Primary Site >> Colorectal Cancer

Gene >> TOP1

Journal: Biochemistry. 1995 May 30;34(21):7200-6.
Title: Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives.
Author: Tanizawa, A|Kohn, K W|Kohlhagen, G|Leteurtre, F|Pommier, Y
PMID: 7766631
Journal: Cancer Res. 1995 May 15;55(10):2116-21.
Title: Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen.
Author: Goldwasser, F|Bae, I|Valenti, M|Torres, K|Pommier, Y
PMID: 7743511
Journal: Cancer Res. 1996 Oct 1;56(19):4430-7.
Title: Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.
Author: Goldwasser, F|Shimizu, T|Jackman, J|Hoki, Y|O'Connor, P M|Kohn, K W|Pommier, Y
PMID: 8813137
Journal: Int J Cancer. 1997 Jan 27;70(3):335-40.
Title: CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants.
Author: Jansen, W J|Zwart, B|Hulscher, S T|Giaccone, G|Pinedo, H M|Boven, E
PMID: 9033637
Journal: Mol Pharmacol. 1997 Jul;52(1):82-7.
Title: Novel 7-alkyl methylenedioxy-camptothecin derivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells.
Author: Valenti, M|Nieves-Neira, W|Kohlhagen, G|Kohn, K W|Wall, M E|Wani, M C|Pommier, Y
PMID: 9224816
Journal: Nucleic Acids Res. 1997 Oct 15;25(20):4111-6.
Title: In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells.
Author: Pondarre, C|Strumberg, D|Fujimori, A|Torres-Leon, R|Pommier, Y
PMID: 9321666
Journal: Clin Cancer Res. 1997 Sep;3(9):1653-60.
Title: Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells.
Author: Gupta, M|Fan, S|Zhan, Q|Kohn, K W|O'Connor, P M|Pommier, Y
PMID: 9815856
Journal: Oncol Res. 1998;10(5):271-6.
Title: Replication-dependent and -independent camptothecin cytotoxicity of seven human colon tumor cell lines.
Author: Borovitskaya, A E|D'Arpa, P
PMID: 9802062
Journal: Jpn J Cancer Res. 2000 May;91(5):551-9.
Title: Identification and characterization of a deletion mutant of DNA topoisomerase I mRNA in a camptothecin-resistant subline of human colon carcinoma.
Author: Yanase, K|Sugimoto, Y|Tsukahara, S|Oh-Hara, T|Andoh, T|Tsuruo, T
PMID: 10835501
Journal: Clin Cancer Res. 2001 Jan;7(1):185-91.
Title: Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression.
Author: Takebayashi, Y|Goldwasser, F|Urasaki, Y|Kohlhagen, G|Pommier, Y
PMID: 11205907
Journal: J Clin Oncol. 2001 Mar 1;19(5):1501-18.
Title: Irinotecan in the treatment of colorectal cancer: clinical overview.
Author: Vanhoefer, U|Harstrick, A|Achterrath, W|Cao, S|Seeber, S|Rustum, Y M
PMID: 11230497
Journal: Cancer Res. 2001 Aug 1;61(15):5926-32.
Title: Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells.
Author: Desai, S D|Li, T K|Rodriguez-Bauman, A|Rubin, E H|Liu, L F
PMID: 11479235
Journal: J Biol Chem. 2002 May 10;277(19):17154-60.
Title: Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin.
Author: Han, Zhiyong|Wei, Wenyi|Dunaway, Stephen|Darnowski, James W|Calabresi, Paul|Sedivy, John|Hendrickson, Eric A|Balan, Kannan V|Pantazis, Panayotis|Wyche, James H
PMID: 11877436
Journal: Cancer Res. 2003 Dec 1;63(23):8400-7.
Title: Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
Author: Li, Tsai-Kun|Houghton, Peter J|Desai, Shyamal D|Daroui, Parima|Liu, Angela A|Hars, Eszter S|Ruchelman, Alexander L|LaVoie, Edmond J|Liu, Leroy F
PMID: 14679002
Journal: Br J Cancer. 2005 Jan 31;92(2):259-64.
Title: Unfavourable expression of pharmacologic markers in mucinous colorectal cancer.
Author: Glasgow, S C|Yu, J|Carvalho, L P|Shannon, W D|Fleshman, J W|McLeod, H L
PMID: 15655543
Journal: FEBS J. 2005 Feb;272(3):696-710.
Title: Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells.
