Primary Site >> Colorectal Cancer

Gene >> MAPK1

Journal: J Biol Chem. 1996 Sep 27;271(39):24144-50.
Title: Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.
Author: Yokosaki, Y|Monis, H|Chen, J|Sheppard, D
PMID: 8798654
Journal: Cancer Res. 1996 Oct 1;56(19):4516-21.
Title: Estradiol activation of human colon carcinoma-derived Caco-2 cell growth.
Author: Di Domenico, M|Castoria, G|Bilancio, A|Migliaccio, A|Auricchio, F
PMID: 8813150
Journal: Oncogene. 1997 May 29;14(21):2563-73.
Title: Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade.
Author: Lengyel, E|Wang, H|Gum, R|Simon, C|Wang, Y|Boyd, D
PMID: 9191056
Journal: Cancer Res. 1997 Nov 1;57(21):4714-7.
Title: Activated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells.
Author: Ohmori, M|Shirasawa, S|Furuse, M|Okumura, K|Sasazuki, T
PMID: 9354428
Journal: Oncogene. 1997 Nov 27;15(22):2705-16.
Title: ErbB kinases and NDF signaling in human prostate cancer cells.
Author: Grasso, A W|Wen, D|Miller, C M|Rhim, J S|Pretlow, T G|Kung, H J
PMID: 9400997
Journal: Dig Dis Sci. 1998 Jul;43(7):1454-64.
Title: Analysis of signaling protein kinases in human colon or colorectal carcinomas.
Author: Licato, L L|Brenner, D A
PMID: 9690379
Journal: Surgery. 1998 Aug;124(2):239-46; discussion 246-7.
Title: Signal transduction mechanisms in neurotensin-mediated cellular regulation.
Author: Ehlers, R A 2nd|Bonnor, R M|Wang, X|Hellmich, M R|Evers, B M
PMID: 9706144
Journal: Br J Cancer. 1998 Nov;78(10):1301-6.
Title: Increased constitutive activity of mitogen-activated protein kinase and renaturable 85 kDa kinase in human-colorectal cancer.
Author: Ostrowski, J|Trzeciak, L|Kolodziejski, J|Bomsztyk, K
PMID: 9823970
Journal: Oncogene. 1999 Mar 11;18(10):1807-17.
Title: Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.
Author: Plattner, R|Gupta, S|Khosravi-Far, R|Sato, K Y|Perucho, M|Der, C J|Stanbridge, E J
PMID: 10086335
Journal: Leukemia. 1999 Apr;13(4):585-9.
Title: Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation.
Author: Iida, M|Towatari, M|Nakao, A|Iida, H|Kiyoi, H|Nakano, Y|Tanimoto, M|Saito, H|Naoe, T
PMID: 10214865
Journal: Gastroenterology. 1999 May;116(5):1072-80.
Title: Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation.
Author: Taupin, D|Podolsky, D K
PMID: 10220499
Journal: Gut. 1999 Jun;44(6):834-8.
Title: Expression and activity of mitogen activated protein kinases in human colorectal carcinoma.
Author: Eggstein, S|Franke, M|Kutschka, I|Manthey, G|von Specht, B U|Ruf, G|Farthmann, E H
PMID: 10323886
Journal: Cancer Res. 1999 May 15;59(10):2445-50.
Title: Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.
Author: Okumura, K|Shirasawa, S|Nishioka, M|Sasazuki, T
PMID: 10344756
Journal: Am J Physiol. 1999 Sep;277(3):G631-41.
Title: Requirement of the MAP kinase cascade for cell cycle progression and differentiation of human intestinal cells.
Author: Aliaga, J C|Deschenes, C|Beaulieu, J F|Calvo, E L|Rivard, N
PMID: 10484389
Journal: Cancer Res. 1999 Oct 1;59(19):4804-7.
Title: Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells.
Author: Jung, Y D|Nakano, K|Liu, W|Gallick, G E|Ellis, L M
PMID: 10519388
Journal: Eur J Cancer. 1999 Jun;35(6):1014-9.
Title: XR3054, structurally related to limonene, is a novel inhibitor of farnesyl protein transferase.
Author: Donaldson, M J|Skoumas, V|Watson, M|Ashworth, P A|Ryder, H|Moore, M|Coombes, R C
PMID: 10533487
Journal: Nat Med. 1999 Dec;5(12):1418-23.
Title: Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing.
Author: Jones, M K|Wang, H|Peskar, B M|Levin, E|Itani, R M|Sarfeh, I J|Tarnawski, A S
PMID: 10581086
Journal: J Biol Chem. 1999 Dec 10;274(50):35505-13.
Title: 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation.
Author: Chen, A|Davis, B H|Bissonnette, M|Scaglione-Sewell, B|Brasitus, T A
PMID: 10585423
Journal: Br J Cancer. 2000 Feb;82(4):905-12.
Title: Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells.
Author: Di Paolo, A|Danesi, R|Nardini, D|Bocci, G|Innocenti, F|Fogli, S|Barachini, S|Marchetti, A|Bevilacqua, G|Del Tacca, M
PMID: 10732765
Journal: J Biol Chem. 2000 May 19;275(20):15090-8.
Title: Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling.
Author: Qiao, D|Chen, W|Stratagoules, E D|Martinez, J D
PMID: 10748108
Journal: Cancer Res. 2000 Apr 1;60(7):2007-17.
Title: Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways.
Author: Remacle-Bonnet, M M|Garrouste, F L|Heller, S|Andre, F|Marvaldi, J L|Pommier, G J
PMID: 10766192
Journal: Cancer Res. 2000 Jul 1;60(13):3631-7.
Title: Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.
Author: Lee, K|Deng, X|Friedman, E
PMID: 10910078
Journal: Zentralbl Chir. 2000;125 Suppl 1:12-5.
Title: [Deregulation of intracellular signal pathways in colorectal carcinoma].
Author: Troppmair, J|Rapp, U R
PMID: 10929640
Journal: J Biol Chem. 2000 Dec 15;275(50):39090-5.
Title: Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells.
Author: Ogier-Denis, E|Pattingre, S|El Benna, J|Codogno, P
PMID: 10993892
Journal: Biochem J. 2000 Dec 1;352 Pt 2:419-24.
Title: Induction of prostaglandin endoperoxide synthase 2 by mitogen-activated protein kinase cascades.
Author: McGinty, A|Foschi, M|Chang, Y W|Han, J|Dunn, M J|Sorokin, A
PMID: 11085935
Journal: Carcinogenesis. 2001 Jan;22(1):35-41.
Title: Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis.
Author: Qiao, D|Stratagouleas, E D|Martinez, J D
PMID: 11159738
Journal: Cancer Res. 2001 Feb 15;61(4):1541-7.
Title: Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites.
Author: Rice, P L|Goldberg, R J|Ray, E C|Driggers, L J|Ahnen, D J
PMID: 11245463
Journal: Br J Cancer. 2001 Mar 23;84(6):844-50.
Title: EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells.
Author: Jung, Y D|Kim, M S|Shin, B A|Chay, K O|Ahn, B W|Liu, W|Bucana, C D|Gallick, G E|Ellis, L M
PMID: 11259102
Journal: Int J Cancer. 2001 Apr 1;92(1):26-30.
Title: Endothelial cell apoptosis is inhibited by a soluble factor secreted by human colon cancer cells.
Author: Liu, W|Davis, D W|Ramirez, K|McConkey, D J|Ellis, L M
PMID: 11279602
Journal: J Surg Res. 2001 May 1;97(1):60-4.
Title: Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer.
Author: Arbabi, S|Rosengart, M R|Garcia, I|Jelacic, S|Maier, R V
PMID: 11319881
Journal: Eur J Cell Biol. 2001 Mar;80(3):213-21.
Title: Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.
Author: Chen, Y C|Tsai, S H|Shen, S C|Lin, J K|Lee, W R
PMID: 11322385
Journal: Carcinogenesis. 2001 Jun;22(6):957-64.
Title: Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation.
Author: Qiao, D|Gaitonde, S V|Qi, W|Martinez, J D
PMID: 11375905
Journal: Biochem Biophys Res Commun. 2001 Jun 8;284(2):282-8.
Title: Alterations of MAPK activities associated with intestinal cell differentiation.
Author: Ding, Q|Wang, Q|Evers, B M
PMID: 11394874
Journal: J Biol Chem. 2001 Sep 7;276(36):33762-72. Epub 2001 Jul 11.
Title: Transendothelial migration of colon carcinoma cells requires expression of E-selectin by endothelial cells and activation of stress-activated protein kinase-2 (SAPK2/p38) in the tumor cells.
Author: Laferriere, J|Houle, F|Taher, M M|Valerie, K|Huot, J
PMID: 11448946
Journal: Neoplasia. 2001 May-Jun;3(3):215-26.
Title: The protrusive phase and full development of integrin-dependent adhesions in colon epithelial cells require FAK- and ERK-mediated actin spike formation: deregulation in cancer cells.
Author: Brunton, V G|Fincham, V J|McLean, G W|Winder, S J|Paraskeva, C|Marshall, J F|Frame, M C
PMID: 11494115
Journal: Eur J Cancer Prev. 2001 Aug;10(4):313-21.
Title: Butyrate and propionate downregulate ERK phosphorylation in HT-29 colon carcinoma cells prior to differentiation.
Author: Davido, D J|Richter, F|Boxberger, F|Stahl, A|Menzel, T|Luhrs, H|Loffler, S|Dusel, G|Rapp, U R|Scheppach, W
PMID: 11535873
Journal: Oncol Rep. 2001 Nov-Dec;8(6):1409-13.
Title: Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Author: Feng, J|Hua, F|Shuo, R|Chongfeng, G|Huimian, X|Nakajima, T|Subao, W|Tsuchida, N
PMID: 11605075
Journal: Oncogene. 2001 Dec 6;20(56):8066-74.
Title: Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells.
Author: Yao, J|Xiong, S|Klos, K|Nguyen, N|Grijalva, R|Li, P|Yu, D
PMID: 11781819
Journal: Angiogenesis. 2001;4(2):155-62.
Title: Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway.
Author: Jung, Y D|Liu, W|Reinmuth, N|Ahmad, S A|Fan, F|Gallick, G E|Ellis, L M
PMID: 11806247
Journal: Biol Chem. 2001 Dec;382(12):1663-8.
Title: Beta-carotene inhibits growth of human colon carcinoma cells in vitro by induction of apoptosis.
Author: Briviba, K|Schnabele, K|Schwertle, E|Blockhaus, M|Rechkemmer, G
PMID: 11843179
Journal: Nutr Cancer. 2001;41(1-2):172-9.
Title: Neurotensin-and EGF-induced metabolic activation of colon carcinoma cells is diminished by dietary flavonoid cyanidin but not by its glycosides.
Author: Briviba, K|Abrahamse, S L|Pool-Zobel, B L|Rechkemmer, G
PMID: 12094622
Journal: Mol Cancer Ther. 2001 Nov;1(1):29-41.
Title: Inhibition of Kirsten-ras expression in human colorectal cancer using rationally selected Kirsten-ras antisense oligonucleotides.
Author: Ross, P J|George, M|Cunningham, D|DiStefano, F|Andreyev, H J|Workman, P|Clarke, P A
PMID: 12467236
Journal: Oncogene. 2002 Jan 3;21(1):78-86.
Title: Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells.
Author: Venkateswarlu, Srinivas|Dawson, Dawn M|St Clair, Patricia|Gupta, Anjana|Willson, James K V|Brattain, Michael G
PMID: 11791178
Journal: Biochem Pharmacol. 2002 Jan 15;63(2):163-70.
Title: Role of redox status on the activation of mitogen-activated protein kinase cascades by NSAIDs.
Author: Lennon, Ana Maria|Ramauge, Martine|Pierre, Michel
PMID: 11841790
Journal: Oncogene. 2002 Feb 21;21(9):1370-80.
Title: Direct integrin alphavbeta6-ERK binding: implications for tumour growth.
Author: Ahmed, Nuzhat|Niu, Jun|Dorahy, Douglas J|Gu, Xinhua|Andrews, Sarah|Meldrum, Cliff J|Scott, Rodney J|Baker, Mark S|Macreadie, Ian G|Agrez, Michael V
PMID: 11857080
Journal: Nat Med. 2002 Mar;8(3):289-93.
Title: Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.
Author: Pai, Rama|Soreghan, Brian|Szabo, Imre L|Pavelka, Meredith|Baatar, Dolgor|Tarnawski, Andrzej S
PMID: 11875501
Journal: Cancer Lett. 2002 May 28;179(2):185-95.
Title: Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells.
Author: Kim, Jin-Ah|Park, Ki-Sook|Kim, Ha-Il|Oh, So-Young|Ahn, Yongho|Oh, Jong-Won|Choi, Kang-Yell
PMID: 11888673
Journal: Am J Pathol. 2002 Mar;160(3):1129-41.
Title: Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas.
Author: Niki, Toshiro|Kohno, Takashi|Iba, Sanae|Moriya, Yasumitsu|Takahashi, Yoko|Saito, Miyuki|Maeshima, Arafumi|Yamada, Tesshi|Matsuno, Yoshihiro|Fukayama, Masashi|Yokota, Jun|Hirohashi, Setsuo
PMID: 11891209
Journal: Gastroenterology. 2002 Apr;122(4):985-93.
Title: Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line.
Author: Yoon, Jung-Hwan|Higuchi, Hajime|Werneburg, Nathan W|Kaufmann, Scott H|Gores, Gregory J
PMID: 11910351
Journal: Nature. 2002 May 23;417(6887):443-7. Epub 2002 May 1.
Title: Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation.
Author: Forcet, Christelle|Stein, Elke|Pays, Laurent|Corset, Veronique|Llambi, Fabien|Tessier-Lavigne, Marc|Mehlen, Patrick
PMID: 11986622
Journal: Exp Mol Med. 2002 Mar 31;34(1):27-31.
Title: Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells.
Author: Oh, So-Young|Park, Ki-Sook|Kim, Jin-Ah|Choi, Kang-Yell
PMID: 11989975
Journal: Int J Cancer. 2002 May 20;99(3):323-7.
Title: The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells.
Author: Elder, Douglas J E|Halton, Dawn E|Playle, Laura C|Paraskeva, Christos
PMID: 11992399
Journal: Int J Cancer. 2002 Jun 1;99(4):529-37.
Title: Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the beta6 integrin subunit.
Author: Niu, Jun|Dorahy, Douglas J|Gu, Xinhua|Scott, R J|Draganic, Brian|Ahmed, Nuzhat|Agrez, Michael V
PMID: 11992542
Journal: J Biol Chem. 2002 Sep 6;277(36):32624-31. Epub 2002 Jun 20.
Title: Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.
Author: Lee, Hae-Wan|Ahn, Dae-Ho|Crawley, Suzanne C|Li, Jian-Dong|Gum, James R Jr|Basbaum, Carol B|Fan, Nancy Q|Szymkowski, David E|Han, Sang-Young|Lee, Bong H|Sleisenger, Marvin H|Kim, Young S
PMID: 12077118
Journal: Br J Cancer. 2002 Jul 29;87(3):348-51.
Title: Integrin alpha(v)beta6-associated ERK2 mediates MMP-9 secretion in colon cancer cells.
Author: Gu, X|Niu, J|Dorahy, D J|Scott, R|Agrez, M V
PMID: 12177807
Journal: Mol Carcinog. 2002 Sep;35(1):21-8.
Title: Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
Author: Lin, Shyr-Yi|Liang, Yu-Chih|Ho, Yuan-Soon|Tsai, Shu-Huei|Pan, Shiann|Lee, Wen-Sen
PMID: 12203364
Journal: FEBS Lett. 2002 Sep 11;527(1-3):109-13.
Title: Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells.
Author: Qu, Xiangping|Xiao, Dongmei|Weber, H Christian
PMID: 12220644
Journal: J Nutr. 2002 Sep;132(9):2814-8.
Title: Red wine polyphenols inhibit the growth of colon carcinoma cells and modulate the activation pattern of mitogen-activated protein kinases.
Author: Briviba, Karlis|Pan, Lydia|Rechkemmer, Gerhard
PMID: 12221251
Journal: Toxicol Appl Pharmacol. 2002 Sep 15;183(3):160-7.
Title: Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: involvement in NAD(P)H:quinone reductase activity and cell proliferation.
Author: Patten Hitt, Emma|DeLong, Mary J|Merrill, Alfred H Jr
PMID: 12383707
Journal: Br Med Bull. 2002;64:227-54.
Title: Therapeutics targeting signal transduction for patients with colorectal carcinoma.
Author: de Bono, Johann S|Rowinsky, Eric K
PMID: 12421735
Journal: J Biol Chem. 2003 Feb 21;278(8):5845-53.
Title: Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.
Author: Baek, Seung Joon|Wilson, Leigh C|Hsi, Linda C|Eling, Thomas E
PMID: 12475986
Journal: Cancer Res. 2003 Feb 1;63(3):616-20.
Title: Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
Author: Rice, Pamela L|Washington, Michele|Schleman, Shea|Beard, K Scott|Driggers, Linda J|Ahnen, Dennis J
PMID: 12566304
Journal: Biochem Biophys Res Commun. 2003 Mar 7;302(2):330-5.
Title: Regulation of leukotriene-dependent induction of cyclooxygenase-2 and Bcl-2.
Author: Wikstrom, Katarina|Ohd, John F|Sjolander, Anita
PMID: 12604350
Journal: Br J Cancer. 2003 Mar 10;88(5):748-53.
Title: Opposing effects of butyrate and bile acids on apoptosis of human colon adenoma cells: differential activation of PKC and MAP kinases.
Author: McMillan, L|Butcher, S K|Pongracz, J|Lord, J M
PMID: 12618885
Journal: Proteomics. 2003 Mar;3(3):288-98.
Title: Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach.
Author: Ahmed, Nuzhat|Oliva, Karen|Wang, Yao|Quinn, Michael|Rice, Greg
PMID: 12627382
Journal: J Biol Chem. 2003 May 30;278(22):19861-9.
Title: Integrin alpha2 and extracellular signal-regulated kinase are functionally linked in highly malignant autocrine transforming growth factor-alpha-driven colon cancer cells.
Author: Sawhney, Rajinder S|Sharma, Bhavya|Humphrey, Lisa E|Brattain, Michael G
PMID: 12657625
Journal: Exp Cell Res. 2003 Apr 15;285(1):59-71.
Title: Alpha2beta1-integrin signaling by itself controls G1/S transition in a human adenocarcinoma cell line (Caco-2): implication of NADPH oxidase-dependent production of ROS.
Author: Honore, Stephane|Kovacic, Herve|Pichard, Veronique|Briand, Claudette|Rognoni, Jean-Baptiste
PMID: 12681287
Journal: Oncogene. 2003 Apr 10;22(14):2186-91.
Title: Platelet-activating factor activates mitogen-activated protein kinases, inhibits proliferation, induces differentiation and suppresses the malignant phenotype of human colon carcinoma cells.
Author: Wang, Hongmei|Chakrabarty, Subhas
PMID: 12687020
Journal: Cancer Res. 2003 May 1;63(9):2330-4.
Title: Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1.
Author: Fukuda, Ryo|Kelly, Brian|Semenza, Gregg L
PMID: 12727858
Journal: J Cancer Res Clin Oncol. 2003 May;129(5):272-8. Epub 2003 May 14.
Title: Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells.
Author: Ukegawa, J-I|Takeuchi, Y|Kusayanagi, S|Mitamura, K
PMID: 12748850
Journal: Biochim Biophys Acta. 2003 Jun 5;1653(1):25-40.
Title: Raf proteins and cancer: B-Raf is identified as a mutational target.
Author: Mercer, Kathryn E|Pritchard, Catrin A
PMID: 12781369
Journal: Mol Biol Cell. 2003 May;14(5):1790-800. Epub 2003 Jan 26.
Title: Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids.
Author: Bates, Richard C|Mercurio, Arthur M
PMID: 12802055
Journal: Am J Physiol Gastrointest Liver Physiol. 2003 Dec;285(6):G1181-8.
Title: The ERK pathway involves positive and negative regulations of HT-29 colorectal cancer cell growth by extracellular zinc.
Author: Park, Ki-Sook|Lee, Nam-Gu|Lee, Ki-Hoo|Seo, Jeong Taeg|Choi, Kang-Yell
PMID: 12816758
Journal: Carcinogenesis. 2003 Aug;24(8):1361-7.
Title: The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.
Author: Hu, Rong|Kim, Bok Ryang|Chen, Chi|Hebbar, Vidya|Kong, A-N Tony
PMID: 12819185
Journal: Br J Cancer. 2003 Jul 21;89(2):374-84.
Title: Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells.
Author: Ahmed, N|Oliva, K|Wang, Y|Quinn, M|Rice, G
PMID: 12865932
Journal: Cell Physiol Biochem. 2003;13(3):135-46.
Title: Absence of adhesion triggers differential FAK and SAPKp38 signals in SW620 human colon cancer cells that may inhibit adhesiveness and lead to cell death.
Author: Walsh, Mary F|Thamilselvan, Vijayalakshmi|Grotelueschen, Rainer|Farhana, Lulu|Basson, Marc
PMID: 12876384
Journal: J Nutr. 2003 Aug;133(8):2675-81.
Title: Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells.
Author: Kim, Eun Ji|Kang, Il-Jun|Cho, Han Jin|Kim, Woo Kyoung|Ha, Yeong-Lae|Park, Jung Han Yoon
PMID: 12888657
Journal: Cancer Cell. 2003 Jul;4(1):67-79.
Title: ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility.
Author: Vial, Emmanuel|Sahai, Erik|Marshall, Christopher J
PMID: 12892714
Journal: J Nutr. 2003 Sep;133(9):2901-6.
Title: Diallyl disulfide induces ERK phosphorylation and alters gene expression profiles in human colon tumor cells.
Author: Knowles, L M|Milner, J A
PMID: 12949385
Journal: J Mol Med (Berl). 2003 Oct;81(10):627-36.
Title: Inhibition of angiogenesis by NSAIDs: molecular mechanisms and clinical implications.
Author: Tarnawski, Andrzej S|Jones, Michael K
PMID: 13679997
Journal: Life Sci. 2003 Oct 17;73(22):2817-29.
Title: MAP kinase-mediated proliferation of DLD-1 carcinoma by the stimulation of protease-activated receptor 2.
Author: Jikuhara, Atsushi|Yoshii, Masanori|Iwagaki, Hiromi|Mori, Shuji|Nishibori, Masahiro|Tanaka, Noriaki
PMID: 14511767
Journal: Cancer Sci. 2003 Oct;94(10):886-93.
Title: Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine.
Author: Aizawa, Shu|Ookawa, Keizou|Kudo, Toshihiro|Asano, Junpei|Hayakari, Makoto|Tsuchida, Shigeki
PMID: 14556662
Journal: J Nutr. 2003 Nov;133(11 Suppl 1):3800S-3804S.
Title: The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines.
Author: Van Dross, Rukiyah|Xue, Yue|Knudson, Alexandra|Pelling, Jill C
PMID: 14608117
Journal: J Cell Biol. 2003 Nov 24;163(4):847-57.
Title: Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
Author: Conacci-Sorrell, Maralice|Simcha, Inbal|Ben-Yedidia, Tamar|Blechman, Janna|Savagner, Pierre|Ben-Ze'ev, Avri
PMID: 14623871
Journal: J Cell Sci. 2003 Dec 15;116(Pt 24):4957-63.
Title: Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells.
Author: Vial, Emmanuel|Marshall, Christopher J
PMID: 14625389
Journal: Cancer Res. 2003 Dec 1;63(23):8132-7.
Title: Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors.
Author: Ikenoue, Tsuneo|Hikiba, Yohko|Kanai, Fumihiko|Tanaka, Yasuo|Imamura, Jun|Imamura, Takaaki|Ohta, Miki|Ijichi, Hideaki|Tateishi, Keisuke|Kawakami, Takayuki|Aragaki, Jun|Matsumura, Masayuki|Kawabe, Takao|Omata, Masao
PMID: 14678966
Journal: Gastroenterology. 2004 Jan;126(1):8-18.
Title: Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling.
Author: Thamilselvan, Vijayalakshmi|Basson, Marc D
PMID: 14699482
Journal: J Nutr. 2004 Feb;134(2):483-6.
Title: Ursodeoxycholic acid (UDCA) can inhibit deoxycholic acid (DCA)-induced apoptosis via modulation of EGFR/Raf-1/ERK signaling in human colon cancer cells.
Author: Im, Eunok|Martinez, Jesse D
PMID: 14747693
Journal: Oncogene. 2004 Mar 11;23(10):1885-95.
Title: Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway.
Author: Wang, Xiaofu|Wang, Qingding|Hu, Wanqin|Evers, B Mark
PMID: 14981539
Journal: J Pathol. 2004 Mar;202(3):336-40.
Title: In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours.
Author: Sieben, Nathalie L G|Macropoulos, Patricia|Roemen, Guido M J M|Kolkman-Uljee, Sandra M|Jan Fleuren, Gert|Houmadi, Rifat|Diss, Tim|Warren, Bretta|Al Adnani, Mudher|De Goeij, Anton P M|Krausz, Thomas|Flanagan, Adrienne M
PMID: 14991899
Journal: J Biol Chem. 2004 Jun 18;279(25):26176-83. Epub 2004 Apr 12.
Title: Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK.
Author: Nishihara, Hiroshi|Hwang, Michael|Kizaka-Kondoh, Shinae|Eckmann, Lars|Insel, Paul A
PMID: 15078890
Journal: Oncogene. 2004 Jun 24;23(29):4984-92.
Title: Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK.
Author: Zhu, Hongbo|Zhang, Lidong|Wu, Shuhong|Teraishi, Fuminori|Davis, John J|Jacob, Dietmar|Fang, Bingliang
PMID: 15122344
Journal: J Biol Chem. 2004 Jul 9;279(28):29797-804. Epub 2004 May 3.
Title: Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation.
Author: Pozzi, Ambra|Yan, Xuexian|Macias-Perez, Ines|Wei, Shouzuo|Hata, Aaron N|Breyer, Richard M|Morrow, Jason D|Capdevila, Jorge H
PMID: 15123663
Journal: Am J Pathol. 2004 Jun;164(6):2139-51.
Title: Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis.
Author: Parikh, Alexander A|Fan, Fan|Liu, Wen Biao|Ahmad, Syed A|Stoeltzing, Oliver|Reinmuth, Niels|Bielenberg, Diane|Bucana, Corazon D|Klagsbrun, Michael|Ellis, Lee M
PMID: 15161648
Journal: Prostaglandins Other Lipid Mediat. 2004 Jan;73(1-2):111-22.
Title: 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells.
Author: Yoshinaga, Masahiro|Buchanan, F Gregory|DuBois, Raymond N
PMID: 15165036
Journal: Pharmacol Res. 2004 Aug;50(2):201-7.
Title: Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway.
Author: Park, Ju Youn|Park, Su Jung|Shim, Kwang Yong|Lee, Kyu Jae|Kim, Yun-Bong|Kim, Yong Hae|Kim, Soo Kie
PMID: 15177310
Journal: Semin Oncol. 2004 Apr;31(2 Suppl 7):36-44.
Title: COX-2 inhibitors and other nonsteroidal anti-inflammatory drugs in genitourinary cancer.
Author: Sabichi, Anita L|Lippman, Scott M
PMID: 15179622
Journal: Drug Metab Dispos. 2004 Jul;32(7):685-8.
Title: C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression.
Author: Yasunami, Yoko|Hara, Hirokazu|Iwamura, Tatsunori|Kataoka, Tadashi|Adachi, Tetsuo
PMID: 15205382
Journal: J Biol Chem. 2004 Oct 1;279(40):41377-83.
Title: Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin.
Author: Yu, Lu-Gang|Packman, Len C|Weldon, Mike|Hamlett, Jane|Rhodes, Jonathan M
PMID: 15247276
Journal: Carcinogenesis. 2004 Nov;25(11):2183-9. Epub 2004 Jul 15.
Title: Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells.
Author: Collett, Gavin P|Campbell, Frederick Charles
PMID: 15256484
Journal: J Biol Chem. 2004 Nov 5;279(45):47379-90. Epub 2004 Aug 10.
Title: Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells.
Author: Sawhney, Rajinder S|Cookson, Michelle M|Sharma, Bhavya|Hauser, Jennie|Brattain, Michael G
PMID: 15304500
Journal: Carcinogenesis. 2004 Dec;25(12):2303-10. Epub 2004 Sep 9.
Title: n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway.
Author: Calviello, Gabriella|Di Nicuolo, Fiorella|Gragnoli, Simona|Piccioni, Elisabetta|Serini, Simona|Maggiano, Nicola|Tringali, Giuseppe|Navarra, Pierluigi|Ranelletti, Franco O|Palozza, Paola
PMID: 15358633
Journal: Biochem Biophys Res Commun. 2004 Nov 26;324(4):1220-6.
Title: p38 MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression.
Author: Daniel, Carolin|Schroder, Oliver|Zahn, Nadine|Gaschott, Tanja|Stein, Jurgen
PMID: 15504345
Journal: Anticancer Res. 2004 Sep-Oct;24(5A):2885-91.
Title: EGF-receptor related protein causes cell cycle arrest and induces apoptosis of colon cancer cells in vitro and in vivo.
Author: Levi, Edi|Mohammad, Ramzi|Kodali, Udayini|Marciniak, Dorota|Reddy, Sudha|Aboukameel, Amro|Sarkar, Fazlul H|Kucuk, Omer|Rishi, Arun K|Majumdar, Adhip P N
PMID: 15517892
Journal: J Clin Oncol. 2004 Nov 15;22(22):4584-94.
Title: Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation.
Author: Nagasaka, Takeshi|Sasamoto, Hiromi|Notohara, Kenji|Cullings, Harry M|Takeda, Masanori|Kimura, Keigo|Kambara, Takeshi|MacPhee, Donald G|Young, Joanne|Leggett, Barbara A|Jass, Jeremy R|Tanaka, Noriaki|Matsubara, Nagahide
PMID: 15542810
Journal: Cell Prolif. 2004 Dec;37(6):427-41.
Title: Extracellular pressure stimulates colon cancer cell proliferation via a mechanism requiring PKC and tyrosine kinase signals.
Author: Walsh, M F|Woo, R K-Y|Gomez, R|Basson, M D
PMID: 15548175
Journal: Cancer Res. 2004 Nov 15;64(22):8148-51.
Title: Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites.
Author: Rice, Pamela L|Beard, K Scott|Driggers, Linda J|Ahnen, Dennis J
PMID: 15548677
Journal: Postepy Hig Med Dosw (Online). 2004;58:428-37.
Title: [Complex forms of immune insufficiency to some cytokines (TNF-alpha, interferons) in colorectal cancers as exemplified by the COLO 205 cell line. Mechanism of resistance with special reference to signaling proteins and cytokines].
Author: Pajak, Beata|Orzechowski, Arkadiusz
PMID: 15577750
Journal: Exp Mol Med. 2004 Dec 31;36(6):557-62.
Title: p21Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells.
Author: Park, Ki Sook|Jeon, Soung Hoo|Oh, Jong Won|Choi, Kang Yell
PMID: 15665589
Journal: Carcinogenesis. 2005 Jan;26(1):109-17.
Title: Selenomethionine induces sustained ERK phosphorylation leading to cell-cycle arrest in human colon cancer cells.
Author: Goulet, Anne-Christine|Chigbrow, Marianne|Frisk, Peter|Nelson, Mark A
PMID: 15513932
Journal: Cancer Chemother Pharmacol. 2005 Apr;55(4):369-78. Epub 2004 Nov 5.
Title: Quinoxaline 1,4-dioxides induce G2/M cell cycle arrest and apoptosis in human colon cancer cells.
Author: Gali-Muhtasib, Hala U|Diab-Assaf, Mona|Haddadin, Makhluf J
PMID: 15538569
Journal: J Biol Chem. 2005 Feb 11;280(6):4544-52.
Title: The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1.
Author: Vlahakis, Nicholas E|Young, Bradford A|Atakilit, Amha|Sheppard, Dean
PMID: 15590642
Journal: Carcinogenesis. 2005 Mar;26(3):665-71. Epub 2004 Dec 23.
Title: Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells.
Author: Nakamura, Yasushi|Chang, Chia-Cheng|Mori, Toshio|Sato, Kenji|Ohtsuki, Kozo|Upham, Brad L|Trosko, James E
PMID: 15618237
Journal: J Pharmacol Sci. 2005 Jan;97(1):25-30. Epub 2005 Jan 15.
Title: Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell.
Author: Nishibori, Masahiro|Mori, Shuji|Takahashi, Hideo K
PMID: 15655297
Journal: Cell Cycle. 2005 Mar;4(3):456-64.
Title: Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.
Author: Caron, Ruben W|Yacoub, Adly|Mitchell, Clint|Zhu, Xiaoyu|Hong, Young|Sasazuki, Takehiko|Shirasawa, Senji|Hagan, Michael P|Grant, Steven|Dent, Paul
PMID: 15655348
Journal: Br J Pharmacol. 2005 Feb;144(3):338-48.
Title: Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production.
Author: Colucci, Rocchina|Blandizzi, Corrado|Tanini, Marzia|Vassalle, Cristina|Breschi, Maria Cristina|Del Tacca, Mario
PMID: 15655524
Journal: Carcinogenesis. 2005 May;26(5):900-7.
Title: The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cells.
Author: Wollmann, Wyatt|Goodman, Mike L|Bhat-Nakshatri, Poornima|Kishimoto, Hiromitsu|Goulet, Robert J Jr|Mehrotra, Sanjana|Morimiya, Akira|Badve, Sunil|Nakshatri, Harikrishna
PMID: 15677629
Journal: Int J Cancer. 2005 Jul 10;115(5):673-7.
Title: Mutations of the BRAF gene in ulcerative colitis-related colorectal carcinoma.
Author: Aust, Daniela E|Haase, Michael|Dobryden, Lyudmyla|Markwarth, Annett|Lohrs, Udo|Wittekind, Christian|Baretton, Gustavo B|Tannapfel, Andrea
PMID: 15704157
Journal: Mol Cancer Ther. 2005 Feb;4(2):243-55.
Title: H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.
Author: Caron, Ruben W|Yacoub, Adly|Zhu, Xiaoyu|Mitchell, Clint|Han, Song Iy|Sasazuki, Takehiko|Shirasawa, Senji|Hagan, Michael P|Grant, Steven|Dent, Paul
PMID: 15713896
Journal: Mol Cancer Ther. 2005 Feb;4(2):281-90.
Title: Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells.
Author: Ko, Ching-Huai|Shen, Shing-Chuan|Lee, Tony J F|Chen, Yen-Chou
PMID: 15713899
Journal: Int J Cancer. 2005 Jul 20;115(6):943-50.
Title: BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms.
Author: Ikehara, Nobunao|Semba, Shuho|Sakashita, Masanori|Aoyama, Nobuo|Kasuga, Masato|Yokozaki, Hiroshi
PMID: 15729718
Journal: Oncogene. 2005 Apr 21;24(18):3011-9.
Title: Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation.
Author: Kobayashi, Shinichiro|Nantz, Regan|Kitamura, Tetsuya|Higashikubo, Ryuji|Horikoshi, Nobuo
PMID: 15735687
Journal: Oncogene. 2005 Apr 14;24(16):2647-53.
Title: Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells.
Author: Fan, Fan|Wey, Jane S|McCarty, Marya F|Belcheva, Anna|Liu, Wenbiao|Bauer, Todd W|Somcio, Ray J|Wu, Yan|Hooper, Andrea|Hicklin, Daniel J|Ellis, Lee M
PMID: 15735759
Journal: Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G70-8. Epub 2005 Mar 3.
Title: Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor signaling.
Author: Nkabyo, Yvonne S|Go, Young-Mi|Ziegler, Thomas R|Jones, Dean P
PMID: 15746213
Journal: Carcinogenesis. 2005 Sep;26(9):1553-62. Epub 2005 Apr 28.
Title: (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells.
Author: Kim, Mihye|Murakami, Akira|Kawabata, Kyuichi|Ohigashi, Hajime
PMID: 15860507
Journal: Cancer Res. 2005 May 1;65(9):3853-60.
Title: Supra-additive growth inhibition by a celecoxib analogue and carboxyamido-triazole is primarily mediated through apoptosis.
Author: Winters, Mary E|Mehta, Arpita I|Petricoin, Emanuel F 3rd|Kohn, Elise C|Liotta, Lance A
PMID: 15867384
Journal: Cancer Lett. 2005 Jun 8;223(2):313-22.
Title: Interactions between human colon carcinoma cells, fibroblasts and monocytic cells in coculture--regulation of cathepsin B expression and invasiveness.
Author: Krueger, Sabine|Kalinski, Thomas|Wolf, Hella|Kellner, Udo|Roessner, Albert
PMID: 15896466
Journal: Clin Cancer Res. 2005 May 15;11(10):3633-41.
Title: In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models.
Author: Lee, Sang Hoon|Lopes de Menezes, Daniel|Vora, Jayesh|Harris, Alex|Ye, Helen|Nordahl, Lara|Garrett, Evelyn|Samara, Emil|Aukerman, Sharon Lea|Gelb, Arnold B|Heise, Carla
PMID: 15897558
Journal: World J Gastroenterol. 2005 May 28;11(20):3065-9.
Title: Ornithine decarboxylase, mitogen-activated protein kinase and matrix metalloproteinase-2 expressions in human colon tumors.
Author: Nemoto, Takahiro|Kubota, Shunichiro|Ishida, Hideyuki|Murata, Nobuo|Hashimoto, Daijo
PMID: 15918191
Journal: Exp Cell Res. 2005 Jul 1;307(1):231-46. Epub 2005 Apr 19.
Title: Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis.
Author: Halder, Sunil K|Beauchamp, R Daniel|Datta, Pran K
PMID: 15922743
Journal: J Endocrinol. 2005 Jun;185(3):577-92.
Title: Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells.
Author: Gilad, Liat Abovich|Bresler, Tali|Gnainsky, Julia|Smirnoff, Patricia|Schwartz, Betty
PMID: 15930183
Journal: Cells Tissues Organs. 2005;179(1-2):73-80.
Title: The SRC-induced mesenchymal state in late-stage colon cancer cells.
Author: Avizienyte, Egle|Brunton, Valerie G|Fincham, Valerie J|Frame, Margaret C
PMID: 15942195
Journal: Carcinogenesis. 2005 Nov;26(11):1988-98.
Title: Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells.
Author: Parhamifar, Ladan|Jeppsson, Bengt|Sjolander, Anita
PMID: 15975962
Journal: Cancer Res. 2005 Jul 15;65(14):6275-81.
Title: Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner.
Author: Krysan, Kostyantyn|Reckamp, Karen L|Dalwadi, Harnisha|Sharma, Sherven|Rozengurt, Enrique|Dohadwala, Mariam|Dubinett, Steven M
PMID: 16024629
Journal: Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1646-52.
Title: Leptin, insulin-like growth factor-1, and insulin-like growth factor-2 are mitogens in ApcMin/+ but not Apc+/+ colonic epithelial cell lines.
Author: Fenton, Jenifer I|Hord, Norman G|Lavigne, Jackie A|Perkins, Susan N|Hursting, Stephen D
PMID: 16030096
Journal: J Cell Biochem. 2005 Sep 1;96(1):155-69.
Title: Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells.
Author: Liao, Chiung-Ho|Sang, Shengmin|Ho, Chi-Tang|Lin, Jen-Kun
PMID: 16052481
Journal: Mol Pharmacol. 2005 Nov;68(5):1203-13. Epub 2005 Aug 2.
Title: 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal tra
Author: Chen, Zhi Yi|Tseng, Chi-Chuan
PMID: 16077033
Journal: Exp Cell Res. 2005 Oct 15;310(1):117-30.
Title: CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation.
Author: Brand, Stephan|Dambacher, Julia|Beigel, Florian|Olszak, Torsten|Diebold, Joachim|Otte, Jan-Michel|Goke, Burkhard|Eichhorst, Soren T
PMID: 16125170
Journal: World J Gastroenterol. 2005 Sep 7;11(33):5142-50.
Title: Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid decreases ErbB3 expression in HT-29 human colon cancer cells.
Author: Cho, Han Jin|Kim, Woo Kyoung|Jung, Jae In|Kim, Eun Ji|Lim, Soon Sung|Kwon, Dae Young|Park, Jung Han Yoon
PMID: 16127743
Journal: Cell Biol Toxicol. 2005 Mar;21(2):115-25.
Title: Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells.
Author: Jeon, H-K|Choi, S-u|Jung, N-P
PMID: 16142585
Journal: Gastroenterology. 2005 Sep;129(3):952-68.
Title: Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo.
Author: Muerkoster, Susanne|Isberner, Anett|Arlt, Alexander|Witt, Maike|Reimann, Babette|Blaszczuk, Ewelina|Werbing, Veronika|Folsch, Ulrich R|Schmitz, Frank|Schafer, Heiner
PMID: 16143134
Journal: Biochem Pharmacol. 2005 Oct 15;70(8):1147-57.
Title: Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells.
Author: Lee, Seung Ho|Lee, Chung Woo|Lee, Jae Woong|Choi, Myoung Suk|Son, Dong Ju|Chung, Youn Bok|Lee, Chong Kil|Oh, Ki Wan|Moon, Dong Chul|Kwon, Byoung Mog|Hong, Jin Tae
PMID: 16143316
Journal: Br J Cancer. 2005 Dec 12;93(12):1364-71.
Title: Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signalling in the regulation of growth and differentiation in colon carcinoma.
Author: Bhagavathula, N|Kelley, E A|Reddy, M|Nerusu, K C|Leonard, C|Fay, K|Chakrabarty, S|Varani, J
PMID: 16278666
Journal: Cancer Res. 2005 Nov 15;65(22):10623-31.
Title: Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea.
Author: Ju, Jihyeung|Hong, Jungil|Zhou, Jian-nian|Pan, Zui|Bose, Mousumi|Liao, Jie|Yang, Guang-yu|Liu, Ying Ying|Hou, Zhe|Lin, Yong|Ma, Jianjie|Shih, Weichung Joe|Carothers, Adelaide M|Yang, Chung S
PMID: 16288056
Journal: Cancer Biol Ther. 2005 Oct;4(10):1159-67. Epub 2005 Oct 23.
Title: Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation.
Author: Caraglia, Michele|Marra, Monica|Budillon, Alfredo|Meo, Giuseppina|Ricciardiello, Filippo|Bismuto, Ettore|Brachelente, Giovanni|Francini, Guido|Giordano, Antonio|Correale, Pierpaolo|Abbruzzese, Alberto
PMID: 16294035
Journal: Ann Surg. 2005 Dec;242(6):880-7, discussion 887-9.
Title: Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen activated protein kinase cell signaling.
Author: Mulsow, Jurgen J W|Watson, R William G|Fitzpatrick, John M|O'Connell, P Ronan
PMID: 16327498
Journal: J Exp Ther Oncol. 2005;5(1):69-78.
Title: EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells.
Author: Shimizu, Masahito|Deguchi, Atsuko|Joe, Andrew K|Mckoy, Judith F|Moriwaki, Hisataka|Weinstein, I Bernard
PMID: 16416603
Journal: Regul Pept. 2006 Mar 15;134(1):1-8.
Title: Glycine-extended gastrin stimulates proliferation and inhibits apoptosis in colon cancer cells via cyclo-oxygenase-independent pathways.
Author: Ogunwobi, Olorunseun Olatunji|Beales, Ian L P
PMID: 16169610
Journal: Int J Biochem Cell Biol. 2006 Feb;38(2):244-54.
Title: Molecular signaling cascade in DNA bisintercalator, echinomycin-induced apoptosis of HT-29 cells: evidence of the apoptotic process via activation of the cytochrome c-ERK-caspase-3 pathway.
Author: Park, Ju Youn|Ryang, Yong Suk|Shim, Kwang Yong|Lee, Jong In|Kim, Hong Sup|Kim, Yong Hae|Kim, Soo-Ki
PMID: 16214385
Journal: J Cell Biochem. 2006 Mar 1;97(4):709-23.
Title: Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells.
Author: Brand, Stephan|Olszak, Torsten|Beigel, Florian|Diebold, Joachim|Otte, Jan-Michel|Eichhorst, Soeren T|Goke, Burkhard|Dambacher, Julia
PMID: 16215992
Journal: Biochem J. 2006 Mar 15;394(Pt 3):647-56.
Title: Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling.
