Home
Virus
Gene
Disease
Dataset
Download
Help
 
Overview of HBV associated Hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and is the most common cause of death in people with cirrhosis. It occurs in the setting of chronic liver inflammation, and is most closely linked to chronic viral hepatitis infection (hepatitis B or C) or exposure to toxins such as alcohol or aflatoxin.


ID Literature Title Group
1 10481738 Clinical implications of mutations C-to-T1653 and T-to-C/A/G1753 of hepatitis B virus genotype C genome in chronic liver disease.
Mutation
2 10534721 Hepatitis B virus core promoter mutations in children with multiple anti-HBe/HBeAg reactivations result in enhanced promoter activity.
Mutation
3 10535488 Detection of pre-S/S gene mutants in chronic hepatitis B carriers with concurrent hepatitis B surface antibody and hepatitis B surface antigen.
Mutation
4 10607231 Hepatitis B envelope protein mutants in human hepatocellular carcinoma tissues.
Mutation
5 10949955 Detection of hepatitis B virus surface antigen mutants in paraffin-embedded hepatocellular carcinoma tissues.
Mutation
6 11002246 Hepatitis B virus X gene variability in French-born patients with chronic hepatitis and hepatocellular carcinoma.
Mutation
7 11424118 Full-length genomic analysis of hepatitis B virus isolates in a patient progressing from hepatitis to hepatocellular carcinoma.
Mutation
8 11468748 Full-length genomic analysis of hepatitis B virus isolates in a patient progressing from hepatitis to hepatocellular carcinoma.
Mutation
9 12805468 Coexistence of two distinct secretion mutations (P5T and I97L) in hepatitis B virus core produces a wild-type pattern of secretion.
Mutation
10 14756274 Efficacy of combined lamivudine and adefovir dipivoxil treatment for severe HBV graft reinfection after living donor liver transplantation.
Mutation
11 15543574 Comparison of full length sequences of hepatitis B virus isolates in hepatocellular carcinoma patients and asymptomatic carriers of Korea.
Mutation
12 16080797 HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers.
Mutation
13 16618410 High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases.
Mutation
14 16907843 Virological analysis, genotypes and mutational patterns of the HBV precore/core gene in HBV/HCV-related hepatocellular carcinoma.
Mutation
15 17203204 Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam.
Mutation
16 17259736 G1862T mutation among hepatitis B virus-infected individuals: association with viral genotypes and disease outcome in Kolkata, Eastern India.
Mutation
17 17464459 A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in Japan.
Mutation
18 17652471 Influence of hepatitis B virus X and core promoter mutations on hepatocellular carcinoma among patients infected with subgenotype C2.
Mutation
19 17888035 Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis and hepatocellular carcinoma.
Mutation
20 18216102 Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus.
Mutation
21 18507754 Clinical significance of precore and core promoter mutations in genotype D hepatitis B-related chronic liver disease.
Mutation
22 18508941 Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus.
Mutation
23 18551606 Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection.
Mutation
24 18695135 Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma.
Mutation
25 18844615 HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study.
Mutation
26 18939932 Combined mutations in pre-s/surface and core promoter/precore regions of hepatitis B virus increase the risk of hepatocellular carcinoma: a case-control study.
Mutation
27 18952249 Analysis of hepatitis B virus X gene phylogeny, genetic variability and its impact on pathogenesis: implications in Eastern Indian HBV carriers.
Mutation
28 19043921 The oncogenic potential of hepatitis B virus rtA181T/ surface truncation mutant.
Mutation
29 19187787 Rapid and sensitive detection of hepatitis B virus 1762T/1764A double mutation from hepatocellular carcinomas using LNA-mediated PCR clamping and hybridization probes.
Mutation
30 19431214 A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular carcinoma patients in Taiwan.
Mutation
31 19574418 Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.
Mutation
32 19664630 Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression.
Mutation
33 20119580 Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
Mutation
34 20160279 Distribution and hepatocellular carcinoma-related viral properties of hepatitis B virus genotypes in Mainland China: a community-based study.
Mutation
35 20419326 Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma.
Mutation
36 20550526 Nucleotide changes related to hepatocellular carcinoma in the enhancer 1/x-promoter of hepatitis B virus subgenotype C2 in cirrhotic patients.
Mutation
37 20699378 Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma.
Mutation
38 20814897 Hepatitis B virus-DNA level and basal core promoter A1762T/G1764A mutation in liver tissue independently predict postoperative survival in hepatocellular carcinoma.
Mutation
39 20820820 A population-based cohort study for the risk factors of HCC among hepatitis B virus mono-infected subjects in Japan.