Author: Penuelas, Silvia|Noe, Veronique|Ciudad, Carlos J
PMID: 15670151
Journal: World J Gastroenterol. 2005 Sep 7;11(33):5156-61.
Title: Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells.
Author: Park, Hae-Jeong|Yoon, Seo-Hyun|Han, Long-Shan|Zheng, Long-Tai|Jung, Kyung-Hee|Uhm, Yoon-Kyung|Lee, Je-Hyun|Jeong, Ji-Seon|Joo, Woo-Sang|Yim, Sung-Vin|Chung, Joo-Ho|Hong, Seon-Pyo
PMID: 16127745
Journal: Br J Cancer. 2006 Oct 9;95(7):906-13.
Title: Identification of gene polymorphisms of human DNA topoisomerase I in the National Cancer Institute panel of human tumour cell lines.
Author: Moisan, F|Longy, M|Robert, J|Le Morvan, V
PMID: 16983402
Journal: J Mol Med (Berl). 2007 Mar;85(3):293-304. Epub 2006 Dec 2.
Title: Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas.
Author: Lassmann, Silke|Weis, Roland|Makowiec, Frank|Roth, Jasmine|Danciu, Mihai|Hopt, Ulrich|Werner, Martin
PMID: 17143621
Journal: Cancer Res. 2007 Oct 15;67(20):9971-9.
Title: Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage.
Author: Rao, V Ashutosh|Agama, Keli|Holbeck, Susan|Pommier, Yves
PMID: 17942930
Journal: Clin Cancer Res. 2008 Mar 15;14(6):1788-96.
Title: Irinotecan pharmacogenetics: influence of pharmacodynamic genes.
Author: Hoskins, Janelle M|Marcuello, Eugenio|Altes, Albert|Marsh, Sharon|Maxwell, Taylor|Van Booven, Derek J|Pare, Laia|Culverhouse, Robert|McLeod, Howard L|Baiget, Montserrat
PMID: 18347181
Journal: Mol Cancer Ther. 2009 Jul;8(7):1964-73.
Title: Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines.
Author: Crea, Francesco|Giovannetti, Elisa|Cortesi, Filippo|Mey, Valentina|Nannizzi, Sara|Gallegos Ruiz, Marielle I|Ricciardi, Simona|Del Tacca, Mario|Peters, Godefridus J|Danesi, Romano
PMID: 19531575
Journal: Mol Cancer Ther. 2009 Jul;8(7):1878-84.
Title: Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity.
Author: Pfister, Thomas D|Reinhold, William C|Agama, Keli|Gupta, Shalu|Khin, Sonny A|Kinders, Robert J|Parchment, Ralph E|Tomaszewski, Joseph E|Doroshow, James H|Pommier, Yves
PMID: 19584232
Journal: Orv Hetil. 2009 Aug 23;150(34):1607-13.
Title: [Tissue microarray (TMA) validated progression markers in colorectal cancer using antibody microarrays].
Author: Spisak, Sandor|Galamb, Barnabas|Wichmann, Barnabas|Sipos, Ferenc|Galamb, Orsolya|Solymosi, Norbert|Nemes, Balazs|Tulassay, Zsolt|Molnar, Bela
PMID: 19648079
Journal: Cancer Res. 2010 Oct 15;70(20):8055-65.
Title: Genome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors.
Author: Solier, Stephanie|Barb, Jennifer|Zeeberg, Barry R|Varma, Sudhir|Ryan, Mike C|Kohn, Kurt W|Weinstein, John N|Munson, Peter J|Pommier, Yves
PMID: 20817775
Journal: Dis Markers. 2010;28(1):1-14.
Title: Applicability of antibody and mRNA expression microarrays for identifying diagnostic and progression markers of early and late stage colorectal cancer.
Author: Spisak, Sandor|Galamb, Barnabas|Sipos, Ferenc|Galamb, Orsolya|Wichmann, Barnabas|Solymosi, Norbert|Nemes, Balazs|Molnar, Jeannette|Tulassay, Zsolt|Molnar, Bela
PMID: 20164542
Journal: Clin Cancer Res. 2011 May 1;17(9):2777-87.
Title: Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.
Author: Kurtzberg, Leslie S|Roth, Stephanie|Krumbholz, Roy|Crawford, Jennifer|Bormann, Christy|Dunham, Sarah|Yao, Min|Rouleau, Cecile|Bagley, Rebecca G|Yu, Xian-Jie|Wang, Fei|Schmid, Steven M|Lavoie, Edmond J|Teicher, Beverly A
PMID: 21415217
Journal: Mol Cancer. 2011 May 27;10:64.