Author: Kato, Kengo|Shiga, Kiyoto|Yamaguchi, Kazunori|Hata, Keiko|Kobayashi, Toshimitsu|Miyazaki, Kaoru|Saijo, Shigeru|Miyagi, Taeko
PMID: 16241905
Journal: Oncogene. 2006 Jan 5;25(1):43-50.
Title: Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase.
Author: Wang, Q|Zhou, Y|Wang, X|Evers, B M
PMID: 16278684
Journal: Food Chem Toxicol. 2006 Jun;44(6):839-46.
Title: Alpha-chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1/2 phosphorylation.
Author: Yang, Seun-Ah|Paek, Seung-Hwan|Kozukue, Nobuyuki|Lee, Kap-Rang|Kim, Jung-Ae
PMID: 16387404
Journal: Eur Urol. 2006 Nov;50(5):1102-9; discussion 1109-10.
Title: Mitogen-activated protein kinase signaling is activated in prostate tumors but not mediated by B-RAF mutations.
Author: Burger, Maximilian|Denzinger, Stefan|Hammerschmied, Christine|Tannapfel, Andrea|Maderstorfer, Armin|Wieland, Wolf Ferdinand|Hartmann, Arndt|Stoehr, Robert
PMID: 16413100
Journal: J Biol Chem. 2006 Mar 31;281(13):8497-510. Epub 2006 Feb 3.
Title: Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway.
Author: Sawhney, Rajinder S|Cookson, Michelle M|Omar, Yasin|Hauser, Jennie|Brattain, Michael G
PMID: 16461767
Journal: Anticancer Res. 2006 Jan-Feb;26(1A):121-7.
Title: Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells.
Author: Ahn, Eun Hyun|Schroeder, Joseph J
PMID: 16475687
Journal: J Cell Sci. 2006 Mar 1;119(Pt 5):819-27. Epub 2006 Feb 14.
Title: APC inhibits ERK pathway activation and cellular proliferation induced by RAS.
Author: Park, Ki-Sook|Jeon, Soung Hoo|Kim, Sung-Eun|Bahk, Young-Yil|Holmen, Sheri L|Williams, Bart O|Chung, Kwang-Chul|Surh, Young-Joon|Choi, Kang-Yell
PMID: 16478791
Journal: Mol Cancer Ther. 2006 Feb;5(2):309-16.
Title: RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling.
Author: Donapaty, Sreenivasa|Louis, Somaja|Horvath, Elizabeth|Kun, Jiang|Sebti, Said M|Malafa, Mokenge P
PMID: 16505104
Journal: Regul Pept. 2006 May 15;134(2-3):105-13.
Title: Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells.
Author: Ogunwobi, Olorunseun Olatunji|Beales, Ian L P
PMID: 16529829
Journal: Cell Death Differ. 2006 Nov;13(11):1982-93.
Title: Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis.
Author: Lin, L|Su, Z|Lebedeva, I V|Gupta, P|Boukerche, H|Rai, T|Barber, G N|Dent, P|Sarkar, D|Fisher, P B
PMID: 16575407
Journal: Oncol Rep. 2006 May;15(5):1327-31.
Title: Effects of extracts from two Native American plants on proliferation of human breast and colon cancer cell lines in vitro.
Author: Daniels, Amber L|Van Slambrouck, Severine|Lee, Robin K|Arguello, Tammy S|Browning, James|Pullin, Michael J|Kornienko, Alexander|Steelant, Wim F A
PMID: 16596206
Journal: Am J Physiol Cell Physiol. 2006 Sep;291(3):C433-44.
Title: Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathway.
Author: Tan, Ernest Y|Richard, Cynthia L|Zhang, Hong|Hoskin, David W|Blay, Jonathan
PMID: 16611738
Journal: Anticancer Res. 2006 Mar-Apr;26(2A):1085-90.
Title: The tyrosine kinase inhibitor AG490 inhibits growth of cancer cells and activates ERK in LS174T and HT-29 cells.
Author: Saito, Koichi|Iwashita, Jun|Murata, Jun|Abe, Tatsuya
PMID: 16619510
Journal: Exp Cell Res. 2006 Jul 15;312(12):2203-13.
Title: Requirement of the enzymatic and signaling activities of plasmin for phorbol-ester-induced scattering of colon cancer cells.
Author: Diaz, Victor M|Hurtado, Mariano|Kort, Eric J|Resnati, Massimo|Blasi, Francesco|Thomson, Timothy|Paciucci, Rosanna
PMID: 16631161
Journal: Cell Signal. 2006 Nov;18(11):1967-76. Epub 2006 May 3.
Title: Hepatocyte growth factor installs a survival platform for colorectal cancer cell invasive growth and overcomes p38 MAPK-mediated apoptosis.
Author: Fassetta, Michela|D'Alessandro, Lorenza|Coltella, Nadia|Di Renzo, Maria Flavia|Rasola, Andrea
PMID: 16677802
Journal: Carcinogenesis. 2006 Oct;27(10):1950-60.
Title: Arachidonic acid-induced gene expression in colon cancer cells.
Author: Monjazeb, Arta M|High, Kevin P|Connoy, Abbie|Hart, Lori S|Koumenis, Constantinos|Chilton, Floyd H
PMID: 16704987
Journal: Oncogene. 2006 Oct 26;25(50):6563-73. Epub 2006 May 22.
Title: Regulation of transendothelial migration of colon cancer cells by E-selectin-mediated activation of p38 and ERK MAP kinases.
Author: Tremblay, P-L|Auger, F A|Huot, J
PMID: 16715142
Journal: Endocr Relat Cancer. 2006 Jun;13(2):571-81.
Title: Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner.
Author: Attias, Z|Werner, H|Vaisman, N
PMID: 16728583
Journal: Mol Cancer Ther. 2006 May;5(5):1352-61.
Title: A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells.
Author: Yamaguchi, Kiyoshi|Lee, Seong-Ho|Eling, Thomas E|Baek, Seung Joon
PMID: 16731769
Journal: Ai Zheng. 2006 Jun;25(6):683-8.
Title: [Role of calcium signal in apoptosis and protective mechanism of colon cancer cell line SW480 in response to 5-aminolevulinic acid-photodynamic therapy].
Author: Zheng, Jiang-Hua|Shi, De|Zhao, Yu|Chen, Zu-Lin
PMID: 16764761
Journal: Cell Stress Chaperones. 2006 Summer;11(2):135-47.
Title: Stress-induced phosphorylation of caveolin-1 and p38, and down-regulation of EGFr and ERK by the dietary lectin jacalin in two human carcinoma cell lines.
Author: Sahasrabuddhe, Anagh A|Ahmed, Neesar|Krishnasastry, M V
PMID: 16817319
Journal: Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14122-7. Epub 2006 Sep 7.
Title: Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Author: Sansom, Owen J|Meniel, Valerie|Wilkins, Julie A|Cole, Alicia M|Oien, Karin A|Marsh, Victoria|Jamieson, Thomas J|Guerra, Carmen|Ashton, Gabrielle H|Barbacid, Mariano|Clarke, Alan R
PMID: 16959882
Journal: Int J Oncol. 2006 Oct;29(4):869-76.
Title: Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells.
Author: Yoshizaki, Ayumi|Nakayama, Toshiyuki|Yamazumi, Kazuyuki|Yakata, Yuichi|Taba, Mitsuru|Sekine, Ichiro
PMID: 16964382
Journal: Cancer Res. 2006 Sep 15;66(18):9117-24.
Title: Death receptor-3, a new E-Selectin counter-receptor that confers migration and survival advantages to colon carcinoma cells by triggering p38 and ERK MAPK activation.
Author: Gout, Stephanie|Morin, Chantale|Houle, Francois|Huot, Jacques
PMID: 16982754
Journal: World J Gastroenterol. 2006 Sep 21;12(35):5635-43.
Title: Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer.
Author: Hopfner, Michael|Sutter, Andreas P|Huether, Alexander|Baradari, Viola|Scherubl, Hans
PMID: 17007015
Journal: Cancer Res. 2006 Oct 15;66(20):10057-63.
Title: Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells.
Author: Hwang, Jin-Taek|Kim, Young Min|Surh, Young-Joon|Baik, Haing Woon|Lee, Seong-Kyu|Ha, Joohun|Park, Ock Jin
PMID: 17047069
Journal: J Endocrinol. 2006 Nov;191(2):387-98.
Title: Phytoestrogens regulate transcription and translation of vitamin D receptor in colon cancer cells.
Author: Gilad, Liat Abovich|Tirosh, Oren|Schwartz, Betty
PMID: 17088408
Journal: FEBS Lett. 2006 Dec 11;580(28-29):6565-9.
Title: Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells.
Author: Vaculova, Alena|Hofmanova, Jirina|Soucek, Karel|Kozubik, Alois
PMID: 17113582
Journal: Cell Signal. 2007 Feb;19(2):261-8. Epub 2006 Aug 9.
Title: MAGI-3 regulates LPA-induced activation of Erk and RhoA.
Author: Zhang, Huanchun|Wang, Dongsheng|Sun, Hong|Hall, Randy A|Yun, C Chris
PMID: 16904289
Journal: J Nutr Biochem. 2007 May;18(5):332-40.
Title: Conjugated linoleic acid inhibits Caco-2 cell growth via ERK-MAPK signaling pathway.
Author: Bocca, Claudia|Bozzo, Francesca|Gabriel, Ludovica|Miglietta, Antonella
PMID: 16963252
Journal: Gynecol Oncol. 2007 Feb;104(2):461-9. Epub 2006 Oct 9.
Title: L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells.
Author: Stoeck, Alexander|Gast, Daniela|Sanderson, Michael P|Issa, Yasmin|Gutwein, Paul|Altevogt, Peter
PMID: 17030349
Journal: Oncogene. 2007 May 10;26(21):3006-19.
Title: Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells.
Author: Hawcroft, G|Ko, C W S|Hull, M A
PMID: 17130837
Journal: Virchows Arch. 2007 Feb;450(2):151-9.
Title: Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations.
Author: Schmitz, K J|Wohlschlaeger, J|Alakus, H|Bohr, J|Stauder, M A|Worm, K|Winde, G|Schmid, K W|Baba, H A
PMID: 17149612
Journal: Cancer Lett. 2007 Jun 28;251(2):237-46. Epub 2006 Dec 26.
Title: Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells.
Author: Half, Elizabeth|Sun, Yunjie|Sinicrope, Frank A
PMID: 17189670
Journal: J Pharmacol Sci. 2007 Jan;103(1):24-32. Epub 2007 Jan 13.
Title: Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer.
Author: Ihara, Aya|Wada, Koichiro|Yoneda, Masato|Fujisawa, Nobutaka|Takahashi, Hirokazu|Nakajima, Atsushi
PMID: 17220595
Journal: Cancer Res. 2007 Jan 15;67(2):665-73.
Title: A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo.
Author: Rajput, Ashwani|Koterba, Alan P|Kreisberg, Jeffrey I|Foster, Jason M|Willson, James K V|Brattain, Michael G
PMID: 17234777
Journal: Mol Carcinog. 2007 Apr;46(4):275-83.
Title: Involvement of Ras/Raf-1/ERK actions in the magnolol-induced upregulation of p21 and cell-cycle arrest in colon cancer cells.
Author: Hsu, Yi-Fan|Lee, Tong-Sheng|Lin, Shyr-Yi|Hsu, Sung-Po|Juan, Shu-Hui|Hsu, Yuan-Hsun|Zhong, Wen-Bin|Lee, Wen-Sen
PMID: 17295239
Journal: J Biol Chem. 2007 Apr 20;282(16):12249-59. Epub 2007 Feb 16.
Title: Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells.
Author: Lu, Rong|Wang, Xia|Chen, Zhao-Fei|Sun, Dan-Feng|Tian, Xiao-Qing|Fang, Jing-Yuan
PMID: 17307743
Journal: Cell Signal. 2007 Jul;19(7):1465-72. Epub 2007 Jan 24.
Title: BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK.
Author: Beck, Stayce E|Jung, Barbara H|Del Rosario, Eunice|Gomez, Jessica|Carethers, John M
PMID: 17317101
Journal: Food Chem Toxicol. 2007 Aug;45(8):1356-67. Epub 2007 Jan 24.
Title: Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation.
Author: Chou, Yean-Hwei|Ho, Yuan-Soon|Wu, Chi-Chen|Chai, Chiah-Yang|Chen, Soul-Chin|Lee, Chia-Hwa|Tsai, Pei-Shan|Wu, Chih-Hsiung
PMID: 17329004
Journal: Biochem Biophys Res Commun. 2007 May 11;356(3):599-603. Epub 2007 Mar 12.
Title: The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T.
Author: Hatayama, Hajime|Iwashita, Jun|Kuwajima, Akiko|Abe, Tatsuya
PMID: 17374366
Journal: Cancer Biol Ther. 2007 Apr;6(4):494-503.
Title: Profiling of selenomethionine responsive genes in colon cancer by microarray analysis.
Author: Goulet, Anne-Christine|Watts, George|Lord, Jean L|Nelson, Mark A
PMID: 17374985
Journal: Cancer. 2007 May 15;109(10):1996-2003.
Title: XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer.
Author: Yu, Li Fen|Wang, Jide|Zou, Bing|Lin, Marie C M|Wu, Yun Lin|Xia, Harry H X|Sun, Yun Wei|Gu, Qing|He, Hua|Lam, S K|Kung, Hsiang Fu|Wong, Benjamin C Y
PMID: 17385215
Journal: Cancer Res. 2007 Apr 1;67(7):3286-94.
Title: Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells.
Author: Abdelrahim, Maen|Baker, Cheryl H|Abbruzzese, James L|Sheikh-Hamad, David|Liu, Shengxi|Cho, Sung Dae|Yoon, Kyungsil|Safe, Stephen
PMID: 17409437
Journal: Gut. 2007 Sep;56(9):1257-65. Epub 2007 Apr 20.
Title: Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease.
Author: Dambacher, Julia|Beigel, Florian|Seiderer, Julia|Haller, Dirk|Goke, Burkhard|Auernhammer, Christoph J|Brand, Stephan
PMID: 17449633
Journal: Cell Signal. 2007 Aug;19(8):1722-32. Epub 2007 Mar 28.
Title: Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells.
Author: Grijelmo, Clara|Rodrigue, Christelle|Svrcek, Magalie|Bruyneel, Erik|Hendrix, An|de Wever, Olivier|Gespach, Christian
PMID: 17478078
Journal: Mol Pharmacol. 2007 Aug;72(2):395-406.
Title: Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells.
Author: Merighi, Stefania|Benini, Annalisa|Mirandola, Prisco|Gessi, Stefania|Varani, Katia|Simioni, Carolina|Leung, Edward|Maclennan, Stephen|Baraldi, Pier Giovanni|Borea, Pier Andrea
PMID: 17488804
Journal: Mol Cancer Ther. 2007 May;6(5):1579-87.
Title: ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway.
Author: Koyama, Makoto|Matsuzaki, Youichirou|Yogosawa, Shingo|Hitomi, Toshiaki|Kawanaka, Mayumi|Sakai, Toshiyuki
PMID: 17513607
Journal: J Biol Chem. 2007 Aug 3;282(31):22298-306.
Title: Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6.
Author: Fu, Ping|Thompson, Julian A|Bach, Leon A
PMID: 17519236
Journal: Chin Med J (Engl). 2007 May 5;120(9):743-8.
Title: Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways.
Author: Zhang, Yu-hua|Wei, Wei|Xu, Hao|Wang, Yan-yan|Wu, Wen-xi
PMID: 17531111
Journal: Biochim Biophys Acta. 2007 Aug;1770(8):1194-203. Epub 2007 May 3.
Title: Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad.
Author: Rusovici, Raluca|Ghaleb, Amr|Shim, Hyunsuk|Yang, Vincent W|Yun, C Chris
PMID: 17544220
Journal: J Surg Res. 2007 Oct;142(2):239-45.
Title: A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model.
Author: Fichera, Alessandro|Little, Nathaniel|Dougherty, Urszula|Mustafi, Reba|Cerda, Sonia|Li, Yan Chun|Delgado, Jorge|Arora, Amrita|Campbell, Lucas K|Joseph, Loren|Hart, John|Noffsinger, Amy|Bissonnette, Marc
PMID: 17574271
Journal: Int J Cancer. 2007 Nov 15;121(10):2172-80.
Title: The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.
Author: Greenhough, Alexander|Patsos, Helena A|Williams, Ann C|Paraskeva, Christos
PMID: 17583570
Journal: Dis Colon Rectum. 2007 Aug;50(8):1230-40.
Title: RAGE activation by S100P in colon cancer stimulates growth, migration, and cell signaling pathways.
Author: Fuentes, Maren K|Nigavekar, Shraddha S|Arumugam, Thiruvengadam|Logsdon, Craig D|Schmidt, Ann Marie|Park, Juliet C|Huang, Emina H
PMID: 17587138
Journal: Mol Cancer Ther. 2007 Jul;6(7):2092-102.
Title: Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein.
Author: Katayama, Kazuhiro|Yoshioka, Sho|Tsukahara, Satomi|Mitsuhashi, Junko|Sugimoto, Yoshikazu
PMID: 17620438
Journal: Gastroenterology. 2007 Jul;133(1):219-31. Epub 2007 Apr 25.
Title: Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells.
Author: Zhu, Feng|Zykova, Tatyana A|Kang, Bong Seok|Wang, Zhe|Ebeling, Mara C|Abe, Yasuhito|Ma, Wei-Ya|Bode, Ann M|Dong, Zigang
PMID: 17631144
Journal: Exp Cell Res. 2007 Aug 15;313(14):2969-79.
Title: The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.
Author: Cherukuri, Durga Prasad|Chen, Xiao B O|Goulet, Anne-Christine|Young, Robert N|Han, Yongxin|Heimark, Ronald L|Regan, John W|Meuillet, Emmanuelle|Nelson, Mark A
PMID: 17631291
Journal: Cancer Lett. 2007 Oct 28;256(2):207-17. Epub 2007 Jul 20.
Title: Bone morphogenetic protein-4 inhibits heat-induced apoptosis by modulating MAPK pathways in human colon cancer HCT116 cells.
Author: Deng, Haiyun|Ravikumar, T S|Yang, Weng-Lang
PMID: 17640799
Journal: Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G719-28. Epub 2007 Jul
Title: HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts.
Author: Di Mari, J F|Saada, J I|Mifflin, R C|Valentich, J D|Powell, D W
PMID: 17640979
Journal: Zhonghua Yi Xue Za Zhi. 2007 Apr 10;87(14):982-6.
Title: [Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells].
Author: Wang, Xia|Lu, Rong|Fang, Jing-yuan
PMID: 17650425
Journal: Oncogene. 2007 Sep 6;26(41):6071-81. Epub 2007 Jul 30.
Title: Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2.
Author: Moniz, S|Verissimo, F|Matos, P|Brazao, R|Silva, E|Kotelevets, L|Chastre, E|Gespach, C|Jordan, P
PMID: 17667937
Journal: Cancer Res. 2007 Aug 1;67(15):7106-12.
Title: Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.
Author: Ma, Li|Teruya-Feldstein, Julie|Bonner, Pauline|Bernardi, Rosa|Franz, David Neal|Witte, David|Cordon-Cardo, Carlos|Pandolfi, Pier Paolo
PMID: 17671177
Journal: J Biochem. 2007 Jul;142(1):55-64.
Title: A cholesterol-independent membrane microdomain serves as a functional counter-receptor for E-selectin at the Colo201 cell surface and initiates signalling on E-selectin binding.
Author: Suzuki, Chikako|Kojima, Naoya
PMID: 17684030
Journal: Exp Mol Pathol. 2007 Dec;83(3):443-52.
Title: Keratinocyte growth factor-transfection-stimulated adhesion of colorectal cancer cells to extracellular matrices.
Author: Kudo, Mitsuhiro|Ishiwata, Toshiyuki|Nakazawa, Nando|Kawahara, Kiyoko|Fujii, Takenori|Teduka, Kiyoshi|Naito, Zenya
PMID: 17706640
Journal: Surgery. 2007 Sep;142(3):384-92.
Title: Thermal sensitization through ROS modulation: a strategy to improve the efficacy of hyperthermic intraperitoneal chemotherapy.
Author: Wang, Chia-Chi|Chen, Fei|Kim, Eugene|Harrison, Lawrence E
PMID: 17723891
Journal: J Med Chem. 2007 Oct 18;50(21):5090-102.
Title: 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
Author: Spicer, Julie A|Rewcastle, Gordon W|Kaufman, Michael D|Black, Shannon L|Plummer, Mark S|Denny, William A|Quin, John 3rd|Shahripour, Aurash B|Barrett, Stephen D|Whitehead, Christopher E|Milbank, Jared B J|Ohren, Jeffrey F|Gowan, Richard C|Omer, Charles|Cam
PMID: 17880056
Journal: Cancer Res. 2007 Oct 1;67(19):9286-93.
Title: Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation.
Author: Ying, Lei|Hofseth, Anne B|Browning, Darren D|Nagarkatti, Mitzi|Nagarkatti, Prakash S|Hofseth, Lorne J
PMID: 17909036
Journal: Regul Pept. 2007 Dec 4;144(1-3):34-42. Epub 2007 Jun 7.
Title: The CCK-2/gastrin splice variant receptor retaining intron 4 transactivates the COX-2 promoter in vitro.
Author: Huang, He|Ansorge, Nikolaus|Schrader, Henning|Banasch, Matthias|Yu, Hong-Gang|Schmidt, Wolfgang E|Hocker, Michael|Schmitz, Frank
PMID: 17936921
Journal: Beijing Da Xue Xue Bao. 2007 Oct 18;39(5):453-7.
Title: [Regulation of promatrilysin expression by tissue factor/actived coagulation factor VII complex in LoVo colon cancer cell line].
Author: Tang, Jian-qiang|Wan, Yuan-lian|Liu, Yu-cun|Rong, Long|Wang, Xin|Wu, Tao|Pan, Yi-sheng|Zhu, Jing
PMID: 17940558
Journal: Cell Cycle. 2007 Dec 15;6(24):3078-85.
Title: Bilirubin inhibits tumor cell growth via activation of ERK.
Author: Ollinger, Robert|Kogler, Pamela|Troppmair, Jakob|Hermann, Martin|Wurm, Martin|Drasche, Astrid|Konigsrainer, Ingmar|Amberger, Albert|Weiss, Helmut|Ofner, Dietmar|Bach, Fritz H|Margreiter, Raimund
PMID: 18073533
Journal: Oncology. 2007;73(1-2):98-103.
Title: Proteasome inhibition potentiates the cytotoxic effects of hyperthermia in HT-29 colon cancer cells through inhibition of heat shock protein 27.
Author: Chen, Fei|Rezavi, Reza|Wang, Cha-Chi|Harrison, Lawrence E
PMID: 18337621
Journal: Oncogene. 2008 Jan 3;27(1):85-97. Epub 2007 Jun 25.
Title: Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models.
Author: Desnoyers, L R|Pai, R|Ferrando, R E|Hotzel, K|Le, T|Ross, J|Carano, R|D'Souza, A|Qing, J|Mohtashemi, I|Ashkenazi, A|French, D M
PMID: 17599042
Journal: J Cell Biochem. 2008 May 1;104(1):259-73.
Title: Regulation of apoptosis by modified naringenin derivatives in human colorectal carcinoma RKO cells.
Author: Lee, Eung-Ryoung|Kang, Yong-Jin|Kim, Hyun-Jeong|Choi, Hye-Yeon|Kang, Geun-Ho|Kim, Jung-Hyun|Kim, Bong-Woo|Jeong, Hyo-Soon|Park, Yong-Sun|Cho, Ssang-Goo
PMID: 18004724
Journal: J Biol Chem. 2008 Feb 15;283(7):4094-104. Epub 2007 Dec 15.
Title: Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells.
Author: Kang, Dong Woo|Park, Mi Hee|Lee, Young Jun|Kim, Hyung Sik|Kwon, Taeg Kyu|Park, Won-Sang|Min, Do Sik
PMID: 18084005
Journal: Br J Pharmacol. 2008 Mar;153(5):870-8. Epub 2007 Dec 17.
Title: Celecoxib decreases expression of the adhesion molecules ICAM-1 and VCAM-1 in a colon cancer cell line (HT29).
Author: Gallicchio, M|Rosa, A C|Dianzani, C|Brucato, L|Benetti, E|Collino, M|Fantozzi, R
PMID: 18084318
Journal: J Biol Chem. 2008 Feb 22;283(8):5023-33. Epub 2007 Dec 17.
Title: Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway.
Author: Liang, Fong-Pin|Lin, Chao-Hsiung|Kuo, Cheng-Deng|Chao, Hsueh-Ping|Fu, Shu-Ling
PMID: 18086662
Journal: J Biol Chem. 2008 Feb 29;283(9):5533-41.
Title: A sensitive flow cytometry-based nucleotide excision repair assay unexpectedly reveals that mitogen-activated protein kinase signaling does not regulate the removal of UV-induced DNA damage in human cells.
Author: Rouget, Raphael|Auclair, Yannick|Loignon, Martin|Affar, El Bachir|Drobetsky, Elliot A
PMID: 18093981
Journal: Biol Pharm Bull. 2008 Jan;31(1):79-84.
Title: Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (--)-epigallocatechin against HCT116 colorectal carcinoma cells.
Author: Inaba, Hiroyuki|Nagaoka, Yasuo|Kushima, Yukihiro|Kumagai, Ayako|Matsumoto, Yoshinori|Sakaguchi, Minoru|Baba, Kimiye|Uesato, Shinichi
PMID: 18175946
Journal: Oncol Rep. 2008 Feb;19(2):567-73.
Title: Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers.
Author: Hofmanova, Jirina|Vaculova, Alena|Hyzd'alova, Martina|Kozubik, Alois
PMID: 18202809
Journal: Mol Cell Biochem. 2008 Apr;311(1-2):157-65.
Title: Diallyl sulfide induces apoptosis in Colo 320 DM human colon cancer cells: involvement of caspase-3, NF-kappaB, and ERK-2.
Author: Sriram, Narayanan|Kalayarasan, Srinivasan|Ashokkumar, Pandurangan|Sureshkumar, Ananthasadagopan|Sudhandiran, Ganapasam
PMID: 18256791
Journal: J Biol Chem. 2008 Apr 25;283(17):11565-74.
Title: A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
Author: Wang, Chunmei|Li, Nan|Liu, Xingguang|Zheng, Yuanyuan|Cao, Xuetao
PMID: 18305109
Journal: Cancer Biol Ther. 2008 Jun;7(6):902-8. Epub 2008 Mar 17.
Title: The BH3-only protein PUMA is involved in green tea polyphenol-induced apoptosis in colorectal cancer cell lines.
Author: Wang, Xi|Wang, Rui|Hao, Miao-Wang|Dong, Ke|Wei, San-Hua|Lin, Fang|Ren, Ji-Hong|Zhang, Hui-Zhong
PMID: 18367875
Journal: Curr Med Chem. 2008;15(10):978-90.
Title: ANTI-ADHESION evolves to a promising therapeutic concept in oncology.
Author: Schmidmaier, R|Baumann, P
PMID: 18393855
Journal: Oncogene. 2008 Aug 21;27(36):4921-32.
Title: Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6.
Author: Adachi, Y|Shibai, Y|Mitsushita, J|Shang, W H|Hirose, K|Kamata, T
PMID: 18454176
Journal: Biochem Biophys Res Commun. 2008 Jul 18;372(1):45-50.
Title: Down-modulation of B cell signal transduction by ligation of mucins to CD22.
Author: Toda, Munetoyo|Akita, Kaoru|Inoue, Mizue|Taketani, Shigeru|Nakada, Hiroshi
PMID: 18474217
Journal: Anticancer Res. 2008 Mar-Apr;28(2A):895-906.
Title: Rosiglitazone induces caveolin-1 by PPARgamma-dependent and PPRE-independent mechanisms: the role of EGF receptor signaling and its effect on cancer cell drug resistance.
Author: Tencer, Lilach|Burgermeister, Elke|Ebert, Matthias P|Liscovitch, Mordechai
PMID: 18507034
Journal: Am J Clin Oncol. 2008 Jun;31(3):255-8.
Title: ERK signaling in colorectal cancer: a preliminary report on the expression of phosphorylated ERK and the effects of radiation therapy.
Author: Corn, Benjamin W|Kovner, Felix|Bek, Stella|Wexler, Isaiah|Lifschits, Beatrice|Seger, Rony
PMID: 18525304
Journal: Biochem Biophys Res Commun. 2008 Aug 8;372(4):845-9.
Title: Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells.
Author: Shama, Jessica|Garcia-Medina, Raquel|Pouyssegur, Jacques|Vial, Emmanuel
PMID: 18533112
Journal: Oncol Rep. 2008 Jul;20(1):3-11.
Title: Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients.
Author: Georgieva, Milka|Krasteva, Maria|Angelova, Elka|Ralchev, Krassimir|Dimitrov, Valentin|Bozhimirov, Stanislav|Georgieva, Elena|Berger, Martin R
PMID: 18575712
Journal: Br J Pharmacol. 2008 Sep;155(2):198-209.
Title: Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation.
Author: Colucci, R|Blandizzi, C|Ghisu, N|Florio, T|Del Tacca, M
PMID: 18587421
Journal: Cancer Res. 2008 Jul 1;68(13):5167-76.
Title: Mechanisms by which E-selectin regulates diapedesis of colon cancer cells under flow conditions.
Author: Tremblay, Pierre-Luc|Huot, Jacques|Auger, Francois A
PMID: 18593916
Journal: Toxicol Appl Pharmacol. 2008 Nov 1;232(3):408-17.
Title: Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3.
Author: Zeliadt, Nicholette A|Mauro, Laura J|Wattenberg, Elizabeth V
PMID: 18771677
Journal: Biochim Biophys Acta. 2008 Dec;1783(12):2323-31.
Title: Early adhesion induces interaction of FAK and Fyn in lipid domains and activates raft-dependent Akt signaling in SW480 colon cancer cells.
Author: Baillat, Gilbert|Siret, Carole|Delamarre, Estelle|Luis, Jose
PMID: 18805444
Journal: Biochem Biophys Res Commun. 2008 Dec 12;377(2):622-6.
Title: PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells.
Author: Tanaka, Yusuke|Sekiguchi, Fumiko|Hong, Hao|Kawabata, Atsufumi
PMID: 18854173
Journal: Cell Commun Signal. 2008 Oct 24;6:8.
Title: Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells.
Author: Aleksic, Tamara|Feller, Stephan M
PMID: 18950493
Journal: Cell Adh Migr. 2008 Jul-Sep;2(3):151-2. Epub 2008 Jul 19.
Title: Crossing the endothelium: E-selectin regulates tumor cell migration under flow conditions.
Author: Woodward, Julia
PMID: 19262108
Journal: Int J Cancer. 2009 Apr 1;124(7):1517-25.
Title: Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase.
Author: Gratio, Valerie|Walker, Francine|Lehy, Therese|Laburthe, Marc|Darmoul, Dalila
PMID: 19058300
Journal: Cancer Lett. 2009 May 8;277(1):108-13.
Title: p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047.
Author: Adachi, Seiji|Natsume, Hideo|Yamauchi, Junichi|Matsushima-Nishiwaki, Rie|Joe, Andrew K|Moriwaki, Hisataka|Kozawa, Osamu
PMID: 19138820
Journal: Diabetes Metab Res Rev. 2009 Jan;25(1):41-9.
Title: Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells.
Author: Weinstein, Doron|Simon, Meital|Yehezkel, Einat|Laron, Zvi|Werner, Haim
PMID: 19145584
Journal: Int J Mol Med. 2009 Feb;23(2):189-96.
Title: Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line.
Author: Auyeung, Kathy Ka-wai|Law, Pui-ching|Ko, Joshua Ka-shun
PMID: 19148542
Journal: Eur J Nutr. 2009 Apr;48(3):154-61.
Title: Effects of adipocyte-secreted factors on cell cycle progression in HT29 cells.
Author: Schnabele, Kerstin|Roser, Silvia|Rechkemmer, Gerhard|Hauner, Hans|Skurk, Thomas
PMID: 19169726
Journal: Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2835-40.
Title: Knockin of mutant PIK3CA activates multiple oncogenic pathways.
Author: Gustin, John P|Karakas, Bedri|Weiss, Michele B|Abukhdeir, Abde M|Lauring, Josh|Garay, Joseph P|Cosgrove, David|Tamaki, Akina|Konishi, Hiroyuki|Konishi, Yuko|Mohseni, Morassa|Wang, Grace|Rosen, D Marc|Denmeade, Samuel R|Higgins, Michaela J|Vitolo, Michele
PMID: 19196980
Journal: Gastroenterology. 2009 May;136(5):1680-8.e7.
Title: TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.
Author: Trobridge, Patty|Knoblaugh, Sue|Washington, M Kay|Munoz, Nina M|Tsuchiya, Karen D|Rojas, Andres|Song, Xiaoling|Ulrich, Cornelia M|Sasazuki, Takehiko|Shirasawa, Senji|Grady, William M
PMID: 19208363
Journal: Cancer Sci. 2009 Apr;100(4):588-94.
Title: Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice.
Author: Shiozaki, Kazuhiro|Yamaguchi, Kazunori|Sato, Ikuro|Miyagi, Taeko
PMID: 19215228
Journal: Mol Cell Biochem. 2009 Aug;328(1-2):201-8.
Title: MAP kinases in proliferating human colon cancer Caco-2 cells.
Author: Buzzi, Natalia|Colicheo, Andrea|Boland, Ricardo|de Boland, Ana Russo
PMID: 19301097
Journal: Exp Cell Res. 2009 Jul 1;315(11):1840-9.
Title: alphavbeta5/beta6 integrin suppression leads to a stimulation of alpha2beta1 dependent cell migration resistant to PI3K/Akt inhibition.
Author: Defilles, Celine|Lissitzky, Jean-Claude|Montero, Marie-Pierre|Andre, Frederic|Prevot, Charles|Delamarre, Estelle|Marrakchi, Naziha|Luis, Jose|Rigot, Veronique
PMID: 19328197
Journal: PLoS Comput Biol. 2009 Apr;5(4):e1000340.
Title: Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling.
Author: Aldridge, Bree B|Saez-Rodriguez, Julio|Muhlich, Jeremy L|Sorger, Peter K|Lauffenburger, Douglas A
PMID: 19343194
Journal: Mol Cancer Ther. 2009 Apr;8(4):821-33.
Title: Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis.
Author: Kaulfuss, Silke|Burfeind, Peter|Gaedcke, Jochen|Scharf, Jens-Gerd
PMID: 19372555
Journal: Mol Cancer Ther. 2009 Apr;8(4):834-43.
Title: KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.
Author: Yeh, Jen Jen|Routh, Elizabeth D|Rubinas, Tara|Peacock, Janie|Martin, Timothy D|Shen, Xiang Jun|Sandler, Robert S|Kim, Hong Jin|Keku, Temitope O|Der, Channing J
PMID: 19372556
Journal: Mutat Res. 2009 Jul-Aug;682(1):39-53.
Title: Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre.
Author: Scharlau, Daniel|Borowicki, Anke|Habermann, Nina|Hofmann, Thomas|Klenow, Stefanie|Miene, Claudia|Munjal, Umang|Stein, Katrin|Glei, Michael
PMID: 19383551
Journal: Int J Cancer. 2009 Sep 1;125(5):1082-91.
Title: A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene.
Author: Auyeung, Kathy K W|Cho, Chi-Hin|Ko, Joshua K S
PMID: 19384947
Journal: Cell Cycle. 2009 Jul 1;8(13):2122-4. Epub 2009 Jul 9.
Title: MEK1 mutations, but not ERK2 mutations, occur in melanomas and colon carcinomas, but none in thyroid carcinomas.
Author: Murugan, Avaniyapuram Kannan|Dong, Jianli|Xie, Jingwu|Xing, Mingzhao
PMID: 19411838
Journal: Cancer Lett. 2009 Sep 28;283(1):108-17.
Title: Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells.
Author: Palozza, Paola|Torelli, Cristiana|Boninsegna, Alma|Simone, Rossella|Catalano, Assunta|Mele, Maria Cristina|Picci, Nevio
PMID: 19423215
Journal: IUBMB Life. 2009 Jun;61(6):685-92.
Title: Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway.
Author: Song, Chunjiao|Wang, Weimin|Li, Meng|Liu, Yanxin|Zheng, Dexian
PMID: 19472191
Journal: Gut. 2009 Sep;58(9):1234-41.
Title: Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the Ras/Raf signalling pathway in advanced colorectal cancer.
Author: Seth, R|Crook, S|Ibrahem, S|Fadhil, W|Jackson, D|Ilyas, M
PMID: 19474002
Journal: Arch Physiol Biochem. 2009 Jul;115(3):127-36.
Title: Effects of omega-3 and omega-6 fatty acids on IGF-I receptor signalling in colorectal cancer cells.
Author: Seti, Hila|Leikin-Frenkel, Alicia|Werner, Haim
PMID: 19480565
Journal: Gastroenterology. 2009 Sep;137(3):914-23.
Title: Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice.
Author: Chen, Xinhua|Fruehauf, Johannes|Goldsmith, Jeffrey D|Xu, Hua|Katchar, Kianoosh K|Koon, Hon-Wai|Zhao, Dezheng|Kokkotou, Efi G|Pothoulakis, Charalabos|Kelly, Ciaran P
PMID: 19482027
Journal: Cancer Res. 2009 Jun 15;69(12):5226-33.
Title: Biological significance of prolactin in gynecologic cancers.
Author: Levina, Vera V|Nolen, Brian|Su, YunYun|Godwin, Andrew K|Fishman, David|Liu, Jinsong|Mor, Gil|Maxwell, Larry G|Herberman, Ronald B|Szczepanski, Miroslaw J|Szajnik, Marta E|Gorelik, Elieser|Lokshin, Anna E
PMID: 19491263
Journal: Acta Biochim Biophys Sin (Shanghai). 2009 Jun;41(6):504-14.
Title: NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human colorectal cancer.
Author: Peng, Ya|Li, Hongtao|Wu, Minghua|Wang, Xiaoyan|Fan, Songqing|Liu, Fen|Xiang, Bo|Guo, Qin|Tang, Xueyuan|Shen, Shourong
PMID: 19499154
Journal: Anticancer Drugs. 2009 Aug;20(7):601-6.
Title: Inhibition of MEK sensitizes paclitaxel-induced apoptosis of human colorectal cancer cells by downregulation of GRP78.
Author: Mhaidat, Nizar M|Alali, Feras Q|Matalqah, Sina M|Matalka, Ismail I|Jaradat, Saied A|Al-Sawalha, Nour A|Thorne, Rick F
PMID: 19521235
Journal: Biochem Pharmacol. 2009 Nov 1;78(9):1205-13.
Title: Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells.
Author: Yang, Hyun|Choi, Hye Jin|Park, Seong Hwan|Kim, Jong Sik|Moon, Yuseok
PMID: 19540205
Journal: Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G559-66.
Title: Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes.
Author: Miyaki, Akira|Yang, Peiying|Tai, Hsin-Hsiung|Subbaramaiah, Kotha|Dannenberg, Andrew J
PMID: 19608733
Journal: Int J Cancer. 2009 Nov 15;125(10):2332-41.
Title: Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.
Author: Balmanno, Kathryn|Chell, Simon D|Gillings, Annette S|Hayat, Shaista|Cook, Simon J
PMID: 19637312
Journal: Carcinogenesis. 2009 Oct;30(10):1796-804.
Title: HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells.
Author: Moore, Amy E|Greenhough, Alexander|Roberts, Heather R|Hicks, Diane J|Patsos, Helena A|Williams, Ann C|Paraskeva, Christos
PMID: 19638428
Journal: Orv Hetil. 2009 Aug 23;150(34):1607-13.
Title: [Tissue microarray (TMA) validated progression markers in colorectal cancer using antibody microarrays].
Author: Spisak, Sandor|Galamb, Barnabas|Wichmann, Barnabas|Sipos, Ferenc|Galamb, Orsolya|Solymosi, Norbert|Nemes, Balazs|Tulassay, Zsolt|Molnar, Bela
PMID: 19648079
Journal: Mol Cancer Res. 2009 Aug;7(8):1390-8.
Title: Up-regulation of Kruppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha.
Author: Mori, Akira|Moser, Christian|Lang, Sven A|Hackl, Christina|Gottfried, Eva|Kreutz, Marina|Schlitt, Hans J|Geissler, Edward K|Stoeltzing, Oliver
PMID: 19671674
Journal: Chem Biol Interact. 2009 Dec 10;182(2-3):183-90.
Title: Novel nitro-oxy derivatives of celecoxib for the regulation of colon cancer cell growth.
Author: Bozzo, Francesca|Bassignana, Andrea|Lazzarato, Loretta|Boschi, Donatella|Gasco, Alberto|Bocca, Claudia|Miglietta, Antonella
PMID: 19682443
Journal: Mol Nutr Food Res. 2009 Jul;53(7):897-903.
Title: Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1.
Author: Corona, Giulia|Deiana, Monica|Incani, Alessandra|Vauzour, David|Dessi, Maria Assunta|Spencer, Jeremy P E
PMID: 19685549
Journal: Cell Signal. 2009 Dec;21(12):1846-56.
Title: Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway.
Author: Krueger, Felix|Madeja, Zofia|Hemberger, Myriam|McMahon, Martin|Cook, Simon J|Gaunt, Stephen J
PMID: 19686845
Journal: Blood Cells Mol Dis. 2009 Nov-Dec;43(3):243-9.
Title: TfR2 expression in human colon carcinomas.
Author: Calzolari, Alessia|Deaglio, Silvia|Maldi, Elena|Cassoni, Paola|Malavasi, Fabio|Testa, Ugo
PMID: 19729324
Journal: J Zhejiang Univ Sci B. 2009 Sep;10(9):668-74.
Title: Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway.
Author: Shan, Jian-zhen|Xuan, Yan-yan|Zheng, Shu|Dong, Qi|Zhang, Su-zhan
PMID: 19735099
Journal: Cancer Sci. 2009 Dec;100(12):2302-8.
Title: Norcantharidin induces HT-29 colon cancer cell apoptosis through the alphavbeta6-extracellular signal-related kinase signaling pathway.
Author: Peng, Cheng|Liu, Xiangqun|Liu, Enyu|Xu, Kesen|Niu, Weibo|Chen, Rong|Wang, Jiayong|Zhang, Zhaoyang|Lin, Pengfei|Wang, Jian|Agrez, Michael|Niu, Jun
PMID: 19744110
Journal: Cancer Res. 2009 Oct 15;69(20):8191-9.
Title: RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.
Author: Kreeger, Pamela K|Mandhana, Roli|Alford, Shannon K|Haigis, Kevin M|Lauffenburger, Douglas A
PMID: 19789336
Journal: Digestion. 2009;80(4):215-25.
Title: Heregulin-induced VEGF expression via the ErbB3 signaling pathway in colon cancer.
Author: Yonezawa, Masaoki|Wada, Ken|Tatsuguchi, Atsushi|Akamatsu, Tomonori|Gudis, Katya|Seo, Tsuguhiko|Mitsui, Keigo|Nagata, Kazuhiro|Tanaka, Shu|Fujimori, Shunji|Sakamoto, Choitsu
PMID: 19797898
Journal: Biol Pharm Bull. 2009 Oct;32(10):1760-4.
Title: Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells.
Author: Hyun, Jae-Hee|Kim, Sang-Cheol|Kang, Jung-Il|Kim, Min-Kyoung|Boo, Hye-Jin|Kwon, Jung-Mi|Koh, Young-Sang|Hyun, Jin-Won|Park, Deok-Bae|Yoo, Eun-Sook|Kang, Hee-Kyoung
PMID: 19801840
Journal: Biochim Biophys Acta. 2009 Dec;1790(12):1651-9.
Title: Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line.
Author: Buzzi, Natalia|Bilbao, Paola Scodelaro|Boland, Ricardo|de Boland, Ana Russo
PMID: 19836435
Journal: Neoplasia. 2009 Nov;11(11):1116-31.
Title: BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells.
Author: Oikonomou, Eftychia|Makrodouli, Eleni|Evagelidou, Maria|Joyce, Tobias|Probert, Lesley|Pintzas, Alexander
PMID: 19881948
Journal: Oncol Rep. 2009 Dec;22(6):1505-12.
Title: Inhibitory effects of the ethanol extract of Gleditsia sinensis thorns on human colon cancer HCT116 cells in vitro and in vivo.