Mutation
40 20959817 Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma.
Mutation
41 20962085 Novel F141L pre-S2 mutation in hepatitis B virus increases the risk of hepatocellular carcinoma in patients with chronic genotype C infections.
Mutation
42 21063480 A case-control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma.
Mutation
43 21104161 Association of novel mutations and haplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma.
Mutation
44 21108338 A matched case-control study of hepatitis B virus mutations in the preS and core promoter regions associated independently with hepatocellular carcinoma.
Mutation
45 21325784 Hepatitis B virus core protein variations differ in tumor and adjacent nontumor tissues from patients with hepatocellular carcinoma.
Mutation
46 21490166 Impact of hepatitis B virus (HBV) x gene mutations on hepatocellular carcinoma development in chronic HBV infection.
Mutation
47 21865669 Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC.
Mutation
48 21933446 Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B.
Mutation
49 21941645 Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia.
Mutation
50 21950207 Prevalence of hepatitis B genotype and viral basic core promoter and precore mutations among teenagers in Macao: relationship with hepatocellular carcinoma development.
Mutation
51 22012717 Clonal analysis of hepatitis B viruses among blood donors from Joinville, Brazil: evidence of dual infections, intragenotype recombination and markers of risk for hepatocellular carcinoma.
Mutation
52 22014121 Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients.
Mutation
53 22136288 Mutational complex genotype of the hepatitis B virus X /precore regions as a novel predictive marker for hepatocellular carcinoma.
Mutation
54 22178505 Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma in China.
Mutation
55 22675557 Precore mutation of hepatitis B virus may contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis.
Mutation
56 22720023 Hepatitis B virus gene mutations in liver diseases: a report from New Delhi.
Mutation
57 22919746 [Hepatitis B virus (HBV) mutation in enhancer I (HBV Enh I)/X-promoter and the relationship between chronic HBV-related disease spectrum].
Mutation
58 22962577 Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis.
Mutation
59 23071796 Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma.
Mutation
60 23104706 Effects of genomic changes in hepatitis B virus on postoperative recurrence and survival in patients with hepatocellular carcinoma.
Mutation
61 23304671 HBV Subgenotype C2 Infection, A1762T/G1764A Mutations May Contribute To Hepatocellular Carcinoma with Cirrhosis in Southeast China.
Mutation
62 23383661 Synergistic effects of A1896, T1653 and T1762/A1764 mutations in genotype c2 hepatitis B virus on development of hepatocellular carcinoma.
Mutation
63 23386590 Interaction of signal transducer and activator of transcription 3 polymorphisms with hepatitis B virus mutations in hepatocellular carcinoma.
Mutation
64 23516510 Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk.
Mutation
65 23596461 Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naïve chronic HBV patients.
Mutation
66 23621183 Hepatitis B virus gene C1653T polymorphism mutation and hepatocellular carcinoma risk: an updated meta-analysis.
Mutation
67 23805180 Occult and Overt HBV Co-Infections Independently Predict Postoperative Prognosis in HCV-Associated Hepatocellular Carcinoma.
Mutation
68 23903686 Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.
Mutation
69 24118778 Association of a potential functional pre-miR-218 polymorphism and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk.
Mutation
70 24344773 Combinations of eight key mutations in the X/preC region and genomic activity of hepatitis B virus are associated with hepatocellular carcinoma.
Mutation
71 24346287 HBx mutants differentially affect the activation of hypoxia-inducible factor-1α in hepatocellular carcinoma.
Mutation
72 24637457 Mutation profiling of the hepatitis B virus strains circulating in North Indian population.
Mutation
73 24748463 Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk.
Mutation
74 24788140 Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.
Mutation
75 24849936 Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in Qidong, China.
Mutation
76 24973814 Mother-to-child transmission of hepatitis B virus: evolution of hepatocellular carcinoma-related viral mutations in the post-immunization era.
Mutation
77 25281206 Impacts of human leukocyte antigen DQ genetic polymorphisms and their interactions with hepatitis B virus mutations on the risks of viral persistence, liver cirrhosis, and hepatocellular carcinoma.
Mutation
78 25333524 Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Mutation
79 25477976 Hepatitis B virus core promoter mutations in patients with chronic hepatitis B and hepatocellular carcinoma in bucharest, romania.
Mutation
80 25501679 Association between HBV Pre-S mutations and the intracellular HBV DNAs in HBsAg-positive hepatocellular carcinoma in China.
Mutation
81 26290395 Hepatitis B Virus Combo Mutations Improve the Prediction and Active Prophylaxis of Hepatocellular Carcinoma: A Clinic-Based Cohort Study.
