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Overview of HBV associated HBV infection

Hepatitis B virus (HBV) is a hepatotropic virus that can establish a persistent and chronic infection in humans through immune anergy. Currently, 3.5% of the global population is chronically infected with HBV, although the incidence of HBV infections is decreasing owing to vaccination and, to a lesser extent, the use of antiviral therapy to reduce the viral load of chronically infected individuals (PMID: 29877316).


ID Literature Title Group
1 10385663 Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under HBIg immunoglobulin after liver transplantation.
Mutation
2 10430358 Liver graft infection by HBV S-gene mutants in transplant patients receiving long-term HBIg prophylaxis.
Mutation
3 10534721 Hepatitis B virus core promoter mutations in children with multiple anti-HBe/HBeAg reactivations result in enhanced promoter activity.
Mutation
4 10596008 Effect of variation in the common "a" determinant on the antigenicity of hepatitis B surface antigen.
Mutation
5 10628774 Fulminant hepatic failure resulting from lamivudine-resistant hepatitis B virus in a renal transplant recipient: durable response after orthotopic liver transplantation on adefovir dipivoxil and hepatitis B immune globulin.
Mutation
6 10669360 Selection of multiresistant hepatitis B virus during sequential nucleoside-analogue therapy.
Mutation
7 10682123 Analysis of hepatitis B virus quasispecies changes during emergence and reversion of lamivudine resistance in liver transplantation.
Mutation
8 10827158 Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy.
Mutation
9 11120616 Intra-familial evidence of horizontal transmission of hepatitis B virus surface antigen mutant G145R.
Mutation
10 11208474 Analysis of HBs antigen negative variant of hepatitis B virus: unique substitutions, Glu129 to Asp and Gly145 to Ala in the surface antigen gene.
Mutation
11 11509998 Effectiveness of hepatitis B vaccination in babies born to hepatitis B surface antigen-positive mothers in Italy.
Mutation
12 11526151 Phylogenetic origin of hepatitis B virus strains with precore C-1858 variant.
Mutation
13 11596084 Residual hepatitis B virus particles in liver transplant recipients receiving lamivudine: PCR quantitation of HBV DNA and ELISA of preS1 antigen.
Mutation
14 11696228 Characterization of a novel hepatitis B virus mutant: demonstration of mutation-induced hepatitis B virus surface antigen group specific "a" determinant conformation change and its application in diagnostic assays.
Mutation
15 11780452 Hepatitis B virus S gene mutants in infants infected despite immunoprophylaxis.
Mutation
16 11851835 Prevalence of vaccine-induced escape mutants of hepatitis B virus in the adult population in China: a prospective study in 176 restaurant employees.
Mutation
17 12089278 Sensitive detection of HBsAg mutants by a gap ligase chain reaction assay.
Mutation
18 12171302 Identification of a new variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy.
Mutation
19 12358268 Core promoter mutations 3 years after anti-hepatitis B e seroconversion in patients with chronic hepatitis B or hepatitis B and C infection and cancer remission.
Mutation
20 12457969 Presence of hepatitis B surface antigen mutant G145R DNA in the peripheral blood leukocytes of the family members of an asymptomatic carrier and evidence of its horizontal transmission.
Mutation
21 12526951 Genotypic and phenotypic resistance: longitudinal and sequential analysis of hepatitis B virus polymerase mutations in patients with lamivudine resistance after liver transplantation.
Mutation
22 12667359 [The prevalence of hepatitis B virus precore mutant isolated from asymptomatic carriers in Guangxi].
Mutation
23 12747252 Development of peptide nucleic acid mediated polymerase chain reaction clamping (PMPC)--direct sequencing method for detecting lamivudine-resistant hepatitis B virus (HBV) variants with high sensitivity and specificity.
Mutation
24 12757503 High frequency of hepatitis B virus infection in patients with beta-thalassemia receiving multiple transfusions.
Mutation
25 12780567 Characterization of hepatitis B virus surface antigen and polymerase mutations in liver transplant recipients pre- and post-transplant.
Mutation
26 12823591 YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine.
Mutation
27 12870011 [Analysis of three lamivudine-resistant HBV mutants with the method of restriction enzyme digestion and its application].
Mutation
28 14557667 The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro.
Mutation
29 14642631 Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient.
Mutation
30 14748061 Clade analysis and surface antigen polymorphism of hepatitis B virus American genotypes.
Mutation
31 14981758 Identification of rare polymerase variants of hepatitis B virus using a two-stage PCR with peptide nucleic acid clamping.