Author: Lee, Se-Jung|Cho, Young-Hwa|Kim, Heejong|Park, Keerang|Park, Sung-Kyu|Ha, Sang-Do|Kim, Wun-Jae|Moon, Sung-Kwon
PMID: 19885606
Journal: Zhonghua Zhong Liu Za Zhi. 2009 Oct;31(10):746-851.
Title: [Combination with SN-38 on human colon cancer LoVo cells].
Author: Wang, Yan|Xu, Jian-ming|Xu, Qin-zhi|Zhou, Ping-kun|Song, San-tai
PMID: 20021826
Journal: Proteomics Clin Appl. 2009 Apr;3(4):423-32.
Title: Identification and validation of calmodulin as a binding protein of an anti-proliferative small molecule 3,4-dihydroisoquinolinium salt.
Author: Jung, Hye Jin|Shim, Joong Sup|Park, Jungchan|Ha, Hyun-Joon|Kim, Jung-Ho|Kim, Joong-Gon|Kim, Nam Doo|Yoon, Jeong Hyeok|Kwon, Ho Jeong
PMID: 21136969
Journal: Mol Med Rep. 2009 May-Jun;2(3):497-502.
Title: Effect of butyrate on the heregulin/ErbB-mediated proliferation of human colorectal cancer cells.
Author: Lim, Soo-Jeong|Choi, Moon-Kyung|Kim, Min Jung|Lee, Chang-Hun
PMID: 21475856
Journal: Cancer Lett. 2010 Jan 28;287(2):187-95.
Title: Tetrandrine induces apoptosis and growth suppression of colon cancer cells in mice.
Author: Wu, Jiann-Ming|Chen, Yun|Chen, Jin-Cherng|Lin, Tzu-Yu|Tseng, Sheng-Hong
PMID: 19586712
Journal: Int J Cancer. 2010 Feb 15;126(4):864-75.
Title: CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells.
Author: Chao, Celia|Han, Xueliang|Ives, Kirk|Park, Jeseong|Kolokoltsov, Andrey A|Davey, Robert A|Moyer, Mary P|Hellmich, Mark R
PMID: 19697327
Journal: Cancer Lett. 2010 Apr 1;290(1):123-8.
Title: Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells.
Author: Baek, Min Kyung|Park, Jung Sun|Park, Ji Hye|Kim, Mi Ha|Kim, Ho Dong|Bae, Woo Kyun|Chung, Ik Joo|Shin, Boo Ahn|Jung, Young Do
PMID: 19782465
Journal: J Cell Mol Med. 2010 Jun;14(6B):1520-31.
Title: Translational up-regulation of Aurora-A in EGFR-overexpressed cancer.
Author: Lai, Chien-Hsien|Tseng, Joseph T|Lee, Yi-Chao|Chen, Ying-Ju|Lee, Jeng-Chang|Lin, Bo-Wen|Huang, Tai-Chien|Liu, Yao-Wen|Leu, Tzeng-Horng|Liu, Yi-Wen|Chen, Ya-Ping|Chang, Wen-Chang|Hung, Liang-Yi
PMID: 19799648
Journal: Exp Clin Endocrinol Diabetes. 2010 Jul;118(7):410-9.
Title: Antiproliferative/cytotoxic activity of molecular iodine and iodolactones in various human carcinoma cell lines. No interfering with EGF-signaling, but evidence for apoptosis.
Author: Rosner, H|Torremante, P|Moller, W|Gartner, R
PMID: 19802778
Journal: Antioxid Redox Signal. 2010 May 1;12(9):1101-9.
Title: Butyrate-stimulated H2S production in colon cancer cells.
Author: Cao, Qiuhui|Zhang, Li|Yang, Guangdong|Xu, Changqing|Wang, Rui
PMID: 19803745
Journal: Pancreas. 2010 Apr;39(3):332-9.
Title: Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors.
Author: Pham, Hung|Chen, Monica|Li, Aihua|King, Jonathan|Angst, Eliane|Dawson, David W|Park, Jenny|Reber, Howard A|Hines, O Joe|Eibl, Guido
PMID: 19820419
Journal: Biochimie. 2010 Jan;92(1):110-5.
Title: Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells.
Author: Park, Eun Jung|Lim, Jun Hee|Nam, Sung Il|Park, Jong Wook|Kwon, Taeg Kyu
PMID: 19833168
Journal: Cancer Lett. 2010 Apr 1;290(1):24-35.
Title: Geldanamycin and its anti-cancer activities.
Author: Fukuyo, Yayoi|Hunt, Clayton R|Horikoshi, Nobuo
PMID: 19850405
Journal: Apoptosis. 2010 Feb;15(2):183-95.
Title: Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling.
Author: El-Najjar, Nahed|Chatila, Manal|Moukadem, Hiba|Vuorela, Heikki|Ocker, Matthias|Gandesiri, Muktheshwar|Schneider-Stock, Regine|Gali-Muhtasib, Hala
PMID: 19882352
Journal: Eur J Cancer Prev. 2010 Mar;19(2):153-9.
Title: The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells.
Author: Choi, Kyeong-Hee|Kim, Hyung-Kook|Kim, Jun-Hee|Choi, Eun-Sun|Shin, Ji-Ae|Lee, Syng-Ook|Chintharlapalli, Sudhakar|Safe, Stephen|Abdelrahim, Maen|Kong, Gu|Choi, Hong Seok|Jung, Ji-Youn|Cho, Hyun-Tae|Cho, Nam-Pyo|Cho, Sung-Dae
PMID: 19949342
Journal: Prostaglandins Leukot Essent Fatty Acids. 2010 Feb-Mar;82(2-3):131-9.
Title: Hypertonic environment elicits cyclooxygenase-2-driven prostaglandin E2 generation by colon cancer cells: role of cytosolic phospholipase A2-alpha and kinase signaling pathways.
Author: Gentile, Luciana B|Piva, Bruno|Capizzani, Bianca C|Furlaneto, Luiz G B|Moreira, Luciana S|Zamith-Miranda, Daniel|Diaz, Bruno L
PMID: 20004562
Journal: Int J Cancer. 2010 Sep 1;127(5):1220-9.
Title: Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1.
Author: Wang, Lei|Kuang, Lisha|Pan, Xinhua|Liu, Junchen|Wang, Qian|Du, Bing|Li, Dali|Luo, Jian|Liu, Mingyao|Hou, Aijun|Qian, Min
PMID: 20017136
Journal: Nutr Cancer. 2010;62(1):85-92.
Title: Deoxycholic acid and selenium metabolite methylselenol exert common and distinct effects on cell cycle, apoptosis, and MAP kinase pathway in HCT116 human colon cancer cells.
Author: Zeng, Huawei|Botnen, James H|Briske-Anderson, Mary
PMID: 20043263
Journal: Mol Cancer Ther. 2010 Jan;9(1):134-44.
Title: Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor models.
Author: Daouti, Sherif|Higgins, Brian|Kolinsky, Kenneth|Packman, Kathryn|Wang, Huisheng|Rizzo, Christine|Moliterni, John|Huby, Nicholas|Fotouhi, Nader|Liu, Mei|Goelzer, Petra|Sandhu, Harpreet K|Li, Jia Kui|Railkar, Aruna|Heimbrook, David|Niu, Huifeng
PMID: 20053779
Journal: Int J Biochem Cell Biol. 2010 Jun;42(6):911-20.
Title: Oncogenic RAS alters the global and gene-specific histone modification pattern during epithelial-mesenchymal transition in colorectal carcinoma cells.
Author: Pelaez, Ignacio Mazon|Kalogeropoulou, Margarita|Ferraro, Angelo|Voulgari, Angeliki|Pankotai, Tibor|Boros, Imre|Pintzas, Alexander
PMID: 20109579
Journal: PLoS One. 2010 Jan 27;5(1):e8925.
Title: Interaction of Saccharomyces boulardii with Salmonella enterica serovar Typhimurium protects mice and modifies T84 cell response to the infection.
Author: Martins, Flaviano S|Dalmasso, Guillaume|Arantes, Rosa M E|Doye, Anne|Lemichez, Emmanuel|Lagadec, Patricia|Imbert, Veronique|Peyron, Jean-Francois|Rampal, Patrick|Nicoli, Jacques R|Czerucka, Dorota
PMID: 20111723
Journal: Carcinogenesis. 2010 Apr;31(4):597-606.
Title: TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways.
Author: Kim, Semi|Kang, Hee Young|Nam, Eun-Hee|Choi, Myung-Sook|Zhao, Xue-Feng|Hong, Chang Soo|Lee, Jung Weon|Lee, Jae Hyuk|Park, Young-Kyu
PMID: 20118200
Journal: J Agric Food Chem. 2010 Mar 10;58(5):2935-42.
Title: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway.
Author: Lai, Kuang-Chi|Huang, An-Cheng|Hsu, Shu-Chun|Kuo, Chao-Lin|Yang, Jai-Sing|Wu, Shin-Hwar|Chung, Jing-Gung
PMID: 20136087
Journal: Mol Cancer. 2010 Feb 19;9:39.
Title: Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks.
Author: Tabu, Kouichi|Kimura, Taichi|Sasai, Ken|Wang, Lei|Bizen, Norihisa|Nishihara, Hiroshi|Taga, Tetsuya|Tanaka, Shinya
PMID: 20167130
Journal: Cell Commun Signal. 2010 Feb 2;8(1):1.
Title: High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells.
Author: Kress, Theresia R|Raabe, Thomas|Feller, Stephan M
PMID: 20181064
Journal: Cell Biol Int. 2010 Apr 14;34(6):565-72.
Title: Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21.
Author: Cai, Wen-Jie|Wang, Ming-Jie|Ju, Li-Hua|Wang, Cheng|Zhu, Yi-Chun
PMID: 20184555
Journal: Int J Mol Med. 2010 Apr;25(4):635-41.
Title: Decursin inhibits growth of human bladder and colon cancer cells via apoptosis, G1-phase cell cycle arrest and extracellular signal-regulated kinase activation.
Author: Kim, Wun-Jae|Lee, Se-Jung|Choi, Young Deuk|Moon, Sung-Kwon
PMID: 20198313
Journal: Int J Oncol. 2010 Apr;36(4):941-53.
Title: Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway.
Author: Lee, Hwa Young|Crawley, Suzanne|Hokari, Ryota|Kwon, Sungwon|Kim, Young S
PMID: 20198339
Journal: J Biol Chem. 2010 May 7;285(19):14617-27.
Title: AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma.
Author: Kim, Min-Jung|Park, In-Ja|Yun, Hee|Kang, Insug|Choe, Wonchae|Kim, Sung-Soo|Ha, Joohun
PMID: 20220132
Journal: Am J Med Sci. 2010 Apr;339(4):319-26.
Title: Expression and functional research of TLR4 in human colon carcinoma.
Author: Tang, Xiao-Yan|Zhu, You-Qing|Wei, Bai|Wang, Hua
PMID: 20228668
Journal: Cancer Sci. 2010 May;101(5):1212-8.
Title: Mechanism of antitumor effect of a novel bFGF binding peptide on human colon cancer cells.
Author: Wang, Cong|Lin, Shaoqiang|Nie, Yanfang|Jia, Xinglong|Wang, Jing|Xiao, Jian|Wu, Jianzhang|Li, Xiaokun|Wu, Xiaoping
PMID: 20331620
Journal: Cancer Lett. 2010 Sep 1;295(1):7-16.
Title: Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: an update on the molecular mechanisms.
Author: Wu, William Ka Kei|Sung, Joseph Jao Yiu|Lee, Chung Wa|Yu, Jun|Cho, Chi Hin
PMID: 20381235
Journal: J Biol Chem. 2010 Jun 18;285(25):19235-45.
Title: Induction of the apoptosis inhibitor ARC by Ras in human cancers.
Author: Wu, Lily|Nam, Young-Jae|Kung, Gloria|Crow, Michael T|Kitsis, Richard N
PMID: 20392691
Journal: Cell Cycle. 2010 May;9(9):1809-18.
Title: miR-129 regulates cell proliferation by downregulating Cdk6 expression.
Author: Wu, Junjie|Qian, Jun|Li, Chun|Kwok, Letty|Cheng, Feng|Liu, Peijun|Perdomo, Catalina|Kotton, Darrell|Vaziri, Cyrus|Anderlind, Christina|Spira, Avrum|Cardoso, Wellington V|Lu, Jining
PMID: 20404570
Journal: Cell Oncol. 2010 Jan 1;32(4):245-57.
Title: Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.
Author: van Houdt, Winan J|de Bruijn, Menno T|Emmink, Benjamin L|Raats, Danielle|Hoogwater, Frederik J H|Borel Rinkes, Inne H M|Kranenburg, Onno
PMID: 20413844
Journal: Mol Cell Biochem. 2010 Sep;342(1-2):63-70.
Title: 17beta-estradiol inhibits prostaglandin E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon cancer cells.
Author: Lai, Tung-Yuan|Chen, Li-Mien|Lin, Jing-Ying|Tzang, Bor-Show|Lin, James A|Tsai, Chang-Hai|Lin, Yueh-Min|Huang, Chih-Yang|Liu, Chung-Jung|Hsu, Hsi-Hsien
PMID: 20446020
Journal: Mol Biol Cell. 2010 Jul 1;21(13):2338-54.
Title: A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.
Author: Ghosh, Pradipta|Beas, Anthony O|Bornheimer, Scott J|Garcia-Marcos, Mikel|Forry, Erin P|Johannson, Carola|Ear, Jason|Jung, Barbara H|Cabrera, Betty|Carethers, John M|Farquhar, Marilyn G
PMID: 20462955
Journal: Carcinogenesis. 2010 Sep;31(9):1523-30.
Title: Docosahexaenoic acid alters epidermal growth factor receptor-related signaling by disrupting its lipid raft association.
Author: Rogers, Kristina R|Kikawa, Keith D|Mouradian, Michael|Hernandez, Karla|McKinnon, Kristen M|Ahwah, Shayne M|Pardini, Ronald S
PMID: 20525880
Journal: Carcinogenesis. 2010 Aug;31(8):1376-80.
Title: Activation of Akt and MAPK pathways enhances the tumorigenicity of CD133+ primary colon cancer cells.
Author: Wang, Y K|Zhu, Y L|Qiu, F M|Zhang, T|Chen, Z G|Zheng, S|Huang, J
PMID: 20530554
Journal: Planta Med. 2010 Nov;76(16):1827-33.
Title: Andrographolide exhibits anti-invasive activity against colon cancer cells via inhibition of MMP2 activity.
Author: Chao, Hsueh-Ping|Kuo, Cheng-Deng|Chiu, Jen-Hwey|Fu, Shu-Ling
PMID: 20539971
Journal: J Biol Chem. 2010 Aug 13;285(33):25458-66.
Title: Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression.
Author: Chen, Jinn-Shiun|Hsu, Yuan-Ming|Chen, Chia-Chi|Chen, Li-Li|Lee, Chun-Chung|Huang, Tze-Sing
PMID: 20558745
Journal: Biochim Biophys Acta. 2010 Sep;1800(9):946-55.
Title: Signal transduction pathways associated with ATP-induced proliferation of colon adenocarcinoma cells.
Author: Buzzi, Natalia|Boland, Ricardo|Russo de Boland, Ana
PMID: 20562007
Journal: Neoplasia. 2010 Jun;12(6):443-52.
Title: Oncogenic KRAS desensitizes colorectal tumor cells to epidermal growth factor receptor inhibition and activation.
Author: van Houdt, Winan J|Hoogwater, Frederik J H|de Bruijn, Menno T|Emmink, Benjamin L|Nijkamp, Maarten W|Raats, Danielle A E|van der Groep, Petra|van Diest, Paul|Borel Rinkes, Inne H M|Kranenburg, Onno
PMID: 20563247
Journal: Phytother Res. 2010 Dec;24(12):1870-6.
Title: Gleditsia sinensis thorn extract inhibits human colon cancer cells: the role of ERK1/2, G2/M-phase cell cycle arrest and p53 expression.
Author: Lee, Se-Jung|Park, Keerang|Ha, Sang-Do|Kim, Wun-Jae|Moon, Sung-Kwon
PMID: 20564491
Journal: Oncogene. 2010 Sep 16;29(37):5182-92.
Title: Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways.
Author: Lee, S-H|Bahn, J H|Whitlock, N C|Baek, S J
PMID: 20581861
Journal: Biochim Biophys Acta. 2010 Sep;1803(9):1106-13.
Title: P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways.
Author: Huynh, Nhi|Liu, Kevin H|Baldwin, Graham S|He, Hong
PMID: 20595063
Journal: Endocr Relat Cancer. 2010 Aug 16;17(3):823-33.
Title: Obesity hormone leptin induces growth and interferes with the cytotoxic effects of 5-fluorouracil in colorectal tumor stem cells.
Author: Bartucci, Monica|Svensson, Susanne|Ricci-Vitiani, Lucia|Dattilo, Rosanna|Biffoni, Mauro|Signore, Michele|Ferla, Rita|De Maria, Ruggero|Surmacz, Eva
PMID: 20603394
Journal: Oncogene. 2010 Sep 23;29(38):5241-53.
Title: Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas.
Author: Holgren, C|Dougherty, U|Edwin, F|Cerasi, D|Taylor, I|Fichera, A|Joseph, L|Bissonnette, M|Khare, S
PMID: 20661223
Journal: Mol Cancer Ther. 2010 Aug;9(8):2389-98.
Title: Suppression of neurotensin receptor type 1 expression and function by histone deacetylase inhibitors in human colorectal cancers.
Author: Wang, Xiaofu|Jackson, Lindsey N|Johnson, Sara M|Wang, Qingding|Evers, B Mark
PMID: 20663927
Journal: Int J Mol Med. 2010 Sep;26(3):341-9.
Title: Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells.
Author: Auyeung, Kathy Ka-Wai|Mok, Nga-Lai|Wong, Ching-Man|Cho, Chi-Hin|Ko, Joshua Ka-Shun
PMID: 20664949
Journal: Mol Cancer Ther. 2010 Aug;9(8):2196-207.
Title: Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors.
Author: Kannappan, Ramaswamy|Ravindran, Jayaraj|Prasad, Sahdeo|Sung, Bokyung|Yadav, Vivek R|Reuter, Simone|Chaturvedi, Madan M|Aggarwal, Bharat B
PMID: 20682650
Journal: Anticancer Res. 2010 Jul;30(7):2659-66.
Title: Antiproliferative effect of a novel nitro-oxy derivative of celecoxib in human colon cancer cells: role of COX-2 and nitric oxide.
Author: Bocca, Claudia|Bozzo, Francesca|Bassignana, Andrea|Miglietta, Antonella
PMID: 20682995
Journal: Br J Cancer. 2010 Sep 28;103(7):1025-33.
Title: Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer.
Author: Baba, Y|Nosho, K|Shima, K|Meyerhardt, J A|Chan, A T|Engelman, J A|Cantley, L C|Loda, M|Giovannucci, E|Fuchs, C S|Ogino, S
PMID: 20808308
Journal: Int J Oncol. 2010 Oct;37(4):909-26.
Title: Palladin, an actin-associated protein, is required for adherens junction formation and intercellular adhesion in HCT116 colorectal cancer cells.
Author: Tay, Puei Nam|Tan, Patrick|Lan, Yuhong|Leung, Carol Ho-Wing|Laban, Mirtha|Tan, Tze Chin|Ni, Hongmin|Manikandan, Jayapal|Rashid, Suhaimi Bin Abdul|Yan, Benedict|Yap, Celestial Therese|Lim, Lina Hsiu Kim|Lim, Yaw Chyn|Hooi, Shing Chuan
PMID: 20811713
Journal: Int J Oncol. 2010 Oct;37(4):951-62.
Title: P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910.
Author: Li, Liang-Hui|Zheng, Min-Hua|Luo, Qi|Ye, Qing|Feng, Bo|Lu, Ai-Guo|Wang, Ming-Liang|Chen, Xue-Hua|Su, Li-Ping|Liu, Bing-Ya
PMID: 20811717
Journal: Mol Cancer. 2010 Sep 2;9:231.
Title: Sprouty1, a new target of the angiostatic agent 16K prolactin, negatively regulates angiogenesis.
Author: Sabatel, Celine|Cornet, Anne M|Tabruyn, Sebastien P|Malvaux, Ludovic|Castermans, Karolien|Martial, Joseph A|Struman, Ingrid
PMID: 20813052
Journal: Cell Cycle. 2010 Sep 1;9(17):3575-83.
Title: Evidence for a differential modulation of p53-phosphorylating kinases by the cyclin-dependent kinase inhibitor p21WAF1/CIP1.
Author: Neise, Denise|Sohn, Dennis|Budach, Wilfried|Janicke, Reiner U
PMID: 20818156
Journal: J Biol Chem. 2010 Nov 12;285(46):35418-27.
Title: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.
Author: Sung, Bokyung|Ravindran, Jayaraj|Prasad, Sahdeo|Pandey, Manoj K|Aggarwal, Bharat B
PMID: 20837473
Journal: J Agric Food Chem. 2010 Oct 27;58(20):11148-55.
Title: Phenethyl isothiocyanate inhibited tumor migration and invasion via suppressing multiple signal transduction pathways in human colon cancer HT29 cells.
Author: Lai, Kuang-Chi|Hsu, Shu-Chun|Kuo, Chao-Lin|Ip, Siu-Wan|Yang, Jai-Sing|Hsu, Yuan-Man|Huang, Hui-Ying|Wu, Shin-Hwar|Chung, Jing-Gung
PMID: 20863062
Journal: Biomed Pharmacother. 2010 Nov;64(9):583-8.
Title: GABA-receptor agonist, propofol inhibits invasion of colon carcinoma cells.
Author: Miao, Yufeng|Zhang, Youwei|Wan, Haijun|Chen, Longbang|Wang, Fangyu
PMID: 20888181
Journal: Cancer Biol Ther. 2010 Nov 15;10(10):1056-66.
Title: The induction of S100p expression by the Prostaglandin E(2) (PGE(2))/EP4 receptor signaling pathway in colon cancer cells.
Author: Chandramouli, Anupama|Mercado-Pimentel, Melania E|Hutchinson, Anthony|Gibadulinova, Adriana|Olson, Erik R|Dickinson, Sally|Shanas, Renee|Davenport, Jennifer|Owens, Janae|Bhattacharyya, Achyut K|Regan, John W|Pastorekova, Silvia|Arumugam, Thiruvengadam|Log
PMID: 20890108
Journal: Mol Cancer Ther. 2010 Dec;9(12):3351-62.
Title: Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer.
Author: Tentler, John J|Nallapareddy, Sujatha|Tan, Aik Choon|Spreafico, Anna|Pitts, Todd M|Morelli, M Pia|Selby, Heather M|Kachaeva, Maria I|Flanigan, Sara A|Kulikowski, Gillian N|Leong, Stephen|Arcaroli, John J|Messersmith, Wells A|Eckhardt, S Gail
PMID: 20923857
Journal: Mol Cancer. 2010 Oct 13;9:271.
Title: The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis.
Author: Bergeron, Sebastien|Lemieux, Etienne|Durand, Veronique|Cagnol, Sebastien|Carrier, Julie C|Lussier, Jacques G|Boucher, Marie-Josee|Rivard, Nathalie
PMID: 20942929
Journal: Bioorg Med Chem Lett. 2010 Dec 1;20(23):7110-5.
Title: Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities.
Author: Liang, Chun|Ding, Yan|Nguyen, Huu Tung|Kim, Jeong-Ah|Boo, Hye-Jin|Kang, Hee-Kyoung|Nguyen, Mahn Cuong|Kim, Young Ho
PMID: 20951582
Journal: Pharmacology. 2010;86(5-6):313-9.
Title: Pifithrin-alpha, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway.
Author: Kim, Sangmin|Han, Jeonghun|Lee, Se Kyung|Hur, Sung Mo|Koo, Minyoung|Cho, Dong Hui|Bae, Soo Youn|Choi, Min-Young|Shin, Incheol|Yang, Jung-Hyun|Nam, Seok Jin|Lee, Jeong Eon
PMID: 21071999
Journal: Sci Signal. 2010 Nov 23;3(149):ra84.
Title: BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation.
Author: Corcoran, Ryan B|Dias-Santagata, Dora|Bergethon, Kristin|Iafrate, A John|Settleman, Jeffrey|Engelman, Jeffrey A
PMID: 21098728
Journal: PLoS Genet. 2010 Dec 2;6(12):e1001231.
Title: Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.
Author: Jurchott, Karsten|Kuban, Ralf-Jurgen|Krech, Till|Bluthgen, Nils|Stein, Ulrike|Walther, Wolfgang|Friese, Christian|Kielbasa, Szymon M|Ungethum, Ute|Lund, Per|Knosel, Thomas|Kemmner, Wolfgang|Morkel, Markus|Fritzmann, Johannes|Schlag, Peter M|Birchmeier, Wa
PMID: 21170361
Journal: Invest New Drugs. 2011 Apr;29(2):207-24.
Title: Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2.
Author: Nagendraprabhu, Ponnuraj|Sudhandiran, Ganapasam
PMID: 19876598
Journal: Oncogene. 2011 Feb 10;30(6):737-50.
Title: Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling.
Author: Kitajima, S|Miki, T|Takegami, Y|Kido, Y|Noda, M|Hara, E|Shamma, A|Takahashi, C
PMID: 20890302
Journal: Carcinogenesis. 2011 Mar;32(3):318-26.
Title: Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-beta-signaling pathway.
Author: Slattery, Martha L|Lundgreen, Abbie|Herrick, Jennifer S|Caan, Bette J|Potter, John D|Wolff, Roger K
PMID: 21088106
Journal: Phytother Res. 2011 Jun;25(6):833-7.
Title: Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway.
Author: Lee, Myung Sun|Cha, Eun Young|Sul, Ji Young|Song, In Sang|Kim, Ji Yeon
PMID: 21089180
Journal: Cancer Res. 2011 Jan 15;71(2):445-53.
Title: MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy.
Author: Yoon, Juyong|Koo, Kyoung-Hwa|Choi, Kang-Yell
PMID: 21118963
Journal: Cancer Res. 2011 Feb 1;71(3):1071-80.
Title: Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17.
Author: Van Schaeybroeck, Sandra|Kyula, Joan N|Fenton, Audrey|Fenning, Catherine S|Sasazuki, Takehiko|Shirasawa, Senji|Longley, Daniel B|Johnston, Patrick G
PMID: 21148749
Journal: Nutr Cancer. 2011;63(1):139-50.
Title: Estrogen receptor-beta mediates the inhibition of DLD-1 human colon adenocarcinoma cells by soy isoflavones.
Author: Bielecki, Agnieszka|Roberts, Jennifer|Mehta, Rekha|Raju, Jayadev
PMID: 21161820
Journal: Phytother Res. 2011 Jul;25(7):959-64.
Title: Decursin and decursinol from Angelica gigas inhibit the lung metastasis of murine colon carcinoma.
Author: Son, Seung Hwa|Park, Kwang-Kyun|Park, Sun Kyu|Kim, Young Choong|Kim, Yeong Shik|Lee, Sang-Kook|Chung, Won-Yoon
PMID: 21170925
Journal: Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G749-60.
Title: Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion.
Author: Belo, Angelica|Cheng, Kunrong|Chahdi, Ahmed|Shant, Jasleen|Xie, Guofeng|Khurana, Sandeep|Raufman, Jean-Pierre
PMID: 21273532
Journal: Cancer. 2011 Sep 15;117(18):4175-83.
Title: Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer.
Author: Slattery, Martha L|Lundgreen, Abbie|Herrick, Jennifer S|Wolff, Roger K|Caan, Bette J
PMID: 21365634
Journal: PLoS One. 2011 Feb 17;6(2):e16871.
Title: Functional characterization of human cancer-derived TRKB mutations.
Author: Geiger, Thomas R|Song, Ji-Ying|Rosado, Aranzazu|Peeper, Daniel S
PMID: 21379385
Journal: Pathol Int. 2011 Apr;61(4):210-20.
Title: Expression of KITENIN in human colorectal cancer and its relation to tumor behavior and progression.
Author: Lee, Seok|Song, Young-A|Park, Young-Lan|Cho, Sung-Bum|Lee, Wan-Sik|Lee, Jae-Hyuk|Chung, Ik-Joo|Kim, Kyung-Keun|Rew, Jong-Sun|Joo, Young-Eun
PMID: 21418393
Journal: Korean J Physiol Pharmacol. 2011 Feb;15(1):1-7.
Title: Involvement of ROS in Curcumin-induced Autophagic Cell Death.
Author: Lee, Youn Ju|Kim, Nam-Yi|Suh, Young-Ah|Lee, Chuhee
PMID: 21461234
Journal: Oncol Rep. 2011 Jul;26(1):109-14.
Title: Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells.
Author: Lamy, Virginie|Bousserouel, Souad|Gosse, Francine|Minker, Carole|Lobstein, Annelise|Raul, Francis
PMID: 21519792
Journal: Cancer Lett. 2011 Sep 1;308(1):62-70.
Title: RasGAP-derived peptide 38GAP potentiates the cytotoxicity of cisplatin through inhibitions of Akt, ERK and NF-kappaB in colon carcinoma HCT116 cells.
Author: Zhang, Hao|Zhang, Shenghua|He, Hongwei|Zhao, Wuli|Ren, Kaihuan|Chen, Jianhua|Shao, Rong-guang
PMID: 21570766
Journal: Toxicol Appl Pharmacol. 2011 Aug 1;254(3):288-98.
Title: 5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells.
Author: Shin, Soon Young|Hyun, Jiye|Yu, Jae-Ran|Lim, Yoongho|Lee, Young Han
PMID: 21616090
Journal: Tumour Biol. 2011 Oct;32(5):921-30.
Title: Involvement of ERK1/2/NF-kappaB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620.
Author: Guo, Donglin|Zhou, Hong|Wu, Ying|Zhou, Fang|Xu, Guoying|Wen, Haiping|Zhang, Xianmei
PMID: 21625939
Journal: Clin Cancer Res. 2011 Sep 15;17(18):5850-7.
Title: ERK1/2 and p38alpha/beta signaling in tumor cell quiescence: opportunities to control dormant residual disease.
Author: Sosa, Maria Soledad|Avivar-Valderas, Alvaro|Bragado, Paloma|Wen, Huei-Chi|Aguirre-Ghiso, Julio A
PMID: 21673068
Journal: Tumour Biol. 2011 Oct;32(5):965-76.
Title: Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells.
Author: Dabrowska, Magdalena|Skoneczny, Marek|Rode, Wojciech
PMID: 21678067
Journal: Cancer Res. 2011 Aug 15;71(16):5535-45.
Title: Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation.
Author: Wang, Huisheng|Daouti, Sherif|Li, Wen-Hui|Wen, Yang|Rizzo, Christine|Higgins, Brian|Packman, Kathryn|Rosen, Neal|Boylan, John F|Heimbrook, David|Niu, Huifeng
PMID: 21705440
Journal: BMC Cancer. 2011 Jul 1;11:285.
Title: Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFkappaB survival axis downstream of Death receptor-3.
Author: Porquet, Nicolas|Poirier, Andree|Houle, Francois|Pin, Anne-Laure|Gout, Stephanie|Tremblay, Pierre-Luc|Paquet, Eric R|Klinck, Roscoe|Auger, Francois A|Huot, Jacques
PMID: 21722370
Journal: Cancer Lett. 2011 Dec 1;311(1):38-47.
Title: PKC promotes the migration of colon cancer cells by regulating the internalization and recycling of integrin alphavbeta6.
Author: Wang, Jian|Wu, Jingjing|Hong, Jianguo|Chen, Rong|Xu, Kesen|Niu, Weibo|Peng, Cheng|Liu, Enyu|Wang, Jiayong|Liu, Song|Agrez, Michael|Niu, Jun
PMID: 21741165
Journal: Mod Pathol. 2011 Oct;24(10):1404-12.
Title: VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal cancer [corrected] patients.
Author: Vlajnic, Tatjana|Andreozzi, Maria Carla|Schneider, Sandra|Tornillo, Luigi|Karamitopoulou, Eva|Lugli, Alessandro|Ruiz, Christian|Zlobec, Inti|Terracciano, Luigi
PMID: 21743435
Journal: Front Physiol. 2011 Jun 30;2:33.
Title: Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels.
Author: Alzamora, Rodrigo|O'Mahony, Fiona|Ko, Wing-Hung|Yip, Tiffany Wai-Nga|Carter, Derek|Irnaten, Mustapha|Harvey, Brian Joseph
PMID: 21747769
Journal: Tumour Biol. 2011 Oct;32(5):1005-12.
Title: Differential expression of TNF-alpha signaling molecules and ERK1 in distal and proximal colonic tumors associated with obesity.
Author: Jain, Swati S|AshokKumar, Manickaraj|Bird, Ranjana P
PMID: 21761118
Journal: Biol Pharm Bull. 2011;34(8):1231-9.
Title: Deltonin isolated from Dioscorea zingiberensis inhibits cancer cell growth through inducing mitochondrial apoptosis and suppressing Akt and mitogen activated protein kinase signals.
Author: Shu, Dan|Qing, Yong|Tong, Qingyi|He, Yang|Xing, Zhihua|Zhao, Yinglan|Li, Yi|Wei, Yuquan|Huang, Wen|Wu, Xiaohua
PMID: 21804211
Journal: Int J Biol Sci. 2011;7(6):869-80. Epub 2011 Jul 19.
Title: Dimerumic acid inhibits SW620 cell invasion by attenuating H(2)O(2)-mediated MMP-7 expression via JNK/C-Jun and ERK/C-Fos activation in an AP-1-dependent manner.
Author: Ho, Bing-Ying|Wu, Yao-Ming|Chang, King-Jen|Pan, Tzu-Ming
PMID: 21814482
Journal: Mol Cancer Ther. 2011 Oct;10(10):1969-81.
Title: 2-methoxy-5-amino-N-hydroxybenzamide sensitizes colon cancer cells to TRAIL-induced apoptosis by regulating death receptor 5 and survivin expression.
Author: Stolfi, Carmine|Caruso, Roberta|Franze, Eleonora|Rizzo, Angelamaria|Rotondi, Angela|Monteleone, Ivan|Fantini, Massimo Claudio|Pallone, Francesco|Monteleone, Giovanni
PMID: 21817114
Journal: PLoS One. 2011;6(8):e23262.
Title: TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells.
Author: Zhao, Shu-Liang|Hong, Jie|Xie, Zuo-Quan|Tang, Jie-Ting|Su, Wen-Yu|Du, Wan|Chen, Ying-Xuan|Lu, Rong|Sun, Dan-Feng|Fang, Jing-Yuan
PMID: 21826244
Journal: J Med Chem. 2011 Sep 22;54(18):6177-82.
Title: Cancer selective metallocenedicarboxylates of the fungal cytotoxin illudin M.
Author: Schobert, Rainer|Seibt, Sebastian|Mahal, Katharina|Ahmad, Aamir|Biersack, Bernhard|Effenberger-Neidnicht, Katharina|Padhye, Subhash|Sarkar, Fazlul H|Mueller, Thomas
PMID: 21848340
Journal: J Biomed Sci. 2011 Aug 22;18:61.
Title: JNK suppression is essential for 17beta-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells.
Author: Hsu, Hsi-Hsien|Hu, Wei-Syun|Lin, Yueh-Min|Kuo, Wei-Wen|Chen, Li-Mien|Chen, Wei-Kung|Hwang, Jin-Ming|Tsai, Fuu-Jen|Liu, Chung-Jung|Huang, Chih-Yang
PMID: 21859479
Journal: Oncotarget. 2011 Aug;2(8):638-45.
Title: The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.
Author: Mazumdar, Tapati|DeVecchio, Jennifer|Agyeman, Akwasi|Shi, Ting|Houghton, Janet A
PMID: 21860067
Journal: Chem Biol Interact. 2011 Oct 15;194(1):48-57.
Title: Cell cycle arrest and apoptosis induced by methyl 3,5-dicaffeoyl quinate in human colon cancer cells: Involvement of the PI3K/Akt and MAP kinase pathways.
Author: Hu, Weicheng|Shen, Ting|Wang, Myeong-Hyeon
PMID: 21872580
Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;36(7):585-91.
Title: [Transcriptomic regulation and molecular mechanism of polygenic tumor at different stages].
Author: Li, Xiayu|Shen, Shourong|Wu, Minghua|Li, Xiaoling|Xiong, Wei|Lu, Jianhong|Zhou, Ming|Ma, Jian|Xiang, Juanjuan|Zeng, Zhaoyang|Xiang, Bo|Zhou, Yanhong|Xiao, Lan|Zhou, Houde|Fan, Songqing|Li, Guiyuan
PMID: 21873780
Journal: Radiat Oncol. 2011 Sep 12;6:114.
Title: Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy.
Author: Davies, Janine M|Trembath, Dimitri|Deal, Allison M|Funkhouser, William K|Calvo, Benjamin F|Finnegan, Timothy|Weck, Karen E|Tepper, Joel E|O'Neil, Bert H
PMID: 21910869
Journal: J Agric Food Chem. 2011 Oct 26;59(20):11304-18.
Title: Cancer chemopreventive effects of lycopene: suppression of MMP-7 expression and cell invasion in human colon cancer cells.
Author: Lin, Meng-Chiu|Wang, Fu-Yu|Kuo, Yueh-Hsiung|Tang, Feng-Yao
PMID: 21923160
Journal: J Exp Clin Cancer Res. 2011 Sep 16;30:83.
Title: Effects of metastasis-associated in colon cancer 1 inhibition by small hairpin RNA on ovarian carcinoma OVCAR-3 cells.
Author: Zhang, Ruitao|Shi, Huirong|Chen, Zhimin|Wu, Qinghua|Ren, Fang|Huang, Haoliang
PMID: 21923915
Journal: Toxicol In Vitro. 2011 Dec;25(8):1771-81.
Title: Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells.
Author: Ramos, Sonia|Rodriguez-Ramiro, Ildefonso|Martin, Maria Angeles|Goya, Luis|Bravo, Laura
PMID: 21945981
Journal: BMC Cancer. 2011 Oct 2;11:421.
Title: Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells.
Author: Muller, Kristin M|Tveteraas, Ingun H|Aasrum, Monica|Odegard, John|Dawood, Mona|Dajani, Olav|Christoffersen, Thoralf|Sandnes, Dagny L
PMID: 21961726
Journal: Cancer Lett. 2011 Dec 27;313(2):167-80.
Title: Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to alpha5beta1 integrin and suppresses FAK/ERK/NF-kappaB signaling.
Author: Dia, Vermont P|Gonzalez de Mejia, Elvira
PMID: 21963225
Journal: PLoS One. 2011;6(9):e25193.
Title: Hypertonic stress induces VEGF production in human colon cancer cell line Caco-2: inhibitory role of autocrine PGE(2).
Author: Gentile, Luciana B|Piva, Bruno|Diaz, Bruno L
PMID: 21980393
Journal: PLoS One. 2011;6(10):e25806.
Title: BRAF mutations in advanced cancers: clinical characteristics and outcomes.
Author: El-Osta, Hazem|Falchook, Gerald|Tsimberidou, Apostolia|Hong, David|Naing, Aung|Kim, Kevin|Wen, Sijin|Janku, Filip|Kurzrock, Razelle
PMID: 22039425
Journal: Cancer Cell. 2011 Nov 15;20(5):649-60.
Title: The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.
Author: Zaki, Md Hasan|Vogel, Peter|Malireddi, R K Subbarao|Body-Malapel, Mathilde|Anand, Paras K|Bertin, John|Green, Douglas R|Lamkanfi, Mohamed|Kanneganti, Thirumala-Devi
PMID: 22094258
Journal: Oncol Res. 2011;19(12):527-34.
Title: RIN1-Ras-ERK pathway plays an important role in carcinogenesis in colon cancer cell line LoVo.
Author: Inoue, Takeshi|Goi, Takanori|Hirono, Yasuo|Katayama, Kanji|Yamaguchi, Akio
PMID: 22812185
Journal: Mol Carcinog. 2012 Jun;51(6):475-90.
Title: Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-kappaB in colon cancer cells.
Author: Babykutty, Suboj|S, Priya P|J, Nandini R|Kumar, M A Suresh|Nair, Mangalam S|Srinivas, Priya|Gopala, Srinivas
PMID: 21678498
Journal: J Cell Physiol. 2012 May;227(5):1891-8.
Title: The pro-apoptotic effect of quercetin in cancer cell lines requires ERbeta-dependent signals.
Author: Bulzomi, Pamela|Galluzzo, Paola|Bolli, Alessandro|Leone, Stefano|Acconcia, Filippo|Marino, Maria
PMID: 21732360
Journal: J Gastrointest Cancer. 2012 Sep;43(3):444-55.
Title: Expression of EGFR, HER2, phosphorylated ERK and phosphorylated MEK in colonic neoplasms of familial adenomatous polyposis patients.
Author: Wang, Jayson|Hollingshead, James|El-Masry, Nabil|Horncastle, Donna|Talbot, Ian|Tomlinson, Ian|Alison, Malcolm R|El-Bahrawy, Mona
PMID: 21989899
Journal: Mol Cell Biochem. 2012 Feb;361(1-2):235-41.
Title: Thrombin-dependent modulation of beta1-integrin-mediated signaling up-regulates prolidase and HIF-1alpha through p-FAK in colorectal cancer cells.
Author: Karna, Ewa|Szoka, Lukasz|Palka, Jerzy
PMID: 21993963
Journal: Anticancer Agents Med Chem. 2012 Feb;12(2):163-71.
Title: Are KRAS/BRAF mutations potent prognostic and/or predictive biomarkers in colorectal cancers?
Author: Yokota, Tomoya
PMID: 22043994
Journal: Free Radic Biol Med. 2012 Jan 1;52(1):151-9.
Title: Large procyanidins prevent bile-acid-induced oxidant production and membrane-initiated ERK1/2, p38, and Akt activation in Caco-2 cells.
Author: Da Silva, Mathieu|Jaggers, Grayson K|Verstraeten, Sandra V|Erlejman, Alejandra G|Fraga, Cesar G|Oteiza, Patricia I
PMID: 22074817
Journal: Int J Colorectal Dis. 2012 Apr;27(4):437-45.
Title: Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell.
Author: Jia, Zhi-Chao|Wan, Yuan-Lian|Tang, Jian-Qiang|Dai, Yun|Liu, Yu-Cun|Wang, Xin|Zhu, Jing
PMID: 22076613
Journal: Int J Cancer. 2012 Aug 1;131(3):E190-203.
Title: Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells.
Author: Lee, Su-Kyung|Han, Young-Min|Yun, Jieun|Lee, Chang Woo|Shin, Dae-Seop|Ha, Young-Ran|Kim, Jina|Koh, Jong Sung|Hong, Su-Hyung|Han, Dong Cho|Kwon, Byoung-Mog
PMID: 22131018
Journal: Int J Oncol. 2012 Apr;40(4):1251-8.
Title: Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: clinical implications.
Author: Feng, Xiaoying|Aleem, Eiman|Lin, Yingbo|Axelson, Magnus|Larsson, Olle|Stromberg, Thomas
PMID: 22159423
Journal: Cancer Res. 2012 Feb 1;72(3):779-89.
Title: Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer.
Author: Yang, Hong|Higgins, Brian|Kolinsky, Kenneth|Packman, Kathryn|Bradley, William D|Lee, Richard J|Schostack, Kathleen|Simcox, Mary Ellen|Kopetz, Scott|Heimbrook, David|Lestini, Brian|Bollag, Gideon|Su, Fei
PMID: 22180495
Journal: J Mol Med (Berl). 2012 Jun;90(6):707-18.
Title: Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK.
Author: Song, Ling-Jun|Liu, Rui-Jun|Zeng, Zhi|Alper, Seth L|Cui, Heng-Jing|Lu, Yang|Zheng, Lin|Yan, Zhao-Wen|Fu, Guo-Hui
PMID: 22228178
Journal: Hematol Oncol. 2012 Dec;30(4):190-3.
Title: Real-time PCR-based analysis of BRAF V600E mutation in low and intermediate grade lymphomas confirms frequent occurrence in hairy cell leukaemia.
Author: Ewalt, Mark|Nandula, Subhadra|Phillips, Adrienne|Alobeid, Bachir|Murty, Vundavalli V|Mansukhani, Mahesh M|Bhagat, Govind
PMID: 22246856
Journal: Biochem Soc Trans. 2012 Feb;40(1):73-8.
