAg detection.	Mutation
76	32463824	Characterization of occult hepatitis B in high-risk populations in Kenya.	Mutation
77	32472310	The prevalence of occult HBV infection in immunized children with HBsAg-positive parents: a hospital-based analysis.	Mutation
78	32545313	Impact of Lamivudine-Based Antiretroviral Treatment on Hepatitis B Viremia in HIV-Coinfected South Africans.	Mutation
79	32592870	Identification of mutations in the S gene of hepatitis B virus in HIV positive Mexican patients with occult hepatitis B virus infection.	Mutation
80	32763811	The sK122R mutation of hepatitis B virus (HBV) is associated with occult HBV infection: Analysis of a large cohort of Chinese patients.	Mutation
81	32922195	Occult Hepatitis B Virus Infection in Maintenance Hemodialysis Patients: Prevalence and Mutations in "a" Determinant.	Mutation
82	32997000	Molecular and serological characterization of occult hepatitis B among blood donors in Maputo, Mozambique.	Mutation
83	33211768	Prevalence and genetic variability of occult hepatitis B virus in a human immunodeficiency virus positive patient cohort in Gondar, Ethiopia.	Mutation
84	33453326	Role of core protein mutations in the development of occult HBV infection.	Mutation

Contents
Description

Group Note

Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)


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