Mutation
82 26543337 Quantitative evaluation of hepatitis B virus mutations and hepatocellular carcinoma risk: a meta-analysis of prospective studies.
Mutation
83 26706415 A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of hepatitis B virus X protein involved in hepatitis B virus-related hepatocarcinogenesis in HepG2 cell lines.
Mutation
84 26715821 Development of Fok-I based nested polymerase chain reaction-restriction fragment length polymorphism analysis for detection of hepatitis B virus X region V5M mutation.
Mutation
85 26848866 Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis.
Mutation
86 26899956 Molecular characterization of hepatitis B virus from chronically-infected patients in Niamey, Niger.
Mutation
87 27075395 Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.
Mutation
88 27303803 Hepatitis B Virus Core Promoter Double Mutations (A1762T, G1764A) Are Associated with Lower Levels of Serum Dihydrolipoyl Dehydrogenase.
Mutation
89 27340355 Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma.
Mutation
90 27486882 Occult HBV infection in HCC and cirrhotic tissue of HBsAg-negative patients: a virological and clinical study.
Mutation
91 27727182 Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.
Mutation
92 27779207 HBV core promoter mutations and AKT upregulate S-phase kinase-associated protein 2 to promote postoperative hepatocellular carcinoma progression.
Mutation
93 28339094 F221Y mutation in hepatitis B virus reverse transcriptase is associated with hepatocellular carcinoma prognosis following liver resection.
Mutation
94 28373061 Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.
Mutation
95 28902288 Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases.
Mutation
96 29285238 Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients.
Mutation
97 29287068 Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients.
Mutation
98 29434654 Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection.
Mutation
99 29628773 The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
Mutation
100 29893492 An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People.
Mutation
101 30406036 The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
Mutation
102 30472417 The novel HBx mutation F30V correlates with hepatocellular carcinoma in vivo, reduces hepatitis B virus replicative efficiency and enhances anti-apoptotic activity of HBx N terminus in vitro.
Mutation
103 30505167 Hepatitis B virus precore G1896A mutation in chronic liver disease patients with HBeAg negative serology from North India.
Mutation
104 30702819 Analyses of the Genetic Diversities and Mutations of the Hepatitis B Virus Genome BCP/Pre C Region.
Mutation
105 31105017 Association of HBsAg mutation patterns with hepatitis B infection outcome: Asymptomatic carriers versus HCC/cirrhotic patients.
Mutation
106 31341154 Association Between HBx Variations and Development of Severe Liver Disease Among Indonesian Patients.
Mutation
107 31341412 Locus 5p13.1 may be associated with the selection of cancer-related HBV core promoter mutations.
Mutation
108 31434918 High possibility of hepatocarcinogenesis in HBV genotype C1 infected Cambodians is indicated by 340 HBV C1 full-genomes analysis from GenBank.
Mutation
109 31501793 Comparison of pre-S1/S2 variations of hepatitis B virus between asymptomatic carriers and cirrhotic/hepatocellular carcinoma-affected individuals.
Mutation
110 31565220 Association between host TNF-α, TGF-β1, p53 polymorphisms, HBV X gene mutation, HBV viral load and the progression of HBV-associated chronic liver disease in Indonesian patients.
Mutation
111 32155009 [The prevalence clinically significant virus mutations among patients with chronic viral hepatitis B.]
Mutation
112 32504396 Molecular characterization of hepatitis B virus isolated from Black South African cancer patients, with and without hepatocellular carcinoma.
Mutation
113 32523313 Conservation and variability of hepatitis B core at different chronic hepatitis stages.
Mutation
114 32568442 The genetic polymorphism down-regulating HLA-DRB1 enhancer activity facilitates HBV persistence, evolution and hepatocarcinogenesis in the Chinese Han population.
Mutation
115 32722114 Next-Generation Sequencing-Based Quantitative Detection of Hepatitis B Virus Pre-S Mutants in Plasma Predicts Hepatocellular Carcinoma Recurrence.
Mutation
116 33247709 Compartmentalized evolution of hepatitis B virus contributes differently to the prognosis of hepatocellular carcinoma.
Mutation
117 33381105 Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region.
Mutation
118 9824278 The sequential occurrence of viral mutations in a liver transplant recipient re-infected with hepatitis B: hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss.
Mutation
119 9857356 Current aspects of hepatitis B surface antigen mutants in Singapore.
Mutation
120 33857724 LCR based quick detection of hotspot G1896A mutation in patients with different spectrum of hepatitis B.
Mutation
121 33947693 The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients.
Mutation
Contents
Description
Group Note
  • Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
  • VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)