Title: Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling.
Author: Little, Annette S|Balmanno, Kathryn|Sale, Matthew J|Smith, Paul D|Cook, Simon J
PMID: 22260668
Journal: Clin Cancer Res. 2012 Apr 15;18(8):2316-25.
Title: The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.
Author: Shimizu, Toshio|Tolcher, Anthony W|Papadopoulos, Kyriakos P|Beeram, Muralidhar|Rasco, Drew W|Smith, Lon S|Gunn, Shelly|Smetzer, Leslie|Mays, Theresa A|Kaiser, Brianne|Wick, Michael J|Alvarez, Cathy|Cavazos, Aracely|Mangold, Gina L|Patnaik, Amita
PMID: 22261800
Journal: Exp Cell Res. 2012 Mar 10;318(5):550-7.
Title: Dab2 is pivotal for endothelial cell migration by mediating VEGF expression in cancer cells.
Author: Cheong, Seong-Moon|Choi, Hyemin|Hong, Bok Sil|Gho, Yong Song|Han, Jin-Kwan
PMID: 22265793
Journal: Biochem Pharmacol. 2012 Apr 1;83(7):849-57.
Title: Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells.
Author: Park, Jung-Jin|Yi, Jae Youn|Jin, Yeung Bae|Lee, Yoon-Jin|Lee, Jae-Seon|Lee, Yun-Sil|Ko, Young-Gyu|Lee, Minyoung
PMID: 22266356
Journal: BMC Gastroenterol. 2012 Jan 23;12:9.
Title: Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells.
Author: Lim, Do Young|Cho, Han Jin|Kim, Jongdai|Nho, Chu Won|Lee, Ki Won|Park, Jung Han Yoon
PMID: 22269172
Journal: PLoS One. 2012;7(1):e29532.
Title: A new model for raf kinase inhibitory protein induced chemotherapeutic resistance.
Author: Al-Mulla, Fahd|Bitar, Milad S|Feng, Jingwei|Park, Sungdae|Yeung, Kam C
PMID: 22279539
Journal: Cancer Res. 2012 Feb 1;72(3):626-35.
Title: Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.
Author: Duhamel, Stephanie|Hebert, Josee|Gaboury, Louis|Bouchard, Amelie|Simon, Ronald|Sauter, Guido|Basik, Mark|Meloche, Sylvain
PMID: 22298595
Journal: Br J Pharmacol. 2012 Jul;166(5):1724-37.
Title: The omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of PGE2-dependent cell motility.
Author: Hawcroft, G|Volpato, M|Marston, G|Ingram, N|Perry, S L|Cockbain, A J|Race, A D|Munarini, A|Belluzzi, A|Loadman, P M|Coletta, P L|Hull, M A
PMID: 22300262
Journal: Oncol Rep. 2012 May;27(5):1527-34.
Title: NF-kappaB activity is downregulated by KRAS knockdown in SW620 cells via the RAS-ERK-IkappaBalpha pathway.
Author: Lin, Gen|Tang, Zhiwei|Ye, Yun-Bin|Chen, Qiang
PMID: 22327383
Journal: World J Surg Oncol. 2012 Feb 29;10:47.
Title: ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics.
Author: Levidou, Georgia|Saetta, Angelica A|Gigelou, Fanie|Karlou, Maria|Papanastasiou, Polyanthi|Stamatelli, Angeliki|Kavantzas, Nikolaos|Michalopoulos, Nikolaos V|Agrogiannis, George|Patsouris, Efstratios|Korkolopoulou, Penelope
PMID: 22376079
Journal: J Cell Physiol. 2012 Nov;227(11):3648-60.
Title: p38alpha MAPK mediates 17beta-estradiol inhibition of MMP-2 and -9 expression and cell migration in human lovo colon cancer cells.
Author: Hsu, Hsi-Hsien|Liu, Chung-Jung|Shen, Chia-Yao|Chen, Yi-Jyun|Chen, Li-Mien|Kuo, Wu-Hsien|Lin, Yueh-Min|Chen, Ray-Jade|Tsai, Chang-Hai|Tsai, Fuu-Jen|Huang, Chih-Yang
PMID: 22377968
Journal: Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1223-30.
Title: Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines.
Author: Duerr, Eva-Maria|Mizukami, Yusuke|Moriichi, Kentaro|Gala, Manish|Jo, Won-Seok|Kikuchi, Hirotoshi|Xavier, Ramnik J|Chung, Daniel C
PMID: 22383492
Journal: J Agric Food Chem. 2012 Apr 4;60(13):3441-51.
Title: Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice.
Author: Chiou, Yi-Shiou|Ma, Nianhan Jia-Lin|Sang, Shengmin|Ho, Chi-Tang|Wang, Ying-Jan|Pan, Min-Hsiung
PMID: 22409325
Journal: Chem Biol Interact. 2012 Apr 15;197(1):1-7.
Title: Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC delta-independent mechanism.
Author: Lim, Jun Hee|Woo, Seon Min|Min, Kyoung-Jin|Park, Eun Jung|Jang, Ji Hoon|Seo, Bo Ram|Iqbal, Taha|Lee, Tae-Jin|Kim, Sang Hyun|Choi, Yung Hyun|Kwon, Taeg Kyu
PMID: 22410117
Journal: Clin Exp Metastasis. 2012 Jun;29(5):471-92.
Title: Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways.
Author: Babykutty, Suboj|Suboj, Priya|Srinivas, Priya|Nair, Asha S|Chandramohan, K|Gopala, Srinivas
PMID: 22419013
Journal: Cancer Discov. 2012 Mar;2(3):227-35.
Title: EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib.
Author: Corcoran, Ryan B|Ebi, Hiromichi|Turke, Alexa B|Coffee, Erin M|Nishino, Michiya|Cogdill, Alexandria P|Brown, Ronald D|Della Pelle, Patricia|Dias-Santagata, Dora|Hung, Kenneth E|Flaherty, Keith T|Piris, Adriano|Wargo, Jennifer A|Settleman, Jeffrey|Mino-Kenu
PMID: 22448344
Journal: Phytomedicine. 2012 Jun 15;19(8-9):756-62.
Title: Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21.
Author: Liu, Juanjuan|Shen, Min|Yue, Zhenggang|Yang, Zhifu|Wang, Meng|Li, Chen|Xin, Chunyan|Wang, Yukun|Mei, Qibing|Wang, Zhipeng
PMID: 22464014
Journal: Crit Rev Oncog. 2012;17(1):97-121.
Title: Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside.
Author: Roring, Michael|Brummer, Tilman
PMID: 22471666
Journal: Biol Chem. 2012 Apr;393(5):413-20.
Title: Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.
Author: Chung, Hyunjae|Hamza, Magda|Oikonomopoulou, Katerina|Gratio, Valerie|Saifeddine, Mahmoud|Virca, G Duke|Diamandis, Eleftherios P|Hollenberg, Morley D|Darmoul, Dalila
PMID: 22505523
Journal: J Cell Biochem. 2012 Sep;113(9):2937-47.
Title: Inhibition of butyrate uptake by the primary bile salt chenodeoxycholic acid in intestinal epithelial cells.
Author: Goncalves, Pedro|Catarino, Telmo|Gregorio, Ines|Martel, Fatima
PMID: 22552910
Journal: Cancer Lett. 2012 Nov 1;324(1):98-108.
Title: Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models.
Author: Chiacchiera, Fulvio|Grossi, Valentina|Cappellari, Marianna|Peserico, Alessia|Simonatto, Marta|Germani, Aldo|Russo, Silvana|Moyer, Mary P|Resta, Nicoletta|Murzilli, Stefania|Simone, Cristiano
PMID: 22579651
Journal: Biochem Pharmacol. 2012 Aug 1;84(3):320-30.
Title: MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I insulin-like growth factor receptor.
Author: Shen, Ke|Liang, Qiannan|Xu, Ke|Cui, Daling|Jiang, Lin|Yin, Peihao|Lu, Yanhua|Li, Qi|Liu, Jianwen
PMID: 22580051
Journal: Int J Oncol. 2012 Aug;41(2):583-8.
Title: Differential response to EGFR- and VEGF-targeted therapies in patient-derived tumor tissue xenograft models of colon carcinoma and related metastases.
Author: Jin, Ketao|Lan, Huanrong|Cao, Feilin|Han, Na|Xu, Zhenzhen|Li, Guangliang|He, Kuifeng|Teng, Lisong
PMID: 22581265
Journal: Lab Invest. 2012 Aug;92(8):1203-12.
Title: Intestinal epithelial cell-specific CD98 expression regulates tumorigenesis in Apc(Min/+) mice.
Author: Nguyen, Hang Thi Thu|Dalmasso, Guillaume|Yan, Yutao|Laroui, Hamed|Charania, Moiz|Ingersoll, Sarah|Ayyadurai, Saravanan|Zhang, Yuchen|Sitaraman, Shanthi|Merlin, Didier
PMID: 22641098
Journal: Gastroenterology. 2012 Sep;143(3):730-740.
Title: A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans.
Author: Bongers, Gerold|Muniz, Luciana R|Pacer, Michelle E|Iuga, Alina C|Thirunarayanan, Nanthakumar|Slinger, Erik|Smit, Martine J|Reddy, E Premkumar|Mayer, Lloyd|Furtado, Glaucia C|Harpaz, Noam|Lira, Sergio A
PMID: 22643351
Journal: J Mol Med (Berl). 2012 Dec;90(12):1421-38.
Title: Specific alterations of the microRNA transcriptome and global network structure in colorectal cancer after treatment with MAPK/ERK inhibitors.
Author: Ragusa, Marco|Statello, Luisa|Maugeri, Marco|Majorana, Alessandra|Barbagallo, Davide|Salito, Loredana|Sammito, Mariangela|Santonocito, Manuela|Angelica, Rosario|Cavallaro, Andrea|Scalia, Marina|Caltabiano, Rosario|Privitera, Giuseppe|Biondi, Antonio|Di Vi
PMID: 22660396
Journal: Int J Colorectal Dis. 2012 Dec;27(12):1569-78.
Title: Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways.
Author: Liu, Shi-Quan|Huang, Jie-An|Qin, Meng-Bin|Su, Ying-Jie|Lai, Ming-Yu|Jiang, Hai-Xing|Tang, Guo-Du
PMID: 22684547
Journal: Oncol Rep. 2012 Sep;28(3):931-6.
Title: Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas.
Author: Nomura, Miyuki|Shiiba, Ken-Ichi|Katagiri, Chiaki|Kasugai, Isao|Masuda, Kouhei|Sato, Ikuro|Sato, Masayuki|Kakugawa, Yoichiro|Nomura, Eiki|Hayashi, Katsuhisa|Nakamura, Yoshihiro|Nagata, Toshiyuki|Otsuka, Tsunayuki|Katakura, Ryuichi|Yamashita, Yoji|Sato, Mas
PMID: 22711061
Journal: Chembiochem. 2012 Jul 23;13(11):1663-72.
Title: DYZ-2-90, a novel neo-tanshinlactone ring-opened compound, induces ERK-mediated mitotic arrest and subsequent apoptosis by activating JNK in human colorectal cancer cells.
Author: Wang, Li-Ting|Pan, Shiow-Lin|Chen, Tzu-Hsuan|Dong, Yizhou|Lee, Kuo-Hsiung|Teng, Che-Ming
PMID: 22761044
Journal: Glia. 2012 Oct;60(10):1567-78.
Title: The axon guidance molecule Netrin-4 is expressed by Muller cells and contributes to angiogenesis in the retina.
Author: Lange, Johannes|Yafai, Yousef|Noack, Andre|Yang, Xiu Mei|Munk, Anne-Britta|Krohn, Sandra|Iandiev, Ianors|Wiedemann, Peter|Reichenbach, Andreas|Eichler, Wolfram
PMID: 22777897
Journal: Biol Pharm Bull. 2012;35(7):1054-63.
Title: (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a cembrenolide diterpene from soft coral Lobophytum sp., inhibits growth and induces apoptosis in human colon cancer cells through reactive oxygen species generation.
Author: Hong, Ji-Young|Boo, Hye-Jin|Kang, Jung-Il|Kim, Min-Kyoung|Yoo, Eun-Sook|Hyun, Jin-Won|Koh, Young-Sang|Kim, Gi Young|Maeng, Young Hee|Hyun, Chang Lim|Chang, Weon Young|Kim, Young Ho|Kim, Young Ree|Kang, Hee-Kyoung
PMID: 22791152
Journal: J Cancer Res Clin Oncol. 2012 Dec;138(12):2051-60.
Title: Cyclin D1 degradation and p21 induction contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate.
Author: Zhang, Xiaobo|Min, Kyung-Won|Wimalasena, Jay|Baek, Seung Joon
PMID: 22814742
Journal: BMC Complement Altern Med. 2012 Jul 20;12:104.
Title: In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract.
Author: Aisha, Abdalrahim F A|Abu-Salah, Khalid M|Ismail, Zhari|Majid, Amin Malik Shah Abdul
PMID: 22818000
Journal: J Cell Biol. 2012 Jul 23;198(2):185-94.
Title: K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc.
Author: Magudia, Kirti|Lahoz, Aurelia|Hall, Alan
PMID: 22826122
Journal: Carcinogenesis. 2012 Nov;33(11):2228-35.
Title: PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers.
Author: Wang, Xiao|Li, Xuebing|Fan, Fengjuan|Jiao, Shi|Wang, Lingdi|Zhu, Lu|Pan, Yi|Wu, Guohao|Ling, Zhi-Qiang|Fang, Jing|Chen, Yan
PMID: 22828136
Journal: Int J Mol Med. 2012 Oct;30(4):734-8.
Title: Induction of apoptosis by laminarin, regulating the insulin-like growth factor-IR signaling pathways in HT-29 human colon cells.
Author: Park, Hee-Kyoung|Kim, In-Hye|Kim, Joongkyun|Nam, Taek-Jeong
PMID: 22859258
Journal: Pol J Pathol. 2012 Jun;63(2):93-100.
Title: Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer.
Author: Tai, Cheng-Jeng|Chang, Chun-Chao|Jiang, Ming-Chung|Yeh, Chung-Min|Su, Tzu-Cheng|Wu, Pei-Ru|Chen, Chih-Jung|Yeh, Kun-Tu|Lin, Shu-Hui|Chen, Hung-Chang
PMID: 22864777
Journal: Cancer Gene Ther. 2012 Oct;19(10):715-22.
Title: Effect of silencing PARG in human colon carcinoma LoVo cells on the ability of HUVEC migration and proliferation.
Author: Pan, J|Fauzee, N J S|Wang, Y-l|Sheng, Y-T|Tang, Y|Wang, J-Q|Wu, W-q|Yan, J-x|Xu, J
PMID: 22918473
Journal: Carcinogenesis. 2012 Dec;33(12):2398-408.
Title: MAP kinase genes and colon and rectal cancer.
Author: Slattery, Martha L|Lundgreen, Abbie|Wolff, Roger K
PMID: 23027623
Journal: Oncol Res. 2012;20(1):15-24.
Title: TLR4 signaling promotes immune escape of human colon cancer cells by inducing immunosuppressive cytokines and apoptosis resistance.
Author: Tang, Xiaoyan|Zhu, Youqing
PMID: 23035361
Journal: PLoS One. 2012;7(10):e48461.
Title: Src-mediated cross-talk between farnesoid X and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis.
Author: Peng, Zhongsheng|Raufman, Jean-Pierre|Xie, Guofeng
PMID: 23119029
Journal: Life Sci. 2012 Dec 17;91(25-26):1336-44.
Title: Phenethyl caffeate benzo[kl]xanthene lignan with DNA interacting properties induces DNA damage and apoptosis in colon cancer cells.
Author: Vijayakurup, Vinod|Carmela, Spatafora|Carmelo, Daquino|Corrado, Tringali|Srinivas, Priya|Gopala, Srinivas
PMID: 23123449
Journal: Vasc Cell. 2012 Nov 17;4(1):18.
Title: Regulation of endothelial permeability and transendothelial migration of cancer cells by tropomyosin-1 phosphorylation.
Author: Simoneau, Bryan|Houle, Francois|Huot, Jacques
PMID: 23157718
Journal: Asian Pac J Cancer Prev. 2012;13(9):4751-6.
Title: Combined EGFR and c-Src antisense oligodeoxynucleotides encapsulated with PAMAM Denderimers inhibit HT-29 colon cancer cell proliferation.
Author: Nourazarian, Ali Reza|Najar, Ahmad Gholamhoseinian|Farajnia, Safar|Khosroushahi, Ahmad Yari|Pashaei-Asl, Roghiyeh|Omidi, Yadollah
PMID: 23167414
Journal: BMC Cancer. 2012 Dec 21;12:612.
Title: Alternative dosing of dual PI3K and MEK inhibition in cancer therapy.
Author: Jokinen, Elina|Laurila, Niina|Koivunen, Jussi P
PMID: 23259591
Journal: PLoS One. 2012;7(12):e52869.
Title: Butyrate produced by commensal bacteria potentiates phorbol esters induced AP-1 response in human intestinal epithelial cells.
Author: Nepelska, Malgorzata|Cultrone, Antonietta|Beguet-Crespel, Fabienne|Le Roux, Karine|Dore, Joel|Arulampalam, Vermulugesan|Blottiere, Herve M
PMID: 23300800
Journal: Anal Quant Cytopathol Histpathol. 2012 Dec;34(6):309-16.
Title: Quantitative analysis of ERK signaling inhibition in colon cancer cell lines using phospho-specific flow cytometry.
Author: Lim, Sun Min|Hwang, Jee Won|Bae, Soo Kyung|Bae, Soo Hyeon|Ahn, Joong Bae|Rha, Sun Young|Roh, Jae Kyung|Chung, Hyun Cheol|Shin, Sang Joon
PMID: 23304816
Journal: Front Endocrinol (Lausanne). 2013 Jan 17;3:184.
Title: Neurotensin and its high affinity receptor 1 as a potential pharmacological target in cancer therapy.
Author: Wu, Zherui|Martinez-Fong, Daniel|Tredaniel, Jean|Forgez, Patricia
PMID: 23335914
Journal: World J Nucl Med. 2012 May;11(2):65-9.
Title: (18)F-FLT-PET for Response Evaluation of MEK Inhibitor Selumetinib (AZD6244, ARRY-142886) in Patients with Solid Tumors.
Author: Desar, Ingrid M E|Gilles, Rozemarie|van Herpen, Carla M L|Timmer-Bonte, Anja J N H|Cantarini, Mireille V|van der Graaf, Winette T A|Oyen, Wim J G
PMID: 23372439
Journal: Yao Xue Xue Bao. 2012 Dec;47(12):1567-74.
Title: [Progress of anti-tumor study based on BRAF].
Author: Yan, Gui-Rui|Xu, Zhi-Jian|Wang, He-Yao|Zhu, Wei-Liang
PMID: 23460959
Journal: Environ Toxicol. 2013 Sep;28(9):479-88.
Title: Diallyl sulfide, diallyl disulfide, and diallyl trisulfide inhibit migration and invasion in human colon cancer colo 205 cells through the inhibition of matrix metalloproteinase-2, -7, and -9 expressions.
Author: Lai, Kuang-Chi|Hsu, Shu-Chun|Kuo, Chao-Lin|Yang, Jai-Sing|Ma, Chia-Yu|Lu, Hsu-Feng|Tang, Nou-Ying|Hsia, Te-Chun|Ho, Heng-Chien|Chung, Jing-Gung
PMID: 21695758
Journal: Nanotoxicology. 2013 May;7(3):274-93.
Title: In vitro toxicity of amorphous silica nanoparticles in human colon carcinoma cells.
Author: Gehrke, Helge|Fruhmesser, Anne|Pelka, Joanna|Esselen, Melanie|Hecht, Lena L|Blank, Holger|Schuchmann, Heike P|Gerthsen, Dagmar|Marquardt, Clarissa|Diabate, Silvia|Weiss, Carsten|Marko, Doris
PMID: 22264143
Journal: Oncogene. 2013 Jan 31;32(5):564-76.
Title: Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition.
Author: Cagnol, S|Rivard, N
PMID: 22430215
Journal: Invest New Drugs. 2013 Feb;31(1):1-13.
Title: Circulating vascular endothelial growth factor receptor 2/pAkt-positive cells as a functional pharmacodynamic marker in metastatic colorectal cancers treated with antiangiogenic agent.
Author: Shin, Sang Joon|Hwang, Jee Won|Ahn, Joong Bae|Rha, Sun Young|Roh, Jae Kyung|Chung, Hyun Cheol
PMID: 22539090
Journal: Gut. 2013 Apr;62(4):540-9.
Title: A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction.
Author: Tian, Sun|Simon, Iris|Moreno, Victor|Roepman, Paul|Tabernero, Josep|Snel, Mireille|van't Veer, Laura|Salazar, Ramon|Bernards, Rene|Capella, Gabriel
PMID: 22798500
Journal: Int J Cancer. 2013 Feb 1;132(3):E149-57.
Title: Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E inhibition.
Author: Mayes, Patrick A|Degenhardt, Yan Y|Wood, Andrew|Toporovskya, Yana|Diskin, Sharon J|Haglund, Elizabeth|Moy, Christopher|Wooster, Richard|Maris, John M
PMID: 22948716
Journal: J Nat Med. 2013 Jul;67(3):468-79.
Title: Synergistic anticancer activities of the plant-derived sesquiterpene lactones salograviolide A and iso-seco-tanapartholide.
Author: Salla, Mohamed|Fakhoury, Isabelle|Saliba, Najat|Darwiche, Nadine|Gali-Muhtasib, Hala
PMID: 22976170
Journal: Cancer Lett. 2013 Jan 1;328(1):73-82.
Title: Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1-2 signaling in synergy with EGFR.
Author: Benelli, Roberto|Vene, Roberta|Minghelli, Simona|Carlone, Sebastiano|Gatteschi, Beatrice|Ferrari, Nicoletta
PMID: 23010081
Journal: Cancer Lett. 2013 Jan 28;328(2):325-34.
Title: The beta6-integrin-ERK/MAP kinase pathway contributes to chemo resistance in colon cancer.
Author: Liu, Song|Wang, Jian|Niu, Weibo|Liu, Enyu|Wang, Jiayong|Peng, Cheng|Lin, Pengfei|Wang, Ben|Khan, Abdul Qadir|Gao, Huijie|Liang, Benjia|Shahbaz, Muhammad|Niu, Jun
PMID: 23073477
Journal: Oncogene. 2013 Sep 12;32(37):4343-54.
Title: Mesenchymal stem cells promote growth and angiogenesis of tumors in mice.
Author: Huang, W-H|Chang, M-C|Tsai, K-S|Hung, M-C|Chen, H-L|Hung, S-C
PMID: 23085755
Journal: Int J Biochem Cell Biol. 2013 Feb;45(2):243-54.
Title: EZH2 is regulated by ERK/AKT and targets integrin alpha2 gene to control Epithelial-Mesenchymal Transition and anoikis in colon cancer cells.
Author: Ferraro, Angelo|Mourtzoukou, Despoina|Kosmidou, Vivian|Avlonitis, Spiros|Kontogeorgos, George|Zografos, George|Pintzas, Alexander
PMID: 23116973
Journal: Oncol Rep. 2013 Feb;29(2):535-40.
Title: Critical role of aquaporin-3 in epidermal growth factor-induced migration of colorectal carcinoma cells and its clinical significance.
Author: Li, Ang|Lu, Dehong|Zhang, Yupeng|Li, Jia|Fang, Yu|Li, Fei|Sun, Jiabang
PMID: 23165320
Journal: Ann Diagn Pathol. 2013 Apr;17(2):165-71.
Title: High nuclear expression of phosphorylated extracellular signal-regulated kinase in tumor cells in colorectal glands is associated with poor outcome in colorectal cancer.
Author: Tai, Cheng-Jeng|Lee, Ching-Hsiao|Chen, Hung-Chang|Wang, Hsin-Kai|Jiang, Ming-Chung|Su, Tzu-Cheng|Shen, Ko-Hung|Lin, Shu-Hui|Yeh, Chung-Min|Chen, Chih-Jung|Yeh, Kun-Tu|Chang, Chun-Chao
PMID: 23183114
Journal: J Biol Chem. 2013 Jan 25;288(4):2403-13.
Title: Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.
Author: Vartanian, Steffan|Bentley, Carolyn|Brauer, Matthew J|Li, Li|Shirasawa, Senji|Sasazuki, Takehiko|Kim, Jung-Sik|Haverty, Pete|Stawiski, Eric|Modrusan, Zora|Waldman, Todd|Stokoe, David
PMID: 23188824
Journal: Cancer Lett. 2013 Apr 28;330(2):225-32.
Title: Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC alpha/betaII by Gymnasterkoreayne B.
Author: Lee, Kyung-Mi|Kang, Kyungsu|Lee, Saet Byoul|Nho, Chu Won
PMID: 23219897
Journal: Int J Oncol. 2013 Feb;42(2):556-64.
Title: Extracellular signal-regulated kinase and Akt activation play a critical role in the process of hepatocyte growth factor-induced epithelial-mesenchymal transition.
Author: Tanahashi, Toshiyuki|Osada, Shinji|Yamada, Atsuko|Kato, Junko|Yawata, Kazunori|Mori, Ryutaro|Imai, Hisashi|Sasaki, Yoshiyuki|Saito, Shiro|Tanaka, Yoshihiro|Nonaka, Kenichi|Yoshida, Kazuhiro
PMID: 23229794
Journal: Mol Cancer Res. 2013 Feb;11(2):109-21.
Title: Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling.
Author: Tabusa, Hana|Brooks, Teresa|Massey, Andrew J
PMID: 23233484
Journal: Biochem J. 2013 Mar 1;450(2):285-94.
Title: The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance.
Author: Sale, Matthew J|Cook, Simon J
PMID: 23234544
Journal: Cancer Res. 2013 Mar 15;73(6):1912-21.
Title: Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis.
Author: Martini, Miriam|Russo, Mariangela|Lamba, Simona|Vitiello, Elisa|Crowley, Emily Hannah|Sassi, Francesco|Romanelli, Davide|Frattini, Milo|Marchetti, Antonio|Bardelli, Alberto
PMID: 23319808
Journal: Hepatology. 2013 Jun;57(6):2299-313.
Title: MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer.
Author: Peng, Hui|Dara, Lily|Li, Tony W H|Zheng, Yuhua|Yang, Heping|Tomasi, Maria Lauda|Tomasi, Ivan|Giordano, Pasquale|Mato, Jose M|Lu, Shelly C
PMID: 23325601
Journal: Food Chem Toxicol. 2013 May;55:424-33.
Title: Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells.
Author: Park, Eun-Jung|Chung, Hwa-Jin|Park, Hyen Joo|Kim, Gi Dae|Ahn, Yong-Hyun|Lee, Sang Kook
PMID: 23333577
Journal: Food Chem Toxicol. 2013 May;55:229-33.
Title: Anti-inflammatory activity of patchouli alcohol in RAW264.7 and HT-29 cells.
Author: Jeong, Jin Boo|Shin, Yong Kyu|Lee, Seong-Ho
PMID: 23348408
Journal: Biochim Biophys Acta. 2013 Jul;1834(7):1396-401.
Title: Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines.
Author: Rose, Honor May|Stuiver, Marchel|Thongwichian, Rossukon|Theillet, Francois-Xavier|Feller, Stephan M|Selenko, Philipp
PMID: 23360766
Journal: Cancer Sci. 2013 May;104(5):604-10.
Title: Norcantharidin inhibits tumor angiogenesis via blocking VEGFR2/MEK/ERK signaling pathways.
Author: Zhang, Long|Ji, Qing|Liu, Xuan|Chen, Xingzhu|Chen, Zhaohua|Qiu, Yanyan|Sun, Jian|Cai, Jianfeng|Zhu, Huirong|Li, Qi
PMID: 23363445
Journal: Cancer Discov. 2013 May;3(5):520-33.
Title: Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas.
Author: Montero-Conde, Cristina|Ruiz-Llorente, Sergio|Dominguez, Jose M|Knauf, Jeffrey A|Viale, Agnes|Sherman, Eric J|Ryder, Mabel|Ghossein, Ronald A|Rosen, Neal|Fagin, James A
PMID: 23365119
Journal: Cancer Res. 2013 Apr 15;73(8):2682-94.
Title: CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer.
Author: Du, Lei|Rao, Guanhua|Wang, Hongyi|Li, Baowei|Tian, Weili|Cui, Jiantao|He, Leya|Laffin, Brian|Tian, Xiuyun|Hao, Chunyi|Liu, Hongmin|Sun, Xin|Zhu, Yushan|Tang, Dean G|Mehrpour, Maryam|Lu, Youyong|Chen, Quan
PMID: 23418321
Journal: Br J Nutr. 2013 Sep 14;110(5):797-809.
Title: Grape seed extract triggers apoptosis in Caco-2 human colon cancer cells through reactive oxygen species and calcium increase: extracellular signal-regulated kinase involvement.
Author: Dinicola, Simona|Mariggio, Maria Addolorata|Morabito, Caterina|Guarnieri, Simone|Cucina, Alessandra|Pasqualato, Alessia|D'Anselmi, Fabrizio|Proietti, Sara|Coluccia, Pierpaolo|Bizzarri, Mariano
PMID: 23433299
Journal: Clin Cancer Res. 2013 Mar 1;19(5):1232-43.
Title: Multicenter phase I trial of the mitogen-activated protein kinase 1/2 inhibitor BAY 86-9766 in patients with advanced cancer.
Author: Weekes, Colin D|Von Hoff, Daniel D|Adjei, Alex A|Leffingwell, Diane P|Eckhardt, S Gail|Gore, Lia|Lewis, Karl D|Weiss, Glen J|Ramanathan, Ramesh K|Dy, Grace K|Ma, Wen W|Sheedy, Beth|Iverson, Cory|Miner, Jeffrey N|Shen, Zancong|Yeh, Li-Tain|Dubowy, Ronald L
PMID: 23434733
Journal: Autophagy. 2013 May;9(5):697-713.
Title: Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries.
Author: Raina, Komal|Agarwal, Chapla|Wadhwa, Ritambhara|Serkova, Natalie J|Agarwal, Rajesh
PMID: 23445752
Journal: J Agric Food Chem. 2013 Mar 20;61(11):2811-9.
Title: P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo.
Author: Chen, Li-Ching|Lee, Wen-Sen
PMID: 23448150
Journal: Mol Cell Biol. 2013 May;33(9):1859-68.
Title: The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics.
Author: Romano, David|Maccario, Helene|Doherty, Carolanne|Quinn, Niall P|Kolch, Walter|Matallanas, David
PMID: 23459937
Journal: BMC Complement Altern Med. 2013 Mar 18;13:65.
Title: A Chinese herbal formula, Yi-Qi-Fu-Sheng, inhibits migration/invasion of colorectal cancer by down-regulating MMP-2/9 via inhibiting the activation of ERK/MAPK signaling pathways.
Author: Deng, Wanli|Sui, Hua|Wang, Qiaolin|He, Nana|Duan, Chunyan|Han, Liang|Li, Qi|Lu, Ming|Lv, Shuqin
PMID: 23506655
Journal: Asian Pac J Cancer Prev. 2013;14(1):495-8.
Title: EGFR antisense oligonucleotides encapsulated with nanoparticles decrease EGFR, MAPK1 and STAT5 expression in a human colon cancer cell line.
Author: Najar, Ahmad Gholamhoseinian|Pashaei-Asl, Roghiyeh|Omidi, Yadollah|Farajnia, Safar|Nourazarian, Ali Reza
PMID: 23534780
Journal: BMC Cancer. 2013 Apr 1;13:169.
Title: High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer.
Author: Guedes, Joana G|Veiga, Isabel|Rocha, Patricia|Pinto, Pedro|Pinto, Carla|Pinheiro, Manuela|Peixoto, Ana|Fragoso, Maria|Raimundo, Ana|Ferreira, Paula|Machado, Manuela|Sousa, Nuno|Lopes, Paula|Araujo, Antonio|Macedo, Joana|Alves, Fernando|Coutinho, Camila|He
PMID: 23548132
Journal: J Clin Invest. 2013 Apr;123(4):1428-43.
Title: Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK.
Author: Neufert, Clemens|Becker, Christoph|Tureci, Ozlem|Waldner, Maximilian J|Backert, Ingo|Floh, Katharina|Atreya, Imke|Leppkes, Moritz|Jefremow, Andre|Vieth, Michael|Schneider-Stock, Regine|Klinger, Patricia|Greten, Florian R|Threadgill, David W|Sahin, Ugur|Ne
PMID: 23549083
Journal: Peptides. 2013 Jun;44:127-34.
Title: Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity.
Author: Beccari, Serena|Kovalszky, Ilona|Wade, John D|Otvos, Laszlo Jr|Surmacz, Eva
PMID: 23567149
Journal: Magy Onkol. 2013 Mar;57(1):56-62.
Title: [Biomarkers in solid tumors].
Author: Nagy, Zsuzsanna
PMID: 23573523
Journal: Evid Based Complement Alternat Med. 2013;2013:974313.
Title: Activation of AMP-Activated Protein Kinase alpha and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells.
Author: Cho, Sung-Yun|Lee, Hyo-Jeong|Lee, Hyo-Jung|Jung, Deok-Beom|Kim, Hyunseok|Sohn, Eun Jung|Kim, Bonglee|Jung, Ji Hoon|Kwon, Byoung-Mog|Kim, Sung-Hoon
PMID: 23589723
Journal: Toxicol In Vitro. 2013 Sep;27(6):1626-33.
Title: Activation of ERK signaling and induction of colon cancer cell death by piperlongumine.
Author: Randhawa, H|Kibble, K|Zeng, H|Moyer, M P|Reindl, K M
PMID: 23603476
Journal: Tumour Biol. 2013 Oct;34(5):2573-81.
Title: TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCalpha and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620.
Author: Hu, Lichao|Xia, Longfei|Zhou, Hong|Wu, Biao|Mu, Yuan|Wu, Ying|Yan, Jinchuan
PMID: 23616010
Journal: Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7.
Title: In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
Author: Shima, Fumi|Yoshikawa, Yoko|Ye, Min|Araki, Mitsugu|Matsumoto, Shigeyuki|Liao, Jingling|Hu, Lizhi|Sugimoto, Takeshi|Ijiri, Yuichi|Takeda, Azusa|Nishiyama, Yuko|Sato, Chie|Muraoka, Shin|Tamura, Atsuo|Osoda, Tsutomu|Tsuda, Ken-ichiro|Miyakawa, Tomoya|Fukunis
PMID: 23630290
Journal: Cancer Prev Res (Phila). 2013 Jul;6(7):625-33.
Title: Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation.
Author: Derry, Molly M|Raina, Komal|Balaiya, Velmurugan|Jain, Anil K|Shrotriya, Sangeeta|Huber, Kendra M|Serkova, Natalie J|Agarwal, Rajesh|Agarwal, Chapla
PMID: 23639480
Journal: Mol Cell Endocrinol. 2013 Jul 15;374(1-2):101-7.
Title: Cholesterol affects gene expression of the Jun family in colon carcinoma cells using different signaling pathways.
Author: Scheinman, Eyal J|Rostoker, Ran|Leroith, Derek
PMID: 23643895
Journal: J Agric Food Chem. 2013 May 22;61(20):4898-904.
Title: Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice.
Author: Kim, Sung Phil|Nam, Seok Hyun|Friedman, Mendel
PMID: 23668749
Journal: Int J Oncol. 2013 Jul;43(1):141-50.
Title: Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells.
Author: Chen, Hui-Jye|Jiang, Yi-Lin|Lin, Chung-Ming|Tsai, Shih-Chang|Peng, Shu-Fen|Fushiya, Shinji|Hour, Mann-Jen|Yang, Jai-Sing
PMID: 23677180
Journal: J Cell Biochem. 2013 Oct;114(10):2392-404.
Title: Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer.
Author: Callero, Mariana A|Luzzani, Gabriela A|De Dios, Diana O|Bradshaw, Tracey D|Perez, Andrea I Loaiza
PMID: 23696052
Journal: PLoS One. 2013 May 30;8(5):e63872.
Title: Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells.
Author: Wang, Jingshu|Liu, Liqun|Qiu, Huijuan|Zhang, Xiaohong|Guo, Wei|Chen, Wangbing|Tian, Yun|Fu, Lingyi|Shi, Dingbo|Cheng, Jianding|Huang, Wenlin|Deng, Wuguo
PMID: 23737956
Journal: Biochem Biophys Res Commun. 2013 Jun 28;436(2):325-30.
Title: Synergistic induction of cancer cell death and reduction of clonogenic resistance by cisplatin and FK228.
Author: Choudhary, Shambhunath|Sood, Shilpa|Wang, Hwa-Chain Robert
PMID: 23743194
Journal: Anticancer Res. 2013 Jun;33(6):2499-508.
Title: Combination of CYP inhibitor with MEK/ERK inhibitor enhances the inhibitory effect on ERK in BRAF mutant colon cancer cells.
Author: Lim, Sun Min|Hwang, Jee Won|Ahn, Joong Bae|Bae, Soo Kyung|Park, Chan Hee|Kim, Ki-Yeol|Rha, Sun Young|Chung, Hyun Cheol|Roh, Jae Kyung|Shin, Sang Joon
PMID: 23749901
Journal: Int J Oncol. 2013 Aug;43(2):629-37.
Title: Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling.
Author: Chen, Hui-Jye|Lin, Chung-Ming|Lee, Chao-Ying|Shih, Nai-Chen|Amagaya, Sakae|Lin, Yung-Chang|Yang, Jai-Sing
PMID: 23754208
Journal: PLoS One. 2013 Jun 3;8(6):e66439.
Title: Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells.
Author: Jin, Qunyan|Liu, Guangming|Domeier, Phillip P|Ding, Wei|Mulder, Kathleen M
PMID: 23755307
Journal: J Natl Cancer Inst. 2013 Jul 3;105(13):937-46.
Title: MyD88 in DNA repair and cancer cell resistance to genotoxic drugs.
Author: Kfoury, Alain|Le Corf, Katy|El Sabeh, Rana|Journeaux, Alexandra|Badran, Bassam|Hussein, Nader|Lebecque, Serge|Manie, Serge|Renno, Toufic|Coste, Isabelle
PMID: 23766530
Journal: Acta Biochim Biophys Sin (Shanghai). 2013 Sep;45(9):773-9.
Title: Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells.
Author: Hua, Hanju|Chen, Wenbin|Shen, Ling|Sheng, Qinsong|Teng, Lisong
PMID: 23786838
Journal: Cytotechnology. 2013 Dec;65(6):927-36.
Title: Anticancer effect of Tamarix gallica extracts on human colon cancer cells involves Erk1/2 and p38 action on G2/M cell cycle arrest.
Author: Boulaaba, Mondher|Tsolmon, Soninkhishig|Ksouri, Riadh|Han, Junkyu|Kawada, Kiyokazu|Smaoui, Abderrazak|Abdelly, Chedly|Isoda, Hiroko
PMID: 23801270
Journal: Carcinogenesis. 2013 Dec;34(12):2861-9.
Title: GPR48, a poor prognostic factor, promotes tumor metastasis and activates beta-catenin/TCF signaling in colorectal cancer.
Author: Wu, Jinhua|Xie, Na|Xie, Ke|Zeng, Jun|Cheng, Lin|Lei, Yunlong|Liu, Yuan|Song, Linhong|Dong, Dandan|Chen, Yi|Zeng, Rui|Nice, Edouard C|Huang, Canhua|Wei, Yuquan
PMID: 23803691
Journal: Stem Cell Res. 2013 Sep;11(2):820-33.
Title: Fibronectin extra domain A (EDA) sustains CD133(+)/CD44(+) subpopulation of colorectal cancer cells.
Author: Ou, Juanjuan|Deng, Jia|Wei, Xing|Xie, Ganfeng|Zhou, Rongbin|Yu, Liqing|Liang, Houjie
PMID: 23811539
Journal: BMC Cancer. 2013 Jul 1;13:321.
Title: Overexpression of peptide deformylase in breast, colon, and lung cancers.
Author: Randhawa, Harsharan|Chikara, Shireen|Gehring, Drew|Yildirim, Tuba|Menon, Jyotsana|Reindl, Katie M
PMID: 23815882
Journal: PLoS One. 2013 Jul 3;8(7):e67583.
Title: Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions.
Author: King, Alastair J|Arnone, Marc R|Bleam, Maureen R|Moss, Katherine G|Yang, Jingsong|Fedorowicz, Kelly E|Smitheman, Kimberly N|Erhardt, Joseph A|Hughes-Earle, Angela|Kane-Carson, Laurie S|Sinnamon, Robert H|Qi, Hongwei|Rheault, Tara R|Uehling, David E|Laquer
PMID: 23844038
Journal: Nutr Cancer. 2013;65(5):729-38.
Title: Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer.
Author: Slattery, Martha L|Lundgreen, Abbie|Wolff, Roger K
PMID: 23859041
Journal: Mol Cell Biochem. 2013 Nov;383(1-2):179-89.
Title: APRIL depletion induces cell cycle arrest and apoptosis through blocking TGF-beta1/ERK signaling pathway in human colorectal cancer cells.
Author: Wang, Feng|Chen, Lin|Ni, Hongbin|Wang, Guihua|Ding, Weifeng|Cong, Hui|Ju, Shaoqing|Yang, Shumei|Wang, Huimin
PMID: 23867993
Journal: Clin Cancer Res. 2013 Sep 15;19(18):4961-71.
Title: Protein kinase C-delta-mediated recycling of active KIT in colon cancer.
Author: Park, Misun|Kim, Won Kyu|Song, Meiying|Park, Minhee|Kim, Hyunki|Nam, Hye Jin|Baek, Sung Hee|Kim, Hoguen
PMID: 23881925
Journal: Int J Oncol. 2013 Oct;43(4):1235-43.
Title: Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways.
Author: Lin, Jiumao|Chen, Youqin|Wei, Lihui|Shen, Aling|Sferra, Thomas J|Hong, Zhenfeng|Peng, Jun
PMID: 23900560
Journal: Int J Oncol. 2013 Oct;43(4):1111-6.
Title: Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation.
Author: Malilas, Waraporn|Koh, Sang Seok|Kim, Seokho|Srisuttee, Ratakorn|Cho, Il-Rae|Moon, Jeong|Yoo, Hwa-Seung|Oh, Sangtaek|Johnston, Randal N|Chung, Young-Hwa
PMID: 23917355
Journal: Mol Med Rep. 2013 Oct;8(4):973-8.
Title: High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/cJun pathway.
Author: Zhang, Peipei|Suidasari, Sofya|Hasegawa, Tomomi|Yanaka, Noriyuki|Kato, Norihisa
PMID: 23942851
Journal: Cell Commun Signal. 2013 Aug 15;11:59.
Title: Activation state-dependent interaction between Galphaq subunits and the Fhit tumor suppressor.
Author: Zuo, Hao|Chan, Grace P W|Zhu, Jing|Yeung, Wendy W S|Chan, Anthony S L|Ammer, Hermann|Wong, Yung H
PMID: 23947369
Journal: J Nutr Biochem. 2013 Nov;24(11):1849-58.
Title: Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells.
Author: Kumazaki, Minami|Noguchi, Shunsuke|Yasui, Yuki|Iwasaki, Junya|Shinohara, Haruka|Yamada, Nami|Akao, Yukihiro
PMID: 23954321
Journal: Cancer Chemother Pharmacol. 2013 Oct;72(4):767-75.
Title: Effects of pemetrexed, gefitinib, and their combination on human colorectal cancer cells.
Author: Zhang, Guanzhong|Xie, Xiaodong|Liu, Tianyi|Yang, Jihua|Jiao, Shunchang
PMID: 23959460
Journal: Mol Cancer Ther. 2013 Oct;12(10):2121-34.
Title: Sorafenib overcomes irinotecan resistance in colorectal cancer by inhibiting the ABCG2 drug-efflux pump.
Author: Mazard, Thibault|Causse, Annick|Simony, Joelle|Leconet, Wilhem|Vezzio-Vie, Nadia|Torro, Adeline|Jarlier, Marta|Evrard, Alexandre|Del Rio, Maguy|Assenat, Eric|Martineau, Pierre|Ychou, Marc|Robert, Bruno|Gongora, Celine
PMID: 23960095
Journal: Eur J Cancer. 2013 Dec;49(18):3924-35.
