Overview of HPV associated Cervical carcinoma

Cervical carcinoma is a cancer arising from the cervix.It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body. Early on, typically no symptoms are seen.Later symptoms may include abnormal vaginal bleeding, pelvic pain or pain during sexual intercourse.While bleeding after sex may not be serious, it may also indicate the presence of cervical cancer.

ID	Literature	Title	Group
1	29364907	HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression.	VIS-cistrome
2	24201445	Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.	VIS-cistrome
3	26660085	Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer.	VIS-cistrome
4	23740984	Landscape of DNA virus associations across human malignant cancers: analysis of 3,775 cases using RNA-Seq.	VIS-cistrome
5	23824673	Multiplex Identification of Human Papillomavirus 16 DNA Integration Sites in Cervical Carcinomas.	VIS-cistrome
6	18922896	Characterization of naturally occurring HPV16 integration sites isolated from cervical keratinocytes under noncompetitive conditions.	VIS-cistrome
7	30679491	TaME-seq: An efficient sequencing approach for characterisation of HPV genomic variability and chromosomal integration.	VIS-cistrome
8	24418928	Simultaneous characterization of somatic events and HPV-18 integration in a metastatic cervical carcinoma patient using DNA and RNA sequencing.	VIS-cistrome
9	26735580	Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology.	VIS-cistrome
10	27759101	Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology.	VIS-cistrome
11	25485619	A comprehensive transcriptional portrait of human cancer cell lines.	VIS-cistrome
12	32714374	Accurate Detection of HPV Integration Sites in Cervical Cancer Samples Using the Nanopore MinION Sequencer Without Error Correction.	VIS-cistrome
13	33191407	Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site.	VIS-cistrome
14	30567904	Comprehensive genomic variation profiling of cervical intraepithelial neoplasia and cervical cancer identifies potential targets for cervical cancer early warning.	VIS-cistrome
15	32025001	The landscape of viral associations in human cancers.	VIS-cistrome
16	29487700	Increased high mobility group A 2 expression promotes transition of cervical intraepithelial neoplasm into cervical cancer.	VIS-cistrome
17	31014281	HPV DNA integration site as proof of the origin of ovarian metastasis from endocervical adenocarcinoma: three case reports.	VIS-cistrome
18	32631904	The D2 and D3 Sublineages of Human Papilloma Virus 16-Positive Cervical Cancer in Guatemala Differ in Integration Rate and Age of Diagnosis.	VIS-cistrome
19	30728408	Genome-wide profiling of human papillomavirus DNA integration in liquid-based cytology specimens from a Gabonese female population using HPV capture technology.	VIS-cistrome
20	30552977	Characterization of HPV integration, viral gene expression and E6E7 alternative transcripts by RNA-Seq: A descriptive study in invasive cervical cancer.	VIS-cistrome
21	33023834	HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer.	VIS-cistrome
22	10389753	Uniform distribution of HPV 16 E6 and E7 variants in patients with normal histology, cervical intra-epithelial neoplasia and cervical cancer.	Mutation
23	10567656	Human papillomavirus type 16 E6 variants in cervical carcinoma: relationship to host genetic factors and clinical parameters.	Mutation
24	10783118	Absence of antibody against human papillomavirus type 16 E6 and E7 in patients with cervical cancer is independent of sequence variations.	Mutation
25	10880765	Enhanced oncogenicity of human papillomavirus type 16 (HPV16) variants in Japanese population.	Mutation
26	10917543	Uneven distribution of HPV 16 E6 prototype and variant (L83V) oncoprotein in cervical neoplastic lesions.	Mutation
27	11745467	Human papillomavirus 16 E6 polymorphisms in cervical lesions from different European populations and their correlation with human leukocyte antigen class II haplotypes.	Mutation
28	11870518	Variants of the long control region and the E6 oncogene in European human papillomavirus type 16 isolates: implications for cervical disease.	Mutation
29	12189229	Association of human papillomavirus type 58 variant with the risk of cervical cancer.	Mutation
30	12195358	Human papillomavirus type 16 intratypic variant infection and risk for cervical neoplasia in southern China.	Mutation
31	12691704	Association between human papillomavirus 16 E6 variants and human leukocyte antigen class I polymorphism in cervical cancer of Swedish women.	Mutation
32	12820481	Co-mutation of HPV16 E6 and E7 genes in Thai squamous cervical carcinomas.	Mutation
33	12918070	Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer.	Mutation
34	1321216	Geographical dependence of sequence variation in the E7 gene of human papillomavirus type 16.	Mutation
35	15297193	Human papillomavirus type 16 E6, E7, and L1 variants in cervical cancer in Indonesia, Suriname, and The Netherlands.	Mutation
36	15363193	[Analysis of human papillomavirus 16 E6 oncogene mutation in Xinjiang Uygur women with cervical carcinoma].	Mutation
37	15491758	E2 sequence variations of HPV 16 among patients with cervical neoplasia seen in the Indian subcontinent.	Mutation
