Overview of HTLV-1 associated myelopathy/tropical spastic paraparesis

Tropical spastic paraparesis (TSP) is a medical condition that causes weakness, muscle spasms, and sensory disturbance by human T-lymphotropic virus resulting in paraparesis, weakness of the legs. As the name suggests, it is most common in tropical regions, including the Caribbean. Blood transfusion products are screened for HTLV-1 antibodies, as a preventive measure.

ID	Literature	Title	Group
1	29186194	Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo.	VIS-cistrome
2	31154802	Assessment of Genetic Diversity of HTLV-1 ORF-I Sequences Collected from Patients with Different Clinical Profiles.	Mutation
3	27553711	Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome.	Mutation
4	23510700	Molecular characterization of HTLV-1 gp46 glycoprotein from health carriers and HAM/TSP infected individuals.	Mutation
5	17067264	Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.	Mutation
6	23800288	Molecular study of HBZ and gp21 human T cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals.	Mutation
7	26472535	Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers.	Mutation
8	28420387	Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis.	Mutation
9	33835501	Molecular characterization of HTLV-1 genomic region hbz from patients with different clinical conditions.	Mutation

Contents
Description

Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)