Title: miR-133a represses tumour growth and metastasis in colorectal cancer by targeting LIM and SH3 protein 1 and inhibiting the MAPK pathway.
Author: Wang, Hui|An, Hongying|Wang, Bin|Liao, Qing|Li, Weidong|Jin, Xuejun|Cui, Shuzhong|Zhang, Yajie|Ding, Yanqing|Zhao, Liang
PMID: 23968734
Journal: Chem Pharm Bull (Tokyo). 2013;61(11):1149-55. Epub 2013 Aug 27.
Title: Synthesis and evaluation of curcumin-related compounds containing benzyl piperidone for their effects on human cancer cells.
Author: Zhou, Dai-Ying|Zhang, Kun|Conney, Allan H|Ding, Ning|Cui, Xiao-Xing|Wang, Hui|Verano, Michael|Zhao, Su-Qing|Fan, Yan-Xiong|Zheng, Xi|Du, Zhi-Yun
PMID: 23985704
Journal: Cancer Biol Ther. 2013 Nov;14(11):1007-15.
Title: Mitogen-activated protein kinase phosphatase-1 inhibition and sustained extracellular signal-regulated kinase 1/2 activation in camptothecin-induced human colon cancer cell death.
Author: Lee, Minyoung|Young Kim, Sun|Kim, Jongguk|Kim, Hak-Su|Kim, Sang-Man|Kim, Eun Ju
PMID: 24005240
Journal: Cancer Biol Ther. 2013 Nov;14(11):1059-67.
Title: Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer.
Author: Ai, Xi|Wu, Yanhui|Zhang, Wei|Zhang, Zhanguo|Jin, Guannan|Zhao, Jianping|Yu, Jingjing|Lin, Youzhi|Zhang, Wanguang|Liang, Huifang|Datta, Pran K|Zhang, Mingzhi|Zhang, Bixiang|Chen, Xiaoping
PMID: 24025354
Journal: Cell Death Dis. 2013 Sep 12;4:e801.
Title: Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737.
Author: Maamer-Azzabi, A|Ndozangue-Touriguine, O|Breard, J
PMID: 24030153
Journal: Toxicol In Vitro. 2013 Dec;27(8):2256-63.
Title: Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs.
Author: Dinicola, Simona|Morini, Veronica|Coluccia, Pierpaolo|Proietti, Sara|D'Anselmi, Fabrizio|Pasqualato, Alessia|Masiello, Maria Grazia|Palombo, Alessandro|De Toma, Giorgio|Bizzarri, Mariano|Cucina, Alessandra
PMID: 24095863
Journal: J Clin Endocrinol Metab. 2013 Dec;98(12):E1909-17.
Title: Shikonin inhibits thyroid cancer cell growth and invasiveness through targeting major signaling pathways.
Author: Yang, Qi|Ji, Meiju|Guan, Haixia|Shi, Bingyin|Hou, Peng
PMID: 24106286
Journal: Mol Cancer Ther. 2013 Dec;12(12):2640-50.
Title: Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263.
Author: Shao, Huanjie|Jing, Kai|Mahmoud, Esraa|Huang, Haihong|Fang, Xianjun|Yu, Chunrong
PMID: 24126433
Journal: J Agric Food Chem. 2013 Nov 13;61(45):10730-40.
Title: Coumarins and lignans from Zanthoxylum schinifolium and their anticancer activities.
Author: Li, Wei|Sun, Ya Nan|Yan, Xi Tao|Yang, Seo Young|Kim, Eun-Ji|Kang, Hee Kyoung|Kim, Young Ho
PMID: 24144361
Journal: Evid Based Complement Alternat Med. 2013;2013:458075.
Title: A Type II Arabinogalactan from Anoectochilus formosanus for G-CSF Production in Macrophages and Leukopenia Improvement in CT26-Bearing Mice Treated with 5-Fluorouracil.
Author: Yang, Li-Chan|Lu, Ting-Jang|Lin, Wen-Chuan
PMID: 24191166
Journal: BMC Cancer. 2013 Nov 8;13:531.
Title: Activation of pro-oncogenic pathways in colorectal hyperplastic polyps.
Author: Do, Catherine|Bertrand, Claudine|Palasse, Julien|Delisle, Marie-Bernadette|Cohen-Jonathan-Moyal, Elizabeth|Seva, Catherine
PMID: 24209454
Journal: Anticancer Res. 2013 Nov;33(11):4855-65.
Title: Differential expression and prognostic role of selected genes in colorectal cancer patients.
Author: Pitule, Pavel|Vycital, Ondrej|Bruha, Jan|Novak, Petr|Hosek, Petr|Treska, Vladislav|Hlavata, Ivona|Soucek, Pavel|Kralickova, Milena|Liska, Vaclav
PMID: 24222123
Journal: Acta Pharmacol Sin. 2013 Dec;34(12):1535-44.
Title: A new bisphosphonate derivative, CP, induces gastric cancer cell apoptosis via activation of the ERK1/2 signaling pathway.
Author: Wang, Hai-jun|Liu, Yu|Fan, Li-qiao|Han, Cai-li|Jiang, Ye|Cheng, Shu-jie|Li, Yong
PMID: 24241351
Journal: PLoS One. 2013 Nov 18;8(11):e79335.
Title: CRF2 signaling is a novel regulator of cellular adhesion and migration in colorectal cancer cells.
Author: Ducarouge, Benjamin|Pelissier-Rota, Marjolaine|Laine, Michele|Cristina, Nadine|Vachez, Yvan|Scoazec, Jean-Yves|Bonaz, Bruno|Jacquier-Sarlin, Muriel
PMID: 24260200
Journal: J Transl Med. 2013 Nov 27;11:295.
Title: Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.
Author: Zins, Karin|Gunawardhana, Sandun|Lucas, Trevor|Abraham, Dietmar|Aharinejad, Seyedhossein
PMID: 24279335
Journal: Front Oncol. 2013 Nov 15;3:281.
Title: Toward a Molecular Classification of Colorectal Cancer: The Role of BRAF.
Author: Thiel, Alexandra|Ristimaki, Ari
PMID: 24298448
Journal: PLoS One. 2013 Nov 27;8(11):e81592.
Title: Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: targeting vascular endothelial growth factor receptor signaling and angiogenesis.
Author: Yang, Hung-Yu|Hsu, Ya-Fen|Chiu, Pei-Ting|Ho, Shiau-Jing|Wang, Chi-Han|Chi, Chih-Chin|Huang, Yu-Han|Lee, Cheng-Feng|Li, Ying-Shiuan|Ou, George|Hsu, Ming-Jen
PMID: 24312323
Journal: Evid Based Complement Alternat Med. 2013;2013:529375.
Title: In Vitro Antiproliferative Effect of Arthrocnemum indicum Extracts on Caco-2 Cancer Cells through Cell Cycle Control and Related Phenol LC-TOF-MS Identification.
Author: Boulaaba, Mondher|Mkadmini, Khaoula|Tsolmon, Soninkhishig|Han, Junkyu|Smaoui, Abderrazak|Kawada, Kiyokazu|Ksouri, Riadh|Isoda, Hiroko|Abdelly, Chedly
PMID: 24348703
Journal: Food Chem Toxicol. 2013 Dec;62:892-900.
Title: Butyrate suppresses proliferation and migration of RKO colon cancer cells though regulating endocan expression by MAPK signaling pathway.
Author: Zuo, Li|Lu, Man|Zhou, Qing|Wei, Wei|Wang, Yuan
PMID: 24416777
Journal: Food Chem Toxicol. 2013 Oct 25. pii: S0278-6915(13)00703-5.
Title: Butyrate suppresses proliferation and migration of RKO colon cancer cells though regulating endocan expression by MAPK signaling pathway.
Author: Zuo, Li|Lu, Man|Zhou, Qing|Wei, Wei|Wang, Yuan
PMID: 24513060
Journal: Enzymes. 2013;33 Pt A:213-48.
Title: A two-hybrid approach to identify inhibitors of the RAS-RAF interaction.
Author: Khazak, Vladimir|Eyrisch, Susanne|Kato, Juran|Tamanoi, Fuyuhiko|Golemis, Erica A
PMID: 25033807
Journal: Enzymes. 2013;34 Pt. B:1-23.
Title: Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras.GTP-effector interaction.
Author: Shima, Fumi|Yoshikawa, Yoko|Matsumoto, Shigeyuki|Kataoka, Tohru
PMID: 25034098
Journal: Mol Carcinog. 2014 Feb;53 Suppl 1:E62-71.
Title: The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK.
Author: Huang, John|Che, Mei-Ieng|Lin, Neng-Yu|Hung, Ji-Shiang|Huang, Yu-Ting|Lin, Wei-Chou|Huang, Hsiu-Chin|Lee, Po-Huang|Liang, Jin-Tung|Huang, Min-Chuan
PMID: 23390052
Journal: Oncogene. 2014 Apr 3;33(14):1828-39.
Title: ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer.
Author: Ye, Q|Cai, W|Zheng, Y|Evers, B M|She, Q-B
PMID: 23624914
Journal: Mol Carcinog. 2014 Feb;53 Suppl 1:E72-84.
Title: The role of ERK2 in colorectal carcinogenesis is partly regulated by TRAPPC4.
Author: Weng, Yu-Rong|Kong, Xuan|Yu, Ya-Nan|Wang, Ying-Chao|Hong, Jie|Zhao, Shu-Liang|Fang, Jing-Yuan
PMID: 23625650
Journal: Gut. 2014 Apr;63(4):622-34.
Title: Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling.
Author: Pope, Jillian L|Bhat, Ajaz A|Sharma, Ashok|Ahmad, Rizwan|Krishnan, Moorthy|Washington, Mary K|Beauchamp, Robert D|Singh, Amar B|Dhawan, Punita
PMID: 23766441
Journal: Carcinogenesis. 2014 Jan;35(1):227-36.
Title: Female-specific rectal carcinogenesis in cyclin D1b transgenic mice.
Author: Kim, Chul Jang|Tambe, Yukihiro|Mukaisho, Ken-Ichi|Sugihara, Hiroyuki|Isono, Takahiro|Sonoda, Hiromichi|Shimizu, Tomoharu|Kondoh, Gen|Inoue, Hirokazu
PMID: 23975835
Journal: Mol Carcinog. 2014 Feb;53 Suppl 1:E119-29.
Title: N-acetyl-L-cysteine enhances fisetin-induced cytotoxicity via induction of ROS-independent apoptosis in human colonic cancer cells.
Author: Wu, Ming-Shun|Lien, Gi-Shih|Shen, Shing-Chuan|Yang, Liang-Yo|Chen, Yen-Chou
PMID: 24019108
Journal: Carcinogenesis. 2014 Feb;35(2):282-91.
Title: SDF-1/CXCR4 axis promotes directional migration of colorectal cancer cells through upregulation of integrin alphavbeta6.
Author: Wang, Ben|Wang, Wenke|Niu, Weibo|Liu, Enyu|Liu, Xiangjuan|Wang, Jiayong|Peng, Cheng|Liu, Song|Xu, Ling|Wang, Lei|Niu, Jun
PMID: 24085800
Journal: Mol Cancer Res. 2014 Feb;12(2):228-38.
Title: The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation.
Author: Choi, Gigi C G|Li, Jisheng|Wang, Yajun|Li, Lili|Zhong, Lan|Ma, Brigette|Su, Xianwei|Ying, Jianming|Xiang, Tingxiu|Rha, Sun Young|Yu, Jun|Sung, Joseph J Y|Tsao, Sai Wah|Chan, Anthony T C|Tao, Qian
PMID: 24184540
Journal: Dig Dis Sci. 2014 Mar;59(3):598-606.
Title: PAX6, a novel target of microRNA-7, promotes cellular proliferation and invasion in human colorectal cancer cells.
Author: Li, Yanwen|Li, Yuehui|Liu, Yanhong|Xie, Pingli|Li, Feng|Li, Guancheng
PMID: 24185687
Journal: Integr Cancer Ther. 2014 May;13(3):240-8.
Title: Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways.
Author: Lin, Jiumao|Chen, Youqin|Cai, Qiaoyan|Wei, Lihui|Zhan, Youzhi|Shen, Aling|Sferra, Thomas J|Peng, Jun
PMID: 24231788
Journal: Am J Physiol Gastrointest Liver Physiol. 2014 Jan 1;306(1):G27-36.
Title: Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway.
Author: Zhang, Jingjing|Dou, Wei|Zhang, Eryun|Sun, Aning|Ding, Lili|Wei, Xiaohui|Chou, Guixin|Mani, Sridhar|Wang, Zhengtao
PMID: 24232001
Journal: Carcinogenesis. 2014 Apr;35(4):795-806.
Title: Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner.
Author: Neradugomma, Naveen K|Subramaniam, Dharmalingam|Tawfik, Ossama W|Goffin, Vincent|Kumar, T Rajendra|Jensen, Roy A|Anant, Shrikant
PMID: 24265293
Journal: Biochim Biophys Acta. 2014 Mar;1843(3):618-28.
Title: Disrupted interaction between CFTR and AF-6/afadin aggravates malignant phenotypes of colon cancer.
Author: Sun, Ting Ting|Wang, Yan|Cheng, Hong|Xiao, Hu Zhang|Xiang, Juan Juan|Zhang, Jie Ting|Yu, Siu Bun Sydney|Martin, Tracey Amanda|Ye, Lin|Tsang, Lai Ling|Jiang, Wen Guo|Xiaohua, Jiang|Chan, Hsiao Chang
PMID: 24373847
Journal: Int J Oncol. 2014 Mar;44(3):781-90.
Title: S100A6 stimulates proliferation and migration of colorectal carcinoma cells through activation of the MAPK pathways.
Author: Duan, Liang|Wu, Rui|Zou, Zhengyu|Wang, Haiyan|Ye, Liwei|Li, Huan|Yuan, Shimei|Li, Xueru|Zha, He|Sun, Hui|Zhang, Yunyuan|Chen, Xian|Zhou, Lan
PMID: 24378749
Journal: Int J Oncol. 2014 Mar;44(3):905-11.
Title: MHY-449, a novel dihydrobenzofuro[4,5-b][1,8] naphthyridin-6-one derivative, induces apoptotic cell death through modulation of Akt/FoxO1 and ERK signaling in PC3 human prostate cancer cells.
Author: Lee, Sun Hwa|Kang, Yong Jung|Sung, Bokyung|Kim, Dong Hwan|Lim, Hyun Sook|Kim, Hye Rim|Kim, Seong Jin|Yoon, Jeong-Hyun|Moon, Hyung Ryong|Chung, Hae Young|Kim, Nam Deuk
PMID: 24424889
Journal: Int J Clin Oncol. 2014 Apr;19(2):211-9.
Title: Is biomarker research advancing in the era of personalized medicine for head and neck cancer?
Author: Yokota, Tomoya
PMID: 24442754
Journal: Biochem Pharmacol. 2014 Mar 15;88(2):150-7.
Title: Paris saponin VII inhibits growth of colorectal cancer cells through Ras signaling pathway.
Author: Li, Yuhua|Sun, Yang|Fan, Lei|Zhang, Feng|Meng, Jin|Han, Jin|Guo, Xin|Zhang, Dian|Zhang, Rong|Yue, Zhenggang|Mei, Qibing
PMID: 24462916
Journal: Anticancer Agents Med Chem. 2014;14(7):1051-61.
Title: ent-kaurane diterpenoids from Croton tonkinensis induce apoptosis in colorectal cancer cells through the phosphorylation of JNK mediated by reactive oxygen species and dual-specificity JNK kinase MKK4.
Author: Thuong, Phuong Thien|Khoi, Nguyen Minh|Ohta, Saho|Shiota, Shinichiro|Kanta, Hironori|Takeuchi, Kenji|Ito, Fumiaki
PMID: 24476312
Journal: PLoS One. 2014 Jan 30;9(1):e86911.
Title: Lack of association between insulin receptor substrate2 rs1805097 polymorphism and the risk of colorectal and breast cancer: a meta-analysis.
Author: Hu, Yue|Zhou, Min|Zhang, Kai|Kong, Xiangquan|Hu, Xiaoyan|Li, Kang|Liu, Li
PMID: 24497996
Journal: Oncotarget. 2014 Jan 30;5(2):519-29.
Title: Collagen triple helix repeat containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells.
Author: Kim, Hee Cheol|Kim, Yong Sung|Oh, Hyun-Woo|Kim, Kwoneel|Oh, Sang-Seok|Kim, Jong-Tae|Kim, Bo Yeon|Lee, Seon-Jin|Choe, Yong-Kyung|Kim, Dong Hyeok|Kim, Seok-Hyung|Chae, Seoung Wan|Kim, Kwang Dong|Lee, Hee Gu
PMID: 24504172
Journal: Sci Transl Med. 2014 Feb 19;6(224):224ra26.
Title: Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer.
Author: Misale, Sandra|Arena, Sabrina|Lamba, Simona|Siravegna, Giulia|Lallo, Alice|Hobor, Sebastijan|Russo, Mariangela|Buscarino, Michela|Lazzari, Luca|Sartore-Bianchi, Andrea|Bencardino, Katia|Amatu, Alessio|Lauricella, Calogero|Valtorta, Emanuele|Siena, Salvato
PMID: 24553387
Journal: World J Gastroenterol. 2014 Feb 28;20(8):2071-8.
Title: Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway.
Author: Wang, Pan|Zeng, Yun|Liu, Tao|Zhang, Chao|Yu, Pei-Wu|Hao, Ying-Xue|Luo, Hua-Xin|Liu, Gang
PMID: 24587680
Journal: Biochem Biophys Res Commun. 2014 Apr 4;446(2):487-92.
Title: Interleukin-1alpha promotes extracellular shedding of syndecan-2 via induction of matrix metalloproteinase-7 expression.
Author: Kwon, Mi-Jung|Hong, Eunkyoung|Choi, Youngsil|Kang, Duk-Hee|Oh, Eok-Soo
PMID: 24613844
Journal: J Pineal Res. 2014 May;56(4):415-26.
Title: Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-kappabeta.
Author: Leon, Josefa|Casado, Jorge|Jimenez Ruiz, Sergio M|Zurita, Maria Sol|Gonzalez-Puga, Cristina|Rejon, Juan D|Gila, Ana|Munoz de Rueda, Paloma|Pavon, Esther J|Reiter, Russel J|Ruiz-Extremera, Angela|Salmeron, Javier
PMID: 24628039
Journal: Mol Cancer. 2014 Mar 14;13:58.
Title: Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer.
Author: Romain, Benoit|Hachet-Haas, Muriel|Rohr, Serge|Brigand, Cecile|Galzi, Jean-Luc|Gaub, Marie-Pierre|Pencreach, Erwan|Guenot, Dominique
PMID: 24629239
Journal: Pharm Biol. 2014 Sep;52(9):1158-65.
Title: Diterpenoid C of Radix Curcumae: an inhibitor of proliferation and inducer of apoptosis in human colon adenocarcinoma cells acting via inhibiting MAPK signaling pathway.
Author: Shen, Yan|Lu, Bin|Zhang, Shuo|Ma, Zhong-Jun
PMID: 24646305
Journal: J Clin Endocrinol Metab. 2014 Jul;99(7):E1163-72.
Title: ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a.
Author: Qiang, Wei|Zhao, Yuan|Yang, Qi|Liu, Wei|Guan, Haixia|Lv, Siqing|Ji, Meiju|Shi, Bingyin|Hou, Peng
PMID: 24684457
Journal: J Clin Invest. 2014 May;124(5):2172-87. Epub 2014 Apr 1.
Title: Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer.
Author: Li, Cunxi|Ma, Haiting|Wang, Yang|Cao, Zheng|Graves-Deal, Ramona|Powell, Anne E|Starchenko, Alina|Ayers, Gregory D|Washington, Mary Kay|Kamath, Vidya|Desai, Keyur|Gerdes, Michael J|Solnica-Krezel, Lila|Coffey, Robert J
PMID: 24691442
Journal: Oncol Rep. 2014 Jun;31(6):2493-8.
Title: Leptin-induced adhesion and invasion in colorectal cancer cell lines.
Author: Yoon, Kyung-Won|Park, Seon-Young|Kim, Ji-Young|Lee, Su-Mi|Park, Chang-Hwan|Cho, Sung-Bum|Lee, Wan-Sik|Joo, Young-Eun|Lee, Jae-Hyuk|Kim, Hyun-Soo|Choi, Sung-Kyu|Rew, Jong-Sun
PMID: 24700392
Journal: Biomed Environ Sci. 2014 Mar;27(3):197-203.
Title: Sodium butyrate induces apoptosis of human colon cancer cells by modulating ERK and sphingosine kinase 2.
Author: Xiao, Min|Liu, Yun Gang|Zou, Meng Chen|Zou, Fei
PMID: 24709100
Journal: Biochim Biophys Acta. 2014 Sep;1842(9):1423-32.
Title: MFAP3L activation promotes colorectal cancer cell invasion and metastasis.
Author: Lou, Xiaomin|Kang, Bin|Zhang, Jun|Hao, Chunyi|Tian, Xiuyun|Li, Wenmei|Xu, Ningzhi|Lu, Youyong|Liu, Siqi
PMID: 24735981
Journal: Tumour Biol. 2014 Jul;35(7):7035-45.
Title: AQP5 silencing suppresses p38 MAPK signaling and improves drug resistance in colon cancer cells.
Author: Shi, Xiaoming|Wu, Shengchun|Yang, Yongbin|Tang, Lei|Wang, Yuexin|Dong, Junjie|Lu, Bonan|Jiang, Guangwei|Zhao, Wei
PMID: 24752576
Journal: Recent Results Cancer Res. 2014;201:215-25.
Title: Vemurafenib.
Author: Garbe, Claus|Abusaif, Sail|Eigentler, Thomas K
PMID: 24756795
Journal: Clin Cancer Res. 2014 Jul 1;20(13):3434-45.
Title: Overexpression of sirt7 exhibits oncogenic property and serves as a prognostic factor in colorectal cancer.
Author: Yu, Hongyan|Ye, Wen|Wu, Jiangxue|Meng, Xiangqi|Liu, Ran-Yi|Ying, Xiaofang|Zhou, Yi|Wang, Hui|Pan, Changchuan|Huang, Wenlin
PMID: 24771643
Journal: Mol Cancer. 2014 Apr 29;13:95.
Title: SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1.
Author: Qu, Yingying|Chen, Qin|Lai, Xueping|Zhu, Changhong|Chen, Cheng|Zhao, Xian|Deng, Rong|Xu, Ming|Yuan, Haihua|Wang, Yanli|Yu, Jianxiu|Huang, Jian
PMID: 24775912
Journal: Biochim Biophys Acta. 2014 Aug;1840(8):2651-61.
Title: EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules.
Author: Ellina, Maria-Ioanna|Bouris, Panagiotis|Aletras, Alexios J|Theocharis, Achilleas D|Kletsas, Dimitris|Karamanos, Nikos K
PMID: 24792576
Journal: Chin J Integr Med. 2014 Oct;20(10):751-7.
Title: Xihuang Pill () induces mesenchymal-epithelial transition and inhibits loss of apical-basal polarity in colorectal cancer cell through regulating ZEB1-SCRIB loop.
Author: Wang, Miao|Meng, Jing-yan|He, Su-fei
PMID: 24802235
Journal: Chem Biol Interact. 2014 Jul 25;218:42-9.
Title: Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells.
Author: Lin, Mei-Hsiang|Cheng, Chia-Hsiung|Chen, Ku-Chung|Lee, Wai-Theng|Wang, Yen-Fang|Xiao, Cai-Qin|Lin, Cheng-Wei
PMID: 24812029
Journal: Clin Cancer Res. 2014 Jul 15;20(14):3775-86.
Title: Primary and acquired resistance of colorectal cancer cells to anti-EGFR antibodies converge on MEK/ERK pathway activation and can be overcome by combined MEK/EGFR inhibition.
Author: Troiani, Teresa|Napolitano, Stefania|Vitagliano, Donata|Morgillo, Floriana|Capasso, Anna|Sforza, Vincenzo|Nappi, Anna|Ciardiello, Davide|Ciardiello, Fortunato|Martinelli, Erika
PMID: 24812410
Journal: Tumour Biol. 2014 Sep;35(9):8639-43.
Title: Nrdp1 inhibits growth of colorectal cancer cells by nuclear retention of p27.
Author: Lu, Hang|Li, Hua|Mao, Dong|Zhu, Zhitu|Sun, Hongzhi
PMID: 24867101
Journal: Nat Cell Biol. 2014 Jul;16(7):685-94.
Title: Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH.
Author: Urosevic, Jelena|Garcia-Albeniz, Xabier|Planet, Evarist|Real, Sebastian|Cespedes, Maria Virtudes|Guiu, Marc|Fernandez, Esther|Bellmunt, Anna|Gawrzak, Sylwia|Pavlovic, Milica|Mangues, Ramon|Dolado, Ignacio|Barriga, Francisco M|Nadal, Cristina|Kemeny, Nancy
PMID: 24880666
Journal: Mol Cancer. 2014 May 24;13:122.
Title: Genetic targeting of B-RafV600E affects survival and proliferation and identifies selective agents against BRAF-mutant colorectal cancer cells.
Author: Hirschi, Benjamin|Gallmeier, Eike|Ziesch, Andreas|Marschall, Maximilian|Kolligs, Frank T
PMID: 24885690
Journal: Food Chem Toxicol. 2014 Sep;71:51-9.
Title: Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways.
Author: Do, Minh Truong|Na, MinKyun|Kim, Hyung Gyun|Khanal, Tilak|Choi, Jae Ho|Jin, Sun Woo|Oh, Seok Hoon|Hwang, In Hyun|Chung, Young Chul|Kim, Hee Suk|Jeong, Tae Cheon|Jeong, Hye Gwang
PMID: 24930757
Journal: Oncotarget. 2014 May 30;5(10):3220-33.
Title: RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis.
Author: Dahlmann, Mathias|Okhrimenko, Anna|Marcinkowski, Patrick|Osterland, Marc|Herrmann, Pia|Smith, Janice|Heizmann, Claus W|Schlag, Peter M|Stein, Ulrike
PMID: 24952599
Journal: PLoS One. 2014 Jun 24;9(6):e99729.
Title: Activation of JNK contributes to evodiamine-induced apoptosis and G2/M arrest in human colorectal carcinoma cells: a structure-activity study of evodiamine.
Author: Chien, Chih-Chiang|Wu, Ming-Shun|Shen, Shing-Chuan|Ko, Ching-Huai|Chen, Chih-Hung|Yang, Ling-Ling|Chen, Yen-Chou
PMID: 24959718
Journal: PLoS One. 2014 Jun 26;9(6):e98515.
Title: FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival.
Author: Mathur, Anjili|Ware, Christopher|Davis, Lenora|Gazdar, Adi|Pan, Bo-Sheng|Lutterbach, Bart
PMID: 24968263
Journal: Int J Oncol. 2014 Sep;45(3):995-1010.
Title: Enhanced anti-colorectal cancer effects of carfilzomib combined with CPT-11 via downregulation of nuclear factor-kappaB in vitro and in vivo.
Author: Tang, Weiwei|Su, Guangjian|Li, Jieyu|Liao, Jinrong|Chen, Shuping|Huang, Chuanzhong|Liu, Fang|Chen, Qiang|Ye, Yunbin
PMID: 24968890
Journal: Int J Oncol. 2014 Sep;45(3):1036-42.
Title: Phloroglucinol induces apoptosis through the regulation of insulin-like growth factor 1 receptor signaling pathways in human colon cancer HT-29 cells.
Author: Kang, Mi-Hye|Kim, In-Hye|Nam, Taek-Jeong
PMID: 24970012
Journal: Biochim Biophys Acta. 2014 Sep;1842(9):1823-9.
Title: Hyperphosphorylation of PP2A in colorectal cancer and the potential therapeutic value showed by its forskolin-induced dephosphorylation and activation.
Author: Cristobal, Ion|Rincon, Raul|Manso, Rebeca|Madoz-Gurpide, Juan|Carames, Cristina|del Puerto-Nevado, Laura|Rojo, Federico|Garcia-Foncillas, Jesus
PMID: 24997451
Journal: PLoS One. 2014 Jul 8;9(7):e101889.
Title: The study of a novel sorafenib derivative HLC-080 as an antitumor agent.
Author: Tang, Ke|Luo, Can|Li, Yan|Lu, Chenshu|Zhou, Wanqi|Huang, Haihong|Chen, Xiaoguang
PMID: 25004130
Journal: Oncol Lett. 2014 Aug;8(2):493-501.
Title: Progress of cancer research on astrocyte elevated gene-1/Metadherin (Review).
Author: Huang, Yong|Li, LE-Ping
PMID: 25009642
Journal: Amino Acids. 2014 Oct;46(10):2393-401.
Title: Kynurenic acid inhibits colon cancer proliferation in vitro: effects on signaling pathways.
Author: Walczak, Katarzyna|Turski, Waldemar A|Rajtar, Grazyna
PMID: 25012123
Journal: Int J Oncol. 2014 Oct;45(4):1649-57.
Title: Silencing of CXCR7 gene represses growth and invasion and induces apoptosis in colorectal cancer through ERK and beta-arrestin pathways.
Author: Li, Xin-Xiang|Zheng, Hong-Tu|Huang, Li-Yong|Shi, De-Bing|Peng, Jun-Jie|Liang, Lei|Cai, San-Jun
PMID: 25051350
Journal: Biochem Cell Biol. 2014 Aug;92(4):305-15.
Title: Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells.
Author: Calvo, Natalia|Martin, Maria Julia|de Boland, Ana Russo|Gentili, Claudia
PMID: 25051885
Journal: J Cell Biochem. 2014 Dec;115(12):2133-45.
Title: Molecular mechanisms associated with PTHrP-induced proliferation of colon cancer cells.
Author: Martin, Maria Julia|Calvo, Natalia|de Boland, Ana Russo|Gentili, Claudia
PMID: 25053227
Journal: Mol Cancer Res. 2014 Nov;12(11):1655-62.
Title: DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice.
Author: Grill, Jessica I|Neumann, Jens|Herbst, Andreas|Hiltwein, Felix|Ofner, Andrea|Marschall, Maximilian K|Wolf, Eckhard|Kirchner, Thomas|Goke, Burkhard|Schneider, Marlon R|Kolligs, Frank T
PMID: 25053805
Journal: BMC Complement Altern Med. 2014 Jul 30;14:275.
Title: Essential oil of Pinus koraiensis inhibits cell proliferation and migration via inhibition of p21-activated kinase 1 pathway in HCT116 colorectal cancer cells.
Author: Cho, Sun-Mi|Lee, Eun-Ok|Kim, Sung-Hoon|Lee, Hyo-Jeong
PMID: 25074784
Journal: PLoS One. 2014 Aug 4;9(8):e103551.
Title: Activated cMET and IGF1R-driven PI3K signaling predicts poor survival in colorectal cancers independent of KRAS mutational status.
Author: Lee, Jeeyun|Jain, Anjali|Kim, Phillip|Lee, Tani|Kuller, Anne|Princen, Fred|In-GuDo|Kim, Suk Hyeong|Park, Joon Oh|Park, Young Suk|Singh, Sharat|Kim, Hee Cheol
PMID: 25090459
Journal: Oncol Rep. 2014 Oct;32(4):1709-14.
Title: Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells.
Author: Wang, Guojun|Ye, Yanwei|Zhang, Xiefu|Song, Junmin
PMID: 25109623
Journal: Apoptosis. 2014 Oct;19(10):1532-44.
Title: Urokinase-type plasminogen activator receptor regulates apoptotic sensitivity of colon cancer HCT116 cell line to TRAIL via JNK-p53 pathway.
Author: Liu, Xiufeng|Qiu, Fan|Liu, Zhipeng|Lan, Yan|Wang, Kai|Zhou, Ping-Kun|Wang, Yao|Hua, Zi-Chun
PMID: 25113506
Journal: Cancer Lett. 2014 Nov 28;354(2):427-37.
Title: beta6 integrin induces the expression of metalloproteinase-3 and metalloproteinase-9 in colon cancer cells via ERK-ETS1 pathway.
Author: Gao, Huijie|Peng, Cheng|Liang, Benjia|Shahbaz, Muhammad|Liu, Song|Wang, Ben|Sun, Qi|Niu, Zhengchuan|Niu, Weibo|Liu, Enyu|Wang, Jiayong|Lin, Pengfei|Wang, Jian|Niu, Jun
PMID: 25135220
Journal: ScientificWorldJournal. 2014;2014:340271.
Title: Radixin enhances colon cancer cell invasion by increasing MMP-7 production via Rac1-ERK pathway.
Author: Jiang, Qi-Hong|Wang, Ai-Xiang|Chen, Yan
PMID: 25136657
Journal: Cancer Lett. 2014 Nov 28;354(2):245-53.
Title: Interleukin-8 promotes cell migration through integrin alphavbeta6 upregulation in colorectal cancer.
Author: Sun, Qi|Sun, Fengkai|Wang, Ben|Liu, Song|Niu, Weibo|Liu, Enyu|Peng, Cheng|Wang, Jiayong|Gao, Huijie|Liang, Benjia|Niu, Zhengchuan|Zou, Xueqing|Niu, Jun
PMID: 25150782
Journal: Front Physiol. 2014 Aug 8;5:293.
Title: NFAT5-mediated expression of S100A4 contributes to proliferation and migration of renal carcinoma cells.
Author: Kuper, Christoph|Beck, Franz-Xaver|Neuhofer, Wolfgang
PMID: 25152734
Journal: PLoS One. 2014 Aug 26;9(8):e104401.
Title: [6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling.
Author: Radhakrishnan, E K|Bava, Smitha V|Narayanan, Sai Shyam|Nath, Lekshmi R|Thulasidasan, Arun Kumar T|Soniya, Eppurathu Vasudevan|Anto, Ruby John
PMID: 25157570
Journal: Am J Physiol Gastrointest Liver Physiol. 2014 Oct 1;307(7):G749-59.
Title: PDGF receptor-alpha promotes TGF-beta signaling in hepatic stellate cells via transcriptional and posttranscriptional regulation of TGF-beta receptors.
Author: Liu, Chunsheng|Li, Jiachu|Xiang, Xiaoyu|Guo, Luyang|Tu, Kangsheng|Liu, Qinghua|Shah, Vijay H|Kang, Ningling
PMID: 25169976
Journal: Mol Cancer. 2014 Aug 29;13:201.
Title: Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer.
Author: El-Baba, Chirine|Mahadevan, Vijayalakshmi|Fahlbusch, Fabian B|Mohan S, Suma|Rau, Tilman T|Gali-Muhtasib, Hala|Schneider-Stock, Regine
PMID: 25174975
Journal: Ann Oncol. 2014 Nov;25(11):2196-204.
Title: MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of beta-catenin signaling.
Author: Zhang, J X|Mai, S J|Huang, X X|Wang, F W|Liao, Y J|Lin, M C|Kung, H F|Zeng, Y X|Xie, D
PMID: 25193986
Journal: J Transl Med. 2014 Sep 8;12:244.
Title: Tumor suppressor miR-1 restrains epithelial-mesenchymal transition and metastasis of colorectal carcinoma via the MAPK and PI3K/AKT pathway.
Author: Xu, Lijun|Zhang, Yue|Wang, Hui|Zhang, Guanhua|Ding, Yanqing|Zhao, Liang
PMID: 25196260
Journal: Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13505-10.
Title: Phospholipase Cdelta1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells.
Author: Satow, Reiko|Hirano, Tamaki|Batori, Ryosuke|Nakamura, Tomomi|Murayama, Yumi|Fukami, Kiyoko
PMID: 25197077
Journal: Mol Nutr Food Res. 2014 Dec;58(12):2274-85.
Title: Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity.
Author: Kim, Yun-Ji|Kim, Jong-Sang|Seo, Young Rok|Park, Jung Han Yoon|Choi, Myung-Sook|Sung, Mi-Kyung
PMID: 25204550
Journal: Cancer Res. 2014 Nov 15;74(22):6693-704.
Title: TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: a novel target for BRAF-mutated colorectal tumors.
Author: Condelli, Valentina|Piscazzi, Annamaria|Sisinni, Lorenza|Matassa, Danilo Swann|Maddalena, Francesca|Lettini, Giacomo|Simeon, Vittorio|Palladino, Giuseppe|Amoroso, Maria Rosaria|Trino, Stefania|Esposito, Franca|Landriscina, Matteo
PMID: 25239454
Journal: BMC Cancer. 2014 Sep 27;14:723.
Title: Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer.
Author: Ji, Ke|Ye, Lin|Ruge, Fiona|Hargest, Rachel|Mason, Malcolm D|Jiang, Wen G
PMID: 25260785
Journal: Oncotarget. 2014 Oct 15;5(19):9444-59.
Title: miR-524-5p suppresses the growth of oncogenic BRAF melanoma by targeting BRAF and ERK2.
Author: Liu, Szu-Mam|Lu, Jean|Lee, Hoong-Chien|Chung, Feng-Hsiang|Ma, Nianhan
PMID: 25275294
Journal: Biochem Pharmacol. 2014 Dec 1;92(3):415-24.
Title: Platinum(IV) complex LA-12 exerts higher ability than cisplatin to enhance TRAIL-induced cancer cell apoptosis via stimulation of mitochondrial pathway.
Author: Jelinkova, Iva|Safarikova, Barbora|Vondalova Blanarova, Olga|Skender, Belma|Hofmanova, Jirina|Sova, Petr|Moyer, Mary Pat|Kozubik, Alois|Kolar, Zdenek|Ehrmann, Jiri|Hyrslova Vaculova, Alena
PMID: 25285768
Journal: Oncotarget. 2014 Oct 30;5(20):9980-91.
Title: HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy.
Author: Nagaraju, Ganji Purnachandra|Alese, Olatunji B|Landry, Jerome|Diaz, Roberto|El-Rayes, Bassel F
PMID: 25296971
Journal: Nat Commun. 2014 Oct 13;5:5191.
Title: Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.
Author: Schulz, Eduard|Klampfl, Petra|Holzapfel, Stefanie|Janecke, Andreas R|Ulz, Peter|Renner, Wilfried|Kashofer, Karl|Nojima, Satoshi|Leitner, Anita|Zebisch, Armin|Wolfler, Albert|Hofer, Sybille|Gerger, Armin|Lax, Sigurd|Beham-Schmid, Christine|Steinke, Verena|
PMID: 25307848
Journal: Biomed Res Int. 2014;2014:568693.
Title: Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines.
Author: Lange, Falko|Franz, Benjamin|Maletzki, Claudia|Linnebacher, Michael|Huhns, Maja|Jaster, Robert
PMID: 25309914
Journal: Curr Mol Med. 2014;14(9):1126-38.
Title: Cholinergic receptors as target for cancer therapy in a systems medicine perspective.
Author: Russo, P|Del Bufalo, A|Milic, M|Salinaro, G|Fini, M|Cesario, A
PMID: 25324001
Journal: J Cancer Prev. 2014 Sep;19(3):161-9.
Title: Kaempferol Downregulates Insulin-like Growth Factor-I Receptor and ErbB3 Signaling in HT-29 Human Colon Cancer Cells.
Author: Lee, Hyun Sook|Cho, Han Jin|Kwon, Gyoo Taik|Park, Jung Han Yoon
PMID: 25337585
Journal: BMC Complement Altern Med. 2014 Oct 23;14:408.
Title: Anti-cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells.
Author: Park, Gwang Hun|Park, Jae Ho|Song, Hun Min|Eo, Hyun Ji|Kim, Mi Kyoung|Lee, Jin Wook|Lee, Man Hyo|Cho, Kiu-Hyung|Lee, Jeong Rak|Cho, Hyeon Je|Jeong, Jin Boo
PMID: 25338635
Journal: Cell Death Dis. 2014 Nov 6;5:e1510.
Title: Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation.
Author: Kao, C|Chao, A|Tsai, C-L|Chuang, W-C|Huang, W-P|Chen, G-C|Lin, C-Y|Wang, T-H|Wang, H-S|Lai, C-H
PMID: 25375375
Journal: Mol Cells. 2014 Dec 31;37(12):899-906.
Title: Prostaglandin E2 reverses curcumin-induced inhibition of survival signal pathways in human colorectal carcinoma (HCT-15) cell lines.
Author: Shehzad, Adeeb|Ul Islam, Salman|Lee, Jaetae|Lee, Young Sup
PMID: 25431425
Journal: PLoS One. 2014 Dec 1;9(12):e113931.
Title: Distinct behaviour of sorafenib in experimental cachexia-inducing tumours: the role of STAT3.
Author: Toledo, Miriam|Penna, Fabio|Busquets, Silvia|Lopez-Soriano, Francisco J|Argiles, Josep M
PMID: 25436606
Journal: Biomed Pharmacother. 2014 Oct;68(8):1023-9.
Title: Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer.
Author: Setia, Shruti|Nehru, Bimla|Sanyal, Sankar Nath
PMID: 25443414
Journal: Arch Biochem Biophys. 2014 Dec 15;564:203-10.
Title: The contribution of activating transcription factor 3 to apoptosis of human colorectal cancer cells by protocatechualdehyde, a naturally occurring phenolic compound.
Author: Lee, Jeong Rak|Lee, Man Hyo|Eo, Hyun Ji|Park, Gwang Hun|Song, Hun Min|Kim, Mi Kyoung|Lee, Jin Wook|Jeong, Jin Boo
PMID: 25447816
Journal: Oncotarget. 2014 Dec 15;5(23):11847-56.
Title: The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells.
Author: Kawakami, Hisato|Okamoto, Isamu|Yonesaka, Kimio|Okamoto, Kunio|Shibata, Kiyoko|Shinkai, Yume|Sakamoto, Haruka|Kitano, Michiko|Tamura, Takao|Nishio, Kazuto|Nakagawa, Kazuhiko
PMID: 25474137
Journal: Cancer Biol Ther. 2014;15(12):1646-57.
Title: Regulation of dimethyl-fumarate toxicity by proteasome inhibitors.
Author: Booth, Laurence|Cruickshanks, Nichola|Tavallai, Seyedmehrad|Roberts, Jane L|Peery, Matthew|Poklepovic, Andrew|Dent, Paul
PMID: 25482938
Journal: Immunity. 2014 Dec 18;41(6):1052-63.
Title: Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.
Author: Wang, Kepeng|Kim, Min Kyoung|Di Caro, Giuseppe|Wong, Jerry|Shalapour, Shabnam|Wan, Jun|Zhang, Wei|Zhong, Zhenyu|Sanchez-Lopez, Elsa|Wu, Li-Wha|Taniguchi, Koji|Feng, Ying|Fearon, Eric|Grivennikov, Sergei I|Karin, Michael
PMID: 25526314
Journal: World J Gastroenterol. 2014 Dec 28;20(48):18260-70.
Title: PBX3 promotes migration and invasion of colorectal cancer cells via activation of MAPK/ERK signaling pathway.
Author: Han, Hai-Bo|Gu, Jin|Ji, Deng-Bo|Li, Zhao-Wei|Zhang, Yuan|Zhao, Wei|Wang, Li-Min|Zhang, Zhi-Qian
PMID: 25561793
Journal: Int J Clin Exp Pathol. 2014 Dec 1;7(12):8471-9. eCollection 2014.
Title: Enhanced expression of long noncoding RNA CARLo-5 is associated with the development of gastric cancer.
Author: Zhang, Yan|Ma, Mingzhe|Liu, Weiyong|Ding, Wenping|Yu, Honggang
PMID: 25674211
Journal: Tumori. 2014 Nov-Dec;100(6):e230-5.
Title: Extracellular chaperonin 10 augments apoptotic cell death induced by 5-fluorouracil in human colon cancer cells.
Author: Kim, Kun|Yeo, Seung-Gu
PMID: 25688504
Journal: Cancer Cell Microenviron. 2014;1(5).
Title: New insights into 4E-BP1-regulated translation in cancer progression and metastasis.
Author: Wang, Jun|Ye, Qing|She, Qing-Bai
PMID: 26005705
Journal: Mol Carcinog. 2015 Oct;54(10):1205-13.
Title: Overexpression of DNAJB6 promotes colorectal cancer cell invasion through an IQGAP1/ERK-dependent signaling pathway.
Author: Zhang, Tong-Tong|Jiang, Yan-Yi|Shang, Li|Shi, Zhi-Zhou|Liang, Jian-Wei|Wang, Zheng|Zhang, Yu|Hao, Jia-Jie|Jia, Xue-Mei|Xu, Xin|Cai, Yan|Zhan, Qi-Min|Wang, Ming-Rong
PMID: 25044025
Journal: In Vitro Cell Dev Biol Anim. 2015 Jan;51(1):92-101.
