Overview of HPV associated High grade squamous intraepithelial lesion

High-grade squamous intraepithelial lesion (HSIL or HGSIL) indicates moderate or severe cervical intraepithelial neoplasia or carcinoma in situ. It is usually diagnosed following a Pap test. In some cases these lesions can lead to invasive cervical cancer, if not followed appropriately. HSIL does not mean that cancer is present. Of all women with HSIL results, 2% or less have invasive cervical cancer at that time, however about 20% would progress to having invasive cervical cancer without treatment.To combat this progression, HSIL is usually followed by an immediate colposcopy with biopsy to sample or remove the dysplastic tissue. This tissue is sent for pathology testing to assign a histologic classification that is more definitive than a Pap smear result (which is a cytologic finding). HSIL generally corresponds to the histological classification of CIN 2 or 3.

ID	Literature	Title	Group
1	11308254	Variation in the E2-binding domain of HPV 16 is associated with high-grade squamous intraepithelial lesions of the cervix.	Mutation
2	16960775	Human papillomavirus type 33 polymorphisms and high-grade squamous intraepithelial lesions of the uterine cervix.	Mutation
3	22911739	Characterization and whole genome analysis of human papillomavirus type 16 e1-1374^63nt variants.	Mutation
4	23124863	Codon 72 polymorphism of p53 and HPV type 16 E6 variants as risk factors for patients with squamous epithelial lesion of the uterine cervix.	Mutation
5	23136059	Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations.	Mutation
6	24150786	Functional effects of sequence variations in the E6 and E2 genes of human papillomavirus 16 European and Asian variants.	Mutation
7	24236186	Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing.	Mutation
8	25735347	Mutation detection of E6 and LCR genes from HPV 16 associated with carcinogenesis.	Mutation
9	25793187	Prevalence of human papillomavirus variants and genetic diversity in the L1 gene and long control region of HPV16, HPV31, and HPV58 found in North-East Brazil.	Mutation
10	25889023	Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.	Mutation
11	27610192	Molecular analysis of human Papillomavirus detected among women positive for cervical lesions by visual inspection with acetic acid/Lugol's iodine (VIA/VILI) in Libreville, Gabon.	Mutation
12	27977741	Analysis of Sequence Variation and Risk Association of Human Papillomavirus 52 Variants Circulating in Korea.	Mutation
13	30578936	Identification of human papillomavirus type 16 variants circulating in the Calabria region by sequencing and phylogenetic analysis of HPV16 from cervical smears.	Mutation
14	30583341	Phylogeny and Classification of Human Papillomavirus (HPV)16 and HPV18 Variants Based on E6 and L1 genes in Tunisian Women with Cervical Lesions	Mutation
15	31231420	Abundance of HPV L1 Intra-Genotype Variants With Capsid Epitopic Modifications Found Within Low- and High-Grade Pap Smears With Potential Implications for Vaccinology.	Mutation
16	31906371	Analysis of Human Papillomavirus (HPV) 16 Variants Associated with Cervical Infection in Italian Women.	Mutation
17	33238632	E6/E7 Sequence Diversity of High-Risk Human Papillomaviruses in Two Geographically Isolated Populations of French Guiana.	Mutation
18	33660963	Distribution of human papillomavirus genotypes in women with high-grade cervical intraepithelial lesions and cervical carcinoma and analysis of human papillomavirus-16 genomic variants.	Mutation

Contents
Description

Group Note

Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)