Mutation
32 14987532 Detection of hepatitis B virus variants resistant to lamivudine and famciclovir among randomly selected chronic carriers from Spain.
Mutation
33 15016847 Modulation of hepatitis B virus secretion by naturally occurring mutations in the S gene.
Mutation
34 15158343 Real-time quantification of hepatitis B virus core-promoter and pre-core mutants during hepatitis E antigen seroconversion.
Mutation
35 15239096 Usefulness of dried blood samples for quantification and molecular characterization of HBV-DNA.
Mutation
36 15288618 A novel pattern (sW195a) in surface gene of HBV DNA due to YSDD (L180M plus M204S) mutation selected during lamivudine therapy and successful treatment with adefovir dipivoxil.
Mutation
37 15361503 Survey of hepatitis B surface variant infection in children 15 years after a nationwide vaccination programme in Taiwan.
Mutation
38 15472342 Pyrosequencing for detection of lamivudine-resistant hepatitis B virus.
Mutation
39 15661154 Effect of mutating the two cysteines required for HBe antigenicity on hepatitis B virus DNA replication and virion secretion.
Mutation
40 15872296 Prevalence, incidence, and clinical relevance of the reverse transcriptase V207I mutation outside the YMDD motif of the hepatitis B virus polymerase during lamivudine therapy.
Mutation
41 15918335 Evaluation of methods for monitoring drug resistance in chronic hepatitis B patients during lamivudine therapy based on mass spectrometry and reverse hybridization.
Mutation
42 15962387 Optimization of competitively differentiated polymerase chain reaction in detection of HBV basal core promoter mutation.
Mutation
43 16246191 Community-based epidemiology of hepatitis B virus infection in West Bengal, India: prevalence of hepatitis B e antigen-negative infection and associated viral variants.
Mutation
44 16299725 Frequency of hepatitis B virus 'a' determinant variants in unselected Spanish chronic carriers.
Mutation
45 16372296 Characteristics of hepatitis B virus in Ghana: full length genome sequences indicate the endemicity of genotype E in West Africa.
Mutation
46 16373428 Genotypic resistance to lamivudine among hepatitis B virus isolates in Mexico.
Mutation
47 16378967 Dynamics of hepatitis B virus resistance to lamivudine.
Mutation
48 16380661 [The incidence rate of hepatitis B virus surface gene variants in Korean children with immunoprophylaxis failure of perinatal infection].
Mutation
49 16419114 Hepatitis B virus genotyping, core promoter, and precore/core mutations among Afghan patients infected with hepatitis B: a preliminary report.
Mutation
50 16611347 Case report of lamivudine-resistant hepatitis B virus infection post liver transplantation from a hepatitis B core antibody donor.
Mutation
51 16789016 Detection of a hepatitis B surface antigen variant emerging in a patient with chronic lymphocytic leukaemia treated with fludarabine.
Mutation
52 16954295 Detection of hepatitis B virus (HBV) genotype E carried--even in the presence of high titers of anti-HBs antibodies--by an Argentinean patient of African descent who had received vaccination against HBV.
Mutation
53 17063521 A low rate of hepatitis B virus vaccine breakthrough infections in Mongolia.
Mutation
54 17115304 Analysis of hepatitis B surface antigen mutations in Mongolia: molecular epidemiology and implications for mass vaccination.
Mutation
55 17201657 Hepatitis B virus DNA in unusual serological profiles of hepatitis B surface antigen-positive sera.
Mutation
56 17210268 A new hepatitis B virus vaccine escape mutation in a renal transplant recipient.
Mutation
57 17217533 Molecular analysis of hepatitis B virus "a" determinant in asymptomatic and symptomatic Mexican carriers.
Mutation
58 17352033 Fatal liver failure caused by reactivation of lamivudine-resistant hepatitis B virus: a case report.
Mutation
59 17573951 Changes in viral loads of lamivudine-resistant mutants during entecavir therapy.
Mutation
60 17576389 Long-term surveillance of haematopoietic stem cell recipients with resolved hepatitis B: high risk of viral reactivation even in a recipient with a vaccinated donor.
Mutation
61 17607789 Virological features of hepatitis B virus-associated nephropathy in Japan.
Mutation
62 17711443 Molecular epidemiological study of hepatitis B virus in Thailand based on the analysis of pre-S and S genes.
Mutation
63 17935165 Successful treatment of an entecavir-resistant hepatitis B virus variant.
Mutation
64 18008227 Hepatitis B virus containing the I233V mutation in the polymerase reverse-transcriptase domain remains sensitive to inhibition by adefovir.
