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Overview of HBV associated Liver cirrhosis

Liver cirrhosis is a condition in which the liver does not function properly due to long-term damage.This damage is characterized by the replacement of normal liver tissue by scar tissue.Typically, the disease develops slowly over months or years [1]. Early on, there are often no symptoms.As the disease worsens, a person may become tired, weak, itchy, have swelling in the lower legs, develop yellow skin, bruise easily, have fluid buildup in the abdomen, or develop spider-like blood vessels on the skin.


ID Literature Title Group
1 10320044 Hepatitis B virus variants with lamivudine-related mutations in the DNA polymerase and the 'a' epitope of the surface antigen are sensitive to ganciclovir.
Mutation
2 12436473 Hepatitis B virus S gene mutants in a patient with chronic active hepatitis with circulating Anti-HBs antibodies.
Mutation
3 15048802 Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin.
Mutation
4 15338371 Prognostic indicators of breakthrough hepatitis during lamivudine monotherapy for chronic hepatitis B virus infection.
Mutation
5 16618410 High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases.
Mutation
6 17030194 Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient.
Mutation
7 17203204 Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam.
Mutation
8 17239478 Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient.
Mutation
9 17259736 G1862T mutation among hepatitis B virus-infected individuals: association with viral genotypes and disease outcome in Kolkata, Eastern India.
Mutation
10 18507754 Clinical significance of precore and core promoter mutations in genotype D hepatitis B-related chronic liver disease.
Mutation
11 18508941 Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus.
Mutation
12 18551606 Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection.
Mutation
13 19008175 Core promoter mutant HBV non-responding to adefovir after viral breakthrough on lamivudine: rapid virologic response to tenofovir plus lamivudine in a cirrhotic patient.
Mutation
14 20087936 Molecular evolutionary analysis and mutational pattern of full-length genomes of hepatitis B virus isolated from Belgian patients with different clinical manifestations.
Mutation
15 20119580 Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
Mutation
16 20419326 Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma.
Mutation
17 20559531 A YIDD Mutation in a Case of Recurrent Hepatitis B after Liver Transplantation Induced by an S-escape Mutant.
Mutation
18 20959817 Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma.
Mutation
19 21159112 Prevention of lamivudine-resistant hepatitis B recurrence after liver transplantation with entecavir plus tenofovir combination therapy and perioperative hepatitis B immunoglobulin only.
Mutation
20 21392168 Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection.
Mutation
21 21863638 [One-year combination therapy de novo of adefovir dipivoxil and lamivudine for decompensated cirrhosis related to HBV].
Mutation
22 21941645 Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia.
Mutation
23 22313146 Reactivation of hepatitis B virus with mutated hepatitis B surface antigen in a liver transplant recipient receiving a graft from an antibody to hepatitis B surface antigen- and antibody to hepatitis B core antigen-positive donor.
Mutation
24 22720023 Hepatitis B virus gene mutations in liver diseases: a report from New Delhi.
Mutation
25 22919746 [Hepatitis B virus (HBV) mutation in enhancer I (HBV Enh I)/X-promoter and the relationship between chronic HBV-related disease spectrum].
Mutation
26 23304671 HBV Subgenotype C2 Infection, A1762T/G1764A Mutations May Contribute To Hepatocellular Carcinoma with Cirrhosis in Southeast China.
Mutation
27 23596461 Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naïve chronic HBV patients.
Mutation
28 23903686 Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.
Mutation
29 24637457 Mutation profiling of the hepatitis B virus strains circulating in North Indian population.
Mutation
30 24763132 Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers.
Mutation
31 25281206 Impacts of human leukocyte antigen DQ genetic polymorphisms and their interactions with hepatitis B virus mutations on the risks of viral persistence, liver cirrhosis, and hepatocellular carcinoma.
Mutation
32 25333524 Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Mutation
33 26577140 Hepatitis B virus basal core promoter/precore mutants and association with liver cirrhosis in children with chronic hepatitis B virus infection.
Mutation
34 26899956 Molecular characterization of hepatitis B virus from chronically-infected patients in Niamey, Niger.
Mutation
35 27486882 Occult HBV infection in HCC and cirrhotic tissue of HBsAg-negative patients: a virological and clinical study.
Mutation
36 28373061 Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.
Mutation
37 28902288 Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases.
Mutation
38 29285238 Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients.
Mutation
39 30406036 The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
Mutation
40 30505167 Hepatitis B virus precore G1896A mutation in chronic liver disease patients with HBeAg negative serology from North India.
Mutation
41 31105017 Association of HBsAg mutation patterns with hepatitis B infection outcome: Asymptomatic carriers versus HCC/cirrhotic patients.
Mutation
42 31308922 Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
Mutation
43 31341154 Association Between HBx Variations and Development of Severe Liver Disease Among Indonesian Patients.
Mutation
44 31501793 Comparison of pre-S1/S2 variations of hepatitis B virus between asymptomatic carriers and cirrhotic/hepatocellular carcinoma-affected individuals.
Mutation
45 31565220 Association between host TNF-α, TGF-β1, p53 polymorphisms, HBV X gene mutation, HBV viral load and the progression of HBV-associated chronic liver disease in Indonesian patients.
Mutation
46 32155009 [The prevalence clinically significant virus mutations among patients with chronic viral hepatitis B.]
Mutation
47 32523313 Conservation and variability of hepatitis B core at different chronic hepatitis stages.
Mutation
48 32568442 The genetic polymorphism down-regulating HLA-DRB1 enhancer activity facilitates HBV persistence, evolution and hepatocarcinogenesis in the Chinese Han population.
Mutation
49 9425945 Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation.
Mutation
50 33857724 LCR based quick detection of hotspot G1896A mutation in patients with different spectrum of hepatitis B.
Mutation
51 33947693 The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients.
Mutation
Contents
Description
Group Note
  • Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
  • VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)