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Overview of HBV associated Chronic hepatitis B

Chronic hepatitis B is an chronic infectious disease caused by the hepatitis B virus (HBV) that affects the liver.In those who get infected around the time of birth 90% develop chronic hepatitis B while less than 10% of those infected after the age of five do. Most of those with chronic disease have no symptoms; however, cirrhosis and liver cancer may eventually develop.


ID Literature Title Group
1 10365797 Absence of mutations in the YMDD motif/B region of the hepatitis B virus polymerase in famciclovir therapy failure.
Mutation
2 10502255 Novel patterns of amino acid mutations in the hepatitis B virus polymerase in association with resistance to lamivudine therapy in japanese patients with chronic hepatitis B.
Mutation
3 10514111 Diversity of core promoter mutations in immune clearance phase of chronic HBV infection.
Mutation
4 10535488 Detection of pre-S/S gene mutants in chronic hepatitis B carriers with concurrent hepatitis B surface antibody and hepatitis B surface antigen.
Mutation
5 10589947 Famciclovir treatment of chronic hepatitis B in heart transplant recipients: a prospective trial.
Mutation
6 10607231 Hepatitis B envelope protein mutants in human hepatocellular carcinoma tissues.
Mutation
7 10655370 Line probe assay for monitoring drug resistance in hepatitis B virus-infected patients during antiviral therapy.
Mutation
8 10762559 Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B.
Mutation
9 10996115 In vivo dynamics and pathogenicity of wild-type and resistant Hepatitis B virus during long-term lamivudine monotherapy - a clinical note.
Mutation
10 11002246 Hepatitis B virus X gene variability in French-born patients with chronic hepatitis and hepatocellular carcinoma.
Mutation
11 11020004 Genotypic succession of mutations of the hepatitis B virus polymerase associated with lamivudine resistance.
Mutation
12 11050059 Early detection of viral resistance by determination of hepatitis B virus polymerase mutations in patients treated by lamivudine for chronic hepatitis B.
Mutation
13 11124839 A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group.
Mutation
14 11472634 Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers.
Mutation
15 11480792 Efficacy and tolerability of long-term therapy using high lamivudine doses for the treatment of chronic hepatitis B.
Mutation
16 11502520 In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.
Mutation
17 11584376 Factors associated with hepatitis B virus DNA breakthrough in patients receiving prolonged lamivudine therapy.
Mutation
18 11792996 Efficacy of famciclovir in the treatment of lamivudine resistance related to an atypical hepatitis B virus mutant.
Mutation
19 11907436 Seroconversion after the addition of famciclovir therapy in a child with hepatitis B virus infection after liver transplantation who developed lamivudine resistance.
Mutation
20 11938042 Lamivudine therapy of chronic hepatitis B in three groups of patients: non transplanted patients, liver recipients, and kidney recipients.
Mutation
21 11993512 Hepatitis B genotypes and precore/basal core promoter mutants in HBeAg-negative chronic hepatitis B.
Mutation
22 12010505 Sequential analysis of hepatitis B virus core promoter and precore regions in cancer survivor patients with chronic hepatitis B before, during and after interferon treatment.
Mutation
23 12033768 In vivo suppression of precore mRNA synthesis is associated with mutations in the hepatitis B virus core promoter.
Mutation
24 12135788 'Hbe minus' mutants of hepatitis B virus. Molecular characterization and its relation to viral genotypes.
Mutation
25 12358268 Core promoter mutations 3 years after anti-hepatitis B e seroconversion in patients with chronic hepatitis B or hepatitis B and C infection and cancer remission.
Mutation
26 12368144 [Evaluation of a quantitative HBV-DNA PCR assay in lamivudine treated hepatitis B-infected patients].
Mutation
27 12436473 Hepatitis B virus S gene mutants in a patient with chronic active hepatitis with circulating Anti-HBs antibodies.
Mutation
28 12445424 Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy.
Mutation
29 12657823 [Natural YMDD motif mutations of HBV polymerase in the chronic hepatitis B virus infected patients].
Mutation
30 12727536 Lamivudine and Famciclovir resistant hepatitis B virus associated with fatal hepatic failure.
Mutation
31 12759956 [Dynamic changes of basal core promoter and pre-core mutants of hepatitis B virus in patients with chronic hepatitis B virus infection].
Mutation
32 12794713 Molecular epidemiology and transmission of hepatitis B virus in close family contacts of HBV-related chronic liver disease patients.
Mutation
33 12823594 Analysis of clinical, biochemical and viral factors associated with early relapse after lamivudine treatment for hepatitis B e antigen-negative chronic hepatitis B patients in Taiwan.
Mutation
34 12829991 Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B.
Mutation
35 12891527 Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase.
Mutation
36 12918112 Novel assay of competitively differentiated polymerase chain reaction for screening point mutation of hepatitis B virus.
Mutation
37 12931030 Low HBeAg serum levels correlate with the presence of the double A1762T/G1764A core promoter mutation and a positive response to interferon in patients with chronic hepatitis B virus infection.
Mutation
38 12966541 Evolution of hepatitis B virus sequence from a liver transplant recipient with rapid breakthrough despite hepatitis B immune globulin prophylaxis and lamivudine therapy.
Mutation
39 12974898 Identification of a novel pre-S2 mutation in a subgroup of chronic carriers with spontaneous clearance of hepatitis B virus surface antigen.
Mutation
40 14654974 Early response to interferon alpha treatment and long-term clinical outcome in Japanese patients with chronic HBV genotype C infection.
Mutation
41 14675262 Evolution of wild type and mutants of the YMDD motif of hepatitis B virus polymerase during lamivudine therapy.
Mutation
42 14752824 Identification of HBV DNA sequences that are predictive of response to lamivudine therapy.
Mutation
43 14756274 Efficacy of combined lamivudine and adefovir dipivoxil treatment for severe HBV graft reinfection after living donor liver transplantation.
Mutation
44 15078472 Sequential combination therapy of HBe antigen-negative/virus-DNA-positive chronic hepatitis B with famciclovir or lamivudine and interferon-alpha-2a.
Mutation
45 15240859 Longitudinal study on mutation profiles of core promoter and precore regions of the hepatitis B virus genome in children.
Mutation
46 15308845 Detection of YMDD motif mutants by oligonucleotide chips in lamivudine-untreated patients with chronic hepatitis B virus infection.
Mutation
47 15311721 Efficacy of alpha interferon therapy for lamivudine resistance in chronic hepatitis B.
Mutation
48 15328117 Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine.
Mutation
49 15338371 Prognostic indicators of breakthrough hepatitis during lamivudine monotherapy for chronic hepatitis B virus infection.
Mutation
50 15340520 [A study on detection method of lamivudine related mutations in hepatitis B virus polymerase gene].
Mutation
51 15544736 [Determination of hepatitis B virus genotype and detection of lamivudine-resistance mutations].
Mutation
52 15572007 The precore mutation is associated with severity of liver damage in Brazilian patients with chronic hepatitis B.
Mutation
53 15618847 Long-term therapy with lamivudine in renal transplant recipients with chronic hepatitis B.
Mutation
54 15634980 Development of a molecular-beacon assay to detect the G1896A precore mutation in hepatitis B virus-infected individuals.
Mutation
55 15648063 Clinical and virological characteristics of lamivudine resistance in chronic hepatitis B patients: a single center experience.
Mutation
56 15655050 Activity of adefovir dipivoxil against all patterns of lamivudine-resistant hepatitis B viruses in patients.