Title: New Topoisomerase I mutations are associated with resistance to camptothecin.
Author: Gongora, Celine|Vezzio-Vie, Nadia|Tuduri, Sandie|Denis, Vincent|Causse, Annick|Auzanneau, Celine|Collod-Beroud, Gwenaelle|Coquelle, Arnaud|Pasero, Philippe|Pourquier, Philippe|Martineau, Pierre|Del Rio, Maguy
PMID: 21619602
Journal: Mol Cancer Ther. 2011 Aug;10(8):1490-9.
Title: Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.
Author: Sooryakumar, Dhriti|Dexheimer, Thomas S|Teicher, Beverly A|Pommier, Yves
PMID: 21636699
Journal: Curr Cancer Drug Targets. 2011 Oct;11(8):976-86.
Title: RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors.
Author: Martin, S E|Wu, Z-H|Gehlhaus, K|Jones, T L|Zhang, Y-W|Guha, R|Miyamoto, S|Pommier, Y|Caplen, N J
PMID: 21834757
Journal: Cancer Res. 2012 Feb 15;72(4):979-89.
Title: Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.
Author: Aris, Sheena M|Pommier, Yves
PMID: 22189968
Journal: Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):15030-5.
Title: Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents.
Author: Zoppoli, Gabriele|Regairaz, Marie|Leo, Elisabetta|Reinhold, William C|Varma, Sudhir|Ballestrero, Alberto|Doroshow, James H|Pommier, Yves
PMID: 22927417
Journal: Mol Oncol. 2013 Feb;7(1):101-11.
Title: Topoisomerase 1(TOP1) gene copy number in stage III colorectal cancer patients and its relation to prognosis.
Author: Romer, Maria Unni|Nygard, Sune Boris|Christensen, Ib Jarle|Nielsen, Signe Lykke|Nielsen, Kirsten Vang|Muller, Sven|Smith, David Hersi|Vainer, Ben|Nielsen, Hans Jorgen|Brunner, Nils
PMID: 23110915
Journal: PLoS One. 2013;8(4):e60613.
Title: Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort.
Author: Smith, David Hersi|Christensen, Ib Jarle|Jensen, Niels Frank|Markussen, Bo|Romer, Maria Unni|Nygard, Sune Boris|Muller, Sven|Nielsen, Hans Jorgen|Brunner, Nils|Nielsen, Kirsten Vang
PMID: 23577133
Journal: Int J Oncol. 2013 Jul;43(1):210-8.
Title: Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan.
Author: Tentori, Lucio|Leonetti, Carlo|Muzi, Alessia|Dorio, Annalisa Susanna|Porru, Manuela|Dolci, Susanna|Campolo, Federica|Vernole, Patrizia|Lacal, Pedro Miguel|Praz, Francoise|Graziani, Grazia
PMID: 23653048
Journal: Oncol Rep. 2013 Sep;30(3):1053-8.
Title: Three missense mutations of DNA topoisomerase I in highly camptothecin-resistant colon cancer cell sublines.
Author: Arakawa, Yasuhiro|Ozaki, Koji|Okawa, Yutaka|Yamada, Hisashi
PMID: 23836376
Journal: Curr Top Med Chem. 2014;14(23):2722-8.
Title: Synthesis and biological evaluation of 1,5-naphthyridines as topoisomerase I inhibitors. A new family of antiproliferative agents.
Author: Alonso, Concepcion|Fuertes, Maria|Gonzalez, Maria|Rodriguez-Gascon, Alicia|Rubiales, Gloria|Palacios, Francisco
PMID: 25515747
Journal: J Med Chem. 2014 Feb 27;57(4):1289-98.
Title: Optimization of the lactam side chain of 7-azaindenoisoquinoline topoisomerase I inhibitors and mechanism of action studies in cancer cells.
Author: Kiselev, Evgeny|Sooryakumar, Dhriti|Agama, Keli|Cushman, Mark|Pommier, Yves
PMID: 24502276
Journal: Mol Oncol. 2015 Jun;9(6):1207-17.
Title: Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers.