Title: [10]-Gingerol induces mitochondrial apoptosis through activation of MAPK pathway in HCT116 human colon cancer cells.
Author: Ryu, Min Ju|Chung, Ha Sook
PMID: 25148824
Journal: Anat Rec (Hoboken). 2015 Feb;298(2):376-85.
Title: 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells.
Author: Xu, Dao Gun|Lv, Wang|Dai, Chun Yan|Zhu, Fan Fan|Xu, Gua Hua|Ma, Zhong Jun|Chen, Zhe
PMID: 25178491
Journal: J Med Food. 2015 Jan;18(1):45-53.
Title: Steroidal constituents from the edible sea urchin Diadema savignyi Michelin induce apoptosis in human cancer cells.
Author: Thao, Nguyen Phuong|Luyen, Bui Thi Thuy|Kim, Eun Ji|Kang, Jung Il|Kang, Hee Kyoung|Cuong, Nguyen Xuan|Nam, Nguyen Hoai|Kiem, Phan Van|Minh, Chau Van|Kim, Young Ho
PMID: 25211186
Journal: Cancer Lett. 2015 Jan 28;356(2 Pt B):579-88.
Title: Thymosin alpha1 enhanced cytotoxicity of iNKT cells against colon cancer via upregulating CD1d expression.
Author: Ni, Chao|Wu, Pin|Wu, Xianguo|Zhang, Ting|Zhang, Tao|Wang, Zhen|Zhang, Sai|Qiu, Fuming|Huang, Jian
PMID: 25304368
Journal: Int J Oncol. 2015 Jan;46(1):342-50.
Title: A novel pyrido-thieno-pyrimidine derivative activates p53 through induction of phosphorylation and acetylation in colorectal cancer cells.
Author: Kang, Mi Ae|Kim, Mi-Sook|Kim, Ji Young|Shin, Young-Joo|Song, Jie-Young|Jeong, Jae-Hoon
PMID: 25338966
Journal: Tumour Biol. 2015 Mar;36(3):1773-80.
Title: Biglycan up-regulated vascular endothelial growth factor (VEGF) expression and promoted angiogenesis in colon cancer.
Author: Xing, Xiaojing|Gu, Xiaohu|Ma, Tianfei|Ye, Huinan
PMID: 25371074
Journal: Int J Cancer. 2015 Jul 1;137(1):243-50.
Title: PKC/MEK inhibitors suppress oxaliplatin-induced neuropathy and potentiate the antitumor effects.
Author: Tsubaki, Masanobu|Takeda, Tomoya|Tani, Tadahumi|Shimaoka, Hirotaka|Suzuyama, Naohiro|Sakamoto, Kotaro|Fujita, Arisa|Ogawa, Naoki|Itoh, Tatsuki|Imano, Motohiro|Funakami, Yoshinori|Ichida, Seiji|Satou, Takao|Nishida, Shozo
PMID: 25430564
Journal: Biochim Biophys Acta. 2015 Apr;1850(4):640-6.
Title: Spontaneously hyperactive MEK-Erk pathway mediates paradoxical facilitation of cell proliferation in mild hypoxia.
Author: Miyamoto, Licht|Yagi, Yuko|Hatano, Aya|Kawazoe, Kazuyoshi|Ishizawa, Keisuke|Minakuchi, Kazuo|Tomita, Shuhei|Tsuchiya, Koichiro
PMID: 25497211
Journal: Anticancer Drugs. 2015 Apr;26(4):371-8.
Title: Effect of KRAS exon 2 mutations on antitumor activity of afatinib and gefitinib.
Author: Gamba, Sebastian|Camaj, Peter|Heinemann, Volker|Laubender, Rudiger P|Wang, Yan|Zhao, Yue|Stintzing, Sebastian|Giessen, Clemens|Boeck, Stefan|Haertl, Christoph|Bruns, Christiane J|Modest, Dominik P
PMID: 25514114
Journal: Oncotarget. 2015 Mar 10;6(7):4745-56.
Title: The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells.
Author: Wei, Ning|Chu, Edward|Wu, Shao-yu|Wipf, Peter|Schmitz, John C
PMID: 25544765
Journal: Mol Cancer Res. 2015 Apr;13(4):659-69.
Title: Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells.
Author: Okamoto, Koichi|Zaanan, Aziz|Kawakami, Hisato|Huang, Shengbing|Sinicrope, Frank A
PMID: 25548100
Journal: Inflamm Bowel Dis. 2015 Feb;21(2):287-96.
Title: Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer.
Author: Khare, Vineeta|Dammann, Kyle|Asboth, Mario|Krnjic, Anita|Jambrich, Manuela|Gasche, Christoph
PMID: 25569743
Journal: Invest New Drugs. 2015 Jun;33(3):720-8.
Title: Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer.
Author: Do, Khanh|Speranza, Giovanna|Bishop, Rachel|Khin, Sonny|Rubinstein, Larry|Kinders, Robert J|Datiles, Manuel|Eugeni, Michelle|Lam, Michael H|Doyle, L Austin|Doroshow, James H|Kummar, Shivaani
PMID: 25637165
Journal: Oncol Rep. 2015 Apr;33(4):1579-84.
Title: Inhibitory effect of maple syrup on the cell growth and invasion of human colorectal cancer cells.
Author: Yamamoto, Tetsushi|Uemura, Kentaro|Moriyama, Kaho|Mitamura, Kuniko|Taga, Atsushi
PMID: 25647359
Journal: Oncol Lett. 2015 Mar;9(3):1261-1265.
Title: Expression of phosphorylated extracellular signal-regulated kinase at the invasive front of hepatic colorectal metastasis.
Author: Kim, Hyun-Soo|DO, Sung-Im|Noh, Byeong-Joo|Jeong, Young In|Park, Sun Jin|Kim, Youn Wha
PMID: 25663894
Journal: Cancer Discov. 2015 Apr;5(4):358-67.
Title: Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations.
Author: Ahronian, Leanne G|Sennott, Erin M|Van Allen, Eliezer M|Wagle, Nikhil|Kwak, Eunice L|Faris, Jason E|Godfrey, Jason T|Nishimura, Koki|Lynch, Kerry D|Mermel, Craig H|Lockerman, Elizabeth L|Kalsy, Anuj|Gurski, Joseph M Jr|Bahl, Samira|Anderka, Kristin|Green,
PMID: 25673644
Journal: Cancer Lett. 2015 May 28;361(1):22-32.
Title: CXCL8, overexpressed in colorectal cancer, enhances the resistance of colorectal cancer cells to anoikis.
Author: Xiao, You-Chuan|Yang, Zhi-Bin|Cheng, Xian-Shuo|Fang, Xing-Bao|Shen, Tao|Xia, Cui-Feng|Liu, Ping|Qian, Hai-Hua|Sun, Bin|Yin, Zheng-Feng|Li, Yun-Feng
PMID: 25687885
Journal: Tumour Biol. 2015 Jul;36(7):5641-8.
Title: AZD-4547 exerts potent cytostatic and cytotoxic activities against fibroblast growth factor receptor (FGFR)-expressing colorectal cancer cells.
Author: Yao, Ting-Jing|Zhu, Jin-Hai|Peng, De-Feng|Cui, Zhen|Zhang, Chao|Lu, Pei-hua
PMID: 25691251
Journal: Cancer Biol Ther. 2015;16(1):34-42.
Title: The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent.
Author: Li, Chen|Cui, Jian-Feng|Chen, Min-Bin|Liu, Chao-Ying|Liu, Feng|Zhang, Qian-De|Zou, Jian|Lu, Pei-Hua
PMID: 25692620
Journal: Front Oncol. 2015 Feb 2;5:13.
Title: Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer.
Author: Pereira, Lloyd|Mariadason, John M|Hannan, Ross D|Dhillon, Amardeep S
PMID: 25699236
Journal: Ann Coloproctol. 2015 Feb;31(1):9-15.
Title: Clinicopathologic Significance of BRAF Mutation and Extracellular Signal Regulated Kinase 1/2 Expression in Patients With a Colorectal Adenocarcinoma.
Author: Kim, Hyung Ook|Kim, Beom Gyu|Cha, Seong Jae|Park, Yong Gum|Lee, Tae Jin
PMID: 25745621
Journal: Cancer Biol Ther. 2015;16(4):511-7.
Title: HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway.
Author: Liu, Weijun|Zhang, Zhenyong|Zhang, Yongxue|Chen, Xinju|Guo, Shikui|Lei, Yi|Xu, Yu|Ji, Chao|Bi, Zhigang|Wang, Kunhua
PMID: 25778491
Journal: Am J Pathol. 2015 Apr;185(4):1135-44.
Title: Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.
Author: Peng, Hui|Li, Tony W H|Yang, Heping|Moyer, Mary P|Mato, Jose M|Lu, Shelly C
PMID: 25794709
Journal: Eur J Pharmacol. 2015 Jun 15;757:21-7.
Title: Quinaldic acid inhibits proliferation of colon cancer ht-29 cells in vitro: effects on signaling pathways.
Author: Langner, Ewa|Walczak, Katarzyna|Jeleniewicz, Witold|Turski, Waldemar A|Rajtar, Grazyna
PMID: 25797283
Journal: Sci Rep. 2015 Mar 24;5:9429.
Title: HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion.
Author: Feng, Yingying|Xu, Xiaojie|Zhang, Yunjing|Ding, Jianhua|Wang, Yonggang|Zhang, Xiaopeng|Wu, Zhe|Kang, Lei|Liang, Yingchun|Zhou, LiYing|Song, Santai|Zhao, Ke|Ye, Qinong
PMID: 25800793
Journal: Int J Cancer. 2015 Oct 1;137(7):1560-73.
Title: Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling.
Author: Takahashi, Kohta|Hosono, Masahiro|Sato, Ikuro|Hata, Keiko|Wada, Tadashi|Yamaguchi, Kazunori|Nitta, Kazuo|Shima, Hiroshi|Miyagi, Taeko
PMID: 25810027
Journal: Anticancer Drugs. 2015 Jul;26(6):657-66.
Title: ERK-dependent phosphorylation of HSF1 mediates chemotherapeutic resistance to benzimidazole carbamates in colorectal cancer cells.
Author: Wales, Christina T K|Taylor, Frederick R|Higa, Allan T|McAllister, Harvey A|Jacobs, Aaron T
PMID: 25811962
Journal: Int J Mol Med. 2015 Jun;35(6):1603-9.
Title: Human neutrophil peptides induce interleukin-8 in intestinal epithelial cells through the P2 receptor and ERK1/2 signaling pathways.
Author: Ibusuki, Kazunari|Sakiyama, Toshio|Kanmura, Shuji|Maeda, Takuro|Iwashita, Yuji|Nasu, Yuichiro|Sasaki, Fumisato|Taguchi, Hiroki|Hashimoto, Shinichi|Numata, Masatsugu|Uto, Hirofumi|Tsubouchi, Hirohito|Ido, Akio
PMID: 25816245
Journal: Oncotarget. 2015 Apr 20;6(11):8698-708.
Title: Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87.
Author: Huang, Chi-Chou|Wu, De-Wei|Lin, Po-Lin|Lee, Huei
PMID: 25826088
Journal: Acta Pharmacol Sin. 2015 Apr;36(4):517-27.
Title: Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro.
Author: Ma, Yi-ming|Han, Wei|Li, Jia|Hu, Li-hong|Zhou, Yu-bo
PMID: 25832431
Journal: Cell Physiol Biochem. 2015;35(5):1821-30.
Title: Cinnamaldehyde derivative (CB-PIC) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of MDR1 and its upstream STAT3 and AKT signalling.
Author: Yun, Miyong|Lee, Duckgue|Park, Moon-Nyeo|Kim, Eun-Ok|Sohn, Eun Jung|Kwon, Byung-Mog|Kim, Sung-Hoon
PMID: 25833196
Journal: Drug Des Devel Ther. 2015 Mar 18;9:1679-89.
Title: Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses.
Author: Xie, Zhaohui|Qu, Yine|Leng, Yanli|Sun, Wenxiu|Ma, Siqi|Wei, Jingbo|Hu, Jiangong|Zhang, Xiaolan
PMID: 25834404
Journal: Eur J Med Chem. 2015 May 5;95:453-63.
Title: Design, synthesis, in vitro antiproliferative evaluation, and kinase inhibitory effects of a new series of imidazo[2,1-b]thiazole derivatives.
Author: Abdel-Maksoud, Mohammed S|Kim, Mi-Ryeong|El-Gamal, Mohammed I|Gamal El-Din, Mahmoud M|Tae, Jinsung|Choi, Hong Seok|Lee, Kyung-Tae|Yoo, Kyung Ho|Oh, Chang-Hyun
PMID: 25841200
Journal: Cancer Discov. 2015 Apr;5(4):348-50.
Title: Old Habits Die Hard: Addiction of BRAF-Mutant Cancer Cells to MAP Kinase Signaling.
Author: Meador, Catherine B|Pao, William
PMID: 25847954
Journal: Cancer Sci. 2015 Jun;106(6):692-9.
Title: Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(Delta716) mice involves stromal COX-2.
Author: Fujishita, Teruaki|Kajino-Sakamoto, Rie|Kojima, Yasushi|Taketo, Makoto Mark|Aoki, Masahiro
PMID: 25855137
Journal: Clin Colorectal Cancer. 2015 Sep;14(3):154-61.
Title: A Phase II Study of Sorafenib Combined With Cetuximab in EGFR-Expressing, KRAS-Mutated Metastatic Colorectal Cancer.
Author: Do, Khanh|Cao, Liang|Kang, Zhigang|Turkbey, Baris|Lindenberg, Maria L|Larkins, Erin|Holkova, Beata|Steinberg, Seth M|Raffeld, Mark|Peer, Cody J|Figg, William D|Eugeni, Michelle|Jacobs, Paula|Choyke, Peter|Wright, John J|Doroshow, James H|Kummar, Shivaani
PMID: 25861837
Journal: BMC Cancer. 2015 Apr 12;15:275.
Title: Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancer.
Author: Yamamoto, Takuro|Mori, Taisuke|Sawada, Morio|Matsushima, Hiroshi|Ito, Fumitake|Akiyama, Makoto|Kitawaki, Jo
PMID: 25879875
Journal: BMC Cancer. 2015 Apr 8;15:240.
Title: HGUE-C-1 is an atypical and novel colon carcinoma cell line.
Author: Grasso, Silvina|Martinez-Lacaci, Isabel|Barbera, Victor Manuel|Castillejo, Adela|Soto, Jose Luis|Gallego-Plazas, Javier|Lopez-Riquelme, Natividad|Garcia-Morales, Pilar|Mata-Balaguer, Trinidad|Ferragut, Jose Antonio|Saceda, Miguel
PMID: 25885658
Journal: J Transl Med. 2015 Feb 12;13:57.
Title: Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib.
Author: Wong, Andrea Li Ann|Lim, Joline Si Jing|Sinha, Arvind|Gopinathan, Anil|Lim, Robert|Tan, Chee-Seng|Soh, Thomas|Venkatesh, Sudhakar|Titin, Christina|Sapari, Nur Sabrina|Lee, Soo-Chin|Yong, Wei-Peng|Tan, David Shao Ping|Pang, Brendan|Wang, Ting-Ting|Zee, Yin
PMID: 25889309
Journal: Nutr J. 2015 Apr 1;14:31.
Title: Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells.
Author: Tahir, Analhuda Abdullah|Sani, Nur Fathiah Abdul|Murad, Noor Azian|Makpol, Suzana|Ngah, Wan Zurinah Wan|Yusof, Yasmin Anum Mohd
PMID: 25889965
Journal: BMC Cancer. 2015 Apr 17;15:301.
Title: Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an independent prognostic marker in wild-type KRAS metastatic colorectal cancer after colorectal liver metastasectomy.
Author: Chen, Kuen-Feng|Yen, Chueh-Chuan|Lin, Jen-Kou|Chen, Wei-Shone|Yang, Shung-Haur|Jiang, Jeng-Kai|Lan, Yuan-Tzu|Lin, Chun-Chi|Yu, Hui-Chuan|Hsu, Hui-Mei|Lin, Wen-Ling|Teng, Hao-Wei
PMID: 25896895
Journal: Mol Oncol. 2015 Aug;9(7):1434-46.
Title: KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells.
Author: Leiser, Dominic|Medova, Michaela|Mikami, Kei|Nisa, Lluis|Stroka, Deborah|Blaukat, Andree|Bladt, Friedhelm|Aebersold, Daniel M|Zimmer, Yitzhak
PMID: 25933688
Journal: Br J Pharmacol. 2015 Aug;172(15):3929-43.
Title: Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway.
Author: Xie, Xin|Zhao, Yu|Ma, Chun-Yan|Xu, Xiao-Ming|Zhang, Yan-Qiu|Wang, Chen-Guang|Jin, Jing|Shen, Xin|Gao, Jin-Lai|Li, Na|Sun, Zhi-Jie|Dong, De-Li
PMID: 25953698
Journal: Tumour Biol. 2015 Sep;36(10):7947-60.
Title: gamma-Synuclein confers both pro-invasive and doxorubicin-mediated pro-apoptotic properties to the colon adenocarcinoma LS 174T cell line.
Author: Goh, Kai-Wey|Say, Yee-How
PMID: 25956278
Journal: Int J Mol Sci. 2015 May 7;16(5):10411-25.
Title: TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer.
Author: Jeong, Jin Boo|Lee, Jihye|Lee, Seong-Ho
PMID: 25961950
Journal: Am J Cancer Res. 2015 Jan 15;5(2):560-74. eCollection 2015.
Title: Prominin-1 (CD133, AC133) and dipeptidyl-peptidase IV (CD26) are indicators of infinitive growth in colon cancer cells.
Author: Grunt, Thomas W|Hebar, Alexandra|Laffer, Sylvia|Wagner, Renate|Peter, Barbara|Herrmann, Harald|Graf, Alexandra|Bilban, Martin|Posch, Martin|Hoermann, Gregor|Mayerhofer, Matthias|Eisenwort, Gregor|Zielinski, Christoph C|Selzer, Edgar|Valent, Peter
PMID: 25973297
Journal: Oncotarget. 2015 May 10;6(13):10994-1008.
Title: Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway.
Author: Conti, Annalisa|Majorini, Maria Teresa|Elliott, Richard|Ashworth, Alan|Lord, Christopher J|Cancelliere, Carlotta|Bardelli, Alberto|Seneci, Pierfausto|Walczak, Henning|Delia, Domenico|Lecis, Daniele
PMID: 26028667
Journal: BMC Cancer. 2015 Jun 5;15:456.
Title: Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour.
Author: Cardoso, Ana P|Pinto, Marta L|Pinto, Ana T|Pinto, Marta T|Monteiro, Catia|Oliveira, Marta I|Santos, Susana G|Relvas, Joao B|Seruca, Raquel|Mantovani, Alberto|Mareel, Marc|Barbosa, Mario A|Oliveira, Maria J
PMID: 26043921
Journal: Int J Oncol. 2015 Aug;47(2):773-81.
Title: Inhibitory effect of vitamin K1 on growth and polyamine biosynthesis of human gastric and colon carcinoma cell lines.
Author: Linsalata, Michele|Orlando, Antonella|Tutino, Valeria|Notarnicola, Maria|D'Attoma, Benedetta|Russo, Francesco
PMID: 26043965
Journal: Oncotarget. 2015 Aug 28;6(25):21655-74.
Title: Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.
Author: Nam, Seo Hee|Kim, Doyeun|Lee, Mi-Sook|Lee, Doohyung|Kwak, Tae Kyoung|Kang, Minkyung|Ryu, Jihye|Kim, Hye-Jin|Song, Haeng Eun|Choi, Jungeun|Lee, Gyu-Ho|Kim, Sang-Yeob|Park, Song Hwa|Kim, Dae Gyu|Kwon, Nam Hoon|Kim, Tai Young|Thiery, Jean Paul|Kim, Sunghoon|
PMID: 26091349
Journal: Sci Rep. 2015 Jun 22;5:11541.
Title: Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling.
Author: House, Carrie D|Wang, Bi-Dar|Ceniccola, Kristin|Williams, Russell|Simaan, May|Olender, Jacqueline|Patel, Vyomesh|Baptista-Hon, Daniel T|Annunziata, Christina M|Gutkind, J Silvio|Hales, Tim G|Lee, Norman H
PMID: 26096612
Journal: J Pharmacol Exp Ther. 2015 Sep;354(3):269-78.
Title: Orally Administered Mucolytic Drug l-Carbocisteine Inhibits Angiogenesis and Tumor Growth in Mice.
Author: Shinya, Tomohiro|Yokota, Tsubasa|Nakayama, Shiori|Oki, Sayuri|Mutoh, Junpei|Takahashi, Satoru|Sato, Keizo
PMID: 26126534
Journal: Cancer Immunol Res. 2015 Nov;3(11):1227-35.
Title: IL10R2 Overexpression Promotes IL22/STAT3 Signaling in Colorectal Carcinogenesis.
Author: Khare, Vineeta|Paul, Gregor|Movadat, Oliver|Frick, Adrian|Jambrich, Manuela|Krnjic, Anita|Marian, Brigitte|Wrba, Friedrich|Gasche, Christoph
PMID: 26130064
Journal: Int J Oncol. 2015 Sep;47(3):1034-42.
Title: Cortactin promotes colon cancer progression by regulating ERK pathway.
Author: Ni, Qing-Feng|Yu, Jia-Wei|Qian, Fei|Sun, Nai-Zhi|Xiao, Jian-Jia|Zhu, Jian-Wei
PMID: 26151562
Journal: Cancer Sci. 2015 Oct;106(10):1278-87.
Title: FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7.
Author: Bai, Yu-Pan|Shang, Kun|Chen, Huan|Ding, Fei|Wang, Zhen|Liang, Chen|Xu, Ye|Sun, Meng-Hong|Li, Ying-Yi
PMID: 26183471
Journal: FEBS Lett. 2015 Aug 19;589(18):2388-93.
Title: The S100P/RAGE signaling pathway regulates expression of microRNA-21 in colon cancer cells.
Author: Mercado-Pimentel, Melania E|Onyeagucha, Benjamin C|Li, Qing|Pimentel, Angel C|Jandova, Jana|Nelson, Mark A
PMID: 26193421
Journal: Physiol Rep. 2015 Jul;3(7). pii: 3/7/e12417.
Title: Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis.
Author: Cabral, Marisol|Martin-Venegas, Raquel|Moreno, Juan J
PMID: 26216432
Journal: PLoS One. 2015 Jul 29;10(7):e0133901.
Title: An Integrative Approach for Mapping Differentially Expressed Genes and Network Components Using Novel Parameters to Elucidate Key Regulatory Genes in Colorectal Cancer.
Author: Sehgal, Manika|Gupta, Rajinder|Moussa, Ahmed|Singh, Tiratha Raj
PMID: 26222778
Journal: Cancer Cell Int. 2015 Aug 1;15:77.
Title: Antisense oligonucleotides against microRNA-21 reduced the proliferation and migration of human colon carcinoma cells.
Author: Tao, Yi-Jing|Li, Yong-Ju|Zheng, Wen|Zhao, Juan-Juan|Guo, Meng-Meng|Zhou, Ya|Qin, Na-Lin|Zheng, Jing|Xu, Lin
PMID: 26236156
Journal: Cancer Cell. 2015 Aug 10;28(2):183-97.
Title: ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development.
Author: Fang, Lekun|Lu, Weisi|Choi, Hyun Ho|Yeung, Sai-Ching J|Tung, Jung-Yu|Hsiao, Chwan-Deng|Fuentes-Mattei, Enrique|Menter, David|Chen, Chuangqi|Wang, Lei|Wang, Jianping|Lee, Mong-Hong
PMID: 26267535
Journal: Clin Cancer Res. 2015 Dec 15;21(24):5499-5510.
Title: MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.
Author: Garcia-Garcia, Celina|Rivas, Martin A|Ibrahim, Yasir H|Calvo, Maria Teresa|Gris-Oliver, Albert|Rodriguez, Olga|Grueso, Judit|Anton, Pilar|Guzman, Marta|Aura, Claudia|Nuciforo, Paolo|Jessen, Katti|Argiles, Guillem|Dienstmann, Rodrigo|Bertotti, Andrea|Truso
PMID: 26272063
Journal: J Cancer. 2015 Jul 15;6(9):825-31.
Title: Hypothesis: Obesity Is Associated with a Lower Mutation Threshold in Colon Cancer.
Author: Bordonaro, Michael|Lazarova, Darina
PMID: 26284133
Journal: Int J Mol Sci. 2015 Aug 17;16(8):19401-18.
Title: Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest.
Author: Lan, Qiusheng|Li, Shoufeng|Lai, Wei|Xu, Heyang|Zhang, Yang|Zeng, Yujie|Lan, Wenjian|Chu, Zhonghua
PMID: 26287184
Journal: Nat Commun. 2015 Aug 24;6:8022.
Title: Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway.
Author: Song, Wei|Liu, Wenjie|Zhao, Hong|Li, Shangze|Guan, Xin|Ying, Jianming|Zhang, Yefan|Miao, Fei|Zhang, Mengmeng|Ren, Xiaoxia|Li, Xiaolu|Wu, Fan|Zhao, Yuechao|Tian, Yuanyuan|Wu, Wenming|Fu, Jun|Liang, Junbo|Wu, Wei|Liu, Changzheng|Yu, Jia|Zong, Shudong|Miao,
PMID: 26300397
Journal: Oncotarget. 2015 Oct 20;6(32):33500-11.
Title: Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis.
Author: Chang, Jian|Vacher, Jean|Yao, Bing|Fan, Xiaofeng|Zhang, Bixiang|Harris, Raymond C|Zhang, Ming-Zhi
PMID: 26378024
Journal: J Clin Oncol. 2015 Dec 1;33(34):4023-31.
Title: Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.
Author: Corcoran, Ryan B|Atreya, Chloe E|Falchook, Gerald S|Kwak, Eunice L|Ryan, David P|Bendell, Johanna C|Hamid, Omid|Messersmith, Wells A|Daud, Adil|Kurzrock, Razelle|Pierobon, Mariaelena|Sun, Peng|Cunningham, Elizabeth|Little, Shonda|Orford, Keith|Motwani, Mo
PMID: 26392102
Journal: BMC Complement Altern Med. 2015 Sep 24;15:336.
Title: Fermented So-Cheong-Ryong-Tang (FCY) induces apoptosis via the activation of caspases and the regulation of MAPK signaling pathways in cancer cells.
Author: Yim, Nam-Hui|Kim, Aeyung|Jung, Young Pil|Kim, Taesoo|Ma, Choong Je|Ma, Jin Yeul
PMID: 26403976
Journal: J Exp Clin Cancer Res. 2015 Oct 1;34:108.
Title: Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer.
Author: Giordano, Guido|Febbraro, Antonio|Tomaselli, Eugenio|Sarnicola, Maria Lucia|Parcesepe, Pietro|Parente, Domenico|Forte, Nicola|Fabozzi, Alessio|Remo, Andrea|Bonetti, Andrea|Manfrin, Erminia|Ghasemi, Somayehsadat|Ceccarelli, Michele|Cerulo, Luigi|Bazzoni, F
PMID: 26427914
Journal: J Proteome Res. 2015 Dec 4;14(12):4995-5006.
Title: Integrated Proteomic and Genomic Analysis of Gastric Cancer Patient Tissues.
Author: Yan, Julia Fangfei|Kim, Hoguen|Jeong, Seul-Ki|Lee, Hyoung-Joo|Sethi, Manveen K|Lee, Ling Y|Beavis, Ronald C|Im, Hogune|Snyder, Michael P|Hofree, Matan|Ideker, Trey|Wu, Shiaw-Lin|Paik, Young-Ki|Fanayan, Susan|Hancock, William S
PMID: 26435392
Journal: Sci Rep. 2015 Oct 16;5:15239.
Title: Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity.
Author: Tolba, Mai F|Abdel-Rahman, Sherif Z
PMID: 26472352
Journal: Biomed Res Int. 2015;2015:397563.
Title: Synergistic Inhibitory Effects of Cetuximab and Cisplatin on Human Colon Cancer Cell Growth via Inhibition of the ERK-Dependent EGF Receptor Signaling Pathway.
Author: Son, Dong Ju|Hong, Ji Eun|Ban, Jung Ok|Park, Ju Ho|Lee, Hye Lim|Gu, Sun Mi|Hwang, Jae Yeon|Jung, Myung Hee|Lee, Dong Won|Han, Sang-Bae|Hong, Jin Tae
PMID: 26491668
Journal: Mol Cancer. 2015 Oct 24;14:182.
Title: Activin and TGFbeta use diverging mitogenic signaling in advanced colon cancer.
Author: Bauer, Jessica|Ozden, Ozkan|Akagi, Naomi|Carroll, Timothy|Principe, Daniel R|Staudacher, Jonas J|Spehlmann, Martina E|Eckmann, Lars|Grippo, Paul J|Jung, Barbara
PMID: 26497569
Journal: J Control Release. 2015 Dec 28;220(Pt A):160-168.
Title: Cytotoxicity of PEGylated liposomes co-loaded with novel pro-apoptotic drug NCL-240 and the MEK inhibitor cobimetinib against colon carcinoma in vitro.
Author: Sriraman, Shravan Kumar|Geraldo, Vananelia|Luther, Ed|Degterev, Alexei|Torchilin, Vladimir
PMID: 26497930
Journal: Anticancer Res. 2015 Nov;35(11):5983-91.
Title: Synergistic Effect of SN-38 in Combination with Cetuximab on Angiogenesis and Cancer Cell Invasion.
Author: Pham, Minh Hien|Delestre, Laure|Dewitte, Amelie|Wattez, Nicole|Lepretre, Frederic|Lansiaux, Amelie
PMID: 26504021
Journal: Endocr J. 2015;62(12):1133-7.
Title: Effect of dapagliflozin on colon cancer cell [Rapid Communication].
Author: Saito, Tsugumichi|Okada, Shuichi|Yamada, Eijiro|Shimoda, Yoko|Osaki, Aya|Tagaya, Yuko|Shibusawa, Ryo|Okada, Junichi|Yamada, Masanobu
PMID: 26522271
Journal: PLoS One. 2015 Nov 25;10(11):e0142928.
Title: Mechanism of Action of Two Flavone Isomers Targeting Cancer Cells with Varying Cell Differentiation Status.
Author: LeJeune, Timothy M|Tsui, Hei Yin|Parsons, Laura B|Miller, Gerald E|Whitted, Crystal|Lynch, Kayla E|Ramsauer, Robert E|Patel, Jasmine U|Wyatt, Jarrett E|Street, Doris S|Adams, Carolyn B|McPherson, Brian|Tsui, Hei Man|Evans, Julie A|Livesay, Christopher|Tor
PMID: 26606169
Journal: Asian Pac J Cancer Prev. 2015;16(17):7943-57.
Title: Mechanism of Action of Nigella sativa on Human Colon Cancer Cells: the Suppression of AP-1 and NF-kappaB Transcription Factors and the Induction of Cytoprotective Genes.
Author: Elkady, Ayman I|Hussein, Rania A|El-Assouli, Sufian M
PMID: 26625825
Journal: Int J Clin Exp Med. 2015 Sep 15;8(9):14805-15. eCollection 2015.
Title: Anticolorectal cancer effects and pharmacokinetic application of 2, 2-Bis [4-(4-amino-3-hydroxyphenoxy) phenyl] adamantane.
Author: Yang, Po-Sheng|Wang, Jane-Jen|Tsai, Tung-Hu|Wang, Yea-Hwey|Jan, Woan-Ching|Cheng, Shih-Ping|Chi, Chin-Wen|Hsu, Yi-Chiung
PMID: 26628962
Journal: Am J Cancer Res. 2015 Sep 15;5(10):3085-97. eCollection 2015.
Title: Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2/Akt and ERK signaling pathways.
Author: Yang, Dong|Wang, Lin-Lin|Dong, Tao-Tao|Shen, Yi-Hang|Guo, Xiao-Sun|Liu, Chuan-Yong|Liu, Jie|Zhang, Pei|Li, Juan|Sun, Yu-Ping
PMID: 26693061
Journal: J Recept Signal Transduct Res. 2016;36(1):21-5.
Title: Controversial effect on Erk activation of some cytotoxic drugs in human LOVO colon cancer cells.
Author: Jemel-Oualha, Ikram|Elloumi-Mseddi, Jihene|Beji, Abdelhamid|Hakim, Bochra|Aifa, Sami
PMID: 25343691
Journal: Tumour Biol. 2016 Feb;37(2):2353-63.
Title: Tubb3 regulation by the Erk and Akt signaling pathways: a mechanism involved in the effect of arginine ADP-ribosyltransferase 1 (Art1) on apoptosis of colon carcinoma CT26 cells.
Author: Xiao, Ming|Tang, Yi|Chen, Wen-Wen|Wang, Ya-Lan|Yang, Lian|Li, Xian|Song, Guang-Lin|Kuang, Jing
PMID: 26373733
Journal: Cell Death Differ. 2016 Apr;23(4):707-22.
Title: DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53.
Author: Alam, S K|Yadav, V K|Bajaj, S|Datta, A|Dutta, S K|Bhattacharyya, M|Bhattacharya, S|Debnath, S|Roy, S|Boardman, L A|Smyrk, T C|Molina, J R|Chakrabarti, S|Chowdhury, S|Mukhopadhyay, D|Roychoudhury, S
PMID: 26494468
Journal: Oncol Rep. 2016 Jan;35(1):107-16.
Title: Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression.
Author: Weng, Wen-Hui|Leung, Wai-Hung|Pang, Yeu-Jye|Hsu, Hsi-Hsien
PMID: 26496897
Journal: Oncogene. 2016 Jun 16;35(24):3190-200.
Title: The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer.
Author: Rey, C|Faustin, B|Mahouche, I|Ruggieri, R|Brulard, C|Ichas, F|Soubeyran, I|Lartigue, L|De Giorgi, F
PMID: 26522728
Journal: Oncol Rep. 2016 Jan;35(1):205-10.
Title: Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway.
Author: Xiang, Tao|Fei, Rushan|Wang, Zhe|Shen, Zhonglei|Qian, Jing|Chen, Wenbin
PMID: 26530054
Journal: Oncol Rep. 2016 Jan;35(1):409-17.
Title: Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells.
Author: Du, Chuang|Wang, Xin|Zhang, Junling|Liu, Xiangzheng|Zhu, Jing|Liu, Yucun
PMID: 26530439
Journal: Int J Mol Med. 2016 Jan;37(1):126-32.
Title: Orexin A induces autophagy in HCT-116 human colon cancer cells through the ERK signaling pathway.
Author: Wen, Jing|Zhao, Yuyan|Guo, Lei
PMID: 26572581
Journal: Cancer Res. 2016 Feb 1;76(3):724-35.
Title: Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.
Author: Marusiak, Anna A|Stephenson, Natalie L|Baik, Hayeon|Trotter, Eleanor W|Li, Yaoyong|Blyth, Karen|Mason, Susan|Chapman, Phil|Puto, Lorena A|Read, Jon A|Brassington, Claire|Pollard, Hannah K|Phillips, Chris|Green, Isabelle|Overman, Ross|Collier, Matthew|Test
PMID: 26637668
Journal: Clin Cancer Res. 2016 May 15;22(10):2368-76.
Title: A Phase I Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Combination Therapy with Refametinib plus Sorafenib in Patients with Advanced Cancer.
Author: Adjei, Alex A|Richards, Donald A|El-Khoueiry, Anthony|Braiteh, Fadi|Becerra, Carlos H R|Stephenson, Joe J Jr|Hezel, Aram F|Sherman, Morris|Garbo, Lawrence|Leffingwell, Diane P|Iverson, Cory|Miner, Jeffrey N|Shen, Zancong|Yeh, Li-Tain|Gunawan, Sonny|Wilson
PMID: 26644411
Journal: Int J Oncol. 2016 Jan;48(1):305-12.
Title: Exosomes derived from SW480 colorectal cancer cells promote cell migration in HepG2 hepatocellular cancer cells via the mitogen-activated protein kinase pathway.
Author: Chiba, Mitsuru|Watanabe, Narumi|Watanabe, Miki|Sakamoto, Maki|Sato, Akika|Fujisaki, Mizuki|Kubota, Shiori|Monzen, Satoru|Maruyama, Atsushi|Nanashima, Naoki|Kashiwakura, Ikuo|Nakamura, Toshiya
PMID: 26647805
Journal: Invest New Drugs. 2016 Apr;34(2):168-75.
Title: A phase I study of selumetinib (AZD6244/ARRY-142866), a MEK1/2 inhibitor, in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal cancer.
Author: Deming, Dustin A|Cavalcante, Ludmila L|Lubner, Sam J|Mulkerin, Daniel L|LoConte, Noelle K|Eickhoff, Jens C|Kolesar, Jill M|Fioravanti, Suzanne|Greten, Tim F|Compton, Kathryn|Doyle, Austin G|Wilding, George|Duffy, Austin|Liu, Glenn
PMID: 26666244
Journal: Cancer Res Treat. 2016 Jul;48(3):1141-53.
Title: Dexamethasone Inhibits TGF-beta1-Induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61.
Author: Han, Sanghoon|Bui, Ngoc Thuy|Ho, Manh Tin|Kim, Young Mee|Cho, Moonjae|Shin, Dong Bok
PMID: 26693911
Journal: J Biol Chem. 2016 Feb 26;291(9):4589-602.
Title: p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance.
Author: Antoine-Bertrand, Judith|Duquette, Philippe M|Alchini, Ricardo|Kennedy, Timothy E|Fournier, Alyson E|Lamarche-Vane, Nathalie
PMID: 26710849
Journal: Tumour Biol. 2016 Jul;37(7):8811-24.
Title: Upregulation of CD44v6 contributes to acquired chemoresistance via the modulation of autophagy in colon cancer SW480 cells.
Author: Lv, Lin|Liu, Hai-Guang|Dong, Si-Yang|Yang, Fan|Wang, Qing-Xuan|Guo, Gui-Long|Pan, Yi-Fei|Zhang, Xiao-Hua
PMID: 26747179
Journal: J Exp Clin Cancer Res. 2016 Jan 12;35:5.
Title: Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer.
Author: Ding, Chenbo|Luo, Junmin|Li, Longmei|Li, Shanshan|Yang, Liwen|Pan, Hongfei|Liu, Qianyi|Qin, Huan|Chen, Chao|Feng, Jihong
PMID: 26754532
Journal: Mol Carcinog. 2016 Dec;55(12):2135-2155.
Title: A novel PI3K axis selective molecule exhibits potent tumor inhibition in colorectal carcinogenesis.
Author: Hussain, Aashiq|Qazi, Asif Khurshid|Mupparapu, Nagaraju|Kumar, Ashok|Mintoo, Mubashir Javeed|Mahajan, Girish|Sharma, Parduman Raj|Singh, Shashank Kumar|Bharate, Sandip B|Zargar, Mohmmad Afzal|Ahmed, Qazi Naveed|Mondhe, Dilip Manikrao|Vishwakarma, Ram A|Ha
PMID: 26764221
Journal: Oncotarget. 2016 Feb 23;7(8):9188-221.
Title: BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells.
Author: Goulielmaki, Maria|Koustas, Evangelos|Moysidou, Eirini|Vlassi, Margarita|Sasazuki, Takehiko|Shirasawa, Senji|Zografos, George|Oikonomou, Eftychia|Pintzas, Alexander
PMID: 26802026
Journal: Molecules. 2016 Jan 30;21(2):169.
Title: Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment.
Author: Afrin, Sadia|Giampieri, Francesca|Gasparrini, Massimiliano|Forbes-Hernandez, Tamara Y|Varela-Lopez, Alfonso|Quiles, Jose L|Mezzetti, Bruno|Battino, Maurizio
PMID: 26840292
Journal: Cell Prolif. 2016 Feb;49(1):69-78.
Title: microRNA-497 inhibits invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor-A.
Author: Qiu, Yanyan|Yu, Hui|Shi, Xiaojing|Xu, Ke|Tang, Qingfeng|Liang, Bo|Hu, Songjiao|Bao, Yijie|Xu, Jianhua|Cai, Jie|Peng, Wen|Cao, Qin|Yin, Peihao
PMID: 26840372
Journal: Sci Rep. 2016 Feb 5;6:20500.
Title: Norcantharidin Suppresses Colon Cancer Cell Epithelial-Mesenchymal Transition by Inhibiting the alphavbeta6-ERK-Ets1 Signaling Pathway.
Author: Peng, Cheng|Li, Zequn|Niu, Zhengchuan|Niu, Wei|Xu, Zongquan|Gao, Huijie|Niu, Weibo|Wang, JiaYong|He, Zhaobin|Gao, Chao|Lin, Pengfei|Agrez, Michael|Zhang, Zongli|Niu, Jun
PMID: 26846153
Journal: Mol Med Rep. 2016 Mar;13(3):2536-42.
Title: Nitidine chloride inhibits proliferation and induces apoptosis in colorectal cancer cells by suppressing the ERK signaling pathway.
Author: Zhai, Huiyuan|Hu, Sanyuan|Liu, Tongxiang|Wang, Feng|Wang, Xixun|Wu, Guochang|Zhang, Yifei|Sui, Minghua|Liu, Huantao|Jiang, Lixin
PMID: 26847477
Journal: Sci Rep. 2016 Feb 5;6:20460.
Title: KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway.
Author: Li, Liping|Duan, Tingmei|Wang, Xin|Zhang, Ru-Hua|Zhang, Meifang|Wang, Suihai|Wang, Fen|Wu, Yuanzhong|Huang, Haojie|Kang, Tiebang
PMID: 26847701
Journal: Anticancer Res. 2016 Feb;36(2):591-8.
Title: Polyphosphate Derived from Lactobacillus brevis Inhibits Colon Cancer Progression Through Induction of Cell Apoptosis.
Author: Sakatani, Aki|Fujiya, Mikihiro|Ueno, Nobuhiro|Kashima, Shin|Sasajima, Junpei|Moriichi, Kentaro|Ikuta, Katsuya|Tanabe, Hiroki|Kohgo, Yutaka
PMID: 26851013
Journal: PLoS One. 2016 Feb 9;11(2):e0148775.
Title: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells.
Author: Phang, Chung-Weng|Karsani, Saiful Anuar|Sethi, Gautam|Abd Malek, Sri Nurestri
PMID: 26859847
Journal: BMB Rep. 2016 Apr;49(4):220-5.
Title: Biphasic activation of extracellular signal-regulated kinase (ERK) 1/2 in epidermal growth factor (EGF)-stimulated SW480 colorectal cancer cells.
Author: Joo, Donghyun|Woo, Jong Soo|Cho, Kwang-Hyun|Han, Seung Hyun|Min, Tae Sun|Yang, Deok-Chun|Yun, Cheol-Heui
PMID: 26879318
Journal: Int J Oncol. 2016 Apr;48(4):1553-60.
Title: Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cellextracellular matrix adhesion for migration.
Author: Nam, Seo Hee|Kang, Minkyung|Ryu, Jihye|Kim, Hye-Jin|Kim, Doyeun|Kim, Dae Gyu|Kwon, Nam Hoon|Kim, Sunghoon|Lee, Jung Weon
PMID: 26891990
Journal: Cancer Genomics Proteomics. 2016 Mar-Apr;13(2):141-50.
Title: GeneGazer: A Toolkit Integrating Two Pipelines for Personalized Profiling and Biosignature Identification.
Author: Luo, Ji-Dung|Chang, Yu-Jia|Chang, Chung-Ming|You, Jeng-Fu|Wei, Po-Li|Chiou, Chiuan-Chian
PMID: 26912804
Journal: Oncotarget. 2016 Mar 29;7(13):16349-61.
Title: AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin.
Author: Gao, Mei|Kong, Qingbin|Hua, Hui|Yin, Yancun|Wang, Jiao|Luo, Ting|Jiang, Yangfu
PMID: 26918349
Journal: Asian Pac J Cancer Prev. 2016;17(2):743-8.
Title: Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA.
Author: Yousef, Amany I|El-Masry, Omar S|Abdel Mohsen, Mohamed A
PMID: 26925673
Journal: Oncotarget. 2016 Apr 12;7(15):20368-80.
