Primary Site >> Colorectal Cancer
Gene >> TOP1
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Ref: Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen. PMID: 7743511 Ref: Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives. PMID: 7766631 |
Ref: Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells. PMID: 8813137 |
Ref: CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants. PMID: 9033637 Ref: Novel 7-alkyl methylenedioxy-camptothecin derivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells. PMID: 9224816 Ref: In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells. PMID: 9321666 Ref: Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells. PMID: 9815856 |
Ref: Replication-dependent and -independent camptothecin cytotoxicity of seven human colon tumor cell lines. PMID: 9802062 |
Ref: Identification and characterization of a deletion mutant of DNA topoisomerase I mRNA in a camptothecin-resistant subline of human colon carcinoma. PMID: 10835501 |
Ref: Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression. PMID: 11205907 Ref: Irinotecan in the treatment of colorectal cancer: clinical overview. PMID: 11230497 Ref: Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells. PMID: 11479235 |
Ref: Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin. PMID: 11877436 |
Ref: Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug. PMID: 14679002 |
Ref: Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. PMID: 15655543 Ref: Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells. PMID: 15670151 Ref: Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. PMID: 16127745 |
Ref: Identification of gene polymorphisms of human DNA topoisomerase I in the National Cancer Institute panel of human tumour cell lines. PMID: 16983402 |
Ref: Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas. PMID: 17143621 Ref: Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage. PMID: 17942930 |
Ref: Irinotecan pharmacogenetics: influence of pharmacodynamic genes. PMID: 18347181 |
Ref: Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines. PMID: 19531575 Ref: Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity. PMID: 19584232 Ref: [Tissue microarray (TMA) validated progression markers in colorectal cancer using antibody microarrays]. PMID: 19648079 |
Ref: Applicability of antibody and mRNA expression microarrays for identifying diagnostic and progression markers of early and late stage colorectal cancer. PMID: 20164542 Ref: Genome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors. PMID: 20817775 |
Ref: Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. PMID: 21415217 Ref: New Topoisomerase I mutations are associated with resistance to camptothecin. PMID: 21619602 Ref: Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. PMID: 21636699 Ref: RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors. PMID: 21834757 |
Ref: Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762. PMID: 22189968 Ref: Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents. PMID: 22927417 |
Ref: Topoisomerase 1(TOP1) gene copy number in stage III colorectal cancer patients and its relation to prognosis. PMID: 23110915 Ref: Mechanisms of topoisomerase I (TOP1) gene copy number increase in a stage III colorectal cancer patient cohort. PMID: 23577133 Ref: Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan. PMID: 23653048 Ref: Three missense mutations of DNA topoisomerase I in highly camptothecin-resistant colon cancer cell sublines. PMID: 23836376 |
Ref: Optimization of the lactam side chain of 7-azaindenoisoquinoline topoisomerase I inhibitors and mechanism of action studies in cancer cells. PMID: 24502276 Ref: Synthesis and biological evaluation of 1,5-naphthyridines as topoisomerase I inhibitors. A new family of antiproliferative agents. PMID: 25515747 |
Ref: Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers. PMID: 25777966 Ref: Colorectal cancer drug target prediction using ontology-based inference and network analysis. PMID: 25818893 Ref: A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2- negative breast cancer and increased copy numbers of the topoisomerase 1 (TOP1) gene: a study protocol. PMID: 25885574 |
Ref: DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer. PMID: 26542057 Ref: Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis. PMID: 26676887 Ref: Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters. PMID: 26784695 Ref: Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations. PMID: 27029323 Ref: A protein fragment derived from DNA-topoisomerase I as a novel tumour-associated antigen for the detection of early stage carcinoma. PMID: 27875523 |
Ref: Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. PMID: 28180300 Ref: Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE. PMID: 29031818 |
Ref: Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors. PMID: 29748210 Ref: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells. PMID: 30197678 |