Overview of MCV associated Merkel cell carcinoma

Merkel cell carcinoma is a rare and aggressive skin cancer occurring in about 3 people per 1,000,000 members of the population.It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. Factors involved in the development of MCC include the Merkel cell polyomavirus (MCPyV or MCV), a weakened immune system, and exposure to ultraviolet radiation.Merkel-cell carcinoma usually arises on the head, neck, and extremities, as well as in the perianal region and on the eyelid.It is more common in people over 60 years old, Caucasian people, and males.

ID	Literature	Title	Group
1	18202256	Clonal integration of a polyomavirus in human Merkel cell carcinoma.	VIS-cistrome
2	19291712	Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis.	Integration
3	20865165	Distinct merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinoma.	Integration
4	21497292	Hybrid capture and next-generation sequencing identify viral integration sites from formalin-fixed, paraffin-embedded tissue.	VIS-cistrome
5	22342276	Genetic variability and integration of Merkel cell polyomavirus in Merkel cell carcinoma.	Integration
6	23085629	Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice.	VIS-cistrome
7	23322199	Detection of Merkel cell polyomavirus with a tumour-specific signature in non-small cell lung cancer.	Integration
8	28049147	Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma.	VIS-cistrome
9	30873613	Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: Integration pattern suggest that large T antigen truncating events occur before or during integration.	VIS-cistrome
10	32833988	High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms.	VIS-cistrome
11	32188490	Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma.	VIS-cistrome
12	32878339	Merkel Cell Polyomavirus in Merkel Cell Carcinoma: Integration Sites and Involvement of the KMT2D Tumor Suppressor Gene.	VIS-cistrome
13	29696010	Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1.	Mutation
14	21841310	Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator.	Mutation

Contents
Description

Group Note

Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)