Mutation
65 18205223 Naturally occurring MHR variants in Turkish patients infected with hepatitis B virus.
Mutation
66 18283732 [Algorithm of serologic screening and assessment of prevalence of serologically meaningful mutations of HBsAg in hepatitis B virus carriers].
Mutation
67 18331765 Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure.
Mutation
68 18373168 Hepatitis B caused by a hepatitis B surface antigen escape mutant.
Mutation
69 18431229 Viral persistence after liver transplantation for hepatitis B virus: a cross-sectional study.
Mutation
70 18435459 Comprehensive evaluation of hepatitis B virus reverse transcriptase substitutions associated with entecavir resistance.
Mutation
71 18649345 Envelope protein variability among HBV-Infected asymptomatic carriers and immunized children with breakthrough infections.
Mutation
72 18713056 Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus.
Mutation
73 18803358 Clinical, virologic and phylogenetic features of hepatitis B infection in Iranian patients.
Mutation
74 18813870 Mutation spectra of the surface-protein-coding region of the HBV genome in HBV-vaccinated and non-vaccinated individuals in Hungary.
Mutation
75 18837083 Virologic characteristics of hepatitis B virus in patients infected via maternal-fetal transmission.
Mutation
76 19041149 The profile of mutational clusters associated with lamivudine resistance can be constrained by HBV genotypes.
Mutation
77 19212700 Influence of HBV gene heterogeneity on the failure of immunization with HBV vaccines in eastern China.
Mutation
78 19222103 Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients.
Mutation
79 19272629 Association between genomic heterogeneity of hepatitis B virus and intrauterine infection.
Mutation
80 19386834 Complete genome sequence and phylogenetic relatedness of hepatitis B virus isolates in Papua, Indonesia.
Mutation
81 19413519 Perinatal transmission of hepatitis B virus: an Australian experience.
Mutation
82 19571620 [Analysis of clinical characteristics and S gene mutation of hepatitis B virus (HBV) in patients with hepatitis B surface antigen RIA negative and HBV DNA positive].
Mutation
83 19586679 Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome.
Mutation
84 19626618 A serological and molecular survey of hepatitis B in children 15 years after inception of the national hepatitis B vaccination program in eastern China.
Mutation
85 19691824 Hepatitis B virus genotypes/subgenotypes in voluntary blood donors in Makassar, South Sulawesi, Indonesia.
Mutation
86 20104776 [The analysis of hepatitis B virus genetic characterization from immuned children and their mother].
Mutation
87 20196797 Diversity of hepatitis B virus infecting Malaysian candidate blood donors is driven by viral and host factors.
Mutation
88 20210630 No increase in prevalence of hepatitis B surface antigen mutant in a population of children and adolescents who were fully covered by universal infant immunization.
Mutation
89 20336717 Comparison of the technical and clinical performance of the Elecsys HBsAg II assay with the Architect, AxSym, and Advia Centaur HBsAg screening assays.
Mutation
90 20337225 T3098C and T53C mutations of HBV genotype C is associated with HBV infection progress.
Mutation
91 20347609 Establishment of an HBsAg mixed titer performance panel and HBsAg working standard for quality control of HBsAg diagnostic kits in Korea.
Mutation
92 20367795 Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern.
Mutation
93 20374224 Main mutations in the hepatitis B virus basic core promoter (A1762T/G1764A) before HBeAg loss are markers that identify patients who will require long-term treatment.
Mutation
94 20409073 Hepatitis B virus transfusion risk in China: proficiency testing for the detection of hepatitis B surface antigen.
Mutation
95 20412171 Performance evaluation of 70 hepatitis B virus (HBV) surface antigen (HBsAg) assays from around the world by a geographically diverse panel with an array of HBV genotypes and HBsAg subtypes.
Mutation
96 20419326 Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma.
Mutation
97 20492719 A novel nucleotide insertion in S gene of hepatitis B virus in a chronic carrier.
Mutation
98 20513074 Molecular and clinical characteristics of hepatitis B virus in Korea.
Mutation
99 20546502 Factors associated with vaccine failure and vertical transmission of hepatitis B among a cohort of Canadian mothers and infants.
Mutation
100 20553432 National survey of hepatitis B virus (HBV) polymorphism in asymptomatic HBV blood donors from 1999 to 2007 in France.
Mutation
101 20572086 Molecular epidemiological study of hepatitis B virus among migrant workers from Cambodia, Laos, and Myanmar to Thailand.