Mutation
57 15664258 Sustained HBs seroconversion during lamivudine and adefovir dipivoxil combination therapy for lamivudine failure.
Mutation
58 15720530 Long-term follow-up of chronic hepatitis B after the emergence of mutations in the hepatitis B virus polymerase region.
Mutation
59 15720534 Three-phase sequential combined treatment with lamivudine and interferon in young patients with chronic hepatitis B.
Mutation
60 15834874 Nucleotide mutations associated with hepatitis B e antigen negativity.
Mutation
61 15893561 A novel accurate amplification created restriction site method for determination of the wild type and the precore mutant hepatitis B virus variants.
Mutation
62 15932365 Changes in different regions of hepatitis B virus gene in hepatitis B 'e' antigen-negative patients with chronic hepatitis B: the effect of long-term lamivudine therapy.
Mutation
63 15953865 Overlapping gene mutations of hepatitis B virus in a chronic hepatitis B patient with hepatitis B surface antigen loss during lamivudine therapy.
Mutation
64 15973769 Character of HBV (hepatitis B virus) polymerase gene rtM204V/I and rtL180M mutation in patients with lamivudine resistance.
Mutation
65 15980328 Emergence of a novel mutation in the FLLA region of hepatitis B virus during lamivudine therapy.
Mutation
66 15985011 Response to long-term lamivudine treatment (up to 5 years) in patients with severe chronic hepatitis B, role of genotype and drug resistance.
Mutation
67 16080797 HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers.
Mutation
68 16099903 T1764G1766 core promoter double mutants are restricted to Hepatitis B virus strains with an A1757 and are common in genotype D.
Mutation
69 16108169 Chronic hepatitis B--treatment with nucleoside analogues.
Mutation
70 16197491 Clinical reactivation during lamivudine treatment correlates with mutations in the precore/core promoter and polymerase regions of hepatitis B virus in patients with anti-hepatitis B e-positive chronic hepatitis.
Mutation
71 16220028 Hepatitis B virus DNA quantitation and detection of core promoter, precore and polymerase mutations in chronic hepatitis B: evaluation and clinical usefulness of three new commercial assays.
Mutation
72 16227269 Reduced secretion of virions and hepatitis B virus (HBV) surface antigen of a naturally occurring HBV variant correlates with the accumulation of the small S envelope protein in the endoplasmic reticulum and Golgi apparatus.
Mutation
73 16358376 Clinical features of chronic hepatitis B patients with YMDD mutation after lamivudine therapy.
Mutation
74 16428891 Characterization of naturally occurring and Lamivudine-induced surface gene mutants of hepatitis B virus in patients with chronic hepatitis B in India.
Mutation
75 16448607 [Lamivudine and adefovir resistance in a patient with HBeAg negative chronic hepatitis B].
Mutation
76 16461777 Resistance to adefovir dipivoxil in lamivudine resistant chronic hepatitis B patients treated with adefovir dipivoxil.
Mutation
77 16517839 Phylogenetic, virological, and clinical characteristics of genotype C hepatitis B virus with TCC at codon 15 of the precore region.
Mutation
78 16618409 Predominance of hepatitis B virus YMDD mutants is prognostic of viral DNA breakthrough.
Mutation
79 16618410 High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases.
Mutation
80 16637865 Association of core promoter/precore mutations and viral load in e antigen-negative chronic hepatitis B patients.
Mutation
81 16637866 Hepatitis B virus genotypes and G1896A precore mutation in 486 Spanish patients with acute and chronic HBV infection.
Mutation
82 16729316 Increased risk of adefovir resistance in patients with lamivudine-resistant chronic hepatitis B after 48 weeks of adefovir dipivoxil monotherapy.
Mutation
83 16757589 Detection of rtN236T and rtA181V/T mutations associated with resistance to adefovir dipivoxil in samples from patients with chronic hepatitis B virus infection by the INNO-LiPA HBV DR line probe assay (version 2).
Mutation
84 16757620 Unusual naturally occurring humoral and cellular mutated epitopes of hepatitis B virus in a chronically infected argentine patient with anti-HBs antibodies.
Mutation
85 16789011 Changes in viral loads of lamivudine-resistant mutants and evolution of HBV sequences during adefovir dipivoxil therapy.
Mutation
86 16789012 Basal core promoter, precore region mutations of HBV and their association with e antigen, genotype, and severity of liver disease in patients with chronic hepatitis B in India.
Mutation
87 16830379 Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs.
Mutation
88 16847965 Identification of hepatitis B virus subgenotype A3 in rural Gabon.
Mutation
89 16856618 The clinical impact of early detection of the YMDD mutant on the outcomes of long-term lamivudine therapy in patients with chronic hepatitis B.
Mutation
90 16871563 Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy.
Mutation
91 16928212 Association of core promoter mutations with viral breakthrough in chronic hepatitis B patients on long-term lamivudine therapy.
Mutation
92 16963200 A unique amino acid substitution, T126I, in human genotype C of hepatitis B virus S gene and its possible influence on antigenic structural change.
Mutation
93 16982790 Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.
Mutation
94 17030194 Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient.
Mutation
95 17178796 Two-year assessment of entecavir resistance in Lamivudine-refractory hepatitis B virus patients reveals different clinical outcomes depending on the resistance substitutions present.
Mutation
96 17187404 Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein.
Mutation
97 17203204 Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam.
Mutation
98 17239478 Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient.
Mutation
99 17258721 Identification of a hepatitis B virus S gene mutant in lamivudine-treated patients experiencing HBsAg seroclearance.
Mutation
100 17259736 G1862T mutation among hepatitis B virus-infected individuals: association with viral genotypes and disease outcome in Kolkata, Eastern India.
Mutation
101 17302381 Unusual selection of rtA181V HBV mutants cross-resistant to adefovir following prolonged lamivudine monotherapy: report of two cases.
Mutation
102 17317127 Dynamic changes of hepatitis B virus polymerase gene including YMDD motif in lamivudine-treated patients with chronic hepatitis B.
Mutation
103 17400303 Adefovir dipivoxil treatment of lamivudine-resistant chronic hepatitis B.
Mutation
104 17498248 Analysis of the core gene of hepatitis B virus in Korean patients.
Mutation
105 17627632 Impact of viral genotypes and naturally occurring mutations on biological properties of hepatitis B virus.
Mutation
106 17652045 Sequential treatment with lamivudine and alpha-interferon in anti-HBe-positive chronic hepatitis B patients: a pilot study.
Mutation
107 17682718 [A case of chronic hepatitis B with primary adefovir resistance].
Mutation
108 17692425 Pooled analysis of amino acid changes in the HBV polymerase in patients from four major adefovir dipivoxil clinical trials.
Mutation
109 17697019 Association between lamivudine sensitivity and the number of substitutions in the reverse transcriptase region of the hepatitis B virus polymerase.
Mutation
110 17713159 A novel mutation pattern emerging during lamivudine treatment shows cross-resistance to adefovir dipivoxil treatment.
Mutation
111 17825452 Five subgenotypes of hepatitis B virus genotype B with distinct geographic and virological characteristics.
Mutation
112 17854034 Mutational patterns of hepatitis B virus genome and clinical outcomes after emergence of drug-resistant variants during lamivudine therapy: analyses of the polymerase gene and full-length sequences.
Mutation
113 17888035 Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis and hepatocellular carcinoma.
