Overview of HBV associated Hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and is the most common cause of death in people with cirrhosis. It occurs in the setting of chronic liver inflammation, and is most closely linked to chronic viral hepatitis infection (hepatitis B or C) or exposure to toxins such as alcohol or aflatoxin.


ID Literature Title Group
1 27453547 HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant.
VIS-cistrome
2 30070724 Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region.
VIS-cistrome
3 27703150 Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma.
VIS-cistrome
4 29861854 Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.
VIS-cistrome
5 29437961 Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles.
VIS-cistrome
6 30271481 Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma.
VIS-cistrome
7 22267523 The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.
VIS-cistrome
8 28622513 Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma.
VIS-cistrome
9 27339696 Divergent viral presentation among human tumors and adjacent normal tissues.
VIS-cistrome
10 26867494 Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma.
VIS-cistrome
11 22634754 Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma.
VIS-cistrome
12 29212479 A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis.
VIS-cistrome
13 25901726 Identification of HBV-MLL4 Integration and Its Molecular Basis in Chinese Hepatocellular Carcinoma.
VIS-cistrome
14 23236287 Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach.
VIS-cistrome
15 28414318 Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma.
VIS-cistrome
16 25627239 Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma.
VIS-cistrome
17 23867110 HIVID: an efficient method to detect HBV integration using low coverage sequencing.
VIS-cistrome
18 27064257 Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
VIS-cistrome
19 30531861 Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress.
VIS-cistrome
20 26553052 Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features.
VIS-cistrome
21 25815780 DNA methylation consistency implicates the primary tumor cell origin of recurrent hepatocellular carcinoma.
VIS-cistrome
22 23740984 Landscape of DNA virus associations across human malignant cancers: analysis of 3,775 cases using RNA-Seq.
VIS-cistrome
23 24085110 The landscape of viral expression and host gene fusion and adaptation in human cancer.
VIS-cistrome
24 22634756 Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.
VIS-cistrome
25 27639803 Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents.
VIS-cistrome
26 22962577 Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis.
VIS-cistrome
27 12802289 Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers.
VIS-cistrome
28 24582836 Viral-human chimeric transcript predisposes risk to liver cancer development and progression.
VIS-cistrome
29 18023912 Impact of hepatitis B virus (HBV) X gene integration in liver tissue on hepatocellular carcinoma development in serologically HBV-negative chronic hepatitis C patients.
VIS-cistrome
30 30535432 Different types of viral‑host junction found in HBV integration breakpoints in HBV‑infected patients.
VIS-cistrome
31 23842217 Impact of hepatitis B virus integration into liver tissue on the efficacy of peginterferon and ribavirin therapy in hepatitis B virus-negative chronic hepatitis C patients.
VIS-cistrome
32 11593432 Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging.
VIS-cistrome
33 25636086 Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.
VIS-cistrome
34 12813464 Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene.
VIS-cistrome
35 22989571 Hepatitis B virus DNA integration in tumour tissue of a non-cirrhotic HFE-haemochromatosis patient with hepatocellular carcinoma.
VIS-cistrome
36 26397742 Significance of the quantitative measurement of the chr16: 51320015 integration site in hepatocytes of patients with chronic hepatitis B.
VIS-cistrome
37 31417659 HBV Integration-mediated Cell Apoptosis in HepG2.2.15.
VIS-cistrome
38 31200735 Viral integration drives multifocal HCC during the occult HBV infection.
VIS-cistrome
39 31064734 Retrotransposon elements among initial sites of hepatitis B virus integration into human genome in the HepG2-NTCP cell infection model.
VIS-cistrome
40 25485619 A comprehensive transcriptional portrait of human cancer cell lines.
VIS-cistrome
41 32592629 Deep sequencing of liver explant transcriptomes reveals extensive expression from integrated hepatitis B virus DNA.
VIS-cistrome
42 32570699 Analysis of HBV Genomes Integrated into the Genomes of Human Hepatoma PLC/PRF/5 Cells by HBV Sequence Capture-Based Next-Generation Sequencing.
VIS-cistrome
43 30704462 Detecting virus integration sites based on multiple related sequencing data by VirTect.
VIS-cistrome
44 30016933 HGT-ID: an efficient and sensitive workflow to detect human-viral insertion sites using next-generation sequencing data.
VIS-cistrome
45 32797164 Studies on the correlation between mutation and integration of HBV in hepatocellular carcinoma.
VIS-cistrome
46 32170761 Hepatitis B Virus-Telomerase Reverse Transcriptase Promoter Integration Harnesses Host ELF4, Resulting in Telomerase Reverse Transcriptase Gene Transcription in Hepatocellular Carcinoma.
VIS-cistrome
47 32100258 Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer.
VIS-cistrome
48 33947693 The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients.
VIS-cistrome
Contents
Description
Group Note
  • Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
  • VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)