Primary Site >> Colorectal Cancer

Gene >> MLH3

Journal: Am J Pathol. 2000 Aug;157(2):347-52.
Title: Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer.
Author: Loukola, A|Vilkki, S|Singh, J|Launonen, V|Aaltonen, L A
PMID: 10934138
Journal: Nat Genet. 2000 Jan;24(1):27-35.
Title: MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability.
Author: Lipkin, S M|Wang, V|Jacoby, R|Banerjee-Basu, S|Baxevanis, A D|Lynch, H T|Elliott, R M|Collins, F S
PMID: 10615123
Journal: Comb Chem High Throughput Screen. 2000 Dec;3(6):519-24.
Title: High throughput genetic screening for the detection of hereditary non-polyposis colon cancer (HNPCC) using capillary electrophoresis.
Author: Merkelbach-Bruse, S|Kose, S|Losen, I|Bosserhoff, A K|Buettner, R
PMID: 11121520
Journal: Hum Mutat. 2001 May;17(5):389-96.
Title: Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers.
Author: Lipkin, S M|Wang, V|Stoler, D L|Anderson, G R|Kirsch, I|Hadley, D|Lynch, H T|Collins, F S
PMID: 11317354
Journal: Am J Pathol. 2002 Jun;160(6):1953-8.
Title: Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability.
Author: Kuismanen, Shannon A|Moisio, Anu-Liisa|Schweizer, Pascal|Truninger, Kaspar|Salovaara, Reijo|Arola, Johanna|Butzow, Ralf|Jiricny, Josef|Nystrom-Lahti, Minna|Peltomaki, Paivi
PMID: 12057899
Journal: Hum Genet. 2003 Feb;112(2):105-9. Epub 2002 Nov 21.
Title: Two mismatch repair gene mutations found in a colon cancer patient--which one is pathogenic?
Author: Kariola, Reetta|Otway, Robyn|Lonnqvist, Karin E|Raevaara, Tiina E|Macrae, Finlay|Vos, Yvonne J|Kohonen-Corish, Maija|Hofstra, Robert M W|Nystrom-Lahti, Minna
PMID: 12522549
Journal: Int J Cancer. 2003 Aug 20;106(2):292-6.
Title: Little evidence for involvement of MLH3 in colorectal cancer predisposition.
Author: Hienonen, Tuija|Laiho, Paivi|Salovaara, Reijo|Mecklin, Jukka-Pekka|Jarvinen, Heikki|Sistonen, Pertti|Peltomaki, Paivi|Lehtonen, Rainer|Nupponen, Nina N|Launonen, Virpi|Karhu, Auli|Aaltonen, Lauri A
PMID: 12800209
Journal: Cancer Genet Cytogenet. 2004 Jul 1;152(1):70-1.
Title: No association between two MLH3 variants (S845G and P844L)and colorectal cancer risk.
Author: de Jong, Mirjam M|Hofstra, Robert M W|Kooi, Krista A|Westra, Jantine L|Berends, Maran J W|Wu, Ying|Hollema, Harry|van der Sluis, Tineke|van der Graaf, Winette T A|de Vries, Elisabeth G E|Schaapveld, Michael|Sijmons, Rolf H|te Meerman, Gerard J|Kleibeuker,
PMID: 15193445
Journal: Cancer Res. 2005 Oct 1;65(19):8662-70.
Title: Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.
Author: Chen, Peng-Chieh|Dudley, Sandra|Hagen, Wayne|Dizon, Diana|Paxton, Leslie|Reichow, Denise|Yoon, Song-Ro|Yang, Kan|Arnheim, Norman|Liskay, R Michael|Lipkin, Steven M
PMID: 16204034
Journal: Cancer Res. 2005 Dec 1;65(23):10759-66.
Title: Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair.
Author: Cannavo, Elda|Marra, Giancarlo|Sabates-Bellver, Jacob|Menigatti, Mirco|Lipkin, Steven M|Fischer, Franziska|Cejka, Petr|Jiricny, Josef
PMID: 16322221
Journal: Cancer Res. 2006 Aug 1;66(15):7502-8.
Title: MLH3 mutation in endometrial cancer.
Author: Taylor, Nicholas P|Powell, Matthew A|Gibb, Randall K|Rader, Janet S|Huettner, Phyllis C|Thibodeau, Stephen N|Mutch, David G|Goodfellow, Paul J
PMID: 16885347
Journal: Cancer Lett. 2007 Apr 8;248(1):89-95. Epub 2006 Jul 11.