Mutation
114 17900990 The high prevalence of the I27 mutant HBcAg18-27 epitope in Chinese HBV-infected patients and its cross-reactivity with the V27 prototype epitope.
Mutation
115 17913933 Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay.
Mutation
116 17934636 Hepatitis B virus genotype E detected in Brazil in an African patient who is a frequent traveler.
Mutation
117 17971947 [Efficacy of adefovir dipivoxil was not related to genotypes B and C of hepatitis B virus: a randomized, double-blind, multicenter clinical study].
Mutation
118 17988612 [Adefovir dipivoxil compassionate use program in Spain: efficacy and resistance analysis].
Mutation
119 18036104 Efficacy of hepatitis B virus (HBV) vaccination in treating lamivudine-resistant HBV reactivation following hepatitis B surface antigen seroconversion.
Mutation
120 18036224 Hepatitis B virus genotypes circulating in Brazil: molecular characterization of genotype F isolates.
Mutation
121 18070286 Hepatitis B virus polymerase variants associated with entecavir drug resistance in treatment-naive patients.
Mutation
122 18159582 Lamivudine therapy for korean children with chronic hepatitis B.
Mutation
123 18171343 Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case.
Mutation
124 18211717 Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil.
Mutation
125 18265656 Clinical significance of basal core promoter and precore mutations in chronic hepatitis B.
Mutation
126 18266648 A complete genomic analysis of hepatitis B virus genotypes and mutations in HBeAg-negative chronic hepatitis B in China.
Mutation
127 18329126 Lamivudine compared with lamivudine and adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B.
Mutation
128 18433023 Safety, efficacy, and pharmacokinetics of adefovir dipivoxil in children and adolescents (age 2 to <18 years) with chronic hepatitis B.
Mutation
129 18433925 Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up.
Mutation
130 18504191 [Mutations of HBV polymerase gene sequence in lamivudine-resistant chronic hepatitis B patients].
Mutation
131 18507754 Clinical significance of precore and core promoter mutations in genotype D hepatitis B-related chronic liver disease.
Mutation
132 18537180 The antiviral drug selected hepatitis B virus rtA181T/sW172* mutant has a dominant negative secretion defect and alters the typical profile of viral rebound.
Mutation
133 18551606 Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection.
Mutation
134 18571815 Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance.
Mutation
135 18605187 [HBV gene variants and polymerse gene mutations in children with chronic hepatitis B in the course of the antiviral therapy].
Mutation
136 18606836 Rolling circle amplification, a powerful tool for genetic and functional studies of complete hepatitis B virus genomes from low-level infections and for directly probing covalently closed circular DNA.
Mutation
137 18647234 Expression of hepatitis B virus nuclear core antigen in young cirrhotic patients is associated with an unfavourable long-term outcome.
Mutation
138 18752330 Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B.
Mutation
139 18814242 Clinical significance of a set of single nucleotide polymorphisms of hepatitis B virus core gene in Chinese Han patients with chronic hepatitis B.
Mutation
140 18822888 [YMDD motif variants detected by Inno-Lipa HBV DR assay in chronic hepatitis B patients during lamivudine therapy].
Mutation
141 19065672 Complex dynamics of hepatitis B virus resistance to adefovir.
Mutation
142 19070921 The association of HBV core promoter double mutations (A1762T and G1764A) with viral load differs between HBeAg positive and anti-HBe positive individuals: a longitudinal analysis.
Mutation
143 19107976 Lamivudine monoprophylaxis and adefovir salvage for liver transplantation in chronic hepatitis B: a seven-year follow-up study.
Mutation
144 19119245 [The efficacy of adefovir dipivoxil monotherapy and the incidence of genotypic resistance to adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B infection].
Mutation
145 19125938 Spontaneous HBeAg seroconversion and loss of hepatitis B virus DNA after acute flare due to development of drug resistant mutants during entecavir monotherapy.
Mutation
146 19152408 Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir.
Mutation
147 19152409 Association of lamivudine-resistant mutational patterns with the antiviral effect of adefovir in patients with chronic hepatitis B.
Mutation
148 19195324 Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response.
Mutation
149 19207682 Hepatitis B virus genotypes and hepatitis B surface antigen mutations in family contacts of hepatitis B virus infected patients with occult hepatitis B virus infection.
Mutation
150 19222103 Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients.
Mutation
151 19231002 Entecavir shows limited efficacy in HBeAg-positive hepatitis B patients with a partial virologic response to adefovir therapy.
Mutation
152 19280622 Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy.
Mutation
153 19301976 Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients.
Mutation
154 19302908 Evolution of hepatitis B virus polymerase mutations in a patient with HBeAg-positive chronic hepatitis B virus treated with sequential monotherapy and add-on nucleoside/nucleotide analogues.
Mutation
155 19319958 Prevalence of basal core promoter and precore mutations in Chinese chronic hepatitis B patients and correlation with serum HBeAG titers.
Mutation
156 19323782 Hepatitis B virus with the rtL80V/I mutation is associated with a poor response to adefovir dipivoxil therapy.
Mutation
157 19382250 Frequent detection of hepatitis B virus variants associated with lamivudine resistance in treated South African patients infected chronically with different HBV genotypes.
Mutation
158 19430095 Association of baseline viral factors with response to lamivudine therapy in chronic hepatitis B patients with high serum alanine aminotransferase levels.
Mutation
159 19442845 A sensitive direct sequencing assay based on nested PCR for the detection of HBV polymerase and surface glycoprotein mutations.
Mutation
160 19486254 Characterization of hepatitis B virus reverse transcriptase sequences in Chinese treatment naive patients.
Mutation
161 19489434 [Analysis of the relevance of the mutations of the precore and basic core promoter in HBV genome with the DNA amount of HBV viremia].
Mutation
162 19550344 Monitoring of therapy in patients with chronic hepatitis B virus.
Mutation
163 19566788 Naturally occurring amino-acid substitutions to nucleos(t)ide analogues in treatment naive Turkish patients with chronic hepatitis B.
Mutation
164 19578241 Adefovir dipivoxil resistance patterns in patients with lamivudine-resistant chronic hepatitis B.
Mutation
165 19578244 Clinical and virological responses to clevudine therapy in chronic hepatitis B patients: results at 1 year of an open-labelled prospective study.
Mutation
166 19581770 [Long-term clevudine therapy in nucleos(t)ide-naïve and lamivudine-experienced patients with hepatitis B virus-related chronic liver diseases].
Mutation
167 19651117 Detection of the rtA181V/T and rtN236T mutations associated with resistance to adefovir dipivoxil using a ligase detection reaction assay.
Mutation
168 19785624 Prevalence of hepatitis B virus DNA polymerase mutations in treatment-naïve patients with chronic hepatitis B.
Mutation
169 19795617 [Entecavir resistance in entecavir naive lamivudine treated chronic hepatitis B patients].
Mutation
170 19800842 Hepatitis B precore/core promoter mutations in isolates from HBV-monoinfected and HBV-HIV coinfected patients: a 3-yr prospective study.
Mutation
171 19811086 Downregulation of HLA class II molecules by G1896A pre-core mutation in chronic hepatitis B virus infection.
Mutation
172 19817965 Occult hepatitis B virus infection and lamivudine-resistant mutations in isolates from renal patients undergoing hemodialysis.
Mutation
173 19933798 Mechanism of entecavir resistance of hepatitis B virus with viral breakthrough as determined by long-term clinical assessment and molecular docking simulation.