Mutation
102 20573234 Infection with hepatitis B virus carrying novel pre-S/S gene mutations in female siblings vaccinated at birth: two case reports.
Mutation
103 20580309 Acute hepatitis B infection associated with drug-resistant hepatitis B virus.
Mutation
104 20638744 HBV reactivation after fludarabine chemotherapy identified on investigation of suspected transfusion-transmitted Hepatitis B virus.
Mutation
105 20843617 [Results of a novel real-time PCR, sequence analysis, Inno-LiPA line probe assays in the detection of hepatitis B virus G1896A precore mutation in French blood donors].
Mutation
106 20932594 Evolution of hepatitis B genotype C viral quasi-species during hepatitis B e antigen seroconversion.
Mutation
107 20937597 A classification model for G-to-A hypermutation in hepatitis B virus ultra-deep pyrosequencing reads.
Mutation
108 21087462 Prediction of conformational changes by single mutation in the hepatitis B virus surface antigen (HBsAg) identified in HBsAg-negative blood donors.
Mutation
109 21181917 Molecular characterization of hepatitis B virus isolates from Zimbabwean blood donors.
Mutation
110 21311172 Antiviral resistance mutations and genotype-associated amino acid substitutions in treatment-naïve hepatitis B virus-infected individuals from the Indian subcontinent.
Mutation
111 21360549 Impact of universal vaccination on intrafamilial transmission of hepatitis B virus.
Mutation
112 21462295 Hepatitis B virus quasispecies in hepatic and extrahepatic viral reservoirs in liver transplant recipients on prophylactic therapy.
Mutation
113 21494570 Geographical and ethnic distribution of the HBV C/D recombinant on the Qinghai-Tibet Plateau.
Mutation
114 21503905 Full genome characterization of hepatitis B virus strains from blood donors in Iran.
Mutation
115 21513743 Detection of lamivudine- or adefovir-resistant hepatitis B virus mutations by a liquid array.
Mutation
116 21520137 Analysis of carriers of hepatitis B virus from a tertiary referral hospital: does the viral load change during the natural course of infection?
Mutation
117 21665530 Quantification of complex precore mutations of hepatitis B virus by SimpleProbe real time PCR and dual melting analysis.
Mutation
118 21685535 De novo activation of HBV with escape mutations from hepatitis B surface antibody after living donor liver transplantation.
Mutation
119 21696601 Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations.
Mutation
120 21723325 Development and validation of a hepatitis B virus DNA sequencing assay for assessment of antiviral resistance, viral genotype and surface antigen mutation status.
Mutation
121 21765983 Genomic analysis of hepatitis B virus reveals antigen state and genotype as sources of evolutionary rate variation.
Mutation
122 21777282 rtL180M mutation of hepatitis B virus is closely associated with frequent virological resistance to adefovir dipivoxil therapy.
Mutation
123 21831732 Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development.
Mutation
124 21840251 Mutations in hepatitis B virus DNA from patients with coexisting HBsAg and anti-HBs.
Mutation
125 22001270 Identification of hepatitis B virus rtS117F substitution as a compensatory mutation for rtM204I during lamivudine therapy.
Mutation
126 22097597 [Detection and analysis of gene polymorphism in hepatitis B virus C region].
Mutation
127 22138369 Late hepatitis B virus reactivation after lamivudine prophylaxis interruption in an anti-HBs-positive and anti-HBc-negative patient treated with rituximab-containing therapy.
Mutation
128 22224083 Frequency and mutation patterns of resistance in patients with chronic hepatitis B infection treated with nucleos(t)ide analogs in add-on and switch strategies.
Mutation
129 22274739 Mutations in the S gene region of hepatitis B virus genotype D in Golestan Province-Iran.
Mutation
130 22363813 Large fragment pre-S deletion and high viral load independently predict hepatitis B relapse after liver transplantation.
Mutation
131 22383959 A high variability of mixed infections and recent recombinations of hepatitis B virus in Laos.
Mutation
132 22500577 Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China.
Mutation
133 22510694 Convergence and coevolution of hepatitis B virus drug resistance.
Mutation
134 22669316 Molecular epidemiological study of hepatitis B virus in blood donors from five Chinese blood centers.
Mutation
135 22882650 Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.
Mutation
136 22892524 Evolution of adefovir-resistant HBV polymerase gene variants after switching to tenofovir disoproxil fumarate monotherapy.
Mutation
137 22967107 Specific primer sets used to amplify by PCR the hepatitis B virus overlapping S/Pol region select different viral variants.