Title: Genomic rearrangements in MSH2, MLH1 or MSH6 are rare in HNPCC patients carrying point mutations.
Author: Pistorius, Steffen|Gorgens, Heike|Plaschke, Jens|Hoehl, Ruth|Kruger, Stefan|Engel, Christoph|Saeger, Hans-Detlev|Schackert, Hans K
PMID: 16837128
Journal: Gut. 2008 Aug;57(8):1097-101.
Title: Common variants in mismatch repair genes and risk of colorectal cancer.
Author: Koessler, T|Oestergaard, M Z|Song, H|Tyrer, J|Perkins, B|Dunning, A M|Easton, D F|Pharoah, P D P
PMID: 18364438
Journal: Genes Chromosomes Cancer. 2008 Sep;47(9):803-9.
Title: The first functional study of MLH3 mutations found in cancer patients.
Author: Korhonen, Mari K|Vuorenmaa, Elina|Nystrom, Minna
PMID: 18521850
Journal: PLoS Genet. 2008 Jun 13;4(6):e1000092.
Title: Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.
Author: Chen, Peng-Chieh|Kuraguchi, Mari|Velasquez, John|Wang, Yuxun|Yang, Kan|Edwards, Robert|Gillen, Dan|Edelmann, Winfried|Kucherlapati, Raju|Lipkin, Steven M
PMID: 18551179
Journal: BMC Biol. 2009 Jun 26;7:35.
Title: Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73.
Author: Huang, Vera|Lu, Xin|Jiang, Yong|Wang, Jean Y J
PMID: 19558638
Journal: Sao Paulo Med J. 2009 Jan;127(1):46-51.
Title: Mismatch repair genes in Lynch syndrome: a review.
Author: Silva, Felipe Cavalcanti Carneiro da|Valentin, Mev Dominguez|Ferreira, Fabio de Oliveira|Carraro, Dirce Maria|Rossi, Benedito Mauro
PMID: 19466295
Journal: Int J Cancer. 2009 Apr 15;124(8):1887-91.
Title: Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer.
Author: Koessler, Thibaud|Azzato, Elizabeth M|Perkins, Barbara|Macinnis, Robert J|Greenberg, David|Easton, Douglas F|Pharoah, Paul D P
PMID: 19115210
Journal: Genes Chromosomes Cancer. 2009 Apr;48(4):340-50.
Title: Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome.
Author: Ou, Jianghua|Rasmussen, Merete|Westers, Helga|Andersen, Sofie D|Jager, Paul O|Kooi, Krista A|Niessen, Renee C|Eggen, Bart J L|Nielsen, Finn C|Kleibeuker, Jan H|Sijmons, Rolf H|Rasmussen, Lene J|Hofstra, Robert M W
PMID: 19156873
Journal: Fam Cancer. 2010 Jun;9(2):167-72.
Title: Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutation.
Author: Bouzourene, Hanifa|Hutter, Pierre|Losi, Lorena|Martin, Patricia|Benhattar, Jean
PMID: 19949877
Journal: J Gastrointestin Liver Dis. 2010 Jun;19(2):155-9.
Title: MMR gene expression pattern in sporadic colorectal cancer.
Author: Ioana, Mihai|Angelescu, Cristina|Burada, Florin|Mixich, Francisc|Riza, Anca|Dumitrescu, Theodor|Alexandru, Dragos|Ciurea, Tudorel|Cruce, Mihai|Saftoiu, Adrian
PMID: 20593048
Journal: Int J Cancer. 2011 Oct 1;129(7):1643-50.
Title: Association of low-risk MSH3 and MSH2 variant alleles with Lynch syndrome: probability of synergistic effects.
Author: Duraturo, Francesca|Liccardo, Raffaella|Cavallo, Angela|De Rosa, Marina|Grosso, Michela|Izzo, Paola
PMID: 21128252
Journal: Balkan J Med Genet. 2011 Dec;14(2):25-34.
Title: Alterations of copy number of methylation pattern in mismatch repair genes by methylation specific-multiplex ligation-dependent probe amplification in cases of colon cancer.
Author: Onrat, St|Ceken, I|Ellidokuz, E|Kupelioglu, A
PMID: 24052709
Journal: Mol Biol Rep. 2013 Oct;40(10):5921-9.
Title: Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study.
Author: Polakova Vymetalkova, Veronika|Vannucci, Luca|Korenkova, Vlasta|Prochazka, Pavel|Slyskova, Jana|Vodickova, Ludmila|Rusnakova, Vendula|Bielik, Ludovit|Burocziova, Monika|Rossmann, Pavel|Vodicka, Pavel
PMID: 24065530
Journal: Gynecol Oncol. 2014 Feb;132(2):506-12.