Mutation
174 19950231 PreS deletion mutations of hepatitis B virus in chronically infected patients with simultaneous seropositivity for hepatitis-B surface antigen and anti-HBS antibodies.
Mutation
175 20007398 Selection and counterselection of the rtI233V adefovir resistance mutation during antiviral therapy.
Mutation
176 20034521 Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naïve Chinese patients.
Mutation
177 20077675 [Analysis on mutation of S gene and P gene of hepatitis B virus in two counties of Sichuan Province].
Mutation
178 20087936 Molecular evolutionary analysis and mutational pattern of full-length genomes of hepatitis B virus isolated from Belgian patients with different clinical manifestations.
Mutation
179 20119580 Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
Mutation
180 20164224 Identification and characterization of clevudine-resistant mutants of hepatitis B virus isolated from chronic hepatitis B patients.
Mutation
181 20173647 T1653 mutation in the enhancer II region of the hepatitis B virus genome in southern African Blacks with hepatocellular carcinoma.
Mutation
182 20184927 Molecular characteristics and functional analysis of full-length hepatitis B virus quasispecies from a patient with chronic hepatitis B virus infection.
Mutation
183 20222172 Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application.
Mutation
184 20332649 Response to adefovir depends on mutation patterns in precore region, basal core promoter and reverse transcriptase, and on-treatment responses in Lamivudine-resistant chronic hepatitis B patients.
Mutation
185 20382061 Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B.
Mutation
186 20586936 rtE218G, a novel hepatitis B virus mutation with resistance to adefovir dipivoxil in patients with chronic hepatitis B.
Mutation
187 20848146 Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease: an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure.
Mutation
188 20959817 Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma.
Mutation
189 20970466 Characterization of hepatitis virus B isolated from a multi-drug refractory patient.
Mutation
190 21056552 Variable influence of mutational patterns in reverse-transcriptase domain on replication capacity of hepatitis B virus isolates from antiviral-experienced patients.
Mutation
191 21149924 Profile of HBV antiviral resistance mutations with distinct evolutionary pathways against nucleoside/nucleotide analogue treatment among Chinese chronic hepatitis B patients.
Mutation
192 21168854 Human interleukin-10 genotypes are associated with different precore/core gene mutation patterns in children with chronic hepatitis B virus infection.
Mutation
193 21177673 Detection of hepatitis B virus genotype A3 and primary drug resistance mutations in African immigrants with chronic hepatitis B in Spain.
Mutation
194 21181915 Presence of valine at position 27 of the hepatitis B virus core gene is associated with severe liver inflammation in Chinese patients.
Mutation
195 21181918 Molecular epidemiology of chronic hepatitis B virus infection in Greece.
Mutation
196 21264860 Gender disparity in distribution of the major hydrophilic region variants of hepatitis B virus genotype C according to hepatitis B e antigen serostatus.
Mutation
197 21311107 HBV core region variability: effect of antiviral treatments on main epitopic regions.
Mutation
198 21323729 Natural history of chronic hepatitis B REVEALed.
Mutation
199 21392168 Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection.
Mutation
200 21396961 HBV DNA replication mediated by cloned patient HBV reverse transcriptase genes from HBV genotypes A-H and its use in antiviral phenotyping assays.
Mutation
201 21442057 Predictors for early HBeAg loss during lamivudine therapy in HBeAg-positive chronic hepatitis B patients with acute exacerbation.
Mutation
202 21461076 Association between Hepatitis B Virus X Gene Mutations and Clinical Status in Patients with Chronic Hepatitis B Infection.
Mutation
203 21468263 Precore and core promoter mutations of the hepatitis B virus gene in chronic genotype C-infected children.
Mutation
204 21484144 A comparison of 48-week treatment efficacy between clevudine and entecavir in treatment-naïve patients with chronic hepatitis B.
Mutation
205 21484148 Extended treatment with lamivudine and adefovir dipivoxil in chronic hepatitis B patients with lamivudine resistance.
Mutation
206 21490166 Impact of hepatitis B virus (HBV) x gene mutations on hepatocellular carcinoma development in chronic HBV infection.
Mutation
207 21503906 Clinical course and predictive factors of virological response in long-term lamivudine plus adefovir dipivoxil combination therapy for lamivudine-resistant chronic hepatitis B patients.
Mutation
208 21503942 Emergence of hepatitis B virus S gene mutants in patients experiencing hepatitis B surface antigen seroconversion after peginterferon therapy.
Mutation
209 21569538 A336C/A336T/T337C variations in HBV core gene and spontaneous hepatitis B e antigen loss in chronic hepatitis B patients.
Mutation
210 21601012 Molecular characterization and phylogenetic analysis of full-genome HBV subgenotype D3 sequences from Serbia.
Mutation
211 21640384 Hepatitis B genotypes/subgenotypes and MHR variants among Moroccan chronic carriers.
Mutation
212 21665530 Quantification of complex precore mutations of hepatitis B virus by SimpleProbe real time PCR and dual melting analysis.
Mutation
213 21692935 Large-scale survey of naturally occurring HBV polymerase mutations associated with anti-HBV drug resistance in untreated patients with chronic hepatitis B.
Mutation
214 21734806 Long-term effects of lamivudine treatment in Japanese chronic hepatitis B patients.
Mutation
215 21742757 Ultra-deep pyrosequencing analysis of the hepatitis B virus preCore region and main catalytic motif of the viral polymerase in the same viral genome.
Mutation
216 21784687 Antiviral drug-associated potential vaccine-escape hepatitis B virus mutants in Turkish patients with chronic hepatitis B.
Mutation
217 21785721 Evolution of Hepatitis B Virus in a Chronic HBV-Infected Patient over 2 Years.
Mutation
218 21789847 [Variants and quasispecies of reverse transcriptase region in polymerase gene of hepatitis B virus during lamivudine treatment].
Mutation
219 21814558 The G1613A mutation in the HBV genome affects HBeAg expression and viral replication through altered core promoter activity.
Mutation
220 21816062 Lamivudine plus adefovir is a good option for chronic hepatitis B patients with viral relapse after cessation of lamivudine treatment.
Mutation
221 21863638 [One-year combination therapy de novo of adefovir dipivoxil and lamivudine for decompensated cirrhosis related to HBV].
Mutation
222 21883736 Four-year follow-up of two chronic hepatitis B recipients of hepatitis B surface antigen-positive cadaveric liver grafts from asymptomatic carriers.
Mutation
223 21911882 Evolution of hepatitis B virus during long-term therapy in patients with chronic hepatitis B.
Mutation
224 21933446 Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B.
Mutation
225 21959623 Molecular epidemical characteristics of Lamivudine resistance mutations of HBV in southern China.
Mutation
226 22007495 [Effect of Lamivudine on chronic hepatitis B patients with chemotherapy or immunosuppressive agents therapy and research the drug resistance].
Mutation
227 22052677 Phenotypic assay of a hepatitis B virus strain carrying an rtS246T variant using a new strategy.
Mutation
228 22087110 A study of genotypes, mutants and nucleotide sequence of hepatitis B virus in Pakistan: HBV genotypes in pakistan.
Mutation
229 22097972 Five years of treatment with adefovir dipivoxil in Chinese patients with HBeAg-positive chronic hepatitis B.
Mutation
230 22098177 The influence of YMDD mutation patterns on clinical outcomes in patients with adefovir add-on lamivudine combination treatment.