Mutation
138 23023992 Do different lamivudine-resistant hepatitis B genotypes carry the same risk of entecavir resistance?
Mutation
139 2304145 Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen.
Mutation
140 23114756 Low-level persistence of drug resistance mutations in hepatitis B virus-infected subjects with a past history of Lamivudine treatment.
Mutation
141 23180290 A case of hepatitis B reactivation due to the hepatitis B virus escape mutant in a patient undergoing chemotherapy.
Mutation
142 23197889 Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment.
Mutation
143 23254298 Hepatitis B virus surface antigen (HBsAg)-positive and HBsAg-negative hepatitis B virus infection among mother-teenager pairs 13 years after neonatal hepatitis B virus vaccination.
Mutation
144 23272650 Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment.
Mutation
145 23296324 Epidemiology of HBV S-gene mutants in the Liguria Region, Italy: Implications for surveillance and detection of new escape variants.
Mutation
146 23346148 Investigation of DNA sequence in the Basal core promoter, precore, and core regions of hepatitis B virus from Tunisia shows a shift in genotype prevalence.
Mutation
147 23408582 High frequency of complex mutational patterns in lamivudine resistant hepatitis B virus isolates.
Mutation
148 23409946 Characterization of antiviral resistance mutations among the Eastern Indian Hepatitis B virus infected population.
Mutation
149 23432545 Molecular epidemiology of hepatitis B in the Indigenous people of northern Australia.
Mutation
150 23454647 Combination of allele-specific detection techniques to quantify minority resistance variants in hepatitis B infection: a novel approach.
Mutation
151 23547448 [Significance of the double mutations of C1673T/C1799G in HBV C promoter].
Mutation
152 23679074 Late HBsAg seroreversion of mutated hepatitis B virus after bone marrow transplantation.
Mutation
153 23796863 Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen.
Mutation
154 23804383 Ultrasensitive amplification refractory mutation system real-time PCR (ARMS RT-PCR) assay for detection of minority hepatitis B virus-resistant strains in the era of personalized medicine.
Mutation
155 23903967 Molecular characterisation of hepatitis B virus in the resident Chinese population in Panama City.
Mutation
156 24006443 Change in hepatitis B virus large surface antigen variant prevalence 13 years after implementation of a universal vaccination program in China.
Mutation
157 24031448 Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen.
Mutation
158 24118725 HBV clinical isolates expressing adefovir resistance mutations show similar tenofovir susceptibilities across genotypes B, C and D.
Mutation
159 24157033 Analysis of S gene mutation of the hepatitis B virus in adult liver transplant recipients showing resistance to hepatitis B immunoglobulin therapy.
Mutation
160 24165277 Detection of lamivudine-resistant variants and mutations related to reduced antigenicity of HBsAg in individuals from the cities of Santos and São Paulo, Brazil.
Mutation
161 24249691 Variability in the precore and core promoter region of the hepatitis B virus genome.
Mutation
162 24265811 High endemicity and low molecular diversity of hepatitis B virus infections in pregnant women in a rural district of North Cameroon.
Mutation
163 24273041 The impact of hepatitis B virus precore/core gene carboxyl terminal mutations on viral biosynthesis and the host immune response.
Mutation
164 24329944 Short duration of lamivudine for the prevention of hepatitis B virus transmission in pregnancy: lack of potency and selection of resistance mutations.
Mutation
165 24342744 Mutations in HBV DNA polymerase associated with nucleos(t)ide resistance are rare in treatment-naive patients.
Mutation
166 24369590 [Clinical evaluation of a newly developed high-sensitive detection of hepatitis B virus surface antigen by a semi-automated immune complex transfer chemiluminescent enzyme immunoassay].
Mutation
167 24379746 Naturally occurring hepatitis B virus B-cell and T-cell epitope mutants in hepatitis B vaccinated children.
Mutation
168 24587198 Establishment of real time allele specific locked nucleic acid quantitative PCR for detection of HBV YIDD (ATT) mutation and evaluation of its application.
Mutation
169 24632784 Analysis of complete nucleotide sequences of Angolan hepatitis B virus isolates reveals the existence of a separate lineage within genotype E.
Mutation
170 24637457 Mutation profiling of the hepatitis B virus strains circulating in North Indian population.
Mutation
171 24710668 Screening and identification of a novel adefovir dipivoxil resistance associated mutation, rtN236V, of HBV from a large cohort of HBV-infected patients.
Mutation
172 24777553 Amino acid polymorphism in the reverse transcriptase region of hepatitis B virus and the relationship with nucleos(t)ide analogues treatment for preventing mother-to-infant transmission.