Author: Sonderstrup, Ida Marie Heeholm|Nygard, Sune Boris|Poulsen, Tim Svenstrup|Linnemann, Dorte|Stenvang, Jan|Nielsen, Hans Jorgen|Bartek, Jiri|Brunner, Nils|Norgaard, Peter|Riis, Lene
PMID: 25777966
Journal: Database (Oxford). 2015 Mar 27;2015. pii: bav015.
Title: Colorectal cancer drug target prediction using ontology-based inference and network analysis.
Author: Tao, Cui|Sun, Jingchun|Zheng, W Jim|Chen, Junjie|Xu, Hua
PMID: 25818893
Journal: BMC Cancer. 2015 Feb 21;15:78.
Title: A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2- negative breast cancer and increased copy numbers of the topoisomerase 1 (TOP1) gene: a study protocol.
Author: Kumler, Iben|Balslev, Eva|Stenvang, Jan|Brunner, Nils|Nielsen, Dorte
PMID: 25885574
Journal: Clin Cancer Res. 2016 Apr 1;22(7):1621-31.
Title: DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer.
Author: Nygard, Sune Boris|Vainer, Ben|Nielsen, Signe Lykke|Bosman, Fred|Tejpar, Sabine|Roth, Arnaud|Delorenzi, Mauro|Brunner, Nils|Budinska, Eva
PMID: 26542057
Journal: Int J Mol Med. 2016 Feb;37(2):319-28.
Title: Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis.
Author: Shimamoto, Yuji|Nukatsuka, Mamoru|Takechi, Teiji|Fukushima, Masakazu
PMID: 26676887
Journal: PLoS One. 2016 Jan 19;11(1):e0147053.
Title: Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters.
Author: Marinello, Jessica|Bertoncini, Stefania|Aloisi, Iris|Cristini, Agnese|Malagoli Tagliazucchi, Guidantonio|Forcato, Mattia|Sordet, Olivier|Capranico, Giovanni
PMID: 26784695
Journal: J Exp Clin Cancer Res. 2016 Mar 31;35:56.
Title: Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.
Author: Jensen, Niels Frank|Agama, Keli|Roy, Amit|Smith, David Hersi|Pfister, Thomas D|Romer, Maria Unni|Zhang, Hong-Liang|Doroshow, James H|Knudsen, Birgitta R|Stenvang, Jan|Brunner, Nils|Pommier, Yves
PMID: 27029323
Journal: Br J Cancer. 2016 Dec 6;115(12):1555-1564.
Title: A protein fragment derived from DNA-topoisomerase I as a novel tumour-associated antigen for the detection of early stage carcinoma.
Author: Yie, Shang-Mian|Ye, Shang-Rong|Ma, Xiao-Li|Xie, Ke|Zhang, Jian-Bo|Cao, Mei|He, Xu|Hu, Zhen-Bo|Yang, Cheng-Lu|Zhang, Jia|Zeng, Jie
PMID: 27875523
Journal: Nucleic Acids Res. 2017 Feb 17;45(3):1159-1176.
Title: Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.
Author: Meisenberg, Cornelia|Ashour, Mohamed E|El-Shafie, Lamia|Liao, Chunyan|Hodgson, Adam|Pilborough, Alice|Khurram, Syed A|Downs, Jessica A|Ward, Simon E|El-Khamisy, Sherif F
PMID: 28180300
Journal: Biochem Pharmacol. 2017 Dec 15;146:53-62.
Title: Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.
Author: Khageh Hosseini, Sabrina|Kolterer, Stefanie|Steiner, Marlene|von Manstein, Viktoria|Gerlach, Katharina|Trojan, Jorg|Waidmann, Oliver|Zeuzem, Stefan|Schulze, Jorg O|Hahn, Steffen|Steinhilber, Dieter|Gatterdam, Volker|Tampe, Robert|Biondi, Ricardo M|Proscha
PMID: 29031818
Journal: Mol Cancer Ther. 2018 Aug;17(8):1694-1704.
Title: Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors.
Author: Marzi, Laetitia|Agama, Keli|Murai, Junko|Difilippantonio, Simone|James, Amy|Peer, Cody J|Figg, William D|Beck, Daniel|Elsayed, Mohamed S A|Cushman, Mark|Pommier, Yves
PMID: 29748210
Journal: Oncol Lett. 2018 Oct;16(4):4640-4648.
Title: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells.
Author: Li, Ting|Sun, Wan|Dong, Xiaoqiao|Yu, Wenhua|Cai, Jianyong|Yuan, Qiang|Shan, Letian|Efferth, Thomas
PMID: 30197678