Home
Virus
Gene
Disease
Dataset
Download
Help
 
Overview of HPV associated Low grade squamous intraepithelial lesion

Low grade squamous intraepithelial lesion(LSIL or LGSIL) indicates possible cervical dysplasia. LSIL usually indicates mild dysplasia (CIN 1), more than likely caused by a human papillomavirus infection. It is usually diagnosed following a Pap smear.CIN 1 is the most common and most benign form of cervical intraepithelial neoplasia and usually resolves spontaneously within two years. Because of this, LSIL results can be managed with a simple "watch and wait" philosophy. However, because there is a 12–16% chance of progression to more severe dysplasia, the physician may want to follow the results more aggressively by performing a colposcopy with biopsy.If the dysplasia progresses, treatment may be necessary. Treatment involves removal of the affected tissue, which can be accomplished by LEEP, cryosurgery, cone biopsy, or laser ablation.


ID Literature Title Group
1 11308254 Variation in the E2-binding domain of HPV 16 is associated with high-grade squamous intraepithelial lesions of the cervix.
Mutation
2 16960775 Human papillomavirus type 33 polymorphisms and high-grade squamous intraepithelial lesions of the uterine cervix.
Mutation
3 22001139 Human papillomaviruses 53 and 66: clinical aspects and genetic analysis.
Mutation
4 22911739 Characterization and whole genome analysis of human papillomavirus type 16 e1-1374^63nt variants.
Mutation
5 23124863 Codon 72 polymorphism of p53 and HPV type 16 E6 variants as risk factors for patients with squamous epithelial lesion of the uterine cervix.
Mutation
6 23136059 Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations.
Mutation
7 24150786 Functional effects of sequence variations in the E6 and E2 genes of human papillomavirus 16 European and Asian variants.
Mutation
8 24236186 Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing.
Mutation
9 25735347 Mutation detection of E6 and LCR genes from HPV 16 associated with carcinogenesis.
Mutation
10 25793187 Prevalence of human papillomavirus variants and genetic diversity in the L1 gene and long control region of HPV16, HPV31, and HPV58 found in North-East Brazil.
Mutation
11 25889023 Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.
Mutation
12 27610192 Molecular analysis of human Papillomavirus detected among women positive for cervical lesions by visual inspection with acetic acid/Lugol's iodine (VIA/VILI) in Libreville, Gabon.
Mutation
13 27801430 HPV16 E6 polymorphism and physical state of viral genome in relation to the risk of cervical cancer in women from the south of Poland.
Mutation
14 27977741 Analysis of Sequence Variation and Risk Association of Human Papillomavirus 52 Variants Circulating in Korea.
Mutation
15 30578936 Identification of human papillomavirus type 16 variants circulating in the Calabria region by sequencing and phylogenetic analysis of HPV16 from cervical smears.
Mutation
16 30583341 Phylogeny and Classification of Human Papillomavirus (HPV)16 and HPV18 Variants Based on E6 and L1 genes in Tunisian Women with Cervical Lesions
Mutation
17 31231420 Abundance of HPV L1 Intra-Genotype Variants With Capsid Epitopic Modifications Found Within Low- and High-Grade Pap Smears With Potential Implications for Vaccinology.
Mutation
18 31906371 Analysis of Human Papillomavirus (HPV) 16 Variants Associated with Cervical Infection in Italian Women.
Mutation
19 31933750 Variant sublineages of human papillomavirus type 16 predispose women to persistent infection characterized by a sequence analysis of the E6, L1, and LCR regions.
Mutation
20 33238632 E6/E7 Sequence Diversity of High-Risk Human Papillomaviruses in Two Geographically Isolated Populations of French Guiana.
Mutation
21 33909391 Sequence variation analysis of the E1 and E2 genes of human papillomavirus type 16 in cervical lesions in women from the south of Poland.
Mutation
Contents
Description
Group Note
  • Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
  • VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)