Mutation
231 22138714 Prevalence, virology and antiviral drugs susceptibility of hepatitis B virus rtN238H polymerase mutation from 1865 Chinese patients with chronic hepatitis B.
Mutation
232 22170539 Discrepancy of potential antiviral resistance mutation profiles within the HBV reverse transcriptase between nucleos(t)ide analogue-untreated and -treated patients with chronic hepatitis B in a hospital in China.
Mutation
233 22170540 Pre-existing YMDD mutants in treatment-naïve patients with chronic hepatitis B are not selected during lamivudine therapy.
Mutation
234 22173170 Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion.
Mutation
235 22233650 Hepatitis B surface gene 145 mutant as a minor population in hepatitis B virus carriers.
Mutation
236 22246826 Characterization of hepatitis B virus genome variability in Iranian patients with chronic infection, a nationwide study.
Mutation
237 22260834 Risk factors of gene-resistant mutations in different nucleosides.
Mutation
238 22312387 Multidrug-resistant hepatitis B virus strain in a chronic Turkish patient.
Mutation
239 22312396 Prevalence and clinical significance of hepatitis B Basal core promoter and precore gene mutations in southern Iranian patients.
Mutation
240 22313146 Reactivation of hepatitis B virus with mutated hepatitis B surface antigen in a liver transplant recipient receiving a graft from an antibody to hepatitis B surface antigen- and antibody to hepatitis B core antigen-positive donor.
Mutation
241 22338219 [The mutation patterns of HBV P gene and genotyping in patients with lanivudine-resistant chronic hepatitis B].
Mutation
242 22340383 Characterization of hepatitis B virus genotypes/subgenotypes in 1,301 patients with chronic hepatitis B in North China.
Mutation
243 22342116 Hepatitis B virus variant with the a194t substitution within reverse transcriptase before and under adefovir and tenofovir therapy.
Mutation
244 22398037 The rtL229 substitutions in the reverse transcriptase region of hepatitis B virus (HBV) polymerase are potentially associated with lamivudine resistance as a compensatory mutation.
Mutation
245 22442974 [Heterogeneity of hepatitis B virus and diagnostic potential of modern test systems for the detection of HBsAg].
Mutation
246 22453135 Long-term monitoring drug resistance by ultra-deep pyrosequencing in a chronic hepatitis B virus (HBV)-infected patient exposed to several unsuccessful therapy schemes.
Mutation
247 22510826 Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes.
Mutation
248 22523569 Dynamics of hepatitis B virus quasispecies in association with nucleos(t)ide analogue treatment determined by ultra-deep sequencing.
Mutation
249 22579480 HBV genotypes prevalence, precore and basal core mutants in Morocco.
Mutation
250 22585719 Factors influencing inadequate or suboptimal response to adefovir with or without genotypic resistance.
Mutation
251 22666402 Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome.
Mutation
252 22686039 [Analysis of the complete hepatitis B virus genomes in a patient for repeated seroconversion to anti-HBe antibody due to co-infection with two virus clones].
Mutation
253 22711345 Molecular analysis of hepatitis B virus associated with vaccine failure in infants and mothers: a case-control study in Thailand.
Mutation
254 22720023 Hepatitis B virus gene mutations in liver diseases: a report from New Delhi.
Mutation
255 22728692 Lamivudine plus adefovir or telbivudine plus adefovir for chronic hepatitis B patients with suboptimal response to adefovir.
Mutation
256 22729192 YMDD motif mutations in chronic hepatitis B antiviral treatment naïve patients: a multi-center study.
Mutation
257 22767306 Evaluation of a "home-made" method to determine viral genotype and characterize mutations conferring drug resistance in chronic hepatitis B patients.
Mutation
258 22905181 Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression.
Mutation
259 22919746 [Hepatitis B virus (HBV) mutation in enhancer I (HBV Enh I)/X-promoter and the relationship between chronic HBV-related disease spectrum].
Mutation
260 22941290 High prevalence of the B2+C2 subgenotype mixture in patients with chronic hepatitis B in Eastern China.
Mutation
261 22960603 Hepatitis B virus basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients.
Mutation
262 22997074 Frequency and clinical significance of core promoter and precore region mutations in Tunisian patients infected chronically with hepatitis B.
Mutation
263 23026293 Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy.
Mutation
264 23112104 Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon-induced hepatitis B e antigen seroconversion.
Mutation
265 23113154 Identification of Hepatitis B Virus Surface Antigen (HBsAg) Genotypes and Variations in Chronic Carriers from Isfahan Province, Iran.
Mutation
266 23146520 Hepatitis B reactivation in a renal transplant patient due to a surface antigen mutant strain: a case report.
Mutation
267 23265059 [The panels of serums, containing various subtypes and mutant forms of HBsAg, to evaluate the diagnostics sensitivity of kits oa reagents detecting HBsAg].
Mutation
268 23322992 Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B.
Mutation
269 23355917 Efficacy of 3 years of adefovir monotherapy in chronic hepatitis B patients with lamivudine resistance.
Mutation
270 23423477 Impact of rtI233V mutation in hepatitis B virus polymerase protein and adefovir efficacy: Homology modeling and molecular docking studies.
Mutation
271 23458523 Efficacy and safety of telbivudine plus adefovir dipivoxil combination therapy and entecavir monotherapy for HBeAg-positive chronic hepatitis B patients with resistance to adefovir dipivoxil.
Mutation
272 23485939 Virological response and antiviral resistance mutations in chronic hepatitis B subjects experiencing entecavir therapy: an Indian subcontinent perspective.
Mutation
273 23596461 Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naïve chronic HBV patients.
Mutation
274 23599717 Correlation between viral load of HBV in chronic hepatitis B patients and precore and Basal core promoter mutations.
Mutation
275 23602529 [Low prevalence of hepatitis B virus primary drug resistance in Southern Spain].
Mutation
276 23627028 [Mutation analysis of the HBV reverse transcriptase in nucleos(t)ide-treated patients with chronic HBV infection].
Mutation
277 23678186 The L60V variation in hepatitis B virus core protein elicits new epitope-specific cytotoxic T lymphocytes and enhances viral replication.
Mutation
278 23710315 Quasispecies and pre-existing drug-resistant mutations of hepatitis B virus in patients with chronic hepatitis B.
Mutation
279 23805155 Virological Response and Muscular Adverse Events during Long-Term Clevudine Therapy in Chronic Hepatitis B Patients.
Mutation
280 23805180 Occult and Overt HBV Co-Infections Independently Predict Postoperative Prognosis in HCV-Associated Hepatocellular Carcinoma.
Mutation
281 23852705 A complete genomic analysis of hepatitis B virus isolated from 516 Chinese patients with different clinical manifestations.
Mutation
282 23871771 Positive selection signals of hepatitis B virus and their association with disease stages and viral genotypes.
Mutation
283 23918533 Hepatitis B virus reverse transcriptase mutations in treatment Naïve chronic hepatitis B patients.
Mutation
284 23968804 Dynamics of hepatitis B virus resistance substitutions correlates with virological response in lamivudine-refractory patients with entecavir rescue monotherapy.
Mutation
285 23971933 [HBV vaccine escape mutations in a chronic hepatitis B patient treated with nucleos(t)ide analogues].
Mutation
286 24006435 HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations.
Mutation
287 24009186 Unique surface gene variants of hepatitis B virus isolated from patients in the Philippines.
Mutation
288 24021712 Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions.