38	15572004	The prevalence of HPV-18 and variants of E6 gene isolated from cervical cancer patients in Taiwan.	Mutation
39	15670304	Polymorphism in the E6 gene of human papillomavirus type 16 in the cervical tissues of Korean women.	Mutation
40	15721413	Human papillomavirus type 16 E2 and E6/E7 variants.	Mutation
41	15929080	Interaction of host and viral risk factors for development of cervical carcinoma in situ.	Mutation
42	16012730	Sequence variation and the transcriptional activity of the upstream regulatory region in human papillomavirus 16 E7 variants in cervical cancer of Korean women.	Mutation
43	16099904	Differential splicing of E6 within human papillomavirus type 18 variants and functional consequences.	Mutation
44	16333213	[Investigation of human papillomavirus, its types and variants].	Mutation
45	16603519	Analysis of mutations in the E6/E7 oncogenes and L1 gene of human papillomavirus 16 cervical cancer isolates from China.	Mutation
46	18199779	Human papillomavirus type 16 variant analysis of E6, E7, and L1 genes and long control region in biopsy samples from cervical cancer patients in north India.	Mutation
47	18512138	A non-radioactive PCR-SSCP analysis allows to distinguish between HPV 16 European and Asian-American variants in squamous cell carcinomas of the uterine cervix in Colombia.	Mutation
48	19256739	Distribution of HPV-16 intratypic variants among women with cervical intraepithelial neoplasia and invasive cervical cancer in Mongolia.	Mutation
49	19358280	Molecular variants of HPV-16 associated with cervical cancer in Indian population.	Mutation
50	19699050	Human papillomavirus type 16 E6 gene variations in Chinese population.	Mutation
51	20104743	[Gene characterization of E6 and E7 gene of human papillomavirus of 15 cervical cancer in Beijing].	Mutation
52	20423887	[Human papillomavirus type 16 variant analysis of upstream regulatory region and E6, E7 oncogene from cervical cancer patients in Beijing].	Mutation
53	20870281	Distribution of human papillomavirus 58 and 52 E6/E7 variants in cervical neoplasia in Chinese women.	Mutation
54	21051983	Distribution of human papillomavirus 16 E6/E7 variants in cervical cancer and intraepithelial neoplasia in Chinese women.	Mutation
55	21436703	Genetic diversity of HPV-16 E6, E7, and L1 genes in women with cervical lesions in Liaoning Province, China.	Mutation
56	21593270	Human papillomavirus type 16 variant analysis of E6, E7, and L1 [corrected] genes and long control region in [corrected] cervical carcinomas in patients in northeast China.	Mutation
57	22131113	Prevalence of HPV 16 genomic variant carrying a 63 bp duplicated sequence within the E1 gene in Slovenian women.	Mutation
58	22524831	Whole genome analysis of human papillomavirus type 16 multiple infection in cervical cancer patients.	Mutation
59	22558401	Human papillomavirus (HPV) 16 E6 variants in tonsillar cancer in comparison to those in cervical cancer in Stockholm, Sweden.	Mutation
60	22574185	Whole genome sequencing and evolutionary analysis of human papillomavirus type 16 in central China.	Mutation
61	22622951	Variant lineages of human papillomavirus type 18 in Northeast China populations characterized by sequence analysis of E6, E7, and L1 regions.	Mutation
62	22659102	Variations of human papillomavirus type 58 E6, E7, L1 genes and long control region in strains from women with cervical lesions in Liaoning province, China.	Mutation
63	23136059	Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations.	Mutation
64	23203106	Genomic polymorphism of human papillomavirus type 52 in women from Northeast China.	Mutation
65	23451059	Sequence variation analysis of HPV-18 isolates in southwest China.	Mutation
66	23762404	Differential expression of HPV16 L2 gene in cervical cancers harboring episomal HPV16 genomes: influence of synonymous and non-coding region variations.	Mutation
67	23881083	Nucleotide polymorphisms of the human papillomavirus 16 E1 gene.	Mutation
68	23946477	Molecular and evolutionary analysis of HPV16 E6 and E7 genes in Greek women.	Mutation
69	23953248	Analysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women.	Mutation
70	24099556	Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China.	Mutation
71	24150786	Functional effects of sequence variations in the E6 and E2 genes of human papillomavirus 16 European and Asian variants.	Mutation
72	24236186	Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing.	Mutation
73	24610458	HPV16 E6 variants: frequency, association with HPV types and in silico analysis of the identified novel variants.	Mutation
74	25111286	Prevalence of HPV and variation of HPV 16/HPV 18 E6/E7 genes in cervical cancer in women in South West China.	Mutation
75	25143263	Molecular variants of human papilloma virus 16 E2, E4, E5, E6 and E7 genes associated with cervical neoplasia in Romanian patients.	Mutation
76	25735347	Mutation detection of E6 and LCR genes from HPV 16 associated with carcinogenesis.	Mutation
77	25889023	Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.	Mutation
78	25991921	Genetic variability in E6 and E7 oncogenes of human papillomavirus Type 16 from Congolese cervical cancer isolates.	Mutation
