Merkel cell carcinoma is a rare and aggressive skin cancer occurring in about 3 people per 1,000,000 members of the population.It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. Factors involved in the development of MCC include the Merkel cell polyomavirus (MCPyV or MCV), a weakened immune system, and exposure to ultraviolet radiation.Merkel-cell carcinoma usually arises on the head, neck, and extremities, as well as in the perianal region and on the eyelid.It is more common in people over 60 years old, Caucasian people, and males.
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator.
Mutation
Contents Description
Group Note
Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)
Overview of MCV associated Merkel cell carcinoma