Mutation
289 24064642 Mutation analysis of hepatitis B virus reverse transcriptase region among untreated chronically infected patients in Ahvaz city (South-West of Iran).
Mutation
290 24160943 Profile of hepatitis B virus resistance mutations against nucleoside/nucleotide analogue treatment in Chinese patients with chronic hepatitis B.
Mutation
291 24175847 Prevelance of common YMDD motif mutations in long term treated chronic HBV infections in a Turkish population.
Mutation
292 24187552 The Possible Role of TLR2 in Chronic Hepatitis B Patients with Precore Mutation.
Mutation
293 24237431 [Investigation of baseline antiviral resistance in treatment-naive chronic hepatitis B cases].
Mutation
294 24316031 Amino acid similarities and divergences in the small surface proteins of genotype C hepatitis B viruses between nucleos(t)ide analogue-naïve and lamivudine-treated patients with chronic hepatitis B.
Mutation
295 24348637 Substitution rtq267h of hepatitis B virus increases the weight of replication and Lamivudine resistance.
Mutation
296 24368224 Randomized comparison of tenofovir disoproxil fumarate vs emtricitabine and tenofovir disoproxil fumarate in patients with lamivudine-resistant chronic hepatitis B.
Mutation
297 24399391 Antiviral efficacy of adefovir dipivoxil in the treatment of chronic hepatitis B subjects from Indian subcontinent.
Mutation
298 24406435 Clinical significance of hepatitis B virus precore and core promoter variants in Korean patients with chronic hepatitis B.
Mutation
299 24497877 Drug-resistance associated mutations in polymerase (p) gene of hepatitis B virus isolated from malaysian HBV carriers.
Mutation
300 24589944 Lamivudine and Adefovir Motif Variants Detected in chronic Hepatıtıs B patients.
Mutation
301 24630522 Analysis of potential antiviral resistance mutation profiles within the HBV reverse transcriptase in untreated chronic hepatitis B patients using an ultra-deep pyrosequencing method.
Mutation
302 24637457 Mutation profiling of the hepatitis B virus strains circulating in North Indian population.
Mutation
303 24696492 The impact of the hepatitis B virus polymerase rtA181T mutation on replication and drug resistance is potentially affected by overlapping changes in surface gene.
Mutation
304 24790911 Analysis of reverse transcriptase gene mutations in the hepatitis B virus at a university hospital in Korea.
Mutation
305 24836314 Viral evolutionary changes during tenofovir treatment in a chronic hepatitis B patient with sequential nucleos(t)ide therapy.
Mutation
306 24992206 Investigation into drug-resistant mutations of HBV from 845 nucleoside/nucleotide analogue-naive Chinese patients with chronic HBV infection.
Mutation
307 25028473 Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility.
Mutation
308 25061278 Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir.
Mutation
309 25170961 Correlation between the promoter basal core and precore mutations and HBsAg quantification in French blood donors infected with hepatitis B virus.
Mutation
310 25208639 Performance of LigAmp assay for sensitive detection of drug-resistant hepatitis B virus minor variants in comparison with standard nucleotide sequencing.
Mutation
311 25244642 Hepatitis B virus depicts a high degree of conservation during the immune-tolerant phase in familiarly transmitted chronic hepatitis B infection: deep-sequencing and phylogenetic analysis.
Mutation
312 25287170 Long-term outcomes and dynamics of mutants associated with lamivudine-adefovir rescue therapy in patients with lamivudine-resistant chronic hepatitis B.
Mutation
313 25303802 Different mechanism of selection of adefovir-resistant mutant viruses during adefovir monotherapy in patients with lamivudine-resistant chronic hepatitis B.
Mutation
314 25318660 Incidence of natural resistance mutations in naïve chronic hepatitis B patients: a systematic review and meta-analysis.
Mutation
315 25374716 Death from Liver Failure despite Lamivudine Prophylaxis during R-CHOP Chemotherapy due to Rapid Emergence M204 Mutations.
Mutation
316 25382636 A deep-sequencing method detects drug-resistant mutations in the hepatitis B virus in Indonesians.
Mutation
317 25452041 Specific mutations in the C-terminus domain of HBV surface antigen significantly correlate with low level of serum HBV-DNA in patients with chronic HBV infection.
Mutation
318 25477976 Hepatitis B virus core promoter mutations in patients with chronic hepatitis B and hepatocellular carcinoma in bucharest, romania.
Mutation
319 25626648 Hepatitis B virus genotypes and mutations in the basal core promoter and pre-core/core in chronically infected patients in southern Brazil: a cross-sectional study of HBV genotypes and mutations in chronic carriers.
Mutation
320 25742145 Clinical course of chronic hepatitis B patients receiving nucleos(t)ide analogues after virological breakthrough during monotherapy with lamivudine.
Mutation
321 25788956 Association of Mutations in the Basal Core Promoter and Pre-core Regions of the Hepatitis B Viral Genome and Longitudinal Changes in HBV Level in HBeAg Negative Individuals: Results From a Cohort Study in Northern Iran.
Mutation
322 25817219 Characterization of novel entecavir resistance mutations.
Mutation
323 25822176 Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.
Mutation
324 25825644 Correlation Between Hepatitis B G1896A Precore Mutations and HBeAg in Chronic HBV Patients.
Mutation
325 25982306 Microarray-based genotyping and detection of drug-resistant HBV mutations from 620 Chinese patients with chronic HBV infection.
Mutation
326 25989376 Impact of HBV genotypes A and D genetic variability on infection evolution.
Mutation
327 25997324 [The drug resistance mutation detection and relevant factors analysis of HBV P region in chronic hepatitis B patients in Weifang City, Shandong Province].
Mutation
328 26045705 Efficacy of tenofovir disoproxil fumarate therapy in nucleoside-analogue naive Iranian patients treated for chronic hepatitis B.
Mutation
329 26063382 Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis.
Mutation
330 26164128 Comparison of entecavir monotherapy and de novo lamivudine and adefovir combination therapy in HBeAg-positive chronic hepatitis B with high viral load: 48-week result.
Mutation
331 26194746 Outcomes including liver histology after liver transplantation for chronic hepatitis B using oral antiviral therapy alone.
Mutation
332 26201521 Naturally occurring core immune-escape and carboxy-terminal mutations\truncations in patients with e antigen negative chronic hepatitis B.
Mutation
333 26202027 HBsAg, HBeAg and HBV DNA level changes and precore/basal core promoter mutations in the natural history of chronic hepatitis B in Indonesian patients.
Mutation
334 26309637 Detection and analysis of resistance mutations of hepatitis B virus.
Mutation
335 26313279 [Characterization of basal core promoter/precore gene mutations in chronically infected patients with hepatitis B virus genotype D in Mersin Province, Turkey].
Mutation
336 26382925 Resistant mutations and quasispecies complexity of hepatitis B virus during telbivudine treatment.
Mutation
337 26389515 Predictors of hepatitis B e antigen-negative hepatitis in chronic hepatitis B virus-infected patients from childhood to adulthood.
Mutation
338 26505028 A Nanoscale Mutation-Sensitive On/Off Switch Based Assays for the Detection of Hepatitis B Virus Lamivudine-Resistant Mutations.
Mutation
339 26515673 Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones.
Mutation
340 26524917 [Variability of Reverse Transcriptase Gene and S Gene in Lamivudine-treated Chronic Hepatitis B Patients].
Mutation
341 26571304 Chronic hepatitis B in pregnant women: is hepatitis B surface antigen quantification useful for viral load prediction?