Mutation
173 24797477 Molecular epidemiological study of hepatitis B virus genotypes in Southwest, China.
Mutation
174 24798622 Reactivation from occult HBV carrier status is characterized by low genetic heterogeneity with the wild-type or G1896A variant prevalence.
Mutation
175 24835494 Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.
Mutation
176 25132017 The rtA181S mutation of hepatitis B virus primarily confers resistance to adefovir dipivoxil.
Mutation
177 25323975 Prevalence of mutations in basal core promoter and precore region of hepatitis B virus in vaccinated and nonvaccinated individuals of the aboriginal Nicobarese tribe of Car Nicobar Island, India.
Mutation
178 25351410 Single-nucleotide substitution of Hepatitis B virus in intrauterine infection.
Mutation
179 25418031 Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression.
Mutation
180 25493022 Resistant mutants induced by adefovir dipivoxil in hepatitis B virus isolates.
Mutation
181 25503289 Subgenotypes and mutations in the s and polymerase genes of hepatitis B virus carriers in the West Bank, palestine.
Mutation
182 25593470 Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion.
Mutation
183 25732900 New amino acid changes in drug resistance sites and HBsAg in hepatitis B virus genotype H.
Mutation
184 25737728 S gene mutants occurrence among hepatitis B carriers in malaysia.
Mutation
185 25741368 Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.
Mutation
186 25828947 Upregulation of endoplasmic reticulum stress and reactive oxygen species by naturally occurring mutations in hepatitis B virus core antigen.
Mutation
187 26074702 Precore/basal core promoter mutants quantification throughout phases of hepatitis B virus infection by Simpleprobe.
Mutation
188 26079809 Increased occurrence of mutant rtI233V of HBV in patients receiving adefovir therapy.
Mutation
189 26148052 Occult Hepatitis B Virus Infection in Nigerian Blood Donors and Hepatitis B Virus Transmission Risks.
Mutation
190 26202119 Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients.
Mutation
191 26209374 Performance of HBsAg point-of-care tests for detection of diagnostic escape-variants in clinical samples.
Mutation
192 26283552 Detection and circulation of hepatitis B virus immune escape mutants among asymptomatic community dwellers in Ibadan, southwestern Nigeria.
Mutation
193 26288490 Distribution of hepatitis B virus genotype and cancer predicting precore and basal core promoter mutations.
Mutation
194 26300928 YMDD Motif Mutation Profile Among Patients Receiving Liver Transplant Due to Hepatitis B Virus Infection With Long Term Lamivudine/Immunoglobulin Therapy.
Mutation
195 26612031 Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China.
Mutation
196 26825915 Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study.
Mutation
197 26831605 Antiviral efficacy of entecavir versus entecavir plus adefovir for hepatitis B virus rtA181V/T mutants alone.
Mutation
198 26919858 Reactivation of resolved hepatitis B virus infection with immune escape mutations after long-term corticosteroid therapy.
Mutation
199 26997220 Surface gene variants of hepatitis B Virus in Saudi Patients.
Mutation
200 27131009 Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in China.
Mutation
201 27133305 Discordant diagnostic results due to a hepatitis B virus T123A HBsAg mutant.
Mutation
202 27280884 Impact of Universal Hepatitis B Vaccination on Prevalence, Infection-Associated Morbidity and Mortality, and Circulation of Immune Escape Variants in Russia.
Mutation
203 27328656 Intergenotype recombinant analysis of full-length hepatitis B virus genomes from 516 Chinese patients with different illness categories.
Mutation
204 27354181 HIV therapy with unknown HBV status is responsible for higher rate of HBV genome variability in Ethiopia.
Mutation
205 27402524 Hepatitis B Virus Infection in Indonesia 15 Years After Adoption of a Universal Infant Vaccination Program: Possible Impacts of Low Birth Dose Coverage and a Vaccine-Escape Mutant.
Mutation
206 27422771 The relationship between HBcrAg and HBV reinfection in HBV related post-liver transplantation patients.
Mutation
207 27492206 Different Variants in Reverse Transcriptase Domain Determined by Ultra-deep Sequencing in Treatment-naïve and Treated Indonesian Patients Infected with Hepatitis B Virus.
Mutation
208 27535686 Detection of Anti-Hepatitis B Virus Drug Resistance Mutations Based on Multicolor Melting Curve Analysis.
Mutation
209 27544241 Naturally Occurring Surface Antigen Variants of Hepatitis B Virus in Tunisian Patients.