Title: Antitumor effects of calgranulin B internalized in human colon cancer cells.
Author: Kim, Kun|Kim, Kyung-Hee|Roh, Kangsan|Yoo, Byong Chul|Ku, Ja-Lok|Shin, Young-Kyoung|Cho, Jae Youl|Kim, Minjae|Kwon, Myung-Hee|Goh, Sung Ho|Chang, Hee Jin|Oh, Jae Hwan
PMID: 26933915
Journal: Cell Cycle. 2016;15(4):506-18.
Title: Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.
Author: Lochhead, Pamela A|Clark, Jonathan|Wang, Lan-Zhen|Gilmour, Lesley|Squires, Matthew|Gilley, Rebecca|Foxton, Caroline|Newell, David R|Wedge, Stephen R|Cook, Simon J
PMID: 26959608
Journal: Proteomics. 2016 May;16(10):1557-69.
Title: Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in the Apc(Min/+) mouse model.
Author: Tai, William Chi-Shing|Wong, Wing-Yan|Lee, Magnolia Muk-Lan|Chan, Brandon Dow|Lu, Cheng|Hsiao, Wen-Luan Wendy
PMID: 26970558
Journal: Anticancer Res. 2016 Mar;36(3):1211-9.
Title: Knockdown of EPHA1 by CRISPR/CAS9 Promotes Adhesion and Motility of HRT18 Colorectal Carcinoma Cells.
Author: Wu, B O|Jiang, Wen G|Zhou, Deshan|Cui, Yu-Xin
PMID: 26977017
Journal: Mol Cancer Ther. 2016 Jun;15(6):1217-26.
Title: Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.
Author: Togel, Lars|Nightingale, Rebecca|Chueh, Anderly C|Jayachandran, Aparna|Tran, Hoanh|Phesse, Toby|Wu, Rui|Sieber, Oliver M|Arango, Diego|Dhillon, Amardeep S|Dawson, Mark A|Diez-Dacal, Beatriz|Gahman, Timothy C|Filippakopoulos, Panagis|Shiau, Andrew K|Mariad
PMID: 26983878
Journal: Oncotarget. 2016 Apr 19;7(16):22687-99.
Title: DDX3 enhances oncogenic KRASinduced tumor invasion in colorectal cancer via the betacatenin/ZEB1 axis.
Author: Wu, De-Wei|Lin, Po-Lin|Cheng, Ya-Wen|Huang, Chi-Chou|Wang, Lee|Lee, Huei
PMID: 27007150
Journal: Mol Nutr Food Res. 2016 Sep;60(9):1912-23.
Title: Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis.
Author: Kim, Hyemee|Banerjee, Nivedita|Ivanov, Ivan|Pfent, Catherine M|Prudhomme, Kalan R|Bisson, William H|Dashwood, Roderick H|Talcott, Stephen T|Mertens-Talcott, Susanne U
PMID: 27028006
Journal: Hum Pathol. 2016 Aug;54:37-46.
Title: Localization of active, dually phosphorylated extracellular signal-regulated kinase 1 and 2 in colorectal cancer with or without activating BRAF and KRAS mutations.
Author: Holck, Susanne|Bonde, Jesper|Pedersen, Helle|Petersen, Anja Alex|Chaube, Amita|Nielsen, Hans Jorgen|Larsson, Lars-Inge
PMID: 27036313
Journal: Gene. 2016 Jul 15;586(1):41-7.
Title: SRPK2 promotes the growth and migration of the colon cancer cells.
Author: Wang, Jian|Wu, Hai-Feng|Shen, Wei|Xu, Dong-Yan|Ruan, Ting-Yan|Tao, Guo-Qing|Lu, Pei-Hua
PMID: 27041240
Journal: J Cancer Res Ther. 2016 Jan-Mar;12(1):96-102.
Title: The association of clinicopathological features and survival in colorectal cancer patients with kras mutation status.
Author: Akman, Tulay|Oztop, Ilhan|Baskin, Yasemin|Unek, Ilkay Tugba|Demir, Necla|Ellidokuz, Hulya|Yilmaz, Ahmet Ugur
PMID: 27072218
Journal: Cell Mol Immunol. 2016 Sep;13(5):688-99.
Title: Expression of the novel adipokine C1qTNF-related protein 4 (CTRP4) suppresses colitis and colitis-associated colorectal cancer in mice.
Author: Luo, Yang|Wu, Xiaotong|Ma, Zhuang|Tan, Weifeng|Wang, Lanlan|Na, Daxiang|Zhang, Guoying|Yin, Ang|Huang, He|Xia, Dan|Zhang, Yingmei|Shi, Xueying|Wang, Lu
PMID: 27086950
Journal: Front Genet. 2016 Apr 5;7:42.
Title: Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines.
Author: Wlochowitz, Darius|Haubrock, Martin|Arackal, Jetcy|Bleckmann, Annalen|Wolff, Alexander|Beissbarth, Tim|Wingender, Edgar|Gultas, Mehmet
PMID: 27092172
Journal: Sci Rep. 2016 Apr 20;6:24720.
Title: miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling.
Author: El-Daly, Sherien M|Abba, Mohammed L|Patil, Nitin|Allgayer, Heike
PMID: 27095166
Journal: J Hum Genet. 2016 Aug;61(8):711-20.
Title: Claudin-7 indirectly regulates the integrin/FAK signaling pathway in human colon cancer tissue.
Author: Ding, Lei|Wang, Liyong|Sui, Leiming|Zhao, Huanying|Xu, Xiaoxue|Li, Tengyan|Wang, Xiaonan|Li, Wenjing|Zhou, Ping|Kong, Lu
PMID: 27121327
Journal: Am J Transl Res. 2016 Feb 15;8(2):742-8. eCollection 2016.
Title: BRD7: a novel tumor suppressor gene in different cancers.
Author: Yu, Xin|Li, Zheng|Shen, Jianxiong
PMID: 27158366
Journal: Environ Toxicol Pharmacol. 2016 Jun;44:128-33.
Title: Endoplasmic reticulum stress induces 5-fluorouracil resistance in human colon cancer cells.
Author: Kim, Joon Ki|Kang, Kyoung Ah|Piao, Mei Jing|Ryu, Yea Seong|Han, Xia|Fernando, Pattage Madushan Dilhara Jayatissa|Oh, Min Chang|Park, Jeong Eon|Shilnikova, Kristina|Boo, Sun Jin|Na, Soo-Young|Jeong, Yong Joo|Jeong, Seung Uk|Hyun, Jin Won
PMID: 27163731
Journal: Oncotarget. 2016 Jun 28;7(26):39595-39608.
Title: Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models.
Author: Lee, Michael S|Helms, Timothy L|Feng, Ningping|Gay, Jason|Chang, Qing Edward|Tian, Feng|Wu, Ji Y|Toniatti, Carlo|Heffernan, Timothy P|Powis, Garth|Kwong, Lawrence N|Kopetz, Scott
PMID: 27167191
Journal: Cancers (Basel). 2016 May 14;8(5). pii: cancers8050049.
Title: In Hyperthermia Increased ERK and WNT Signaling Suppress Colorectal Cancer Cell Growth.
Author: Bordonaro, Michael|Shirasawa, Senji|Lazarova, Darina L
PMID: 27187477
Journal: J Cell Biochem. 2016 Dec;117(12):2875-2885.
Title: Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2 Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells.
Author: Semaan, Josiane|Pinon, Aline|Rioux, Benjamin|Hassan, Lama|Limami, Youness|Pouget, Christelle|Fagnere, Catherine|Sol, Vincent|Diab-Assaf, Mona|Simon, Alain|Liagre, Bertrand
PMID: 27192488
Journal: Tumour Biol. 2016 Sep;37(9):12153-12160.
Title: SH3GL1 inhibition reverses multidrug resistance in colorectal cancer cells by downregulation of MDR1/P-glycoprotein via EGFR/ERK/AP-1 pathway.
Author: Guan, Haitao|Zhao, Ping|Dai, Zhijun|Liu, Xiaoxu|Wang, Xijing
PMID: 27220321
Journal: Antioxid Redox Signal. 2016 Sep 10;25(8):467-84.
Title: Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects.
Author: Paillas, Salome|Ladjohounlou, Riad|Lozza, Catherine|Pichard, Alexandre|Boudousq, Vincent|Jarlier, Marta|Sevestre, Samuel|Le Blay, Marion|Deshayes, Emmanuel|Sosabowski, Jane|Chardes, Thierry|Navarro-Teulon, Isabelle|Mairs, Robert J|Pouget, Jean-Pierre
PMID: 27224059
Journal: Oncotarget. 2016 Jun 21;7(25):38191-38209.
Title: Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule.
Author: Djuzenova, Cholpon S|Fiedler, Vanessa|Katzer, Astrid|Michel, Konstanze|Deckert, Stefanie|Zimmermann, Heiko|Sukhorukov, Vladimir L|Flentje, Michael
PMID: 27224913
Journal: Oncotarget. 2016 Jul 12;7(28):43442-43460.
Title: Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs.
Author: Barreto, Rafael|Waning, David L|Gao, Hongyu|Liu, Yunlong|Zimmers, Teresa A|Bonetto, Andrea
PMID: 27259276
Journal: Oncotarget. 2016 Jul 12;7(28):43907-43923.
Title: Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice.
Author: Pajari, Anne-Maria|Paivarinta, Essi|Paavolainen, Lassi|Vaara, Elina|Koivumaki, Tuuli|Garg, Ritu|Heiman-Lindh, Anu|Mutanen, Marja|Marjomaki, Varpu|Ridley, Anne J
PMID: 27270323
Journal: Dev Reprod. 2016 Mar;20(1):1-10.
Title: Blockage of Autophagy Rescues the Dual PI3K/mTOR Inhibitor BEZ235-induced Growth Inhibition of Colorectal Cancer Cells.
Author: Oh, Iljoong|Cho, Hyunchul|Lee, Yonghoon|Cheon, Minseok|Park, Deokbae|Lee, Youngki
PMID: 27294206
Journal: Nutrients. 2016 Jun 13;8(6). pii: nu8060360.
Title: Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer.
Author: Liu, Can|Dai, Longhai|Liu, Yueping|Rong, Long|Dou, Dequan|Sun, Yuanxia|Ma, Lanqing
PMID: 27304964
Journal: Cancer Res. 2016 Aug 1;76(15):4504-15.
Title: Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer.
Author: Oddo, Daniele|Sennott, Erin M|Barault, Ludovic|Valtorta, Emanuele|Arena, Sabrina|Cassingena, Andrea|Filiciotto, Genny|Marzolla, Giulia|Elez, Elena|van Geel, Robin M J M|Bartolini, Alice|Crisafulli, Giovanni|Boscaro, Valentina|Godfrey, Jason T|Buscarino, M
PMID: 27312529
Journal: Cancer Lett. 2016 Sep 28;380(1):87-97.
Title: Inhibition of the NF-kappaB pathway by nafamostat mesilate suppresses colorectal cancer growth and metastasis.
Author: Lu, Yun-Xin|Ju, Huai-Qiang|Wang, Feng|Chen, Le-Zong|Wu, Qi-Nian|Sheng, Hui|Mo, Hai-Yu|Pan, Zhi-Zhong|Xie, Dan|Kang, Tie-Bang|Chen, Gong|Yun, Jing-Ping|Zeng, Zhao-Lei|Xu, Rui-Hua
PMID: 27322737
Journal: Oncotarget. 2016 Jul 19;7(29):46219-46229.
Title: Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer.
Author: Jang, Hyun Joo|Hong, Eun Mi|Kim, Mikang|Kim, Jae Hyun|Jang, Juah|Park, Se Woo|Byun, Hyun Wu|Koh, Dong Hee|Choi, Min Ho|Kae, Sea Hyub|Lee, Jin
PMID: 27323826
Journal: Oncotarget. 2016 Jul 26;7(30):47954-47965.
Title: Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer.
Author: Aguilera, Oscar|Munoz-Sagastibelza, Maria|Torrejon, Blanca|Borrero-Palacios, Aurea|Del Puerto-Nevado, Laura|Martinez-Useros, Javier|Rodriguez-Remirez, Maria|Zazo, Sandra|Garcia, Estela|Fraga, Mario|Rojo, Federico|Garcia-Foncillas, Jesus
PMID: 27323830
Journal: Oncol Lett. 2016 Jul;12(1):250-256.
Title: Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation.
Author: Jang, Hyun Joo|Hong, Eun Mi|Park, Se Woo|Byun, Hyun Woo|Koh, Dong Hee|Choi, Min Ho|Kae, Sea Hyub|Lee, Jin
PMID: 27347133
Journal: Oncotarget. 2016 Jul 26;7(30):47699-47710.
Title: BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells.
Author: He, Kan|Chen, Dongshi|Ruan, Hang|Li, Xiangyun|Tong, Jingshan|Xu, Xiang|Zhang, Lin|Yu, Jian
PMID: 27351224
Journal: Anticancer Res. 2016 Jul;36(7):3383-94.
Title: Enhanced TLR4 Expression on Colon Cancer Cells After Chemotherapy Promotes Cell Survival and Epithelial-Mesenchymal Transition Through Phosphorylation of GSK3beta.
Author: Chung, Yoon Hee|Kim, Daejin
PMID: 27354597
Journal: Oncotarget. 2016 Jul 26;7(30):47637-47649.
Title: CCR4 promotes metastasis via ERK/NF-kappaB/MMP13 pathway and acts downstream of TNF-alpha in colorectal cancer.
Author: Ou, Baochi|Zhao, Jingkun|Guan, Shaopei|Feng, Hao|Wangpu, Xiongzhi|Zhu, Congcong|Zong, Yaping|Ma, Junjun|Sun, Jing|Shen, Xiaohui|Zheng, Minhua|Lu, Aiguo
PMID: 27356745
Journal: Biochem Biophys Res Commun. 2016 Sep 2;477(4):801-806.
Title: Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation.
Author: Tashiro, Etsu|Henmi, Shizuka|Odake, Hiroyuki|Ino, Seitaro|Imoto, Masaya
PMID: 27369075
Journal: Oncotarget. 2016 Aug 2;7(31):49597-49610.
Title: Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922.
Author: Wang, Chun Yan|Guo, Su Tang|Wang, Jia Yu|Yan, Xu Guang|Farrelly, Margaret|Zhang, Yuan Yuan|Liu, Fen|Yari, Hamed|La, Ting|Lei, Fu Xi|Jin, Lei|Zhang, Xu Dong|Jiang, Chen Chen
PMID: 27391062
Journal: Oncogenesis. 2016 Jul 11;5(7):e240.
Title: Expression of the chemokine CXCL14 and cetuximab-dependent tumour suppression in head and neck squamous cell carcinoma.
Author: Kondo, T|Ozawa, S|Ikoma, T|Yang, X-Y|Kanamori, K|Suzuki, K|Iwabuchi, H|Maehata, Y|Miyamoto, C|Taguchi, T|Kiyono, T|Kubota, E|Hata, R-I
PMID: 27399917
Journal: Front Cell Infect Microbiol. 2016 Jun 21;6:68.
Title: Flagellin Induces beta-Defensin 2 in Human Colonic Ex vivo Infection with Enterohemorrhagic Escherichia coli.
Author: Lewis, Steven B|Prior, Alison|Ellis, Samuel J|Cook, Vivienne|Chan, Simon S M|Gelson, William|Schuller, Stephanie
PMID: 27446815
Journal: Exp Mol Med. 2016 Jul 29;48(7):e249.
Title: Sur8 mediates tumorigenesis and metastasis in colorectal cancer.
Author: Lee, Young-Mi|Kaduwal, Saluja|Lee, Kug Hwa|Park, Jong-Chan|Jeong, Woo-Jeong|Choi, Kang-Yell
PMID: 27469030
Journal: Nutr Cancer. 2016 Oct;68(7):1234-46.
Title: Anticancer Activity of Buttermilk Against SW480 Colon Cancer Cells is Associated with Caspase-Independent Cell Death and Attenuation of Wnt, Akt, and ERK Signaling.
Author: Kuchta-Noctor, Anna M|Murray, Brian A|Stanton, Catherine|Devery, Rosaleen|Kelly, Phil M
PMID: 27472445
Journal: J Biol Chem. 2016 Aug 5;291(32):16925.
Title: Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.
Author: Gupta, Subash C|Reuter, Simone|Phromnoi, Kanokkarn|Park, Byoungduck|Hema, Padmanabhan S|Nair, Mangalam|Aggarwal, Bharat B
PMID: 27496966
Journal: Tumour Biol. 2016 Oct;37(10):14205-14215.
Title: Decreased expression of LncRNA SLC25A25-AS1 promotes proliferation, chemoresistance, and EMT in colorectal cancer cells.
Author: Li, Yuan|Huang, Shengkai|Li, Yan|Zhang, Weilong|He, Kun|Zhao, Mei|Lin, Hong|Li, Dongdong|Zhang, Honggang|Zheng, Zhaoxu|Huang, Changzhi
PMID: 27553025
Journal: Nutr Cancer. 2016 Oct;68(7):1225-33.
Title: All-Trans Retinoic Acid Inhibits Human Colorectal Cancer Cells RKO Migration via Downregulating Myosin Light Chain Kinase Expression through MAPK Signaling Pathway.
Author: Zuo, Li|Yang, Xiaoping|Lu, Man|Hu, Ruolei|Zhu, Huaqing|Zhang, Sumei|Zhou, Qing|Chen, Feihu|Gui, Shuyu|Wang, Yuan
PMID: 27564600
Journal: FASEB J. 2016 Dec;30(12):4159-4171.
Title: Role of neutral ceramidase in colon cancer.
Author: Garcia-Barros, Monica|Coant, Nicolas|Kawamori, Toshihiko|Wada, Masayuki|Snider, Ashley J|Truman, Jean-Philip|Wu, Bill X|Furuya, Hideki|Clarke, Christopher J|Bialkowska, Agnieszka B|Ghaleb, Amr|Yang, Vincent W|Obeid, Lina M|Hannun, Yusuf A
PMID: 27609772
Journal: World J Gastroenterol. 2016 Aug 21;22(31):7099-110.
Title: Current understanding concerning intestinal stem cells.
Author: Cui, Shuang|Chang, Peng-Yu
PMID: 27610020
Journal: Apoptosis. 2016 Nov;21(11):1291-1301.
Title: Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation.
Author: Chen, Lei|Meng, Yue|Guo, Xiaoqing|Sheng, Xiaotong|Tai, Guihua|Zhang, Fenglei|Cheng, Hairong|Zhou, Yifa
PMID: 27629794
Journal: Int J Oncol. 2016 Oct;49(4):1505-1512.
Title: Downregulation of RLIP76 is associated with vincristine resistance in human colorectal cancer HCT-8/VCR cells.
Author: Wang, Wenwen|Liu, Juan|Qi, Jianni|Zhang, Junyong|Zhu, Qiang|Ma, Jincai|Qin, Chengyong
PMID: 27633085
Journal: Oncol Rep. 2016 Nov;36(5):2723-2730.
Title: Glucose-regulated protein 78 contributes to the proliferation and tumorigenesis of human colorectal carcinoma via AKT and ERK pathways.
Author: Zhou, Xuan|Xing, Xiaoming|Zhang, Shuping|Liu, Lili|Wang, Chengqin|Li, Lin|Ji, Qiuxia|Liu, Huamin
PMID: 27634156
Journal: Oncotarget. 2016 Nov 1;7(44):71400-71416.
Title: STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways.
Author: Chen, Bing|Zeng, Xiao|He, Yu|Wang, Xixi|Liang, Ziwei|Liu, Jingjing|Zhang, Peng|Zhu, Hongxia|Xu, Ningzhi|Liang, Shufang
PMID: 27662663
Journal: Oncol Lett. 2016 Oct;12(4):2463-2474.
Title: Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells.
Author: Saglam, Atiye Seda Yar|Alp, Ebru|Elmazoglu, Zubeyir|Menevse, Emine Sevda
PMID: 27698814
Journal: BMC Cancer. 2016 Oct 12;16(1):791.
Title: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model.
Author: Ding, Chenbo|Li, Longmei|Yang, Taoyu|Fan, Xiaobo|Wu, Guoqiu
PMID: 27729020
Journal: Sci Signal. 2016 Oct 11;9(449):rs11.
Title: Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks.
Author: Simmons, Alan J|Scurrah, Cherie R|McKinley, Eliot T|Herring, Charles A|Irish, Jonathan M|Washington, M Kay|Coffey, Robert J|Lau, Ken S
PMID: 27729552
Journal: Exp Cell Res. 2016 Nov 15;349(1):119-127.
Title: Claudin-1 promotes TNF-alpha-induced epithelial-mesenchymal transition and migration in colorectal adenocarcinoma cells.
Author: Bhat, Ajaz A|Ahmad, Rizwan|Uppada, SrijayaPrakash B|Singh, Amar B|Dhawan, Punita
PMID: 27742576
Journal: Mol Cancer Ther. 2016 Dec;15(12):3015-3027.
Title: Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer.
Author: Kawakami, Hisato|Huang, Shengbing|Pal, Krishnendu|Dutta, Shamit K|Mukhopadhyay, Debabrata|Sinicrope, Frank A
PMID: 27765849
Journal: Oncotarget. 2016 Dec 6;7(49):81223-81240.
Title: Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into beta-arrestin-dependent ERK signaling.
Author: Liu, Hongda|Zhang, Qun|Li, Kangshuai|Gong, Zheng|Liu, Zhaochen|Xu, Yunfei|Swaney, Mary Hannah|Xiao, Kunhong|Chen, Yuxin
PMID: 27835898
Journal: Cancer Chemother Pharmacol. 2016 Dec;78(6):1269-1281.
Title: Enhanced anti-tumour activity of the combination of the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037.
Author: Haagensen, Emma J|Thomas, Huw D|Schmalix, Wolfgang A|Payne, Andrew C|Kevorkian, Lara|Allen, Rodger A|Bevan, Paul|Maxwell, Ross J|Newell, David R
PMID: 27837257
Journal: Onco Targets Ther. 2016 Nov 30;9:7285-7295.
Title: CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer.
Author: Yang, Kai|Gao, Kai|Hu, Gui|Wen, Yanguang|Lin, Changwei|Li, Xiaorong
PMID: 27942222
Journal: Oncol Lett. 2016 Dec;12(6):4589-4597.
Title: miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer.
Author: Zhang, Nan|Lu, Canrong|Chen, Lin
PMID: 28105166
Journal: Oncol Lett. 2016 Dec;12(6):4850-4856.
Title: Akt-dependent activation of Erk by cyclin D1b contributes to cell invasiveness and tumorigenicity.
Author: Kim, Chul Jang|Tambe, Yukihiro|Mukaisho, Ken-Ichi|Sugihara, Hiroyuki|Kawauchi, Akihiro|Inoue, Hirokazu
PMID: 28105192
Journal: Vascul Pharmacol. 2017 Mar;90:27-35.
Title: Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells.
Author: Huang, Bin|Cheng, Jen-Kun|Wu, Chien-Yi|Chen, Ping-Ho|Tu, Po-Shu|Fu, Yaw-Syan|Wu, Chien-Hsing
PMID: 26239883
Journal: Environ Toxicol. 2017 Feb;32(2):669-678.
Title: Inhibition of NF-kappaB and metastasis in irinotecan (CPT-11)-resistant LoVo colon cancer cells by thymoquinone via JNK and p38.
Author: Chen, Ming-Cheng|Lee, Nien-Hung|Hsu, Hsi-Hsien|Ho, Tsung-Jung|Tu, Chuan-Chou|Chen, Ray-Jade|Lin, Yueh-Min|Viswanadha, Vijaya Padma|Kuo, Wei-Wen|Huang, Chih-Yang
PMID: 27060453
Journal: J Cell Biochem. 2017 Jan;118(1):191-203.
Title: Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, Whereas BAY61-3606, a Synthetic Syk Inhibitor Abrogates Colonocyte Apoptosis by ERK Activation.
Author: Dasgupta, Nirmalya|Thakur, Bhupesh Kumar|Ta, Atri|Dutta, Pujarini|Das, Santasabuj
PMID: 27293079
Journal: Oncogene. 2017 Feb 9;36(6):787-796.
Title: FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.
Author: Tong, J|Tan, S|Zou, F|Yu, J|Zhang, L
PMID: 27399335
Journal: Semin Cancer Biol. 2017 Feb;42:70-80.
Title: Smyd3-associated regulatory pathways in cancer.
Author: Giakountis, Antonis|Moulos, Panagiotis|Sarris, Michalis E|Hatzis, Pantelis|Talianidis, Iannis
PMID: 27554136
Journal: Gut. 2017 Jun;66(6):1106-1115.
Title: Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer.
Author: Borovski, Tijana|Vellinga, Thomas T|Laoukili, Jamila|Santo, Evan E|Fatrai, Szabolcs|van Schelven, Susanne|Verheem, Andre|Marvin, Dieuwke L|Ubink, Inge|Borel Rinkes, Inne H M|Kranenburg, Onno
PMID: 27670374
Journal: Clin Cancer Res. 2017 Apr 15;23(8):2027-2037.
Title: The MAPK Pathway Regulates Intrinsic Resistance to BET Inhibitors in Colorectal Cancer.
Author: Ma, Yufang|Wang, Lihong|Neitzel, Leif R|Loganathan, Sudan N|Tang, Nan|Qin, Lili|Crispi, Emily E|Guo, Yan|Knapp, Stefan|Beauchamp, R Daniel|Lee, Ethan|Wang, Jialiang
PMID: 27678457
Journal: Eur J Pharmacol. 2017 Jan 5;794:1-7.
Title: Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice.
Author: Chung, Eun-Ju|Do, Eun-Ju|Kim, Sang-Yeob|Cho, Eun A|Kim, Dong-Hee|Pak, Sehyung|Hwang, Sung Wook|Lee, Hyo Jeong|Byeon, Jeong-Sik|Ye, Byong Duk|Yang, Dong Hoon|Park, Sang Hyoung|Yang, Suk-Kyun|Kim, Jin-Ho|Myung, Seung-Jae
PMID: 27845068
Journal: Cancer Sci. 2017 Jan;108(1):143-150.
Title: Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression.
Author: Hattori, Takuya|Sentani, Kazuhiro|Naohide, Oue|Sakamoto, Naoya|Yasui, Wataru
PMID: 27859949
Journal: Int J Mol Med. 2017 Jan;39(1):217-222.
Title: SN38 increases IL-8 expression through the MAPK pathways in HCT8 cells.
Author: Zhang, Lei|Lou, Wen-Hui|Xu, Xue-Feng|Wu, Wenchuan|Rong, Ye-Fei|Jin, Da-Yong
PMID: 27878250
Journal: Oncotarget. 2017 Jan 17;8(3):5048-5056.
Title: FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway.
Author: Li, Kun|Guo, Qunfeng|Yang, Jun|Chen, Hui|Hu, Kewen|Zhao, Juan|Zheng, Shunxin|Pang, Xiufeng|Zhou, Sufang|Dang, Yongyan|Li, Lei
PMID: 27926503
Journal: Oncol Rep. 2017 Feb;37(2):1235-1242.
Title: Fibroblast growth factor 18 promotes proliferation and migration of H460 cells via the ERK and p38 signaling pathways.
Author: Chen, Taotao|Gong, Weiyue|Tian, Haishan|Wang, Haijun|Chu, Shenghui|Ma, Jisheng|Yang, Huanhuan|Cheng, Jiliang|Liu, Min|Li, Xiaokun|Jiang, Chao
PMID: 27959447
Journal: Oncotarget. 2017 Feb 7;8(6):9251-9266.
Title: LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer.
Author: Vakana, Eliza|Pratt, Susan|Blosser, Wayne|Dowless, Michele|Simpson, Nicholas|Yuan, Xiu-Juan|Jaken, Susan|Manro, Jason|Stephens, Jennifer|Zhang, Youyan|Huber, Lysiane|Peng, Sheng-Bin|Stancato, Louis F
PMID: 27999210
Journal: Biochem J. 2017 Feb 20;474(5):647-665.
Title: Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells.
Author: Said, Anan H|Hu, Shien|Abutaleb, Ameer|Watkins, Tonya|Cheng, Kunrong|Chahdi, Ahmed|Kuppusamy, Panjamurthy|Saxena, Neeraj|Xie, Guofeng|Raufman, Jean-Pierre
PMID: 28008134
Journal: Biomed Pharmacother. 2017 Mar;87:102-109.
Title: Taspine derivative 12k suppressed A549 cell migration through the Wnt/beta-catenin and EphrinB2 signaling pathway.
Author: Dai, Bingling|Ma, Yujiao|Yang, Tianfeng|Wang, Wenjie|Zhang, Yanmin
PMID: 28049091
Journal: Eur J Pharmacol. 2017 Feb 15;797:1-8.
Title: SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer.
Author: Zhang, Li-Li|Zhan, Lin|Jin, Yong-Dong|Min, Zhen-Li|Wei, Can|Wang, Qiang|Chen, Ya-Jun|Wu, Qing-Ming|Hu, Xia-Min|Yuan, Qiong
PMID: 28088387
Journal: PLoS One. 2017 Jan 26;12(1):e0170595.
Title: Knockdown of NIK and IKKbeta-Binding Protein (NIBP) Reduces Colorectal Cancer Metastasis through Down-Regulation of the Canonical NF-kappaBeta Signaling Pathway and Suppression of MAPK Signaling Mediated through ERK and JNK.
Author: Qin, Mengbin|Zhang, Jinxiu|Xu, Chunyan|Peng, Peng|Tan, Lin|Liu, Shiquan|Huang, Jiean
PMID: 28125661
Journal: Sci Rep. 2017 Feb 6;7:38524.
Title: Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Author: Huang, Tao|Xiao, Yubo|Yi, Lin|Li, Ling|Wang, Meimei|Tian, Cheng|Ma, Hang|He, Kai|Wang, Yue|Han, Bing|Ye, Xiaoli|Li, Xuegang
PMID: 28165459
Journal: ACS Chem Biol. 2017 May 19;12(5):1217-1226.
Title: Biased Signaling by Agonists of Protease Activated Receptor 2.
Author: Jiang, Yuhong|Yau, Mei-Kwan|Kok, W Mei|Lim, Junxian|Wu, Kai-Chen|Liu, Ligong|Hill, Timothy A|Suen, Jacky Y|Fairlie, David P
PMID: 28169521
Journal: Pharmacol Ther. 2017 May;173:58-66.
Title: Targeting TRK family proteins in cancer.
Author: Khotskaya, Yekaterina B|Holla, Vijaykumar R|Farago, Anna F|Mills Shaw, Kenna R|Meric-Bernstam, Funda|Hong, David S
PMID: 28174090
Journal: Oncotarget. 2017 Mar 7;8(10):16633-16641.
Title: microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways.
Author: Wei, Ran|Yang, Qin|Han, Bing|Li, Yan|Yao, Kun|Yang, Xiuyu|Chen, Zexi|Yang, Shanshan|Zhou, Jiaqi|Li, Meizhang|Yu, Haijing|Yu, Min|Cui, Qinghua
PMID: 28186962
Journal: Mol Cell Proteomics. 2017 Apr;16(4):663-679.
Title: Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.
Author: Kubiniok, Peter|Lavoie, Hugo|Therrien, Marc|Thibault, Pierre
PMID: 28188228
Journal: Oncol Rep. 2017 Apr;37(4):2317-2323.
Title: The anti-metastatic effect of baicalein on colorectal cancer.
Author: Chai, Yuxia|Xu, Jizhong|Yan, Baojun
PMID: 28259937
Journal: Cancer Lett. 2017 Jun 28;396:145-154.
Title: Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study.
Author: Wang, Yi-Jun|Zhang, Yun-Kai|Zhang, Guan-Nan|Al Rihani, Sweilem B|Wei, Meng-Ning|Gupta, Pranav|Zhang, Xiao-Yu|Shukla, Suneet|Ambudkar, Suresh V|Kaddoumi, Amal|Shi, Zhi|Chen, Zhe-Sheng
PMID: 28302530
Journal: Cancer Lett. 2017 Jun 28;396:94-102.
Title: Co-targeting of EGFR and autophagy signaling is an emerging treatment strategy in metastatic colorectal cancer.
Author: Koustas, Evangelos|Karamouzis, Michalis V|Mihailidou, Chrysovalantou|Schizas, Dimitrios|Papavassiliou, Athanasios G
PMID: 28323034
Journal: Nucleosides Nucleotides Nucleic Acids. 2017 Apr 3;36(4):243-255.
Title: Antiproliferation effect of guanosine on HCT 116 cells involves MAPK and AMPK pathways.
Author: Teoh, Wuen Yew|Wahab, Norhanom Abdul|Sim, Kae Shin
PMID: 28323520
Journal: Oncol Rep. 2017 May;37(5):3128-3136.
Title: Regulation of intestinal myofibroblasts by KRas-mutated colorectal cancer cells through heparin-binding epidermal growth factor-like growth factor.
Author: Kawasaki, Hideyoshi|Saotome, Takuya|Usui, Tatsuya|Ohama, Takashi|Sato, Koichi
PMID: 28339087
Journal: J Ethnopharmacol. 2017 May 5;203:27-38.
Title: Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1alpha via the mTOR/p70S6K/4E-BP1 and MAPK pathways.
Author: Mi, Chunliu|Ma, Juan|Wang, Ke Si|Zuo, Hong Xiang|Wang, Zhe|Li, Ming Yue|Piao, Lian Xun|Xu, Guang Hua|Li, Xuezheng|Quan, Zhe Shan|Jin, Xuejun
PMID: 28341244
Journal: Cancer Sci. 2017 Jun;108(6):1169-1176.
Title: NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition.
Author: Wang, Yuhui|Wu, Nan|Sun, Donglin|Sun, Haiming|Tong, Dandan|Liu, Duo|Pang, Bo|Li, Su|Wei, Jia|Dai, Jialin|Liu, Yang|Bai, Jing|Geng, Jingshu|Fu, Songbin|Jin, Yan
PMID: 28346728
Journal: Biomed Pharmacother. 2017 Jun;90:179-186.
Title: Assessment of Olea europaea L. fruit extracts: Phytochemical characterization and anticancer pathway investigation.
Author: Maalej, Amina|Bouallagui, Zouhaier|Hadrich, Fatma|Isoda, Hiroko|Sayadi, Sami
PMID: 28360012
Journal: Org Biomol Chem. 2017 Apr 18;15(16):3455-3465.
Title: Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance.
Author: Wang, Lu|Zhu, Gaoyuan|Zhang, Qing|Duan, Chunqi|Zhang, Yanmin|Zhang, Zhimin|Zhou, Yujun|Lu, Tao|Tang, Weifang
PMID: 28368067
Journal: Oncogene. 2017 Jul 27;36(30):4336-4348.
Title: TGFbeta engages MEK/ERK to differentially regulate benign and malignant pancreas cell function.
Author: Principe, D R|Diaz, A M|Torres, C|Mangan, R J|DeCant, B|McKinney, R|Tsao, M-S|Lowy, A|Munshi, H G|Jung, B|Grippo, P J
PMID: 28368414
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2017 Mar 20;37(3):367-372.
Title: [Inhibitory effect of apatinib on HCT-116 cells and its mechanism].
Author: Yin, Liang|Wang, Jin|Huang, Feng-Chang|Zhang, Yun-Fei|Xu, Ning|Wen, Zheng-Qi|Li, Wen-Liang|Dong, Jian
PMID: 28377354
Journal: J Mol Endocrinol. 2017 Jul;59(1):13-27.
Title: RSK activation via ERK modulates human colon cancer cells response to PTHrP.
Author: Calvo, Natalia|Carriere, Pedro|Martin, Maria Julia|Gentili, Claudia
PMID: 28385776
Journal: Nutr Res Pract. 2017 Apr;11(2):90-96.
Title: Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells.
Author: Cha, Jae Hoon|Kim, Woo Kyoung|Ha, Ae Wha|Kim, Myung Hwan|Chang, Moon Jeong
PMID: 28386381
Journal: Oncotarget. 2017 Apr 18;8(16):26323-26333.
Title: Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer.
Author: Wang, Linlin|Yang, Dong|Tian, Jing|Gao, Aiqin|Shen, Yihang|Ren, Xia|Li, Xia|Jiang, Guosheng|Dong, Taotao
PMID: 28412748
Journal: Biochim Biophys Acta Mol Cell Res. 2017 Jul;1864(7):1246-1259.
Title: A crosstalk between muscarinic and CRF2 receptors regulates cellular adhesion properties of human colon cancer cells.
Author: Pelissier-Rota, M|Chartier, N T|Bonaz, B|Jacquier-Sarlin, M R
PMID: 28432022
Journal: Sci Rep. 2017 Apr 24;7:46632.
Title: Rational design of non-resistant targeted cancer therapies.
Author: Martinez-Jimenez, Francisco|Overington, John P|Al-Lazikani, Bissan|Marti-Renom, Marc A
PMID: 28436422
Journal: Cell Signal. 2017 Aug;36:67-78.
Title: Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis.
Author: Zhang, Fan|Lu, Yan-Xia|Chen, Qing|Zou, Hui-Mei|Zhang, Jian-Ming|Hu, Yu-Han|Li, Xiao-Min|Zhang, Wen-Juan|Zhang, Wei|Lin, Chun|Li, Xue-Nong
PMID: 28455144
Journal: Am J Chin Med. 2017;45(4):901-915.
Title: Vitex rotundifolia Fruit Extract Induces Apoptosis Through the Downregulation of ATF3-Mediated Bcl-2 Expression in Human Colorectal Cancer Cells.
Author: Song, Hun Min|Park, Gwang Hun|Koo, Jin Suk|Jeong, Hyung Jin|Jeong, Jin Boo
PMID: 28468511
Journal: Mol Cell Biol. 2017 Jul 14;37(15). pii: MCB.00012-17.
Title: Antagonistic Interactions between Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Retinoic Acid Receptor Signaling in Colorectal Cancer Cells.
Author: Imajo, Masamichi|Kondoh, Kunio|Yamamoto, Takuya|Nakayama, Kei|Nakajima-Koyama, May|Nishida, Eisuke
PMID: 28483913
Journal: Cell Cycle. 2017 Jun 18;16(12):1193-1200.
Title: The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia.
Author: Zhang, Jun|Zhou, Lanlan|Zhao, Shuai|Dicker, David T|El-Deiry, Wafik S
PMID: 28486050
Journal: Mol Oncol. 2017 Aug;11(8):1065-1077.
Title: Panitumumab interaction with TAS-102 leads to combinational anticancer effects via blocking of EGFR-mediated tumor response to trifluridine.
Author: Baba, Yuji|Tamura, Toshiya|Satoh, Yoshihiko|Gotou, Masamitsu|Sawada, Hiroshi|Ebara, Shunsuke|Shibuya, Kazunori|Soeda, Jumpei|Nakamura, Kazuhide
PMID: 28486761
Journal: Mol Carcinog. 2017 Oct;56(10):2267-2278.
Title: Fas signaling induces stemness properties in colorectal cancer by regulation of Bmi1.
Author: Chen, Jiaxuan|Wang, Yadong|Zhuo, Linghao|Liu, Zhizhong|Liu, Tao|Li, Wenjing|Cai, Yidong|Zheng, Haoxuan
PMID: 28543447
Journal: Br J Nutr. 2017 May;117(9):1212-1221.
Title: Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
Author: McCann, Mark J|Rotjanapun, Kunjana|Hesketh, John E|Roy, Nicole C
PMID: 28571588
Journal: Cell J. 2017 Spring;19(Suppl 1):106-112.
Title: Continuous or Transient High Level of Glucose Exposure Differentially Increases Coronary Artery Endothelial Cell Proliferation and Human Colon Cancer Cell Proliferation.
Author: Shimoda, Yoko|Tagaya, Yuko|Saito, Tsugumichi|Yamada, Eijiro|Osaki, Aya|Nakajima, Yasuyo|Ozawa, Atsushi|Satoh, Tetsurou|Okada, Junichi|Okada, Shuichi|Yamada, Masanobu
PMID: 28580314
Journal: BMC Gastroenterol. 2017 Jun 7;17(1):73.
Title: Anti-fibrogenic effect of PPAR-gamma agonists in human intestinal myofibroblasts.
Author: Koo, Jun Bon|Nam, Myeong-Ok|Jung, Younshin|Yoo, Jongman|Kim, Duk Hwan|Kim, Gwangil|Shin, Sung Jae|Lee, Kee Myung|Hahm, Ki Baik|Kim, Jong Woo|Hong, Sung Pyo|Lee, Kwang Jae|Yoo, Jun Hwan
PMID: 28592228
Journal: Oncotarget. 2017 Jul 18;8(29):47931-47942.
Title: TRIB1 promotes colorectal cancer cell migration and invasion through activation MMP-2 via FAK/Src and ERK pathways.
Author: Wang, Yuhui|Wu, Nan|Pang, Bo|Tong, Dandan|Sun, Donglin|Sun, Haiming|Zhang, Chunyu|Sun, Wenjing|Meng, Xiangning|Bai, Jing|Chen, Feng|Geng, Jingshu|Fu, Songbin|Jin, Yan
PMID: 28624785
Journal: Sci Rep. 2017 Jun 19;7(1):3769.
Title: Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner.
Author: Zhang, Chen|Mao, Hai-Lei|Cao, Yi
PMID: 28630428
Journal: PLoS One. 2017 Jun 22;12(6):e0179510.
Title: Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies.
Author: Kuracha, Murali R|Thomas, Peter|Loggie, Brian W|Govindarajan, Venkatesh
PMID: 28640835
Journal: Oncotarget. 2017 Jun 20;8(25):41779.
Title: Correction: CCR4 promotes metastasis via ERK/NF-kappaB/MMP13 pathway and acts downstream of TNF-alpha in colorectal cancer.
Author: Ou, Baochi|Zhao, Jingkun|Guan, Shaopei|Feng, Hao|Wangpu, Xiongzhi|Zhu, Congcong|Zong, Yaping|Ma, Junjun|Sun, Jing|Shen, Xiaohui|Zheng, Minhua|Lu, Aiguo
PMID: 28645139
Journal: NPJ Syst Biol Appl. 2017 Jun 2;3:14.
Title: Clinical responses to ERK inhibition in BRAF(V600E)-mutant colorectal cancer predicted using a computational model.
Author: Kirouac, Daniel C|Schaefer, Gabriele|Chan, Jocelyn|Merchant, Mark|Orr, Christine|Huang, Shih-Min A|Moffat, John|Liu, Lichuan|Gadkar, Kapil|Ramanujan, Saroja
PMID: 28649441
Journal: Mol Cancer Res. 2017 Oct;15(10):1431-1444.
Title: BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity.
Author: Emery, Caroline M|Monaco, Kelli-Ann|Wang, Ping|Balak, Marissa|Freeman, Alyson|Meltzer, Jodi|Delach, Scott M|Rakiec, Daniel|Ruddy, David A|Korn, Joshua M|Haling, Jacob|Acker, Michael G|Caponigro, Giordano
PMID: 28655712
Journal: Mol Med Rep. 2017 Aug;16(2):2211-2216.
Title: Effect of nonylphenol on the regulation of cell growth in colorectal cancer cells.
Author: Yang, Xuefeng|Huang, Handong|Wang, Maijian|Zheng, Xingbin|Xu, Jie|Xie, Ming
PMID: 28656208
Journal: World J Gastroenterol. 2017 Jun 28;23(24):4341-4353.
Title: Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells.
Author: Tischlerova, Viera|Kello, Martin|Budovska, Mariana|Mojzis, Jan
PMID: 28706417
Journal: Mar Drugs. 2017 Jul 20;15(7). pii: md15070221.
Title: Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-kappaB Signaling.
Author: Tarhouni-Jabberi, Safa|Zakraoui, Ons|Ioannou, Efstathia|Riahi-Chebbi, Ichrak|Haoues, Meriam|Roussis, Vassilios|Kharrat, Riadh|Essafi-Benkhadir, Khadija
PMID: 28726723
Journal: J BUON. 2017 May-Jun;22(3):696-703.
Title: Long non-coding RNA XIST functions as an oncogene in human colorectal cancer by targeting miR-132-3p.
Author: Song, Hui|He, Ping|Shao, Tiansong|Li, Yang|Li, Jin|Zhang, Yajing
PMID: 28730777
Journal: Anticancer Res. 2017 Aug;37(8):4345-4352.
Title: miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells.
