Overview of HBV associated Acute on chronic liver failure

Acute-on-chronic liver failure occurs in patients with chronic liver disease and is characterized by acute deterioration of the patient requiring hospitalization and is associated with (1) hepatic and extrahepatic organ dysfunction, (2) systemic inflammation, and (3) a high 28-day mortality rate. Acute-on-chronic liver failure occurs in approximately 30% of the hospitalized cirrhotic patients and affects younger individuals; in approximately 40% there is no previous history of hepatic decompensation—making this a very relevant and devastating complication of cirrhosis.

ID	Literature	Title	Group
1	20070500	Hepatitis B virus genotype and basal core promoter/precore mutations are associated with hepatitis B-related acute-on-chronic liver failure without pre-existing liver cirrhosis.	Mutation
2	20848146	Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease: an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure.	Mutation
3	21186523	[Analysis the relationship of HBV BCP A1762T/G1764A double mutation with HBV related acute on chronic liver failure].	Mutation
4	21503912	T1846 and A/G1913 are associated with acute on chronic liver failure in patients infected with hepatitis B virus genotypes B and C.	Mutation
5	21739444	Hepatitis B virus genotype B with G1896A and A1762T/G1764A mutations is associated with hepatitis B related acute-on-chronic liver failure.	Mutation
6	23852705	A complete genomic analysis of hepatitis B virus isolated from 516 Chinese patients with different clinical manifestations.	Mutation
7	24282424	Association of Hepatitis B Virus Mutations of A1846T and C1913A/G With Acute-on-Chronic Liver Failure Development From Different Underlying Chronic Liver Diseases.	Mutation
8	25849554	New point mutations in surface and core genes of hepatitis B virus associated with acute on chronic liver failure identified by complete genomic sequencing.	Mutation
9	25968238	Accurate Detection of Hepatitis B Virus G1896A Mutant by Developed Taqman-ARMS Followed a Strict Control System.	Mutation
10	26063382	Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis.	Mutation
11	26202756	Hepatitis B virus genotype B and mutations in basal core promoter and pre-core/core genes associated with acute-on-chronic liver failure: a multicenter cross-sectional study in China.	Mutation
12	26984835	Association between hepatitis B virus basal core promoter/precore region mutations and the risk of hepatitis B-related acute-on-chronic liver failure in the Chinese population: an updated meta-analysis.	Mutation
13	29065883	Chronic hepatitis B carriers with acute on chronic liver failure show increased HBV surface gene mutations, including immune escape variants.	Mutation
14	30229977	Clinical Outcome and Viral Genome Variability of Hepatitis B Virus-Induced Acute Liver Failure.	Mutation
15	30505167	Hepatitis B virus precore G1896A mutation in chronic liver disease patients with HBeAg negative serology from North India.	Mutation

Contents
Description

Group Note

Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)