79	26192265	Distribution of human papilloma virus type 16 E6/E7 gene mutation in cervical precancer or cancer: A case control study in Guizhou Province, China.	Mutation
80	27610192	Molecular analysis of human Papillomavirus detected among women positive for cervical lesions by visual inspection with acetic acid/Lugol's iodine (VIA/VILI) in Libreville, Gabon.	Mutation
81	27801430	HPV16 E6 polymorphism and physical state of viral genome in relation to the risk of cervical cancer in women from the south of Poland.	Mutation
82	27977741	Analysis of Sequence Variation and Risk Association of Human Papillomavirus 52 Variants Circulating in Korea.	Mutation
83	28036379	Different Association of Human Papillomavirus 16 Variants with Early and Late Presentation of Cervical Cancer.	Mutation
84	28141822	E6 and E7 Gene Polymorphisms in Human Papillomavirus Types-58 and 33 Identified in Southwest China.	Mutation
85	28270859	Genetic variability in E6, E7 and L1 genes of Human Papillomavirus 62 and its prevalence in Mexico.	Mutation
86	28325903	Whole-Genome Analysis of Human Papillomavirus Types 16, 18, and 58 Isolated from Cervical Precancer and Cancer Samples in Chinese Women.	Mutation
87	28441787	Codon Usage Optimization and Construction of Plasmid Encoding Iranian Human Papillomavirus Type 16 E7 Oncogene for Lactococcus Lactis Subsp. Cremoris MG1363	Mutation
88	28591310	Human papillomavirus type distribution and HPV16 intratype diversity in southern Brazil in women with and without cervical lesions.	Mutation
89	28767682	Genetic variability and functional implication of the long control region in HPV-16 variants in Southwest China.	Mutation
90	28819444	Association of HLA-DRB1, HLA-DQB1 Polymorphisms with HPV 16 E6 Variants among Young Cervical Cancer Patients in China.	Mutation
91	28959092	Naturally occurring capsid protein variants L1 of human papillomavirus genotype 16 in Morocco.	Mutation
92	28988982	Phylogenetic analysis of Human papillomavirus 16 variants isolated from Indian Breast cancer patients showed difference in genetic diversity with that of cervical cancer isolates.	Mutation
93	29783960	Performance of OncoE6 cervical test with collection methods enabling self-sampling.	Mutation
94	29945151	Genetic Variability in E6 and E7 Oncogenes from Human Papillomavirus Type 58 in Mexican Women.	Mutation
95	30008422	The association of human papillomavirus type 16 E2 variations with cervical cancer in a Han Chinese population.	Mutation
96	30081093	HPV16 E2 variants correlated with radiotherapy treatment and biological significance in cervical cell carcinoma.	Mutation
97	30161236	Differences in the viral genome between HPV-positive cervical and oropharyngeal cancer.	Mutation
98	30583341	Phylogeny and Classification of Human Papillomavirus (HPV)16 and HPV18 Variants Based on E6 and L1 genes in Tunisian Women with Cervical Lesions	Mutation
99	30930693	Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China.	Mutation
100	30981880	Human papillomavirus type 16 E6 and E7 gene variations associated with cervical cancer in a Han Chinese population.	Mutation
101	30995759	Whole-Genome Analysis of Human Papillomavirus Type 16 Prevalent in Japanese Women with or without Cervical Lesions.	Mutation
102	31289133	The HPV16 Genome Is Stable in Women Who Progress to In Situ or Invasive Cervical Cancer: A Prospective Population-Based Study.	Mutation
103	31341418	Human Papillomavirus Type 16 E1 Mutations Associated with Cervical Cancer in a Han Chinese Population.	Mutation
104	31493439	Distribution of HPV 16 E6 gene variants in screening women and its associations with cervical lesions progression.	Mutation
105	31552532	Mutational landscape and intra-host diversity of human papillomavirus type 16 long control region and E6 variants in cervical samples.	Mutation
106	32308546	Association of Human Papillomavirus Type 16 Long Control Region Variations with Cervical Cancer in a Han Chinese Population.	Mutation
107	32448303	Fifteen new nucleotide substitutions in variants of human papillomavirus 18 in Korea : Korean HPV18 variants and clinical manifestation.	Mutation
108	32677948	Genetic variability, phylogeny and functional implication of the long control region in human papillomavirus type 16, 18 and 58 in Chengdu, China.	Mutation
109	32986347	Phylogeny and In Silico Structure Analysis of Major Capsid Protein (L1) Human Papillomavirus 45 from Indonesian Isolates.	Mutation
110	33324377	High Levels of Within-Host Variations of Human Papillomavirus 16 E1/E2 Genes in Invasive Cervical Cancer.	Mutation
111	33324386	Human Papillomavirus Infections in Cervical Samples From HIV-Positive Women: Evaluation of the Presence of the Nonavalent HPV Genotypes and Genetic Diversity.	Mutation
112	9485042	Human papillomavirus 16 E6 variants are more prevalent in invasive cervical carcinoma than the prototype.	Mutation
113	33909391	Sequence variation analysis of the E1 and E2 genes of human papillomavirus type 16 in cervical lesions in women from the south of Poland.	Mutation

Contents
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Group Note

Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)


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