Author: Long, Zhi H|Bai, Zhi G|Song, Jian N|Zheng, Zhi|Li, Jun|Zhang, Jun|Cai, Jun|Yao, Hong W|Wang, Jin|Yang, Ying C|Yin, Jie|Zhang, Zhong T
PMID: 28739727
Journal: Cell Rep. 2017 Jul 25;20(4):999-1015.
Title: A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.
Author: Anderson, Grace R|Winter, Peter S|Lin, Kevin H|Nussbaum, Daniel P|Cakir, Merve|Stein, Elizabeth M|Soderquist, Ryan S|Crawford, Lorin|Leeds, Jim C|Newcomb, Rachel|Stepp, Priya|Yip, Catherine|Wardell, Suzanne E|Tingley, Jennifer P|Ali, Moiez|Xu, Mengmeng|Ry
PMID: 28746882
Journal: Lab Invest. 2017 Nov;97(11):1343-1353.
Title: Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth.
Author: Li, Dandan|Zhang, Youyu|Liu, Kun|Zhao, Yujie|Xu, Beibei|Xu, Liang|Tan, Li|Tian, Yuan|Li, Cunxi|Zhang, Wenqing|Cao, Hanwei|Zhan, Yan-Yan|Hu, Tianhui
PMID: 28759012
Journal: Oncol Lett. 2017 Aug;14(2):2125-2130.
Title: Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11.
Author: Chen, Yan|Sun, Jin|Ma, Junyan
PMID: 28781653
Journal: Chem Biol Interact. 2017 Sep 25;275:162-170.
Title: Antitumor activity of beta-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways.
Author: Daaboul, Hamid E|Daher, Costantine F|Bodman-Smith, Kikki|Taleb, Robin I|Shebaby, Wassim N|Boulos, Joelle|Dagher, Carole|Mroueh, Mohamad A|El-Sibai, Mirvat
PMID: 28782499
Journal: PLoS One. 2017 Aug 10;12(8):e0182588.
Title: HspB5 correlates with poor prognosis in colorectal cancer and prompts epithelial-mesenchymal transition through ERK signaling.
Author: Li, Qinghua|Wang, Yanlan|Lai, Yuexing|Xu, Ping|Yang, Zhiwen
PMID: 28796798
Journal: Exp Ther Med. 2017 Aug;14(2):1357-1366.
Title: Dual inhibition of MET and SRC kinase activity as a combined targeting strategy for colon cancer.
Author: Song, Na|Qu, Xiujuan|Liu, Shizhou|Zhang, Simeng|Liu, Jing|Qu, Jinglei|Zheng, Huachuan|Liu, Yunpeng|Che, Xiaofang
PMID: 28810597
Journal: Sci Rep. 2017 Aug 15;7(1):8265.
Title: An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer.
Author: Chen, Yaqiong|Zhao, Zhi|Chen, Yu|Lv, Zhonglin|Ding, Xin|Wang, Renxi|Xiao, He|Hou, Chunmei|Shen, Beifen|Feng, Jiannan|Guo, Renfeng|Li, Yan|Peng, Hui|Han, Gencheng|Chen, Guojiang
PMID: 28811578
Journal: Biomed Pharmacother. 2017 Oct;94:1094-1100.
Title: Leuconostoc mesenteroides-derived anticancer pharmaceuticals hinder inflammation and cell survival in colon cancer cells by modulating NF-kappaB/AKT/PTEN/MAPK pathways.
Author: Zununi Vahed, Sepideh|Barzegari, Abolfazl|Rahbar Saadat, Yalda|Goreyshi, Ali|Omidi, Yadollah
PMID: 28821160
Journal: J Biol Chem. 2017 Sep 29;292(39):16321-16332.
Title: Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase Cgamma-mediated FAK/ERK signaling pathway in colon cancer.
Author: Jang, Bohee|Jung, Hyejung|Choi, Sojoong|Lee, Young Hun|Lee, Seung-Taek|Oh, Eok-Soo
PMID: 28821612
Journal: Biochem Biophys Res Commun. 2017 Oct 21;492(3):310-315.
Title: TIF1beta is phosphorylated at serine 473 in colorectal tumor cells through p38 mitogen-activated protein kinase as an oxidative defense mechanism.
Author: Shen, Larina Tzu-Wei|Chou, Han-Yi E|Kato, Mitsuyasu
PMID: 28864417
Journal: BMC Complement Altern Med. 2017 Sep 5;17(1):445.
Title: Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells.
Author: Park, Su Bin|Park, Gwang Hun|Song, Hun Min|Son, Ho-Jun|Um, Yurry|Kim, Hyun-Seok|Jeong, Jin Boo
PMID: 28870200
Journal: NPJ Syst Biol Appl. 2017 Sep 4;3:25.
Title: Erratum: Clinical responses to ERK inhibition in BRAF(V600E)-mutant colorectal cancer predicted using a computational model.
Author: Kirouac, Daniel C|Schaefer, Gabriele|Chan, Jocelyn|Merchant, Mark|Orr, Christine|Huang, Shih-Min A|Moffat, John|Liu, Lichuan|Gadkar, Kapil|Ramanujan, Saroja
PMID: 28879057
Journal: Oncotarget. 2017 May 15;8(34):56659-56671.
Title: PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition.
Author: Islam, Salman Ul|Shehzad, Adeeb|Sonn, Jong Kyung|Lee, Young Sup
PMID: 28915620
Journal: J Inorg Biochem. 2017 Dec;177:27-38.
Title: In vitro anticancer activity of new gold(III) porphyrin complexes in colon cancer cells.
Author: Dandash, Fatima|Leger, David Yannick|Fidanzi-Dugas, Chloe|Nasri, Soumaya|Bregier, Frederique|Granet, Robert|Karam, Walid|Diab-Assaf, Mona|Sol, Vincent|Liagre, Bertrand
PMID: 28923355
Journal: Oncotarget. 2017 Apr 20;8(35):58587-58600.
Title: Targeting progastrin enhances radiosensitization of colorectal cancer cells.
Author: Kowalski-Chauvel, Aline|Gouaze-Andersson, Valerie|Vignolle-Vidoni, Alix|Delmas, Caroline|Toulas, Christine|Cohen-Jonathan-Moyal, Elizabeth|Seva, Catherine
PMID: 28938581
Journal: Mol Med Rep. 2017 Nov;16(5):7796-7804.
Title: Sulforaphane induces p53deficient SW480 cell apoptosis via the ROSMAPK signaling pathway.
Author: Lan, Hai|Yuan, Hongyin|Lin, Congyao
PMID: 28944886
Journal: World J Gastroenterol. 2017 Sep 7;23(33):6111-6118.
Title: Ca(2+)/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways.
Author: Chen, Wei|An, Ping|Quan, Xiao-Jing|Zhang, Jun|Zhou, Zhong-Yin|Zou, Li-Ping|Luo, He-Sheng
PMID: 28970726
Journal: Cancer Lett. 2017 Dec 28;411:90-99.
Title: SUMOylation of IQGAP1 promotes the development of colorectal cancer.
Author: Liang, Ziwei|Yang, Yanfang|He, Yu|Yang, Pengbo|Wang, Xixi|He, Gu|Zhang, Peng|Zhu, Hongxia|Xu, Ningzhi|Zhao, Xia|Liang, Shufang
PMID: 28987385
Journal: Oncol Rep. 2017 Dec;38(6):3685-3692.
Title: Downregulation of ZNF278 arrests the cell cycle and decreases the proliferation of colorectal cancer cells via inhibition of the ERK/MAPK pathway.
Author: Tian, Xiao-Qing|Guo, Fang-Fang|Sun, Dan-Feng|Wang, Ying-Chao|Yang, Li|Chen, Sheng-Liang|Hong, Jie|Fang, Jing-Yuan
PMID: 29039562
Journal: Oncol Rep. 2017 Nov;38(5):3187-3196.
Title: MicroRNA337 inhibits colorectal cancer progression by directly targeting KRAS and suppressing the AKT and ERK pathways.
Author: Liu, Xuerong|Wang, Yan|Zhao, Jinglong
PMID: 29048669
Journal: Oncotarget. 2017 Aug 29;8(44):76574-76586.
Title: Functional consequence of the p53 codon 72 polymorphism in colorectal cancer.
Author: Katkoori, Venkat R|Manne, Upender|Chaturvedi, Lakshmi S|Basson, Marc D|Haan, Pam|Coffey, Daniel|Bumpers, Harvey L
PMID: 29100333
Journal: BMC Complement Altern Med. 2017 Nov 6;17(1):486.
Title: Coix lacryma-jobi var. ma-yuen Stapf sprout extract has anti-metastatic activity in colon cancer cells in vitro.
Author: Son, Eun Suk|Kim, Young Ock|Park, Chun Geon|Park, Kyung Hun|Jeong, Sung Hwan|Park, Jeong-Woong|Kim, Se-Hee
PMID: 29110726
Journal: Cancer Cell Int. 2017 Oct 28;17:91.
Title: miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1.
Author: Wei, Wen-Ting|Nian, Xin-Xin|Wang, Shu-Yang|Jiao, Hong-Li|Wang, Yong-Xia|Xiao, Zhi-Yuan|Yang, Run-Wei|Ding, Yan-Qing|Ye, Ya-Ping|Liao, Wen-Ting
PMID: 29118671
Journal: J Pharmacol Sci. 2017 Dec;135(4):148-155.
Title: Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner.
Author: Li, Qingran|Ding, Chujie|Meng, Tuo|Lu, Wenjie|Liu, Wenyue|Hao, Haiping|Cao, Lijuan
PMID: 29233468
Journal: Front Cell Neurosci. 2017 Dec 13;11:387.
Title: Netrin-1 Prevents Rat Primary Cortical Neurons from Apoptosis via the DCC/ERK Pathway.
Author: Chen, Jianhao|Du, Houwei|Zhang, Yixian|Chen, Hongbin|Zheng, Mouwei|Lin, Peiqiang|Lan, Quan|Yuan, Qilin|Lai, Yongxing|Pan, Xiaodong|Chen, Ronghua|Liu, Nan
PMID: 29321724
Journal: Oncotarget. 2017 Dec 5;8(67):111943-111965.
Title: Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells.
Author: Diaz-Valdivia, Natalia I|Calderon, Claudia C|Diaz, Jorge E|Lobos-Gonzalez, Lorena|Sepulveda, Hugo|Ortiz, Rina J|Martinez, Samuel|Silva, Veronica|Maldonado, Horacio J|Silva, Patricio|Wehinger, Sergio|Burzio, Veronica A|Torres, Vicente A|Montecino, Martin|L
PMID: 29340103
Journal: Oncol Lett. 2017 Dec;14(6):7923-7930.
Title: Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.
Author: Yan, Zhaokun|Feng, Jianyu|Peng, Jun|Lai, Zijun|Zhang, Ling|Jin, Yiyi|Yang, Hong|Chen, Wujin|Lin, Jiumao
PMID: 29344237
Journal: Oncol Lett. 2017 Dec;14(6):8197-8205.
Title: Hedyotis diffusa willd extract suppresses colorectal cancer growth through multiple cellular pathways.
Author: Feng, Jianyu|Jin, Yiyi|Peng, Jun|Wei, Lihui|Cai, Qiaoyan|Yan, Zhaokun|Lai, Zijun|Lin, Jiumao
PMID: 29344262
Journal: Cell Mol Immunol. 2018 Feb;15(2):135-145.
Title: HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer.
Author: Liu, Shuxun|Yi, Lin|Ling, Ma|Jiang, Jinxia|Song, Lijun|Liu, Juan|Cao, Xuetao
PMID: 27345726
Journal: J Cell Biochem. 2018 Mar;119(3):2460-2469.
Title: Therapeutic Potential of Targeting PI3K/AKT Pathway in Treatment of Colorectal Cancer: Rational and Progress.
Author: Bahrami, Afsane|Khazaei, Majid|Hasanzadeh, Malihe|ShahidSales, Soodabeh|Joudi Mashhad, Mona|Farazestanian, Marjaneh|Sadeghnia, Hamid Reza|Rezayi, Majid|Maftouh, Mina|Hassanian, Seyed Mahdi|Avan, Amir
PMID: 28230287
Journal: Integr Cancer Ther. 2018 Jun;17(2):271-281.
Title: Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-xL and BID Protein Expression by Modulating Signaling Proteins Erk(1/2) and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines.
Author: Al-Asmari, Abdulrahman Khazim|Riyasdeen, Anvarbatcha|Islam, Mozaffarul
PMID: 28438053
Journal: Oncol Res. 2018 Mar 5;26(2):209-217.
Title: Procaine Inhibits the Proliferation and Migration of Colon Cancer Cells Through Inactivation of the ERK/MAPK/FAK Pathways by Regulation of RhoA.
Author: Li, Chang|Gao, Shuohui|Li, Xiaoping|Li, Chang|Ma, Lianjun
PMID: 28492141
Journal: J Cell Commun Signal. 2018 Jun;12(2):451-466.
Title: miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells.
Author: Flum, Marion|Kleemann, Michael|Schneider, Helga|Weis, Benjamin|Fischer, Simon|Handrick, Rene|Otte, Kerstin
PMID: 28905214
Journal: Autophagy. 2018;14(1):134-151.
Title: Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.
Author: Yoo, Byong Hoon|Khan, Iman Aftab|Koomson, Ananda|Gowda, Pramod|Sasazuki, Takehiko|Shirasawa, Senji|Gujar, Shashi|Rosen, Kirill V.
PMID: 28933585
Journal: Oncogene. 2018 Jan 18;37(3):389-402.
Title: Role of JMJD2B in colon cancer cell survival under glucose-deprived conditions and the underlying mechanisms.
Author: Fu, L-N|Wang, Y-Q|Tan, J|Xu, J|Gao, Q-Y|Chen, Y-X|Fang, J-Y
PMID: 28945223
Journal: Anticancer Agents Med Chem. 2018;18(4):583-590.
Title: Oleanolic Acid Inhibits Colorectal Cancer Angiogenesis by Blocking the VEGFR2 Signaling Pathway.
Author: Niu, Guoping|Sun, Li|Pei, Yunfeng|Wang, Duping
PMID: 29065844
Journal: J Cell Biochem. 2018 Mar;119(3):2864-2874.
Title: HOXA3 promotes tumor growth of human colon cancer through activating EGFR/Ras/Raf/MEK/ERK signaling pathway.
Author: Zhang, Xianxiang|Liu, Guangwei|Ding, Lei|Jiang, Tao|Shao, Shihong|Gao, Yuan|Lu, Yun
PMID: 29073728
Journal: Oncogene. 2018 Feb 22;37(8):1031-1040.
Title: MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells.
Author: Schroyer, A L|Stimes, N W|Abi Saab, W F|Chadee, D N
PMID: 29084209
Journal: Cancer Sci. 2018 Jan;109(1):84-93.
Title: Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer.
Author: Wang, Chuanjiang|Wang, Wenxia|Liu, Yujuan|Yong, Min|Yang, Yamei|Zhou, Honggui
PMID: 29095547
Journal: Mol Oncol. 2018 Feb;12(2):224-238.
Title: MAPK inhibitors induce serine peptidase inhibitor Kazal type 1 (SPINK1) secretion in BRAF V600E-mutant colorectal adenocarcinoma.
Author: Rasanen, Kati|Dang, Kien X|Mustonen, Harri|Ho, Tho H|Lintula, Susanna|Koistinen, Hannu|Stenman, Ulf-Hakan|Haglund, Caj|Stenman, Jakob
PMID: 29193645
Journal: Mol Med Rep. 2018 Feb;17(2):2593-2599.
Title: Fibroblast activation protein-alpha in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways.
Author: Cao, Feng|Wang, Songsong|Wang, Huanqin|Tang, Wei
PMID: 29207091
Journal: Mol Cancer Res. 2018 Mar;16(3):378-389.
Title: Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer.
Author: Zhang, Peng|Kawakami, Hisato|Liu, Weizhen|Zeng, Xiangyu|Strebhardt, Klaus|Tao, Kaixiong|Huang, Shengbing|Sinicrope, Frank A
PMID: 29233910
Journal: Mol Cell Proteomics. 2018 Apr;17(4):550-564.
Title: Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells.
Author: Basken, Joel|Stuart, Scott A|Kavran, Andrew J|Lee, Thomas|Ebmeier, Christopher C|Old, William M|Ahn, Natalie G
PMID: 29255136
Journal: Am J Chin Med. 2018;46(1):191-207.
Title: Vitex rotundifolia Fruit Suppresses the Proliferation of Human Colorectal Cancer Cells through Down-regulation of Cyclin D1 and CDK4 via Proteasomal-Dependent Degradation and Transcriptional Inhibition.
Author: Song, Hun Min|Park, Gwang Hun|Park, Su Bin|Kim, Hyun-Seok|Son, Ho-Jun|Um, Yurry|Jeong, Jin Boo
PMID: 29298515
Journal: Cancer Cell Int. 2018 Jan 4;18:4.
Title: Effect of long non-coding RNA Gas5 on proliferation, migration, invasion and apoptosis of colorectal cancer HT-29 cell line.
Author: Li, Jin|Wang, Yuan|Zhang, Cheng-Gong|Xiao, Hai-Juan|Hou, Jun-Ming|He, Jing-Dong
PMID: 29308053
Journal: Oncol Rep. 2018 Mar;39(3):1516-1522.
Title: Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells.
Author: Kim, In-Hye|Nam, Taek-Jeong
PMID: 29328495
Journal: Mol Med Rep. 2018 Mar;17(3):4203-4212.
Title: Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway.
Author: You, Shuping|Li, Weihong|Guan, Yun
PMID: 29344654
Journal: Curr Mol Pharmacol. 2018;11(3):184-190.
Title: Targeting M3 Muscarinic Receptors for Colon Cancer Therapy.
Author: Felton, Jessica|Hu, Shien|Raufman, Jean-Pierre
PMID: 29357811
Journal: Bioorg Chem. 2018 Apr;77:203-214.
Title: Synthesis, anticancer assessment on human breast, liver and colon carcinoma cell lines and molecular modeling study using novel pyrazolo[4,3-c]pyridine derivatives.
Author: Metwally, Nadia Hanafy|Deeb, Emad Abdallah
PMID: 29367077
Journal: Sci Rep. 2018 Jan 29;8(1):1767.
Title: DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.
Author: Togel, Lars|Nightingale, Rebecca|Wu, Rui|Chueh, Anderly C|Al-Obaidi, Sheren|Luk, Ian|Davalos-Salas, Mercedes|Chionh, Fiona|Murone, Carmel|Buchanan, Daniel D|Chatterton, Zac|Sieber, Oliver M|Arango, Diego|Tebbutt, Niall C|Williams, David|Dhillon, Amardeep
PMID: 29379130
Journal: Sci Rep. 2018 Feb 5;8(1):2334.
Title: p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells.
Author: Zhong, Liang|Huot, Jacques|Simard, Martin J
PMID: 29402939
Journal: Cancer Discov. 2018 Apr;8(4):417-427.
Title: Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in BRAF(V600E) Colorectal Cancer.
Author: Hazar-Rethinam, Mehlika|Kleyman, Marianna|Han, G Celine|Liu, David|Ahronian, Leanne G|Shahzade, Heather A|Chen, Lifeng|Parikh, Aparna R|Allen, Jill N|Clark, Jeffrey W|Kwak, Eunice L|Faris, Jason E|Murphy, Janet E|Hong, Theodore S|Van Seventer, Emily E|Nad
PMID: 29431697
Journal: Cell Death Dis. 2018 Feb 13;9(2):217.
Title: Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling.
Author: Wang, Zhou|Ma, Lingman|Su, Mengqi|Zhou, Yiran|Mao, Ke|Li, Chengqin|Peng, Guangyong|Zhou, Changlin|Shen, Baiyong|Dou, Jie
PMID: 29440765
Journal: Adv Biol Regul. 2018 May;68:46-54.
Title: Interaction of the Wnt/beta-catenin and RAS-ERK pathways involving co-stabilization of both beta-catenin and RAS plays important roles in the colorectal tumorigenesis.
Author: Lee, Sang-Kyu|Hwang, Jeong-Ha|Choi, Kang-Yell
PMID: 29449169
Journal: Oncotarget. 2017 Dec 27;9(5):6086-6094.
Title: Construction of key signal regulatory network in metastatic colorectal cancer.
Author: Qi, Lu|Ding, Yanqing
PMID: 29464057
Journal: Oncol Lett. 2018 Mar;15(3):3820-3827.
Title: TNF-alpha promotes colon cancer cell migration and invasion by upregulating TROP-2.
Author: Zhao, Peng|Zhang, Zhongtao
PMID: 29467899
Journal: Oncol Lett. 2018 Mar;15(3):3971-3976.
Title: TGFBR1*6A is a potential modifier of migration and invasion in colorectal cancer cells.
Author: Zhou, Rui|Huang, Ying|Cheng, Boran|Wang, Yulei|Xiong, Bin
PMID: 29467907
Journal: Cancer Sci. 2018 May;109(5):1455-1467.
Title: Impairment of K-Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR-143.
Author: Akao, Yukihiro|Kumazaki, Minami|Shinohara, Haruka|Sugito, Nobuhiko|Kuranaga, Yuki|Tsujino, Takuya|Yoshikawa, Yuki|Kitade, Yukio
PMID: 29498789
Journal: Cell Death Dis. 2018 Mar 2;9(3):355.
Title: Indoleamine 2,3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages.
Author: Xue, Ying|Xiao, Han|Guo, Songhe|Xu, Banglao|Liao, Yuehua|Wu, Yixian|Zhang, Ge
PMID: 29500439
Journal: Cancer Biomark. 2018;21(4):883-891.
Title: Expressions of IGF-1, ERK, GLUT4, IRS-1 in metabolic syndrome complicated with colorectal cancer and their associations with the clinical characteristics of CRC.
Author: Hu, Jianxia|Liu, Xiaoyi|Chi, Jingwei|Che, Kui|Feng, Yan|Zhao, Shihua|Wang, Zhongchao|Wang, Yangang
PMID: 29504525
Journal: Clin Colorectal Cancer. 2018 Jun;17(2):e331-e352.
Title: Phosphorylation of p70 Ribosomal Protein S6 Kinase beta-1 is an Independent Prognostic Parameter in Metastatic Colorectal Cancer.
Author: Wiesweg, Marcel|Reis, Henning|Koster, Tobias|Goetz, Moritz|Worm, Karl|Herold, Thomas|Paul, Andreas|Dechene, Alexander|Schumacher, Brigitte|Markus, Peter|Virchow, Isabel|Kostbade, Karina|Wolf, Nathalie|Zaun, Gregor|Metzenmacher, Martin|Schmid, Kurt W|Schul
PMID: 29526493
Journal: Clin Exp Pharmacol Physiol. 2018 Jul;45(7):729-741.
Title: Inhibition of microRNA-21-3p suppresses proliferation as well as invasion and induces apoptosis by targeting RNA-binding protein with multiple splicing through Smad4/extra cellular signal-regulated protein kinase signalling pathway in human colorectal can
Author: Hou, Nengyi|Guo, Zhiyi|Zhao, Gaoping|Jia, Guiqing|Luo, Bin|Shen, Xiaogang|Bai, Yifeng
PMID: 29542167
Journal: Oncol Lett. 2018 Apr;15(4):5465-5472.
Title: Expression of factors and key components associated with the PI3K signaling pathway in colon cancer.
Author: Chen, Hua|Gao, Junyi|Du, Zhenhua|Zhang, Xuequn|Yang, Fei|Gao, Wei
PMID: 29552187
Journal: Oncotarget. 2017 Dec 8;9(17):13167-13180.
Title: Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells.
Author: Chen, Hsin-Pao|Lee, Yung-Kuo|Huang, Shih Yin|Shi, Pei-Chun|Hsu, Ping-Chi|Chang, Chuan-Fa
PMID: 29568348
Journal: Cancer Discov. 2018 Apr;8(4):389-391.
Title: Advances on the BRAF Front in Colorectal Cancer.
Author: Janku, Filip
PMID: 29610287
Journal: Cell Physiol Biochem. 2018;46(2):492-504.
Title: Propofol Disrupts Aerobic Glycolysis in Colorectal Cancer Cells via Inactivation of the NMDAR-CAMKII-ERK Pathway.
Author: Chen, Xiangyuan|Wu, Qichao|Sun, Pengfei|Zhao, Yanjun|Zhu, Minmin|Miao, Changhong
PMID: 29614493
Journal: Int J Oncol. 2018 Jun;52(6):2031-2040.
Title: p38 inhibitor inhibits the apoptosis of cowanin-treated human colorectal adenocarcinoma cells.
Author: Chowchaikong, Nittiya|Nilwarangkoon, Sirinun|Laphookhieo, Surat|Tanunyutthawongse, Chantra|Watanapokasin, Ramida
PMID: 29620273
Journal: Cell Physiol Biochem. 2018;46(2):829-846.
Title: Gambogic Acid Efficiently Kills Stem-Like Colorectal Cancer Cells by Upregulating ZFP36 Expression.
Author: Wei, Fang|Zhang, Tong|Yang, Zhi|Wei, Jian-Chang|Shen, Hong-Fen|Xiao, Dong|Wang, Qiang|Yang, Ping|Chen, Hua-Cui|Hu, He|Chen, Zhuan-Peng|Huang, Qing|Li, Wang-Lin|Cao, Jie
PMID: 29627822
Journal: Cancer Inform. 2018 Mar 26;17:1176935118766522.
Title: The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs.
Author: Slattery, Martha L|Mullany, Lila E|Sakoda, Lori C|Wolff, Roger K|Samowitz, Wade S|Herrick, Jennifer S
PMID: 29636593
Journal: Oncogene. 2018 Jul;37(28):3790-3805.
Title: Collagen IV-conveyed signals can regulate chemokine production and promote liver metastasis.
Author: Vaniotis, George|Rayes, Roni F|Qi, Shu|Milette, Simon|Wang, Ni|Perrino, Stephanie|Bourdeau, France|Nystrom, Hanna|He, Yi|Lamarche-Vane, Nathalie|Brodt, Pnina
PMID: 29651051
Journal: J Agric Food Chem. 2018 May 23;66(20):5139-5148.
Title: Andrographolide Antagonizes TNF-alpha-Induced IL-8 via Inhibition of NADPH Oxidase/ROS/NF-kappaB and Src/MAPKs/AP-1 Axis in Human Colorectal Cancer HCT116 Cells.
Author: Yuan, Miaomiao|Meng, Wei|Liao, Wenzhen|Lian, Sen
PMID: 29672044
Journal: Oncotarget. 2018 Mar 30;9(24):17066-17077.
Title: Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells.
Author: Scheers, Nathalie M|Pereira, Dora I A|Faria, Nuno|Powell, Jonathan J
PMID: 29682205
Journal: Int J Mol Med. 2018 Jul;42(1):665-673.
Title: MicroRNA125 inhibits RKO colorectal cancer cell growth by targeting VEGF.
Author: Wu, Qi-Bing|Chen, Jing|Zhu, Jia-Wei|Yin, Xin|You, He-Yang|Lin, Yi-Rong|Zhu, Hua-Qing
PMID: 29693153
Journal: Expert Rev Mol Diagn. 2018 Jun;18(6):499-512.
Title: BRAF-mutant colorectal cancer, a different breed evolving.
Author: Lai, Eleonora|Pretta, Andrea|Impera, Valentino|Mariani, Stefano|Giampieri, Riccardo|Casula, Laura|Pusceddu, Valeria|Coni, Pierpaolo|Fanni, Daniela|Puzzoni, Marco|Demurtas, Laura|Ziranu, Pina|Faa, Gavino|Scartozzi, Mario
PMID: 29708446
Journal: Cell Calcium. 2018 Jun;72:70-80.
Title: Oncogenic KRAS suppresses store-operated Ca(2+) entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines.
Author: Pierro, Cristina|Zhang, Xuexin|Kankeu, Cynthia|Trebak, Mohamed|Bootman, Martin D|Roderick, H Llewelyn
PMID: 29748135
Journal: Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2769-2784.
Title: LIFR promotes tumor angiogenesis by up-regulating IL-8 levels in colorectal cancer.
Author: Wu, Hao-Xuan|Cheng, Xi|Jing, Xiao-Qian|Ji, Xiao-Pin|Chen, Xian-Ze|Zhang, Ya-Qi|He, Yong-Gang|Liu, Kun|Ye, Feng|Sun, Han-Xing|Gao, Hao-Ji|Song, Zi-Jia|Wu, Huo|Zhang, Xiao-Jian|Zhang, Tao|Zhao, Ren
PMID: 29751081
Journal: J Cell Biochem. 2018 Sep;119(9):7256-7263.
Title: Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A.
Author: Zhang, Rui|Xu, Jian|Zhao, Jian|Bai, Jing H
PMID: 29761838
Journal: Cell Physiol Biochem. 2018;47(2):680-693.
Title: Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells.
Author: Gong, Shu|Xu, Dongsheng|Zhu, Jialin|Zou, Fangdong|Peng, Rui
PMID: 29794421
Journal: Oncol Rep. 2018 Aug;40(2):813-822.
Title: shRNAinduced knockdown of the SPERT gene inhibits proliferation and promotes apoptosis of human colorectal cancer RKO cells.
Author: Zheng, Long-Zhi|Chen, Si-Zeng
PMID: 29845259
Journal: Mol Carcinog. 2018 Oct;57(10):1300-1310.
Title: AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells.
Author: Huang, Chenfei|Cao, Zhe|Ma, Jun|Shen, Yi|Bu, Yiwen|Khoshaba, Ramina|Shi, Guiyuan|Huang, Dan|Liao, Duan-Fang|Ji, Haitao|Jin, Junfei|Cao, Deliang
PMID: 29846015
Journal: Int J Mol Sci. 2018 May 31;19(6). pii: ijms19061625.
Title: NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway.
Author: Dubey, Navneet Kumar|Peng, Bou-Yue|Lin, Chien-Min|Wang, Peter D|Wang, Joseph R|Chan, Chun-Hao|Wei, Hong-Jian|Deng, Win-Ping
PMID: 29857489
Journal: Biomed Pharmacother. 2018 Aug;104:806-816.
Title: Dioscorea bulbifera induced apoptosis through inhibition of ERK 1/2 and activation of JNK signaling pathways in HCT116 human colorectal carcinoma cells.
Author: Ahmad Hidayat, Ahmad Fadhlurrahman|Chan, Chim Kei|Mohamad, Jamaludin|Abdul Kadir, Habsah
PMID: 29860114
Journal: NPJ Precis Oncol. 2018 Jan 23;2(1):2.
Title: Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a beta1-integrin-FAK-YAP1/TAZ signaling pathway.
Author: Xiang, Xiaoyu|Wang, Yuanguo|Zhang, Hongbin|Piao, Jinhua|Muthusamy, Selvaraj|Wang, Lei|Deng, Yibin|Zhang, Wei|Kuang, Rui|Billadeau, Daniel D|Huang, Shengbing|Lai, Jinping|Urrutia, Raul|Kang, Ningling
PMID: 29872721
Journal: Cell Commun Signal. 2018 Jun 8;16(1):26.
Title: Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1alpha axis.
Author: Li, Qingguo|Li, Yaqi|Liang, Lei|Li, Jing|Luo, Dakui|Liu, Qi|Cai, Sanjun|Li, Xinxiang
PMID: 29884183
Journal: Am J Transl Res. 2018 May 15;10(5):1522-1530. eCollection 2018.
Title: FOXD1 predicts prognosis of colorectal cancer patients and promotes colorectal cancer progression via the ERK 1/2 pathway.
Author: Pan, Fengping|Li, Minjiang|Chen, Wenbin
PMID: 29887965
Journal: Oncol Rep. 2018 Aug;40(2):704-714.
Title: Fibroblast growth factor 18 promotes the growth, migration and invasion of MDAMB231 cells.
Author: Yu, Ziyi|Lou, Longquan|Zhao, Yi
PMID: 29901199
Journal: J Transl Med. 2018 Jun 19;16(1):169.
Title: CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin.
Author: Xu, Jingjing|Zhou, Jun|Dai, Hanjue|Liu, Fei|Li, Wenjing|Wang, Wenjuan|Guo, Feng
PMID: 29921293
Journal: J Cell Physiol. 2018 Nov;233(11):8526-8537.
Title: EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis.
Author: Hong, Guoju|Kuek, Vincent|Shi, Jiaxi|Zhou, Lin|Han, Xiaorui|He, Wei|Tickner, Jennifer|Qiu, Heng|Wei, Qiushi|Xu, Jiake
PMID: 29923200
Journal: Oncol Lett. 2018 Jun;15(6):9719-9724.
Title: Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells.
Author: Xu, Chunyan|Zhang, Wenlu|Liu, Shiquan|Wu, Wenhong|Qin, Mengbin|Huang, Jiean
PMID: 29928348
Journal: Cancer Res. 2018 Sep 1;78(17):4839-4852.
Title: Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer.
Author: Stevens, Payton D|Wen, Yang-An|Xiong, Xiaopeng|Zaytseva, Yekaterina Y|Li, Austin T|Wang, Chi|Stevens, Ashley T|Farmer, Trevor N|Gan, Tong|Weiss, Heidi L|Inagaki, Masaki|Marchetto, Sylvie|Borg, Jean-Paul|Gao, Tianyan
PMID: 29980571
Journal: Br J Cancer. 2018 Jul 10. pii: 10.1038/s41416-018-0174-y.
Title: ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer.
Author: Roseweir, Antonia K|Halcrow, Elaine S|Chichilo, Sergey|Powell, Arfon Gmt|McMillan, Donald C|Horgan, Paul G|Edwards, Joanne
PMID: 29988110
Journal: Mol Cell Endocrinol. 2018 Jul 21. pii: S0303-7207(18)30221-1.
Title: Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP.
Author: Martin, Maria Julia|Gigola, Graciela|Zwenger, Ariel|Carriquiriborde, Martin|Gentil, Florencia|Gentili, Claudia
PMID: 30009852
Journal: Dev Reprod. 2018 Jun;22(2):133-142.
Title: Combination of BEZ235 and Metformin Has Synergistic Effect on Cell Viability in Colorectal Cancer Cells.
Author: Kim, Taewan|Kim, Taehyung|Choi, Soonyoung|Ko, Hyeran|Park, Deokbae|Lee, Youngki
PMID: 30023463
Journal: Cell Physiol Biochem. 2018;48(3):1188-1200.
Title: The Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis in Intestinal Epithelial Cells Regulates Intestinal Barrier Function During Intestinal Epithelial Cells-CD4+T-Cell Interactions.
Author: Chen, Tanzhou|Lin, Ruoyang|Jin, Sisi|Chen, Renpin|Xue, Haibo|Ye, Huajun|Huang, Zhiming
PMID: 30045015
Journal: J Cell Physiol. 2018 Aug 4.
Title: Restoration of miR-152 expression suppresses cell proliferation, survival, and migration through inhibition of AKT-ERK pathway in colorectal cancer.
Author: Ghazanchaei, Ardavan|Mansoori, Behzad|Mohammadi, Ali|Biglari, Alireza|Baradaran, Behzad
PMID: 30076720
Journal: Phytomedicine. 2018 Jul 15;46:131-141.
Title: Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo.
Author: Li, Mingyue|Yue, Grace Gar-Lee|Tsui, Stephen Kwok-Wing|Fung, Kwok-Pui|Lau, Clara Bik-San
PMID: 30097113
Journal: BMC Cancer. 2018 Aug 13;18(1):812.
Title: Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment.
Author: Tosi, Diego|Perez-Gracia, Esther|Atis, Salima|Vie, Nadia|Combes, Eve|Gabanou, Melissa|Larbouret, Christel|Jarlier, Marta|Mollevi, Caroline|Torro, Adeline|Del Rio, Maguy|Martineau, Pierre|Gongora, Celine
PMID: 30103709
Journal: PLoS One. 2018 Aug 17;13(8):e0200836.
Title: Molecular subtypes of colorectal cancer in pre-clinical models show differential response to targeted therapies: Treatment implications beyond KRAS mutations.
Author: Pal, Rekha|Wei, Ning|Song, Nan|Wu, Shaoyu|Kim, Rim S|Wang, Ying|Gavin, Patrick G|Lucas, Peter C|Srinivasan, Ashok|Allegra, Carmen J|Jacobs, Samuel A|Paik, Soonmyung|Schmitz, John C|Pogue-Geile, Katherine L
PMID: 30118499
Journal: Mol Oncol. 2018 Sep 1.
Title: miR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways.
Author: Wang, Lu-Qin|Yu, Peng|Li, Bin|Guo, Yan-Hua|Liang, Zi-Rui|Zheng, Ling-Ling|Yang, Jian-Hua|Xu, Hui|Liu, Shun|Zheng, Li-Si|Zhou, Hui|Qu, Liang-Hu
PMID: 30171794
Journal: J Natl Compr Canc Netw. 2018 Sep;16(9):1035-1040.
Title: Targeting BRAF Mutations in High-Grade Neuroendocrine Carcinoma of the Colon.
Author: Burkart, Jarred|Owen, Dwight|Shah, Manisha H|Abdel-Misih, Sherif R Z|Roychowdhury, Sameek|Wesolowski, Robert|Haraldsdottir, Sigurdis|Reeser, Julie W|Samorodnitsky, Eric|Smith, Amy|Konda, Bhavana
PMID: 30181415
Journal: J Cancer. 2018 Jul 30;9(17):3032-3037.
Title: NCOA4-RET fusion in colorectal cancer: Therapeutic challenge using patient-derived tumor cell lines.
Author: Kim, Sun Young|Oh, Seiyoon Oh|Kim, Kyung|Lee, Jeeyun|Kang, SoYoung|Kim, Kyoung-Mee|Lee, WooYong|Kim, Seung Tae|Nam, Dohyun Nam
PMID: 30210625
Journal: Biomed Pharmacother. 2018 Sep 12;108:119-129.
Title: FABP7 promotes cell proliferation and survival in colon cancer through MEK/ERK signaling pathway.
Author: Ma, Ran|Wang, Lan|Yuan, Fang|Wang, Shaoxuan|Liu, Yingping|Fan, Tingting|Wang, Fulai
PMID: 30218856
Journal: J Exp Clin Cancer Res. 2018 Sep 19;37(1):231.
Title: HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways.
Author: Li, Qing|Wang, Cong|Wang, Yufeng|Sun, Liankang|Liu, Zhikui|Wang, Liang|Song, Tao|Yao, Yingmin|Liu, Qingguang|Tu, Kangsheng
PMID: 30231922
Journal: Front Chem. 2018 Aug 23;6:373.
Title: Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer.
Author: Mioc, Marius|Avram, Sorin|Bercean, Vasile|Kurunczi, Ludovic|Ghiulai, Roxana M|Oprean, Camelia|Coricovac, Dorina E|Dehelean, Cristina|Mioc, Alexandra|Balan-Porcarasu, Mihaela|Tatu, Calin|Soica, Codruta
PMID: 30234098
Journal: Biomed Pharmacother. 2018 Sep 19;108:618-624.
Title: PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/beta-catenin signaling pathway.
Author: Gao, Sikang|Hu, Junwu|Wu, Xiongwen|Liang, Zhihui
PMID: 30243096
Journal: Cell Death Dis. 2018 Sep 26;9(10):1004.
Title: HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer.
Author: Huang, Chih-Yang|Chiang, Shu-Fen|Chen, William Tzu-Liang|Ke, Tao-Wei|Chen, Tsung-Wei|You, Ying-Shu|Lin, Chen-Yu|Chao, K S Clifford|Huang, Chih-Yang
PMID: 30258050
Journal: Arch Virol. 2018 Sep 26. pii: 10.1007/s00705-018-4026-0.
Title: Suppression of angiogenesis and tumor growth by recombinant T4 phages displaying extracellular domain of vascular endothelial growth factor receptor 2.
Author: Zuo, Shuguang|Dai, Gongpeng|Wang, Liping|Wen, Yuqing|Huang, Zhiang|Yang, Wenyi|Ma, Wanli|Ren, Xuequn
PMID: 30259141
Journal: BMB Rep. 2018 Oct 1.
Title: STK899704 inhibits stemness of cancer stem cells and migration via the FAK-MEK-ERK pathway in HT29 cells.
Author: Jang, Hui-Ju|Bak, Yesol|Pham, Thu-Huyen|Kwon, Sae-Bom|Kim, Bo-Yeon|Hong, JinTae|Yoon, Do-Young
PMID: 30269740
Journal: Int J Mol Med. 2018 Oct 1.
Title: MicroRNA-145 regulates the proliferation, migration and invasion of human primary colon adenocarcinoma cells by targeting MAPK1.
Author: Yang, Yong|Li, Xiao-Jia|Li, Peng|Guo, Xiu-Tian
PMID: 30272312
Journal: Mol Med Rep. 2018 Sep 27.
Title: miR124 inhibits cell growth through targeting IQGAP1 in colorectal cancer.
Author: Fan, Jianyu|Zhang, Wenjing|Wu, Yanting|Wan, Ping|Guo, Qiang|Zhang, Yu
PMID: 30272357
Journal: Anticancer Res. 2018 Oct;38(10):5693-5701.
Title: miR-3148 Is a Novel Onco-microRNA that Potentiates Tumor Growth In Vivo.
Author: Akamine, Takaki|Morodomi, Yosuke|Harada, Yui|Teraishi, Koji|Tagawa, Tetsuzo|Okamoto, Tatsuro|Maehara, Yoshihiko|Yonemitsu, Yoshikazu
PMID: 30275189
Journal: Cancer Epidemiol Biomarkers Prev. 2018 Oct 5. pii: 1055-9965.EPI-18-0121.
Title: Incremental Elevations in TNFalpha and IL6 in the Human Colon and Procancerous Changes in the Mucosal Transcriptome Accompany Adiposity.
Author: Pfalzer, Anna C|Leung, Keith|Crott, Jimmy W|Kim, Susan J|Tai, Albert K|Parnell, Laurence D|Kamanu, Frederick K|Liu, Zhenhua|Rogers, Gail|Shea, M Kyla|Garcia, Paloma E|Mason, Joel B
PMID: 30291114
Journal: Mol Ther Nucleic Acids. 2018 Sep 13;13:244-255.
Title: Antisense Oligonucleotides against miR-21 Inhibit the Growth and Metastasis of Colorectal Carcinoma via the DUSP8 Pathway.
Author: Ding, Tao|Cui, Panpan|Zhou, Ya|Chen, Chao|Zhao, Juanjuan|Wang, Hairong|Guo, Mengmeng|He, Zhixu|Xu, Lin
PMID: 30317164
Journal: Biosci Rep. 2018 Oct 17. pii: BSR20181233.
Title: Systematic identification of celastrol-binding proteins reveals that Shoc2 is inhibited by celastrol.
Author: Huang, Xiao-Pei|Chen, Ji-Kuai|Xu, Wei|Dong, Yi-Fan|Yan, Lang|Zhang, Xiao-Fang|Pan, Ya-Min|Chang, Wen-Jun|Zhu, Jiang-Bo
PMID: 30333251
Journal: Biomed Res Int. 2018 Sep 27;2018:2548378.
Title: alpha-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-kappaB Signaling in Colon Cancer Cells.
Author: Sun, Dongdong|Shen, Weixing|Zhang, Feng|Fan, Huisen|Tan, Jiani|Li, Liu|Xu, Changliang|Zhang, Haibin|Yang, Ye|Cheng, Haibo
PMID: 30363706
Journal: Oncol Rep. 2018 Oct 25.
Title: PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway.
Author: Tang, Bo|Liang, Wenjin|Liao, Yong|Li, Zeming|Wang, Yan|Yan, Chao
PMID: 30365128
Journal: Cell Cycle. 2018 Nov 1.
Title: Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1.
Author: Ye, Cheng-Yu|Zheng, Cui-Ping|Ying, Wei-Wei|Weng, Shan-Shan
PMID: 30382763
Journal: BMC Cancer. 2018 Nov 1;18(1):1056.
Title: The small organic molecule C19 binds and strengthens the KRAS4b-PDEdelta complex and inhibits growth of colorectal cancer cells in vitro and in vivo.
Author: Cruz-Nova, Pedro|Schnoor, Michael|Correa-Basurto, Jose|Bello, Martiniano|Briseno-Diaz, Paola|Rojo-Dominguez, Arturo|Ortiz-Mendoza, Carlos M|Guerrero-Aguirre, Jorge|Garcia-Vazquez, Francisco J|Hernandez-Rivas, Rosaura|Thompson-Bonilla, Maria Del Rocio|Varg
PMID: 30382908