Mutation
210 27613286 Low prevalence of hepatitis B vaccine escape mutants among individuals born after the initiation of a nationwide vaccination program in Iran.
Mutation
211 27650283 Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.
Mutation
212 27652086 Molecular epidemiology of hepatitis B virus isolated from Bangladesh.
Mutation
213 27792585 Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China.
Mutation
214 27808472 A novel hepatitis B virus subgenotype D10 circulating in Ethiopia.
Mutation
215 27878103 Role of RNA secondary structure in emergence of compartment specific hepatitis B virus immune escape variants.
Mutation
216 27882062 Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.
Mutation
217 27920641 Severe de novo Hepatitis B Recovered from Late-Onset Liver Insufficiency with Prolonged Ascites and Hypoalbuminemia due to Hepatitis B Virus Genotype Bj with Precore Mutation.
Mutation
218 27998385 Hepatitis B Immunoprophylactic Failure and Characteristics of the Hepatitis B Virus Gene in Mother-Infant Pairs in Parts of China.
Mutation
219 28017671 Analysis of the prevalence of drug-resistant hepatitis B virus in patients with antiviral therapy failure in a Chinese tertiary referral liver centre (2010-2014).
Mutation
220 28103819 Telbivudine versus entecavir in patients with undetectable hepatitis B virus DNA: a randomized trial.
Mutation
221 28325923 Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.
Mutation
222 28392234 Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.
Mutation
223 28607644 Prevalence and Characteristics of Precore Mutation in Iran and Its Correlation with Genotypes of Hepatitis B.
Mutation
224 28673869 Impact of deletions and mutations in Hepatitis B virus envelope proteins on serological profile and clinical evolution.
Mutation
225 28753615 Clustering infection of hepatitis B virus genotype B4 among residents in Vietnam, and its genomic characters both intra- and extra-family.
Mutation
226 28806922 Hepatitis B reactivation characterized by HBsAg negativity and anti-HbsAg antibodies persistence in haematopoietic stem cell transplanted patient after lamivudine withdrawal.
Mutation
227 28939157 Molecular evolution of hepatitis B vaccine escape variants in China, during 2000-2016.
Mutation
228 29016603 Characterization of hepatitis B virus in Amerindian children and mothers from Amazonas State, Colombia.
Mutation
229 29119303 Evolution of drug-resistant mutations in HBV genomes in patients with treatment failure during the past seven years (2010-2016).
Mutation
230 29353073 Serum HBV DNA plus RNA shows superiority in reflecting the activity of intrahepatic cccDNA in treatment-naïve HBV-infected individuals.
Mutation
231 29408943 Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Mutation
232 29414186 Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay.
Mutation
233 29629487 Quasispecies characters of hepatitis B virus in immunoprophylaxis failure infants.
Mutation
234 29630974 Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation.
Mutation
235 29642827 [Analysis of hepatitis B virus (HBV) preS1, preS2 and S gene regions from patient groups infected with HBV genotype D].
Mutation
236 29654894 Trends in hepatitis B virus resistance to nucleoside/nucleotide analogues in North China from 2009-2016: A retrospective study.
Mutation
237 29843851 Fulminant hepatitis B virus (HBV) infection in an infant following mother-to-child transmission of an e-minus HBV mutant: Time to relook at HBV prophylaxis in South African infants.
Mutation
238 30043328 Clinical implication and viral mutation in basal core promoter/pre-core of hepatitis B virus C/D recombinant.
Mutation
239 30184362 Genetic variability in coding regions of the surface antigen and reverse transcriptase domain of hepatitis B virus polymerase, Colombia, 2002-2014
Mutation
240 30202825 Discovery of the Novel Entecavir-Resistant Hepatitis B Virus Reverse Transcriptase A181C Substitution From an Integrated Genotypic Analysis.
Mutation
241 30377627 Hepatitis B Virus (HBV) Infection and Re-activation During Nucleos(t)ide Reverse Transcriptase Inhibitor-Sparing Antiretroviral Therapy in a High-HBV Endemicity Setting.
Mutation
242 30382563 Molecular characterization of hepatitis B virus in blood donors in Botswana.
Mutation
243 30406036 The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
Mutation
244 30570771 Hepatitis B virus in Mar del Plata, Argentina: Genomic characterization and evolutionary analysis of subgenotype F1b.
Mutation
245 30584239 Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection.
Mutation
246 30702819 Analyses of the Genetic Diversities and Mutations of the Hepatitis B Virus Genome BCP/Pre C Region.
Mutation
247 30771531 Diverse immune responses to HBV surface epitope variants after vaccine booster in adolescents immunized in infancy.