Title: Mismatch repair deficiency in ovarian cancer -- molecular characteristics and clinical implications.
Author: Xiao, Xue|Melton, David W|Gourley, Charlie
PMID: 24333356
Journal: Mutagenesis. 2014 Jul;29(4):259-65.
Title: Variations in mismatch repair genes and colorectal cancer risk and clinical outcome.
Author: Vymetalkova, Veronika|Pardini, Barbara|Rosa, Fabio|Di Gaetano, Cornelia|Novotny, Jan|Levy, Miroslav|Buchler, Tomas|Slyskova, Jana|Vodickova, Ludmila|Naccarati, Alessio|Vodicka, Pavel
PMID: 24755277
Journal: Int J Cancer. 2015 Mar 15;136(6):E559-68.
Title: Comprehensive screening for mutations associated with colorectal cancer in unselected cases reveals penetrant and nonpenetrant mutations.
Author: Kraus, Cornelia|Rau, Tilman T|Lux, Philipp|Erlenbach-Wunsch, Katharina|Lohr, Sabine|Krumbiegel, Mandy|Thiel, Christian T|Stohr, Robert|Agaimy, Abbas|Croner, Roland S|Sturzl, Michael|Hohenberger, Werner|Hartmann, Arndt|Reis, Andre
PMID: 25142776
Journal: Gene. 2015 Oct 10;570(2):304-5.
Title: Segregation of a novel MLH1 mutation in an Iranian Lynch syndrome family.
Author: Ghafouri-Fard, Soudeh|Fardaei, Majid|Lankarani, Kamran Bagheri|Miryounesi, Mohammad
PMID: 26149658
Journal: World J Gastroenterol. 2015 Jun 14;21(22):6861-71.
Title: Advances in the study of Lynch syndrome in China.
Author: Lu, Jun-Yu|Sheng, Jian-Qiu
PMID: 26078562
Journal: J Neurooncol. 2016 Sep;129(3):577-578.
Title: Coexistence of MLH3 germline variants in colon cancer patients belonging to families with Lynch syndrome-associated brain tumors.
Author: Duraturo, Francesca|Liccardo, Raffaella|Izzo, Paola
PMID: 27401157
Journal: Oncotarget. 2017 May 10;8(42):71574-71586.
Title: Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair.
Author: Jahid, Sohail|Sun, Jian|Gelincik, Ozkan|Blecua, Pedro|Edelmann, Winfried|Kucherlapati, Raju|Zhou, Kathy|Jasin, Maria|Gumus, Zeynep H|Lipkin, Steven M
PMID: 29069730
Journal: Cancer Med. 2018 Apr;7(4):1264-1274.
Title: The polymorphisms of miRNA-binding site in MLH3 and ERCC1 were linked to the risk of colorectal cancer in a case-control study.
Author: Zhang, Qianye|Zheng, Xiao|Li, Xiaoxia|Sun, Deyu|Xue, Ping|Zhang, Guopei|Xiao, Mingyang|Cai, Yuan|Jin, Cuihong|Yang, Jinghua|Wu, Shengwen|Lu, Xiaobo
PMID: 29516665
Journal: Mol Med Rep. 2018 May;17(5):6942-6946.
Title: Novel MSH2 splice-site mutation in a young patient with Lynch syndrome.
Author: Liccardo, Raffaella|De Rosa, Marina|Izzo, Paola|Duraturo, Francesca
PMID: 29568967
Journal: Oncotarget. 2018 May 22;9(39):25557-25571.
Title: Genome wide DNA differential methylation regions in colorectal cancer patients in relation to blood related family members, obese and non-obese controls - a preliminary report.
Author: Shiao, S Pamela K|Xiao, Haiyan|Dong, Lixin|Wang, Xiaoling|Liu, Kebin|She, Jinxiong|Shi, Huidong
PMID: 29876008
Journal: Zhonghua Zhong Liu Za Zhi. 2018 Jun 23;40(6):433-440.
Title: [Genetic variations in MLH3 and MSH2 genes are associated with the sensitivity and prognosis in locally advanced rectal cancer patients receiving preoperative chemoradiotherapy].
Author: Yang, J|Wang, X|Zou, S M|Li, H M|Xiao, Q|Feng, Y R|Huang, Y|Feng, T|Chen, J N|Lin, D X|Li, Y X|Jin, J|Tan, W
PMID: 29936769