Mutation
342 26571502 Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection.
Mutation
343 26577140 Hepatitis B virus basal core promoter/precore mutants and association with liver cirrhosis in children with chronic hepatitis B virus infection.
Mutation
344 26587040 G1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B.
Mutation
345 26613893 Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBs.
Mutation
346 26647737 Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients.
Mutation
347 26727850 GENOMIC ANALYSIS OF HEPATITIS B VIRUS STRAINS INFECTING ROMANIAN PATIENTS.
Mutation
348 26876337 Prevalence of mutations in HBV DNA polymerase gene associated with nucleos(t)ide resistance in treatment-naive patients with Chronic Hepatitis B in Central China.
Mutation
349 26889227 Evolution of entecavir-resistant hepatitis B virus during entecavir and adefovir dipivoxil combination therapy.
Mutation
350 26901602 Investigation by the Method of INNO-LiPA of Primary Resistance to Lamivudine in Patients with Chronic Hepatitis B Who Have Not Used Antiviral Therapy.
Mutation
351 26984835 Association between hepatitis B virus basal core promoter/precore region mutations and the risk of hepatitis B-related acute-on-chronic liver failure in the Chinese population: an updated meta-analysis.
Mutation
352 26992056 Different precore/core mutations of hepatitis B interact with, limit, or favor liver fibrosis severity.
Mutation
353 27006281 Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2.
Mutation
354 27031988 Functional analysis of 'a' determinant mutations associated with occult HBV in HIV-positive South Africans.
Mutation
355 27055927 Prevalence of mutations within major hydrophilic region of hepatitis B virus and their correlation with genotypes among chronically infected patients in Egypt.
Mutation
356 27386641 [Effect of Telbivudine Tablet Combined Jianpi Bushen Recipe on HBV Specific Cytotoxic T Lymphocyte and HBeAg Seroconversion in Patients with HBeAg Positive Chronic Hepatitis B].
Mutation
357 27446286 Association between clinical features and YMDD mutations in patients with chronic hepatitis B following lamivudine therapy.
Mutation
358 27504160 Mutational analysis of reverse transcriptase and surface proteins of patients with partial virological response during mono and combination antiviral therapies in genotype D chronic hepatitis B.
Mutation
359 27583985 Small surface antigen variants of HBV associated with responses to telbivudine treatment in chronic hepatitis B patients.
Mutation
360 27624502 Hepatitis B virus infection in children of HBV-related chronic liver disease patients: a study of intra-familial HBV transmission.
Mutation
361 27651827 Molecular characterization of hepatitis B virus among chronic hepatitis B patients from Pointe Noire, Republic of Congo.
Mutation
362 27694733 Monitoring of genotypic resistance profile in chronic hepatitis B patients receiving nucleos(t)ide analogues in Huzhou, China.
Mutation
363 27787680 Identification of a new hepatitis B virus recombinant D2/D3 in the city of São Paulo, Brazil.
Mutation
364 27812178 Evaluation of the G145R Mutant of the Hepatitis B Virus as a Minor Strain in Mother-to-Child Transmission.
Mutation
365 27824315 Association study between mannose-binding lectin haplotypes and X gene mutation of hepatitis B virus from treatment naïve patients.
Mutation
366 27894395 Relationship between hepatitis B virus reverse transcriptase 181 mutation and S gene mutation in hepatitis B virus chronically infected patients.
Mutation
367 27998820 Core I97L mutation in conjunction with P79Q is associated with persistent low HBV DNA and HBs antigen clearance in patients with chronic hepatitis B.
Mutation
368 28088502 The nucleotide changes within HBV core promoter/precore during the first 12weeks of nucleos(t)ide treatment might be associated with a better virological response.
Mutation
369 28124958 [Atypical serological profiles in hepatitis B infections: investigation of S gene mutations in cases with concurrently positive for HBsAg and anti-HBs].
Mutation
370 28139541 Comparative evaluation of long-term monotherapies & combination therapies in patients with chronic hepatitis B: A pilot study.
Mutation
371 28152517 Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro.
Mutation
372 28198078 Mutation in the S gene of hepatitis B virus and anti-HBs subtype-nonspecificity contributed to the co-existence of HBsAg and anti-HBs in patients with chronic hepatitis B virus infection.
Mutation
373 28236303 Characterization of hepatitis B virus (HBV) preS/S gene mutations in blood donors with occult HBV infection in the Baoji area of North China.
Mutation
374 28300730 The enrichment of HBV immune-escape mutations during nucleoside/nucleotide analogue therapy.
Mutation
375 28303969 HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
Mutation
376 28322924 Evolutionary trends of resistance mutational patterns of HBV reverse transcriptase over years (2002-2012) of different treatment regimens: The legacy of lamivudine/adefovir combination treatment.
Mutation
377 28376852 Antiviral efficacy of entecavir for hepatitis B virus rtA181V/T mutants.
Mutation
378 28381384 Novel HBV mutations and their value in predicting efficacy of conventional interferon.
Mutation
379 28418295 Phenotypic and Genotypic Shifts in Hepatitis B Virus in Treatment-Naive Patients, Taiwan, 2008-2012.
Mutation
380 28440785 Impacts of HBV rtH55R polymerase substitution on viral replication and rtM204I/V resistance to nucleoside/nucleotide antiviral drugs.
Mutation
381 28445403 Detection of Hepatitis B Virus M204I Mutation by Quantum Dot-Labeled DNA Probe.
Mutation
382 28500726 Mutations associated with drug resistance and prevalence of vaccine escape mutations in patients with chronic hepatitis B infection.
Mutation
383 28582431 Hepatitis B genotypes and surface antigen mutants present in Pakistani blood donors.
Mutation
384 28600703 Prevalence of S gene mutations within the major hydrophilic region of hepatitis B virus in patients in Dongguan, southern China.
Mutation
385 28740410 Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B.
Mutation
386 28751727 Temporal trend of hepatitis B surface mutations in the post-immunization period: 9 years of surveillance (2005-2013) in eastern China.
Mutation
387 28859616 Molecular characterization of hepatitis B virus in Vietnam.
Mutation
388 28870025 Clinical characteristics of patients with chronic hepatitis B who developed genotypic resistance to entecavir: Real-life experience.
Mutation
389 28902288 Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases.
Mutation
390 29248936 Patients with Coexistence of Circulating Hepatitis B Surface Antigen and Its Antibody May Have a Strong Predisposition to Virus Reactivation During Immunosuppressive Therapy: A Hypothesis.
Mutation
391 29393485 Early changes in quasispecies variant after antiviral therapy for chronic hepatitis B.
Mutation
392 29596494 High rates of chronic HBV genotype E infection in a group of migrants in Italy from West Africa: Virological characteristics associated with poor immune clearance.
Mutation
393 29663445 Mutations within the major hydrophilic region (MHR) of Hepatitis B virus from individuals with simultaneous HBsAg and anti-HBs in Guangzhou, Southern China.
Mutation
394 29739114 Mutations in Core Gene Region of Hepatitis B Virus in Patients with Chronic Hepatitis B.
Mutation
395 29859062 Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.
Mutation
396 30095435 Association of characteristics of HBV quasispecies with hepatitis B surface antigen seroconversion after pegylated interferon-α-2a treatment in child patients.
Mutation
397 30285571 Predictors of Therapeutic Outcome to Nucleotide Reverse Transcriptase Inhibitor in Hepatitis B Patients.
