Overview of HBV associated Hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and is the most common cause of death in people with cirrhosis. It occurs in the setting of chronic liver inflammation, and is most closely linked to chronic viral hepatitis infection (hepatitis B or C) or exposure to toxins such as alcohol or aflatoxin.

ID	Literature	Title	Group
1	27453547	HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant.	VIS-cistrome
2	30070724	Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region.	VIS-cistrome
3	27703150	Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma.	VIS-cistrome
4	29861854	Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.	VIS-cistrome
5	29437961	Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles.	VIS-cistrome
6	30271481	Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma.	VIS-cistrome
7	22267523	The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.	VIS-cistrome
8	28622513	Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma.	VIS-cistrome
9	27339696	Divergent viral presentation among human tumors and adjacent normal tissues.	VIS-cistrome
10	26867494	Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma.	VIS-cistrome
11	22634754	Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma.	VIS-cistrome
12	29212479	A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis.	VIS-cistrome
13	25901726	Identification of HBV-MLL4 Integration and Its Molecular Basis in Chinese Hepatocellular Carcinoma.	VIS-cistrome
14	23236287	Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach.	VIS-cistrome
15	28414318	Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma.	VIS-cistrome
16	25627239	Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma.	VIS-cistrome
17	23867110	HIVID: an efficient method to detect HBV integration using low coverage sequencing.	VIS-cistrome
18	27064257	Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.	VIS-cistrome
19	30531861	Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress.	VIS-cistrome
20	26553052	Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features.	VIS-cistrome
21	25815780	DNA methylation consistency implicates the primary tumor cell origin of recurrent hepatocellular carcinoma.	VIS-cistrome
22	23740984	Landscape of DNA virus associations across human malignant cancers: analysis of 3,775 cases using RNA-Seq.	VIS-cistrome
23	24085110	The landscape of viral expression and host gene fusion and adaptation in human cancer.	VIS-cistrome
24	22634756	Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.	VIS-cistrome
25	27639803	Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents.	VIS-cistrome
26	22962577	Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis.	VIS-cistrome
27	12802289	Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers.	VIS-cistrome
28	24582836	Viral-human chimeric transcript predisposes risk to liver cancer development and progression.	VIS-cistrome
29	18023912	Impact of hepatitis B virus (HBV) X gene integration in liver tissue on hepatocellular carcinoma development in serologically HBV-negative chronic hepatitis C patients.	VIS-cistrome
30	30535432	Different types of viral‑host junction found in HBV integration breakpoints in HBV‑infected patients.	VIS-cistrome
31	23842217	Impact of hepatitis B virus integration into liver tissue on the efficacy of peginterferon and ribavirin therapy in hepatitis B virus-negative chronic hepatitis C patients.	VIS-cistrome
32	11593432	Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging.	VIS-cistrome
33	25636086	Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.	VIS-cistrome
34	12813464	Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene.	VIS-cistrome
35	22989571	Hepatitis B virus DNA integration in tumour tissue of a non-cirrhotic HFE-haemochromatosis patient with hepatocellular carcinoma.	VIS-cistrome
36	26397742	Significance of the quantitative measurement of the chr16: 51320015 integration site in hepatocytes of patients with chronic hepatitis B.	VIS-cistrome
37	31417659	HBV Integration-mediated Cell Apoptosis in HepG2.2.15.	VIS-cistrome
38	31200735	Viral integration drives multifocal HCC during the occult HBV infection.	VIS-cistrome
39	31064734	Retrotransposon elements among initial sites of hepatitis B virus integration into human genome in the HepG2-NTCP cell infection model.	VIS-cistrome
40	25485619	A comprehensive transcriptional portrait of human cancer cell lines.	VIS-cistrome
41	32592629	Deep sequencing of liver explant transcriptomes reveals extensive expression from integrated hepatitis B virus DNA.	VIS-cistrome
42	32570699	Analysis of HBV Genomes Integrated into the Genomes of Human Hepatoma PLC/PRF/5 Cells by HBV Sequence Capture-Based Next-Generation Sequencing.	VIS-cistrome
43	30704462	Detecting virus integration sites based on multiple related sequencing data by VirTect.	VIS-cistrome
44	30016933	HGT-ID: an efficient and sensitive workflow to detect human-viral insertion sites using next-generation sequencing data.	VIS-cistrome
45	32797164	Studies on the correlation between mutation and integration of HBV in hepatocellular carcinoma.	VIS-cistrome
46	32170761	Hepatitis B Virus-Telomerase Reverse Transcriptase Promoter Integration Harnesses Host ELF4, Resulting in Telomerase Reverse Transcriptase Gene Transcription in Hepatocellular Carcinoma.	VIS-cistrome
47	32100258	Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer.	VIS-cistrome
48	33947693	The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients.	VIS-cistrome

Contents
Description

Group Note

Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)


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