Mutation
248 30796932 Prevalence of the entecavir-resistance-inducing mutation rtA186T in a large cohort of Chinese hepatitis B virus patients.
Mutation
249 30866789 Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice.
Mutation
250 30867996 Patterns of hepatitis B virus S gene escape mutants and reverse transcriptase mutations among genotype D isolates in Jordan.
Mutation
251 30943997 Molecular and serological characterization of hepatitis B vaccine breakthrough infections in serial samples from two plasma donors.
Mutation
252 31046787 A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus.
Mutation
253 31086664 Analysis of hepatitis B virus genotype and gene mutation in patients with advanced liver disease in East Kalimantan, Indonesia.
Mutation
254 31105017 Association of HBsAg mutation patterns with hepatitis B infection outcome: Asymptomatic carriers versus HCC/cirrhotic patients.
Mutation
255 31147594 Potential resistant mutations within HBV reverse transcriptase sequences in nucleos(t)ide analogues-experienced patients with hepatitis B virus infection.
Mutation
256 31189581 Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.
Mutation
257 31248149 Frequency of Hepatitis B Virus Resistance Mutations in Women Using Tenofovir Gel as Pre-Exposure Prophylaxis.
Mutation
258 31308922 Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
Mutation
259 31501793 Comparison of pre-S1/S2 variations of hepatitis B virus between asymptomatic carriers and cirrhotic/hepatocellular carcinoma-affected individuals.
Mutation
260 31550370 Virological Factors Associated With the Occurrence of Hepatitis B Virus (HBV) Reactivation in Patients With Resolved HBV Infection Analyzed Through Ultradeep Sequencing.
Mutation
261 31558731 Prevalence of Hepatitis B Virus Infection in Shenzhen, China, 2015-2018.
Mutation
262 31682960 Detection of circulating hepatitis B virus immune escape and polymerase mutants among HBV-positive patients attending Institut Pasteur de Bangui, Central African Republic.
Mutation
263 31752732 Deep sequencing of hepatitis B surface antigen gene in the preserved umbilical cords in immunoprophylaxis failure against mother-to-child HBV transmission.
Mutation
264 32102257 A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition in Vitro.
Mutation
265 32124248 Conservative Evolution of Hepatitis B Virus Precore and Core Gene During Immune Tolerant Phase in Intrafamilial Transmission.
Mutation
266 32519312 Spontaneous reactivation of hepatitis B virus with S gene mutations in an elderly patient with diabetic nephropathy.
Mutation
267 32532295 Complete genome analysis of hepatitis B virus in Qinghai-Tibet plateau: the geographical distribution, genetic diversity, and co-existence of HBsAg and anti-HBs antibodies.
Mutation
268 32564557 [Relationship between mutations of HBV basal core promoter region in HBsAg-positive mothers and intrauterine transmission].
Mutation
269 32735901 Revisiting HBV resistance to entecavir with a phenotypic approach.
Mutation
270 32860463 Precore and Basal Core Promoter Hepatitis B Virus (HBV) Variants Are Present From a Young Age and Differ Across HBV Genotypes.
Mutation
271 32978866 Case of hepatitis B virus reactivation after ibrutinib therapy in which the patient remained negative for hepatitis B surface antigens throughout the clinical course.
Mutation
272 33055418 Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.
Mutation
273 33090103 Molecular epidemiology of Hepatitis B virus, Hepatitis C virus, and Hepatitis D virus in general population of Afghanistan.
Mutation
274 33187530 Seroprevalence and genotypic characterization of HBV among low risk voluntary blood donors in Nairobi, Kenya.
Mutation
275 9841851 Identification of hepatitis B surface antigen variants with alterations outside the "a" determinant in immunized Singapore infants.
Mutation
276 33458253 Case Report: Application of hepatitis B virus (HBV) deep sequencing to distinguish between acute and chronic infection.
Mutation
277 33468062 Molecular characteristics of HBV infection among blood donors tested HBsAg reactive in a single ELISA test in southern China.
Mutation
278 33491423 Prevalence of Hepatitis B Virus Infection Among Voluntary Blood Donors from the Northeastern Region of Iran: Genotyping, Viral Load Characterization and Drug Resistance Prediction.
Mutation
279 33687074 Occult and active hepatitis B virus detection in donated blood in São Paulo, Brazil.
Mutation
280 33903819 Entecavir resistance in a patient with treatment-naïve HBV: A case report.
Mutation
Contents
Description
Group Note
  • Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
  • VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)