Mutation
398 30505167 Hepatitis B virus precore G1896A mutation in chronic liver disease patients with HBeAg negative serology from North India.
Mutation
399 30586543 Novel fluoronucleoside analog NCC inhibits lamivudine-resistant hepatitis B virus in a hepatocyte model.
Mutation
400 30669266 Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients.
Mutation
401 30794889 Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.
Mutation
402 30835025 Pre-S/Surface and Core Promoter/Precore Mutations in Chronic Hepatitis B Patients with Severe Acute Exacerbation.
Mutation
403 30906435 Viral quasispecies of hepatitis B virus in patients with YMDD mutation and lamivudine resistance may not predict the efficacy of lamivudine/adefovir rescue therapy.
Mutation
404 31130119 [HBV pol/S gene mutations in chronic hepatitis B patients receiving nucleoside/nucleotide analogues treatment].
Mutation
405 31130120 [Determination of reverse transcriptase inhibitor nucleoside analogue resistance profile in pretreatment phase of patients with viral hepatitis B].
Mutation
406 31179360 Hepatitis B virus reverse transcriptase polymorphisms between treated and treatment-naïve chronically infected patients.
Mutation
407 31189581 Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.
Mutation
408 31308922 Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
Mutation
409 31324819 Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients.
Mutation
410 31341154 Association Between HBx Variations and Development of Severe Liver Disease Among Indonesian Patients.
Mutation
411 31359359 Next generation sequencing identifies baseline viral mutants associated with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B.
Mutation
412 31398372 Investigation of hepatitis B virus (HBV) rtS78T/sC69* mutation in a large cohort of chronic HBV-infected patients with nucleoside/nucleotide analogue treatment.
Mutation
413 31442597 The modulation of HBsAg level by sI126T is affected by additional amino acid substitutions in the S region of HBV.
Mutation
414 31498528 Entecavir resistance mutations rtL180M/T184L/M204V combined with rtA200V lead to tenofovir resistance.
Mutation
415 31543688 Tenofovir is a more suitable treatment than entecavir for chronic hepatitis B patients carrying naturally occurring rtM204I mutations.
Mutation
416 31565220 Association between host TNF-α, TGF-β1, p53 polymorphisms, HBV X gene mutation, HBV viral load and the progression of HBV-associated chronic liver disease in Indonesian patients.
Mutation
417 31624004 Characteristics of amino acid substitutions within the "a" determinant region of hepatitis B virus in chronically infected patients with coexisting HBsAg and anti-HBs.
Mutation
418 31731368 Compare with safety and efficacy of entecavir and adefovir dipivoxil combination therapy and tenofovir disoproxil fumarate monotherapy for chronic hepatitis B patient with adefovir-resistant.
Mutation
419 32155009 [The prevalence clinically significant virus mutations among patients with chronic viral hepatitis B.]
Mutation
420 32216026 Entecavir-resistant hepatitis B virus decreases surface antigenicity: A full genome and functional characterization.
Mutation
421 32312174 Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection.
Mutation
422 32466635 Low-level viremia and cirrhotic complications in patients with chronic hepatitis B according to adherence to entecavir.
Mutation
423 32523313 Conservation and variability of hepatitis B core at different chronic hepatitis stages.
Mutation
424 32545313 Impact of Lamivudine-Based Antiretroviral Treatment on Hepatitis B Viremia in HIV-Coinfected South Africans.
Mutation
425 32568442 The genetic polymorphism down-regulating HLA-DRB1 enhancer activity facilitates HBV persistence, evolution and hepatocarcinogenesis in the Chinese Han population.
Mutation
426 32569703 Hepatitis B virus mutation pattern rtA181S+T184I+M204I may contribute to multidrug resistance in clinical practice: Analysis of a large cohort of Chinese patients.
Mutation
427 32579776 Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapy.
Mutation
428 32663786 Evidence of tenofovir resistance in chronic hepatitis B virus (HBV) infection: An observational case series of South African adults.
Mutation
429 32695898 In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.
Mutation
430 32708399 COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B.
Mutation
431 32765014 Prevalence of Potential Resistance Related Variants Among Chinese Chronic Hepatitis B Patients Not Receiving Nucleos(T)ide Analogues.
Mutation
432 32840739 An antiviral drug-resistant mutant of hepatitis B virus with high replication capacity in association with a large in-frame deletion in the preS1 region of viral surface gene.
Mutation
433 32860707 Impacts of the Percentage of Basal Core Promoter Mutation on the Progression of Liver Fibrosis After Hepatitis B e Antigen Seroconversion.
Mutation
434 32894807 Characterization of Hepatitis B virus polymerase mutations A194T and CYEI and tenofovir disoproxil fumarate or tenofovir alafenamide resistance.
Mutation
435 32911905 [Clinical significance and mutation characteristics in the core promoter/pre-C region of different HBV genotypes in children].
Mutation
436 32994690 Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.
Mutation
437 33124952 Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients.
Mutation
438 8952268 [Detection of hepatitis B virus by using polymerase chain reaction and nonradioactive DNA probes. II. Identification of mutations in the core gene by PCR-direct sequencing and ASO probe method].
Mutation
439 9011456 Pathogenesis of chronic liver disease in patients with chronic hepatitis B virus infection without serum HBeAg.
Mutation
440 9593029 Identification of more than one mutation in the hepatitis B virus polymerase gene arising during prolonged lamivudine treatment.
Mutation
441 9728561 Emergence of an S gene mutant during thymosin alpha1 therapy in a patient with chronic hepatitis B.
Mutation
442 9751010 Incidence and clinical significance of hepatitis B virus precore gene translation initiation mutations in e antigen-negative patients.
Mutation
443 9862871 Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance.
Mutation
444 33462964 Virologic analysis of tenofovir resistance in a patient with chronic hepatitis B experiencing viral breakthrough during combination treatment with tenofovir disoproxil fumarate and entecavir.
Mutation
445 33562603 Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes.
Mutation
446 33571155 Multiple drug-resistant HBV mutation may contribute to poor response of adefovir + entecavir in entecavir-resistant patients.
Mutation
447 33603102 Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients.
Mutation
448 33671832 Predominance of HBV Genotype B and HDV Genotype 1 in Vietnamese Patients with Chronic Hepatitis.
Mutation
449 33708042 Hepatitis B virus precore/core region mutations and genotypes among hepatitis B virus chronic carriers in South-Eastern, Nigeria.
Mutation
450 33758517 The Occurrence of rtA194T Mutant After Long-Term Lamivudine Monotherapy Remains Sensitive to Tenofovir Disoproxil Fumarate: A Case Report.
Mutation
451 33791326 Tenofovir Disoproxil Fumarate Is Superior to Entecavir in Reducing Hepatitis B Surface Antigen for Chronic Hepatitis B in China: 2-Year Comprehensive Comparative Result of a Matched Comparative Study.
Mutation
452 33836203 Natural variability in surface antigen and reverse transcriptase domain of hepatitis B virus in treatment-naïve chronic HBV-infected Egyptian patients.
Mutation
453 33857724 LCR based quick detection of hotspot G1896A mutation in patients with different spectrum of hepatitis B.
Mutation
454 33959934 Spontaneous reactivation of hepatitis B virus with a frameshift mutation in the precore region in an elderly hepatitis B virus carrier with lifestyle-related diseases.
Mutation
455 33986897 High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy.
Mutation
Contents
Description
Group Note
  • Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
  • VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)